Bone morphogenetic protein 4 inhibits cell proliferation and induces apoptosis in glioma stem cells

Cancer Biotherapy and Radiopharmaceuticals

Volumn 26, Issue 1, 2011, Pages 77-83

  Zhou, Zhimin ^a   Sun, Lihua ^a   Wang, Yingyi ^a   Wu, Zhifeng ^a   Geng, Jiong ^a   Miu, Weifeng ^a   Pu, Yi ^a   You, Yongping ^a   Yang, Zhengxiang ^a   Liu, Ning ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; BMP4; glioma; GSCs; proliferation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CYCLIN D1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GLIOMA; HUMAN; HUMAN CELL; NEURAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CYCLIN D1; DOWN-REGULATION; GLIOMA; HUMANS; NEOPLASTIC STEM CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; VINCRISTINE;

EID: 79952180735     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2010.0857     Document Type: Article

References (26)

1. Ohgaki H, Dessen P, Jourde B, et al. Genetic pathways to glioblastoma: A population-based study. Cancer Res 2004; 64:6892.
2. Sanai N, Alvarez-Buylla A, Berger MS. Neural stem cells and the origin of gliomas. N Engl J Med 2005;353:811.
3. Yu SC, Ping YF, Yi L, et al. Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87. Cancer Lett 2008;265:124.
4. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature 2004;432:396.
5. Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105.
6. Moon BS, Yoon JY, Kim MY, et al. Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway. Exp Mol Med 2009;41:116.
7. Miyazono K, ten Dijke P, Heldin CH. TGF-beta signaling by Smad proteins. Adv Immunol 2000;75:115.
8. Mehler MF, Mabie PC, Zhang D, et al. Bone morphogenetic proteins in the nervous system. Trends Neurosci 1997;20:309.
9. Mizuseki K, Sakamoto T, Watanabe K, et al. Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci USA 2003;100:5828.
10. Liu SY, Zhang ZY, Song YC, et al. SVZa neural stem cells differentiate into distinct lineages in response to BMP4. Exp Neurol 2004;190:109.
11. Nakano I, Kornblum HI. Brain tumor stem cells. Pediatr Res 2006;59:54.
12. Ignatova TN, Kukekov VG, Laywell ED, et al. Human cor-tical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002;39:193.
13. Vescovi AL, Galli R, Reynolds BA. Brain tumour stem cells. Nat Rev Cancer 2006;6:425.
14. Wechsler-Reya R, Scott MP. The developmental biology of brain tumors. Annu Rev Neurosci 2001;24:385.
15. Donnellan R, Chetty R. Cyclin D1 and human neoplasia. Mol Pathol 1998;51:1.
16. Ou Y, Guo XL. Tumor stem cells and drug resistance. Sheng Li Ke Xue Jin Zhan 2007;38:115.
17. Bao S, Wu Q, McLendon RE, et al. Glioma stem cells pro-mote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756.
18. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63:5821.
19. Clement V, Dutoit V, Marino D, et al. Limits of CD133 as a marker of glioma self-renewing cells. Int J Cancer 2009; 125:244.
20. Kondo T, Setoguchi T, Taga T. Persistence of a small sub-population of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA 2004;101:781.
21. Perez-Valle S, Peinador M, Herraiz P, et al. Vincristine, an efficacious alternative for diffuse neonatal haemangioma-tosis. Acta Paediatr 2010;99:311.
22. Piccirillo SG, Reynolds BA, Zanetti N, et al. Bone mor-phogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006; 444:761.
23. MacKenzie B, Wolff R, Lowe N, et al. Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice. Dev Biol 2009;328:13.
24. Guha U, Gomes WA, Kobayashi T, et al. In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb. Dev Biol 2002;249:108.
25. Kiyono M, Shibuya M. Bone morphogenetic protein 4 me-diates apoptosis of capillary endothelial cells during rat pu-pillary membrane regression. Mol Cell Biol 2003;23:4627.
26. Lagna G, Nguyen PH, Ni W, et al. BMP-dependent activa-tion of caspase-9 and caspase-8 mediates apoptosis in pul-monary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2006;291:1059.