Phase I Trial: Mesenchymal stem cells transplantation in end stage liver disease

Stem Cell

Volumn 1, Issue 2, 2010, Pages 22-33

  El Ansary, M ^a   Mogawer, Sh ^b   Abdel Aziz, I ^c   Abdel Hamid, S ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c THEODOR BILHARZ RESEARCH INSTITUTE   (Egypt)

Author keywords

End Stage Liver Disease; Mesenchymal Stem Cell; Transplantation

Indexed keywords

ALBUMIN; BILIRUBIN; CD34 ANTIGEN; CREATININE; LIVER ENZYME; PROTHROMBIN;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; AUTOTRANSPLANTATION; BONE MARROW; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CREATININE BLOOD LEVEL; FEMALE; HEPATITIS C; HUMAN; HYPERBILIRUBINEMIA; LIVER CIRRHOSIS; LIVER FAILURE; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; PROTEIN EXPRESSION; THERAPY EFFECT;

HEPATITIS C VIRUS;

EID: 79952135473     PISSN: 19454570     EISSN: 19454732     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Iredale JP (2003): Cirrhosis: new research provides a basis for rational and targeted treatments, BMJ; 327, pp. 143-7.
2. Darwish MA, Faris R, Darwish N, Shouman A, Gadallah M, El-Sharkawy MS, Edelman R, Grumbach K, Rao MR, Clemens JD (2001): Hepatitis C and cirrhotic liver disease in the Nile delta of Egypt: a community-based study.Am J Trop Med Hyg; 64, pp. 147-53.
3. Lorenzini S and Andreone P (2007): Stem cell therapy for human liver cirrhosis:a caution analysis of the results, Stem cell; 25(9), pp. 2383-4.
4. Forbes JS. (2008): Stem cell therapy for liver disease-choosing the right tools for the job. Gut; 57, pp. 153-155
5. Yagi K, Kojima M, Oyagi S, Ikeda E, Hirose M, Isoda K, Kawase M, Kondoh M, Ohgushi H (2008): Application of mesenchymal stem cells to liver regenerative medicine, Yakugaku Zasshi;128(1), pp. 3-9.
6. Abdel Aziz MT, Atta HM, Mahfouz S, Fouad HH, Roshdy NK, Ahmed HH, Rashad LA, Sabry D, Hassouna AA, Hasan NM (2007): Therapeutic potential of bone marrow derive mesenchymal stem cells on experimental liver fibrosis, Clinical Biochemistry; 40, pp. 893-899.
7. Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC (2004): Systemic infusion of FLK1 mesenchymal stem cells ameliorates carbon tetrachloride-induced liver fibrosis in mice,Transplantation; 78, pp. 83-8.
8. Sarah Synkers, Tamora Vanhaecke, Peggy Papeleu, Aernout Luttun, Yuehuga Jiang (2006): Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for in vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-like Cells, Toxicological Sciences; 94 (2), pp. 330-341.
9. Sato Y, Araki H, Kato J, Nakamura K, Kawano Y, Kobune M, et al (2005): Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion, Blood; 106, pp. 756-763.
10. Kale S. et al. (2003): Bone marrow stem cells contribute to repair of the ischemically injured renal tubule, J. Clin. Invest. 112, pp. 42-49.
11. Yokoo T. et al. (2005): Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues, Proc Natl Acad Sci U S A 102; 3296-3300.
12. Wynn TA. (2008): Cellular and molecular mechanisms of fibrosis, J. Pathol. 214, pp. 199-210
13. Kao CL, Lin HT, Chen YW, Chen YC, Tsai FT, Chang YL, Chiou SH, Sheu DC, & Ku HH. (2007): Fibronectin suppresses lipopolysaccharide-induced liver damage and promotes the cytoprotection abilities of hepatocyte-like cells derived from human bone marrow mesenchymal stem cells, Transplant Proce. 39, pp. 3444-3445.
14. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, and Goff JP. (1999): Bone marrow as potential source of hepatic oval cells, Science 284, pp. 1168-1170.
15. Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia, Jacob J, Novelli M, Prentice G, Williamson J. and Wright NA. (2000): Hepatocytes from non-hepatc adult stem cells, Nature 406, pp. 257.
16. Bataller R, and Brenner D. (2005): Liver fibrosis, J. Clin. Invest. 115, pp. 209-218.
17. Friedman SL. (2008): Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol. Rev. 88, pp. 125-172.
18. Zhang B., Inagaki M., Jiang B., Miyakoski M., Arikura J., Ogawa K. & Kasai Sh. (2009): Effects of BM and hepatocyte transplantation on liver injury, Journal of surgical research, Article on press.
19. Parekkadan B, Poll D V, Suganuma K, Carter EA, Berthiaume F, Tilles AW, and Yarmush ML. (2007): Mesenchymal stem cell-derived molecules reverse fulmimant hepatic failure, PLoS One 2 (9), p. 941.
20. Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y, Uchida K, Yamasaki T, Fujii Y, Okita K, and Sakaida I. (2006): Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy, Stem Cells 24, pp. 2292-2298.
21. Gordon MY, Levicar N, Pai M et al. (2006): Characterization and clinical application of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. STEM CELLS; 24:1822-1830.
22. Mohamadnejad M, Namiri M, Bagheri M, Hashemi SM, Ghanaati H, Zare Mehrjardi N, Kazemi S, Malekzadeh R, and Baharvand H. (2007): Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis, World J. Gastroenterol. 13, pp. 3359-3363.
23. Kuo TK, Hung SP, Chuang CH, Chen CT, Shih YR, Fang SC, Yang VW, and Lee OK. (2008): Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells, Gastroenterology 134, pp. 2111-2121.
24. Xu YQ, and Liu ZC. (2008): Therapeutic potential of adult bone marrow stem cells in liver disease and delivery approaches, Stem. Cell Rev. 4, pp. 101-112.
25. Dai LG, Li HY, Guan LX, Ritchie and Jeff X. Zhou JX. (2009): The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis. Stem Cell Res. 2 (1), pp. 16-25.