Synthesis of a novel amphiphilic quaternized chitosan and its distribution in rats

Journal of Biomaterials Science, Polymer Edition

Volumn 22, Issue 9, 2011, Pages 1115-1130

  Liu, Xiaofei ^a   Zeng, Anrong ^a   Li, Lin ^a   Yang, Fan ^a   Wang, Qi ^a   Sun, Zhong ^b   Shen, Jun ^b  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

adipose tissue; cytotoxicity; organ distribution; plasma concentration; Quaternized chitosan

Indexed keywords

CHLORINE COMPOUNDS; CYTOTOXICITY; RATS; TISSUE;

ADIPOSE TISSUE; DEGREE OF SUBSTITUTION; FLUORESCEIN ISOTHIOCYANATE; HYPOCHOLESTEROLEMIC EFFECT; ORGAN DISTRIBUTION; PLASMA CONCENTRATION; QUATERNARY AMMONIUM SALT; QUATERNIZED CHITOSANS;

CHITOSAN;

CHITOSAN DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE; LIPOTROPIC AGENT; N [(2 HYDROXY 3 N,N DIMETHYLHEXADECYLAMMONIUM)PROPYL]CHITOSAN CHLORIDE; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; CHITOSAN; N-((2-HYDROXY-3-N,N-DIMETHYLHEXADECYLAMMONIUM)PROPYL)CHITOSAN CHLORIDE; SOLVENT; SURFACTANT; WATER;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY FAT; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; FEEDING; GASTROINTESTINAL TRACT; HYDROPHILICITY; KIDNEY; LIVER; MALE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; RAT; SPLEEN; THYMUS; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECTS; INFRARED SPECTROSCOPY; LIVER CELL; PHYSIOLOGY; SOLUBILITY; SYNTHESIS; TEMPERATURE; THERMOGRAPHY; WISTAR RAT; X RAY DIFFRACTION;

RATTUS;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL SURVIVAL; CHITOSAN; HEPATOCYTES; MALE; MOLECULAR STRUCTURE; RATS, WISTAR; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE-ACTIVE AGENTS; TEMPERATURE; THERMOGRAPHY; WATER; X-RAY DIFFRACTION;

EID: 79952149981     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1163/092050610X500561     Document Type: Article

References (27)

1. Y. Maezaki, K. Tsuji, Y. Nakagawa, Y. Kawai, M. Akimoto, T. Tsuqita, W. Takekawa, A. Terada, H. Hara and T. Mitsuoka, Biosci. Biotechnol. Biochem. 57, 1439 (1993).
2. R. A. A. Muzzarelli, Carbohydr. Polym. 29, 309 (1996).
3. I. Aranaz, M. Mengibar, R. Harris, I. Panos, B. Miralles, N. Acosta, G. Galed and A. Heras, Curr. Chem. Biol. 3, 203 (2009).
4. B. Krajewska, Enzyme Microb. Technol. 35, 126 (2004).
5. P. Wydro, B. Krajewska and K. Hac-Wydro, Biomacromolecules 8, 2611 (2007).
6. J. Liu, J. Zhang and W. Xia, Food Chem. 107, 419 (2008).
7. D. J. Ormrod, C C Holmes and T. E. Miller, Atherosclerosis 138, 329 (1998).
8. I. Aranaz, R. Harris and A. Heras, Curr. Org. Chem. 14, 308 (2010).
9. Z. Jia, D. Shen and W. Xu, Carbohydr Res. 333, 1 (2001).
10. L. Zeng, C Qin, W. Wang, W. Chi and W. Li, Carbohydr Polym. 71, 435 (2008).
11. J. Zhang, J. Liu, L. Li and W. Xia, Nutr Res. 28, 383 (2008).
12. H. L. Jiang, Y. K. Kim, R. Arote, J. W. Nah, M. H. Cho, Y. J. Choi, T. Akaike and C S. Cho, J. Control. Rel. 117, 273 (2007).
13. K. Kamiyama, H. Onishi and Y. Machida, Biol. Pharm. Bull. 22, 179 (1999).
14. A. Bayat, B. Larijani, S. Ahmadian, H. E. Junginger and M. R. Tehrani, Nanomedicine 4, 115 (2008).
15. M. Thanou, B. Florea, I, M. Geldof, H. E. Junginger and G. Borchard, Biomaterials 23, 153 (2002).
16. K. Wong, G. Sun, X. Zhang, H. Dai, Y. Liu, C He and K. W. Leong, Bioconjug. Chem. 17, 152 (2006).
17. A. M. Brennan and C S. Mantzoros, Nature Rev. Microbiol. 2, 318 (2006).
18. R. Considine, V. M. K. Sinha, M. L. Heiman, A. Kriauciunas, T. W. Stephens, M. R. Nyce, J. P. Ohannesian, C C Marco, L. J. Mckee, T. L. Bauer and J. F. Caro, New Engl. J. Med. 334, 292 (1996).
19. A. M. Neyrinck, L. B. Bindels, F. D. Backer, B. D. Pachikian, P. D. Cani and N. M. Delzenne, Int. Immunopharmacol. 9, 767 (2009).
20. J. Shimoda, H. Ohishi and Y Machida, Drug Dev. Ind. Pharm. 27, 567 (2001).
21. A. Razdan and D. Pettersson, Br J. Nutr. 72, 277 (1994).
22. M. Sumiyoshi and Y Kimura, J. Pharm. Pharmacol. 58, 201 (2006).
23. Y Kawashima, H. Yamamoto, H. Takeuchi and Y Kuno, Pharm. Dev. Technol. 5, 77 (2000).
24. J. Takishima, H. Onishi and Y Machida, Biol. Pharm. Bull. 25, 1498 (2002).
25. Y Kato, H. Onishi and Y Machida, J. Control. Rel. 70, 295 (2001).
26. T. Kosaka, Y Kaneko, Y Nakada, M. Matsuura and S. Tanaka, J. Vet. Med. Sci. 58, 963 (1996).
27. G. Peluso, O. Petillo, M. Ranieri, M. Santin, L. Ambrosio, D. Calabro, B. Avallone and G. Bal-samo, Biomaterials 15, 1215 (1994).