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Volumn 2, Issue 6, 2010, Pages 1381-1398

Molecular mechanism of ochratoxin A transport in the kidney

Author keywords

Kidney; Mycotoxin; Nephrotoxicity; Ochratoxin A; Organic anion transporter

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; MYCOTOXIN; OCHRATOXIN; ORGANIC ANION TRANSPORTER; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2;

EID: 79952087769     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2061381     Document Type: Review
Times cited : (62)

References (72)
  • 1
    • 37049051019 scopus 로고
    • Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh
    • van der Merwe, K.J.; Steyn, P.S.; Fourie, L.; Scott, D.B.; Theron, J.J. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature 1965, 205, 1112-1113.
    • (1965) Nature , vol.205 , pp. 1112-1113
    • van der Merwe, K.J.1    Steyn, P.S.2    Fourie, L.3    Scott, D.B.4    Theron, J.J.5
  • 3
    • 0015758562 scopus 로고
    • Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy
    • Krogh, P.; Hald, B.; Pedersen, E.J. Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy. Acta Pathol. Microbio. Scand. Sect. B 1973, 81, 689-695.
    • (1973) Acta Pathol. Microbio. Scand. Sect. B , vol.81 , pp. 689-695
    • Krogh, P.1    Hald, B.2    Pedersen, E.J.3
  • 4
    • 0003907793 scopus 로고
    • Selected mycotoxins: Ochratoxins, trichothecenes, and ergot
    • WHO, World Health Organization: Geneva, Switzerland
    • WHO. Selected mycotoxins: Ochratoxins, trichothecenes, and ergot. In Environmental Health Criteria; World Health Organization: Geneva, Switzerland, 1990; p. 105.
    • (1990) Environmental Health Criteria , pp. 105
  • 5
    • 33645471606 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans)
    • Dietrich, D.R.; Heussner, A.H.; O'Brien, E. Ochratoxin A: Comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans). Food Addit. Contam. 2005, 22 (Suppl. 1), 45-52.
    • (2005) Food Addit. Contam , vol.22 , Issue.SUPPL. 1 , pp. 45-52
    • Dietrich, D.R.1    Heussner, A.H.2    O'Brien, E.3    Ochratoxin, A.4
  • 7
    • 65749102418 scopus 로고    scopus 로고
    • Bioactivation and DNA adduction as a rationale for ochratoxin A carcinogenesis
    • Manderville, R.A.; Pfohl-Leszkowicz, A. Bioactivation and DNA adduction as a rationale for ochratoxin A carcinogenesis. World Mycotoxin J. 2008, 1, 357-367.
    • (2008) World Mycotoxin J , vol.1 , pp. 357-367
    • Manderville, R.A.1    Pfohl-Leszkowicz, A.2
  • 8
    • 0024723238 scopus 로고
    • Risk assessment of the mycotoxin ochratoxin A
    • Kuiper-Goodman, T.; Scott, P.M. Risk assessment of the mycotoxin ochratoxin A. Biomed. Environ. Sci. 1989, 2, 179-248.
    • (1989) Biomed. Environ. Sci , vol.2 , pp. 179-248
    • Kuiper-Goodman, T.1    Scott, P.M.2
  • 10
    • 0029775136 scopus 로고    scopus 로고
    • Ochratoxin and kidney disease in the human
    • Simon, P. Ochratoxin and kidney disease in the human. J. Toxicol. 1996, 15, 239-249.
    • (1996) J. Toxicol , vol.15 , pp. 239-249
    • Simon, P.1
  • 11
    • 0027489953 scopus 로고
    • Mechanism of ochratoxin A-induced reduction of glomerular filtration rate in rats
    • Gekle, M.; Silbernagl, S. Mechanism of ochratoxin A-induced reduction of glomerular filtration rate in rats. J. Pharmacol. Exp. Ther. 1993, 267, 316-321.
