Endogenous nucleosides in the guinea-pig eye: Analysis of transport and metabolites

Experimental Eye Research

Volumn 66, Issue 3, 1998, Pages 315-325

  Redžić, Zoran B ^a   Marković, Ivanka D ^a   Vidović, Vanesa P ^b   Vranić, Valentina P ^b   Gašić, Jovana M ^c   Duričić, Bogdan M ^a   Pokrajac, Milena ^d   Dordević, Jelica B ^e   Segal, Malcolm B ^f   Rakić, Ljubiša M ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b ICN Yugoslavia   (Yugoslavia)

^c Faculty of Biology   (Yugoslavia)

^d School of Pharmacy   (Yugoslavia)

^e Clinical Center of   (Yugoslavia)

^f ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Aqueous humour; Blood aqueous humour barrier; Ciliary epithelium; Guinea pig; HPLC analysis; Lens; Nucleosides; Transport; Xanthine

Indexed keywords

ADENOSINE; CYTIDINE; DEOXYADENOSINE; DEOXYGUANOSINE; GUANOSINE; LACTIC ACID; NUCLEOSIDE; THYMIDINE; XANTHINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; BLOOD EYE BARRIER; CAPILLARY; CILIARY BODY EPITHELIUM; CONTROLLED STUDY; EYE; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LENS; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE TRANSPORT; PERFUSION; PRIORITY JOURNAL;

EID: 0032033465     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1997.0424     Document Type: Article

References (30)

1. Belt J. A., Marina N. M., Pheleps D. A., Crawford C. R. Nucleoside transport in normal and neoplastic cells. Adv. Enzyme Reg. 33:1993;235-252.
2. Berlin R. D., and Oliver J. M. Membrane transport of purine and pyrimidine bases and nucleosides in animal cells. Int. Rev. Cytol. 42:1975;287-336.
3. Burtis C. A., Ashwood E. R. Tietz textbook of clinical chemistry. 1996;W. B. Saunders Company. p. 367-.
4. Cole D. F. Secretion of the aqueous humour. Exp. Eye Res. Suppl. 161:1977;76.
5. Cory J. G. Purine and pyrimidine nucleotide metabolism. Textbook of biochemistry. 1993;A John Wiley & Sons Inc. p. 529-72.
6. Davson H. Physiology of the eye. 1990;The Macmillan Press.
7. Davson, H. and Segal, M. B. (1996). Physiology of the CSF and blood-brain barrier. Pp. 25-49. CRC Press, Boca Raton, U.S.A.
8. Ennis S. R., Ren X., Betz L. A. Mechanisms of sodium transport at the blood brain barrier studied within situ. J. Neurochem. 66 (2):1996;756-763.
9. Farooqui A. A, Haun S. E., Horrocks L. A. Ishemia and hypoxia. Siegel G. J, Agranoff B. W, Albers R. W., Molinoff P. B. Basic neurochemistry. 1993;867-882 Raven Press.
10. Flowers A., Levin V. A. Chemotherapy for brain tumors. Kaye A. H., Laws E. R. Brain Tumors. 1995;349-361 Churchill Livingstone.
11. Goodenough D. A. Lens gap junctions: structural evidence for non-regulated low resistance intercellular pathways. Invest. Ophthalmol. 18:1979;1104-1122.
12. Goodenough D. A., Dick J. S. B., Lyons J. E. Lens metabolic cooperation: a study of mouse lens transport and permeability visualized with free-substitution autoradiography. J. Cell Biol. 86:1980;576-589.
13. +. Biochim. Biophys. Acta. 1993;1149, 202-8.
14. Gutierrez M. M., Brett C. M., Ott R. J., Hui A. C., Giacomini K. M. Nucleoside transport in brush border membrane vesicles from human kidney. Biochim. Biophys. Acta. 1992;1105, 1-9.
15. +cif. J. Biol. Chem. 268:1993;20613-20619.
16. Iseki K., Mitsuru S., Fujiwara T., Naasani I., Kobayashi M., Miyazaki K. Transport mechanisms of nucleosides and the derivative, 6-mercaptopurine riboside across rat intestitial brush border membranes. Biochim. Biophys. Acta. 1278:1996;105-110.
17. Lo W. K., Harding C. V. Tight junctions in the lens epithelium of human and frog: freeze fracture and protein tracer studies. Invest. Ophthalmol. 18:1983;1104-1122.
18. Mackić J. B., Jinaguoda S., McComb G J., Weiss M. H., Kannan R., Kaplowitz N., Zloković B. V. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp. Eye Res. 62:1996;29-37.
19. +. J. Biol. Chem. 267:1992;3557-3560.
20. Pardridge W. M., Yoshikawa T., Kang Y. S., Miller L. P. Blood-brain transport and brain metabolism of adenosine and adenosine analogs. J. Pharmacol. Exp. Ther. 268 (1):1994;14-18.
21. Plagemann P. G. W., Wohlhueter R. M., Woffendin C. Nucleoside and nucleobase transport in animal cells. Biochem. Biophys. Acta. 947:1988;405-443.
22. 3. Eur. J. Ophthalmol. 5 (2):1995;131-135.
23. 3. Meth. Find. Exp. Clin. Pharmacol. 18 (6):1996;413-418.
24. Redžić Z. B., Segal M. B., Marković I. D., Gašić J. M., Vidović V., Rakić Lj. M. The characteristics of basolateral nucleoside transport in the perfused sheep choroid plexus and the effect of NO inhibition on these processes. Brain Res. 767:1997;26-33.
25. Stocchi V., Cucchiarini L., Canestrari F., Piacentini M. P., Fornaini G. A very fast reversed-phase HPLC method for the separation of the most significant nucleotides and their degradation products in human red blood cells. Analyt. Biochem. 167:1987;181-190.
26. Voet D., Voet J. G. Biochemistry. 1995;John Wiley and Sons. p. 816-21.
27. Wu H., Yuan G., Brett C. M., Hui A. C., Giacomini K. M. Sodium dependent nucleoside transport in choroid plexus from rabbit. J. Biol. Chem. 267:1992;8813-8818.
28. Yarchoan R., Klecker R. W., Weinhold K. J., Markham P. D., Lyerly H. K., Durach D. T., Gelmann E., Lehrman S. N., Blum R. M., Barry D. W. et al. Administration of 3"-azido-3"-deoxythymidine, an inhibitor of HTLV-II/LAV replication, to patients with AIDS or AIDS-related complex. Lancet. 1:1986;575-580.
29. Zloković B., Mackić J., McComb G., Kannan R., Weiss M. Anin situ. Exp. Eye Res. 54:1992;471-477.
30. Zloković B., Mackić J., McComb G. J., Kaplowitz N., Weiss N. H., Kannan R. Blood-to-lens transport of reduced glutathione in anin situ. Exp. Eye Res. 59:1994;487-496.