Moringa oleifera Lam. leaves prevent cyclophosphamide-induced micronucleus and DNA damage in mice

International Journal of Phytomedicine

Volumn 2, Issue 2, 2010, Pages 147-154

  Sathya, T N ^a   Aadarsh, P ^a   Deepa, V ^a   Balakrishna Murthy, P ^a  

^a International Institute of Biotechnology and Toxicology   (India)

Author keywords

Anti genotoxic; Chemoprevention; Comet assay; M. oleifera; Micronucleus assay

Indexed keywords

CYCLOPHOSPHAMIDE; MORINGA OLEIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; COMET ASSAY; CONTROLLED STUDY; DIABETES MELLITUS; DNA DAMAGE; DRUG EFFICACY; ERYTHROCYTE; FEMALE; GENOTOXICITY; IN VIVO STUDY; MICRONUCLEUS; MOUSE; NONHUMAN; PLANT LEAF;

EID: 79952169367     PISSN: None     EISSN: 09750185     Source Type: Journal    
DOI: 10.5138/ijpm.2010.0975.0185.02023     Document Type: Article

References (44)

1. Renner HW. In vivo effect of single or combined dietary antimutagens on mutagen induced chromosomal aberrations. Mutat Res. 1990; 244: 185-188.
2. Hartwell JL. Plants used against cancer: a survey. Lloydia. 1967-197; 130-34.
3. Fahey JW, Zalcmann AT and Talalay P. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 2001; 56(1): 5-51. [Corrigendum: Phytochemistry 59: 237].
4. Bennett RN, Mellon FA, Foidl N, Pratt JH, DuPont MS, Perkins L and Kroon PA. Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (Horseradish tree) and Moringa stenopetala L. J. Agri. Food Chem.2003; 3546-3553.
5. Fahey JW, Dinkova-Kostova AT and Talalay P. The "Prochaska" microtiter plate bioassay for inducers of NQO1. Chapter 14 in Methods in Enzymology, 2004. Vol. 382, Part B, pp. 243-258 (Eds.) H. Sies & L. Packer, Elsevier Science, San Diego, CA.
6. Guevara AP, Vargas C, Sakurai H, Fujiwara Y, Hashimoto K, Maoka T, Kozuka M, Ito Y, Tokuda H and Nishino H. An antitumor promoter from Moringa oleifera Lam. Mutat. Res.1999; 440: 181-188.
7. Murakami A, Kitazono Y, Jiwajinda S, Koshimizu K, Ohigashi H. Niaziminin, thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation. Planta Med. 1998; 64 (4): 319-323.
8. Bharali R, Tabassum J and Azad MRH. Chemomodulatory effect of Moringa oleifera, Lam, on hepatic carcinogen metabolizing enzymes, antioxidant parameters and skin papillomagenesis in mice. Asian Pacific Journal of Cancer Prevention 2003; 4: 131-139
9. Kirtikar KR and Basu BD. In: Bishen Singh and Mahendra Pal Singh (Eds) Indian Medicinal Plant, Dehradun, 1935. pp. 677-681.
10. Caceres A, Saravia A, Rizzo S, Zabala L, Leon ED, Nave F. Pharmacological properties of Moringa oleifera: screening for antispasmodic, anti-inflammatory and diuretic activity. J. Ethnopharmacol. 1992; 36, 233-237.
11. Udupa SL, Udupa AL, Kulkarni DR. Studies on the anti-in.ammatory and wound healing properties of Moringa oleifera and Aegle marmelos. Fitoterapia 1994; 65: 119-123.
12. Pal SK, Mukherjee PK, Saha BP. Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats. Phytother Res.1995; 9: 463-465.
13. Pal SK, Mukherjee PK, Saha K, Pal M and Saha BP. Studies on some psychopharmacological actions of Moringa oleifera Lam. (moringaceae) leaf extract. Phytother Res 1996; 10: 402-405.
14. Jaiswal, Prashant KR, Amit K, Shikha M and Geeta W. J. Ethnopharmacol. 2009; 123:392-396
15. Shukla S, Mathur R and Prakash AO. Effects of aqueous extract of Moringa oleifera Lam. on the periodicity of oestrous cycle in adult intact rats. Indian J Pharma sci. 1981; 49: 218-219.
16. Prakash A. Ovarian response to aqueous extract of Moringa oleifera. Fitoterapia 1998;59: 89-91.
17. Tahiliani P and Kar A. Role of Moringa oleifera leaf extract in regulation of thyroid hormone status in adult male and female rats. Pharma. Res. 2000; 41: 319-323.
18. Makkar HPS and Becker K. Nutritional value and anti-nutritional components of whole and ethanol extracted Moringa oleifera leaves. Animal Feed Sci Tech 1996; 63: 211-228.