    • (1993) J. Pharmacol. Exp. Ther , vol.267 , pp. 316-321
    • Gekle, M.1    Silbernagl, S.2
  • 12
    • 0028366309 scopus 로고
    • The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: Toxicodynamic and toxokinetic aspects
    • Gekle, M.; Silbernagl, S. The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: Toxicodynamic and toxokinetic aspects. Renal Physiol. Biochem. 1994, 17, 40-49.
    • (1994) Renal Physiol. Biochem , vol.17 , pp. 40-49
    • Gekle, M.1    Silbernagl, S.2
  • 13
    • 0031849799 scopus 로고    scopus 로고
    • Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: The nephrotoxin can be reabsorbed in all nephron segments by different mechanisms
    • Dahlmann, A.; Dantzler, W.H.; Silbernagl, S.; Gekle, M. Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: The nephrotoxin can be reabsorbed in all nephron segments by different mechanisms. J. Pharmacol. Exp. Ther. 1998, 286, 157-162.
    • (1998) J. Pharmacol. Exp. Ther , vol.286 , pp. 157-162
    • Dahlmann, A.1    Dantzler, W.H.2    Silbernagl, S.3    Gekle, M.4
  • 14
    • 0022312847 scopus 로고
    • Renal tubular secretion and reabsorption as factors in ochratoxicosis: Effects of probenecid on nephrotoxicity
    • Stein, A.F.; Phillips, T.D.; Kubena, L.F.; Harvey, R.B. Renal tubular secretion and reabsorption as factors in ochratoxicosis: Effects of probenecid on nephrotoxicity. J. Toxicol. Environ. Health 1985, 16, 593-605.
    • (1985) J. Toxicol. Environ. Health , vol.16 , pp. 593-605
    • Stein, A.F.1    Phillips, T.D.2    Kubena, L.F.3    Harvey, R.B.4
  • 15
    • 0021136215 scopus 로고
    • High affinity binding of ochratoxin A to plasma constituents
    • Stojković, R.; Hult, K.; Gamulin, S.; Plestina R. High affinity binding of ochratoxin A to plasma constituents. Biochem. Int. 1984, 9, 33-38.
    • (1984) Biochem. Int , vol.9 , pp. 33-38
    • Stojković, R.1    Hult, K.2    Gamulin, S.3    Plestina, R.4
  • 16
    • 0024597101 scopus 로고
    • Toxicokinetics of ochratoxin A in several species and its plasma-binding properties
    • Hagelberg, S.; Hult, K.; Fuchs, R. Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J. Appl. Toxicol. 1989, 9, 91-96.
    • (1989) J. Appl. Toxicol , vol.9 , pp. 91-96
    • Hagelberg, S.1    Hult, K.2    Fuchs, R.3
  • 17
    • 15044361939 scopus 로고    scopus 로고
    • Ochratoxin A at nanomolar concentrations: A signal modulator in renal cells
    • Gekle, M.; Sauvant, C.; Schwerdt, G. Ochratoxin A at nanomolar concentrations: A signal modulator in renal cells. Mol. Nutr. Food Res. 2005, 49, 118-130.
    • (2005) Mol. Nutr. Food Res , vol.49 , pp. 118-130
    • Gekle, M.1    Sauvant, C.2    Schwerdt, G.3
  • 18
    • 0018779082 scopus 로고
    • In vivo and in vitro changes in renal function caused by ochratoxin A in the rat
    • Berndt, W.O.; Hayes, A.W. In vivo and in vitro changes in renal function caused by ochratoxin A in the rat. Toxicology 1979, 12, 5-17.
    • (1979) Toxicology , vol.12 , pp. 5-17
    • Berndt, W.O.1    Hayes, A.W.2
  • 19
    • 0023698104 scopus 로고
    • Uptake of ochratoxin A by slices of pig kidney cortex
    • Friis, C.; Brinn, R.; Hald, B. Uptake of ochratoxin A by slices of pig kidney cortex. Toxicology 1988, 52, 209-217.
