Glaucoma patients present increased levels of diadenosine tetraphosphate, Ap4A, in the aqueous humour

Experimental Eye Research

Volumn 92, Issue 3, 2011, Pages 221-226

  Castany, Marta ^a,b   Jordi, Isabel ^a   Catala, Jaume ^a,c   Gual, Arcadi ^d   Morales, Miguel ^e   Gasull, Xavier ^d   Pintor, Jesus ^f  

^a HOSPITAL UNIVERSITARI SAGRAT COR   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e CENTER FOR BIOMEDICAL RESEARCH OF LA RIOJA CIBIR   (Spain)

^f UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Ap4A; Ap5A; Diadenosine polyphosphates; Glaucoma; Intraocular pressure

Indexed keywords

DIADENOSINE PENTAPHOSPHATE; DIADENOSINE POLYPHOSPHATE; DIADENOSINE TETRAPHOSPHATE;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; CATARACT EXTRACTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; OPEN ANGLE GLAUCOMA; PARACENTESIS; PRIORITY JOURNAL;

AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; AQUEOUS HUMOR; CATARACT EXTRACTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DINUCLEOSIDE PHOSPHATES; FEMALE; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; SEX DISTRIBUTION;

EID: 79952103980     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.12.004     Document Type: Article

References (38)

1. Carracedo, G., Peral, A., Pintor, J., 2010. Diadenosine polyphosphates in tears of Sjogren syndrome patients. Invest. Ophthalmol. Vis. Sci., 51 (11), 5452-5459.
2. Crosson C.E. Intraocular pressure responses to the adenosine agonist cyclohexyladenosine: evidence for a dual mechanism of action. Invest. Ophthalmol. Vis. Sci. 2001, 42:1837-1840.
3. Crosson C.E., Gray T. Characterization of ocular hypertension induced by adenosine agonists. Invest. Ophthalmol. Vis. Sci. 1996, 37:1833-1839.
4. Farahbakhsh N.A. Purinergic signaling in the rabbit ciliary body epithelium. J. Exp. Zool. Part A, Comp. Exp. Biol. 2003, 300:14-24.
5. Farahbakhsh N.A., Cilluffo M.C. P2 purinergic receptor-coupled signaling in the rabbit ciliary body epithelium. Invest. Ophthalmol. Vis. Sci. 2002, 43:2317-2325.
6. Gomes P., Srinivas S.P., Van Driessche W., Vereecke J., Himpens B. ATP release through connexin hemichannels in corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 2005, 46:1208-1218.
7. Guzman-Aranguez A., Crooke A., Peral A., Hoyle C.H., Pintor J. Dinucleoside polyphosphates in the eye: from physiology to therapeutics. Prog. Retin. Eye Res. 2007, 26:674-687.
8. Hoyle C.H.V., Pintor J. Diadenosine tetraphosphate protects sympathetic terminals from 6-hydroxxydopamine-induced degeneration in the eye. Acta Physiol. (Oxf.) 2010, 199:205-210.
9. Janssens R., Communi D., Pirotton S., Samson M., Parmentier M., Boeynaems J.M. Cloning and tissue distribution of the human P2Y1 receptor. Biochem. Biophys. Res. Commun. 1996, 221:588-593.
10. Knight G.E., Bodin P., De Groat W.C., Burnstock G. ATP is released from guinea pig ureter epithelium on distension. Am. J. Physiol. Ren. Physiol. 2002, 282:F281-F288.
11. Luna C., Li G., Qiu J., Challa P., Epstein D.L., Gonzalez P. Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 2009, 50:5805-5810.
12. Martin-Gil A., Pintor J. P2Y2 nucleotide receptors increase the presence of aquaporin-1 in rabbit non pigmented ciliary epithelial cells. Invest. Ophthalmol. Vis. Sci. 2010, 51:691S.
13. Mediero A., Peral A., Pintor J. Dual roles of diadenosine polyphosphates in corneal epithelial cell migration. Invest. Ophthalmol. Vis. Sci. 2006, 47:4500-4506.
14. Mediero A., Guzman-Aranguez A., Crooke A., Peral A., Pintor J. Corneal re-epithelialization stimulated by diadenosine polyphosphates recruits RhoA/ROCK and ERK1/2 pathways. Invest. Ophthalmol. Vis. Sci. 2008, 49:4982-4992.
15. Miras-Portugal M.T., Gualix J., Mateo J., Diaz-Hernandez M., Gomez-Villafuertes R., Castro E., Pintor J. Diadenosine polyphosphates, extracellular function and catabolism. Prog. Brain Res. 1999, 120:397-409.
16. Mitchell C.H., Carre D.A., McGlinn A.M., Stone R.A., Civan M.M. A release mechanism for stored ATP in ocular ciliary epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:7174-7178.