19. Freiberger CE, Vanderjagt DJ, Pastuszyn A, Glew RS, Mounkaila G, Millson M and Glew RH. Nutrient contents of the edible leaves of seven wild plants from Niger. Plant Foods for Human Nutrition 1998; 53, 57-69.
20. Nambiar VS and Seshadri S. Bioavailability trials of ¡-carotene from fresh and dehydrated drumstick leaves (Moringa oleifera) in a rat model. Plant Foods for Human Nutrition. 2001; 56: 83-95.
21. Lakshminarayana R, Raju M, Krishnakantha TP and Baskaran V. Determination of major carotenoids in a few Indian leafy vegetables by high-performance liquid chromatography. J Agri Food Chem 2005; 53, 2838-2842.
22. Sanchez MDI, Lopez CJ and Vazquez NJR. High-performance liquid chromatography method to measure 2- and ¡-tocopherol in leaves, flowers and fresh beans from Moringa oleifera. J. Chrom. 2006; 1105: 111-114.
23. Mondal S, Chakraborty I, Pramanik M, Rout D and Islamm SS. Structural studies of an immunoenhancing polysaccharide isolated from mature pods (fruits) of Moringa oleifera (Sajina). Med Chem Res 2004; 13: 390-400.
24. Nair AGR and Subramanian SS. Pigments of the lowers of Moringa pterygosperma. Curr Sci. 1962; 31: 155-156.
25. Siddhuraju P and Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agro climatic origins of drumsticks tree (Moringa oleifera Lam.) leaves. J. Agri. Food Chem. 2003; 51: 44-55.
26. Chuang PH, Lee CW, Chou JY, Murugan M, Shieh BJ and Chen HM. Antifungal activity of crude extracts and essential oils of Moringa oleifera Lam. Biores. Tech. 2007; 98, 232-236.
27. Nepolean P, Anitha J and Emilin RR. Isolation, analysis and identification of phytochemicals of antimicrobial activity of Moringa oleifera Lam. Current Biotica. 2009; 3 (1).
28. Rao AV, Devi PU and Kamath R. In vivo radioprotective effect of Moringa oleifera leaves. Indian J Exp Biol. 2001; 39(9): 858-63.
29. Krishna G and Hayashi M. In vivo rodent Micronucleus assay: protocol, conduct and data interpretation. Mutat Res. 2000; 455: 155-166.
30. Sasaki YF, Tsuda S, Izumiyama F, Nishidate E. Detection chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay. Mutat Res 1997; 388: 33-44.
31. Regildo MGS, Neila CS, Ulrich G, Mário AS. Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster. Gen. Mol. Bio.2008; 31(3).
32. Schmid W. The micronucleus test. Mutat Res. 1975; 31:9-15.
33. Singh NP, McCoy MT, Tice RR and Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175:184-191.
34. Collins AR, Duthie SJ and Dobson VL. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 1993; 14, 1733-1735.
35. Kanekal S, Fraiser L and Kehrer JP. Pharmacokinetics, metabolic activation and lung toxicity of cyclophosphamide in C57BL6 and ICR mice. Tox Appl Pharmacol. 1992; 114:1-8.
36. Chumark P, Khunawat P, Sanvarinda Y, Phornchirasilp S, Morales NP. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam Leaves. J Ethnopharmacol. 2008; 116, 439-446.
37. Iqbal S and Bhanger MI. Effect of season and production location on antioxidant activity of Moringa oleifera leaves grown in Pakistan. J Food Comp Anal. 2006; 19: 544-551.
38. Dahot MU. Antimicrobial activity of small protein of Moringa oleifera leaves. Journal of the Islamic Academy of Sciences 1998; 11(1): 6 pp.
39. Costa-Lotufo LV, Khan MTH, Ather A, Wilke DV, Jimenez PC, Pessoa C, de Moraes MEA and de Moraes MO. Studies of the anticancer potential of plants used in Bangladeshi folk medicine. J Ethnopharmacol. 2005; 99: 21-30.
40. Gilani AH, Aftab K, Suria A, Siddiqui S, Saleem R, Siddiqui BS and Faizi S. Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phyto res 1994; 8(2): 87-91.
41. Greenwald P, Clifford CK and Miner JA. 2001. Diet and Cancer prevention. Eur J Cancer.2001; 37, 948- 965.
42. Steinmetz KA and Potter JD. Vegetables, fruit, and cancer. II. Mechanisms, Cancer Causes Control, 1991; 2, 427-442.
43. Steinrnetz KA and Potter JD. Vegetables, fruit, and cancer. I. Epidemiology, Cancer Causes Control, 1991; 2, 325-357.
44. Chorvatoviovfi D and Bauer V. Stobadine-inhibitor of cyclophosphamide-induced micronuclei in mice. Mutagenesis 1994; 9, 241-244.