    • (1988) Toxicology , vol.52 , pp. 209-217
    • Friis, C.1    Brinn, R.2    Hald, B.3
  • 21
    • 0030894541 scopus 로고    scopus 로고
    • Reabsorption of the nephrotoxin ochratoxin A along the rat nephron in vivo
    • Zingerle, M.; Silbernagl, S.; Gekle M. Reabsorption of the nephrotoxin ochratoxin A along the rat nephron in vivo. J. Pharmacol. Exp. Ther. 1997, 280, 220-224.
    • (1997) J. Pharmacol. Exp. Ther , vol.280 , pp. 220-224
    • Zingerle, M.1    Silbernagl, S.2    Gekle, M.3
  • 22
    • 0031935556 scopus 로고    scopus 로고
    • Peritubular transport of ochratoxin A in rabbit renal proximal tubules
    • Groves, C.E.; Morales, M.; Wright, S.H. Peritubular transport of ochratoxin A in rabbit renal proximal tubules. J. Pharmacol. Exp. Ther. 1998, 284, 943-948.
    • (1998) J. Pharmacol. Exp. Ther , vol.284 , pp. 943-948
    • Groves, C.E.1    Morales, M.2    Wright, S.H.3
  • 23
    • 0032920134 scopus 로고    scopus 로고
    • Ochratoxin A secretion in primary cultures of rabbit renal proximal tubule cells
    • Groves, C.E.; Nowak, G.; Morales, M. Ochratoxin A secretion in primary cultures of rabbit renal proximal tubule cells. J. Am. Soc. Nephrol. 1999, 10, 13-20.
    • (1999) J. Am. Soc. Nephrol , vol.10 , pp. 13-20
    • Groves, C.E.1    Nowak, G.2    Morales, M.3
  • 24
    • 0030972892 scopus 로고    scopus 로고
    • Apical-to-basolateral transepithelial transport of Ochratoxin A by two subtypes of Madin-Darby canine kidney cells
    • Schwerdt, G.; Gekle, M.; Freudinger, R.; Mildenberger, S.; Silbernagl, S. Apical-to-basolateral transepithelial transport of Ochratoxin A by two subtypes of Madin-Darby canine kidney cells. Biochim. Biophys. Acta 1997, 1324, 191-199.
    • (1997) Biochim. Biophys. Acta , vol.1324 , pp. 191-199
    • Schwerdt, G.1    Gekle, M.2    Freudinger, R.3    Mildenberger, S.4    Silbernagl, S.5
  • 25
    • 0032538887 scopus 로고    scopus 로고
    • Apical uptake of radiolabelled ochratoxin A into Madin-Darby canine kidney cells
    • Schwerdt, G.; Freudinger, R.; Silbernagl, S.; Gekle, M. Apical uptake of radiolabelled ochratoxin A into Madin-Darby canine kidney cells. Toxicology 1998, 131, 193-202.
    • (1998) Toxicology , vol.131 , pp. 193-202
    • Schwerdt, G.1    Freudinger, R.2    Silbernagl, S.3    Gekle, M.4
  • 27
    • 0032455110 scopus 로고    scopus 로고
    • Exposure to ochratoxin A impairs organic anion transport in proximal-tubule-derived opossum kidney cells
    • Sauvant, C.; Silbernagl, S.; Gekle, M. Exposure to ochratoxin A impairs organic anion transport in proximal-tubule-derived opossum kidney cells. J. Pharmacol. Exp. Ther. 1998, 287, 13-20.
    • (1998) J. Pharmacol. Exp. Ther , vol.287 , pp. 13-20
    • Sauvant, C.1    Silbernagl, S.2    Gekle, M.3
  • 28
    • 0031727559 scopus 로고    scopus 로고
    • Peritubular transport of ochratoxin A by single rabbit renal proximal tubules
    • Welborn, J.R.; Groves, C.E.; Wright, S.H. Peritubular transport of ochratoxin A by single rabbit renal proximal tubules. J. Am. Soc. Nephrol. 1998, 9, 1973-1982.
    • (1998) J. Am. Soc. Nephrol , vol.9 , pp. 1973-1982
    • Welborn, J.R.1    Groves, C.E.2    Wright, S.H.3
  • 29
    • 0038728565 scopus 로고    scopus 로고
    • Transport of organic anions across the basolateral membrane of proximal tubule cells
    • Burckhardt, B.C.; Burckhardt, G. Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev. Physiol. Biochem. Pharmacol. 2003, 146, 95-158.