17. Pedersen S., Pedersen S.F., Nilius B., Lambert I.H., Hoffmann E.K. Mechanical stress induces release of ATP from Ehrlich ascites tumor cells. Biochim. Biophys. Acta 1999, 1416:271-284.
18. Peral A., Carracedo G., Acosta M.C., Gallar J., Pintor J. Increased levels of diadenosine polyphosphates in dry eye. Invest. Ophthalmol. Vis. Sci. 2006, 47:4053-4058.
19. Peral A., Rivas L., Pintor J. Characterization of ocular mucins in Aniridia and Sjogren patients by laser scanning microscopy. Invest. Ophthalmol. Vis. Sci. 2010, 51:5673S.
20. Perez de Lara M., Crooke A., Santano C., Pintor J. Silencing P2Y2 receptors reduce intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2009, 50:1480S.
21. Pintor J., Miras-Portugal M.T. A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat midbrain synaptosomes. Br. J. Pharmacol. 1995, 115:895-902.
22. Pintor J., Torres M., Miras-Portugal M.T. Carbachol induced release of diadenosine polyphosphates - Ap4A and Ap5A - from perfused bovine adrenal medulla and isolated chromaffin cells. Life Sci. 1991, 48:2317-2324.
23. Pintor J., Diaz-Rey M.A., Torres M., Miras-Portugal M.T. Presence of diadenosine polyphosphates - Ap4A and Ap5A - in rat brain synaptic terminals. Ca2+ dependent release evoked by 4-aminopyridine and veratridine. Neurosci. Lett. 1992, 136:141-144.
24. Pintor J., Porras A., Mora F., Miras-Portugal M.T. Dopamine receptor blockade inhibits the amphetamine-induced release of diadenosine polyphosphates, diadenosine tetraphosphate and diadenosine pentaphosphate, from neostriatum of the conscious rat. J. Neurochem 1995, 64(2):670-676.
25. Pintor J., Carracedo G., Alonso M.C., Bautista A., Peral A. Presence of diadenosine polyphosphates in human tears. Pflugers Archiv 2002, 443:432-436.
26. Pintor J., Peral A., Hoyle C.H.V., Redick C., Douglass J., Sims I., Yerxa B. Effects of diadenosine polyphosphates on tear secretion in New Zealand white rabbits. J. Pharmacol. Exp. Ther. 2002, 300:291-297.
27. Pintor J., Peral A., Pelaez T., Martin S., Hoyle C.H. Presence of diadenosine polyphosphates in the aqueous humor: their effect on intraocular pressure. J. Pharmacol. Exp. Ther. 2003, 304:342-348.
28. Pintor J., Sanchez-Nogueiro J., Irazu M., Mediero A., Pelaez T., Peral A. Immunolocalisation of P2Y receptors in the rat eye. Purinergic Signal 2004, 1:83-90.
29. Reigada D., Lu W., Zhang M., Mitchell C.H. Elevated pressure triggers a physiological release of ATP from the retina: possible role for pannexin hemichannels. Neuroscience 2008, 157:396-404.
30. Redzic Z.B., Markovic I.D., Vidovic V.P., Vranic V.P., Gasic J.M., Duricic B.M., Pokrajac M., Dordevic J.B., Segal M.B., Rakic Endogenous nucleosides in the guinea-pig eye: analysis of transport and metabolites. Exp. Eye Res. 1998, 66:315-325.
31. Reigada D., Mitchell C.H. Release of ATP from retinal pigment epithelial cells involves both CFTR and vesicular transport. Am. J. Physiol. Cell Physiol. 2005, 288:C132-C140.
32. Rodriguez del Castillo A., Torres M., Delicado E.G., Miras-Portugal M.T. Subcellular distribution studies of diadenosine polyphosphates - Ap4A and Ap5A - in bovine adrenal medulla: presence in chromaffin granules. J. Neurochem. 1988, 51:1696-1703.
33. Rotllan Pascual P., Ramos Carrillo A., Rodriguez del Castillo A. Reversed-phase high-performance liquid chromatography of dinucleoside polyphosphates. J. Chromatogr. A 1991, 563:37-52.
34. Soto D., Pintor J., Peral A., Gual A., Gasull X. Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility. J. Pharmacol. Exp. Ther. 2005, 314:1042-1051.
35. Vollmayer P., Clair T., Goding J.W., Sano K., Servos J., Zimmermann H. Hydrolysis of diadenosine polyphosphates by nucleotide pyrophosphatases/phosphodiesterases. Eur. J. Biochem. 2003, 270:2971-2978.
36. Zamecnik P.C., Stephenson M.L., Janeway C.M., Randerath K. Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase. Biochem. Biophys. Res. Commun. 1966, 24:91-97.
37. Zhang X., Li A., Ge J., Reigada D., Laties A.M., Mitchell C.H. Acute increase of intraocular pressure releases ATP into the anterior chamber. Exp. Eye. Res. 2007, 85:637-643.
38. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn. Schmiedebergs Arch. Pharmacol. 2000, 362:299-309.