    • (2003) Rev. Physiol. Biochem. Pharmacol , vol.146 , pp. 95-158
    • Burckhardt, B.C.1    Burckhardt, G.2
  • 30
    • 3042542425 scopus 로고    scopus 로고
    • Molecular and cellular physiology of renal organic cation and anion transport
    • Wright, S.H.; Dantzler, W.H. Molecular and cellular physiology of renal organic cation and anion transport. Physiol. Rev. 2004, 84, 987-1049.
    • (2004) Physiol. Rev , vol.84 , pp. 987-1049
    • Wright, S.H.1    Dantzler, W.H.2
  • 31
    • 33747616258 scopus 로고    scopus 로고
    • Organic anion transporter family: Current knowledge
    • Anzai, N.; Kanai, Y.; Endou, H. Organic anion transporter family: Current knowledge. J. Pharmacol. Sci. 2006, 100, 411-426.
    • (2006) J. Pharmacol. Sci , vol.100 , pp. 411-426
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 33
    • 48749084010 scopus 로고    scopus 로고
    • Physiology, structure, and regulation of the cloned organic anion transporters
    • Srimaroeng, C.; Perry, J.L.; Pritchard, J.B. Physiology, structure, and regulation of the cloned organic anion transporters. Xenobiotica 2008, 38, 889-935.
    • (2008) Xenobiotica , vol.38 , pp. 889-935
    • Srimaroeng, C.1    Perry, J.L.2    Pritchard, J.B.3
  • 34
    • 58149357521 scopus 로고    scopus 로고
    • Update on the molecular physiology of organic anion transporters
    • Ahn, S.Y.; Bhatnagar, V. Update on the molecular physiology of organic anion transporters. Curr. Opin. Nephrol. Hypertens. 2008, 17, 499-505.
    • (2008) Curr. Opin. Nephrol. Hypertens , vol.17 , pp. 499-505
    • Ahn, S.Y.1    Bhatnagar, V.2
  • 35
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • Sekine, T.; Watanabe, N.; Hosoyamada, M.; Kanai, Y.; Endou, H. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 1997, 272, 18526-18529.
    • (1997) J. Biol. Chem , vol.272 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 36
    • 0033938669 scopus 로고    scopus 로고
    • The multispecific organic anion transporter (OAT) family
    • Sekine, T.; Cha, S.H.; Endou, H. The multispecific organic anion transporter (OAT) family. Pflugers Arch. 2000, 440, 337-350.
    • (2000) Pflugers Arch , vol.440 , pp. 337-350
    • Sekine, T.1    Cha, S.H.2    Endou, H.3
  • 37
    • 17144449057 scopus 로고    scopus 로고
    • Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
    • Sekine, T.; Cha, S.H.; Tsuda, M.; Apiwattanakul, N.; Nakajima, N.; Kanai, Y.; Endou, H. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998, 429, 179-182.
    • (1998) FEBS Lett , vol.429 , pp. 179-182
    • Sekine, T.1    Cha, S.H.2    Tsuda, M.3    Apiwattanakul, N.4    Nakajima, N.5    Kanai, Y.6    Endou, H.7
  • 39
    • 0000518648 scopus 로고    scopus 로고
    • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    • Cha, S.H.; Sekine, T.; Kusuhara, H.; Yu, E.; Kim, J.Y.; Kim, D.K.; Sugiyama, Y.; Kanai, Y.; Endou, H. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem. 2000, 275, 4507-4512.
    • (2000) J. Biol. Chem , vol.275 , pp. 4507-4512
    • Cha, S.H.1    Sekine, T.2    Kusuhara, H.3    Yu, E.4    Kim, J.Y.5    Kim, D.K.6    Sugiyama, Y.7    Kanai, Y.8    Endou, H.9
  • 45
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/ SLC21 family: Phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch, B.; Meier, P.J. Organic anion transporting polypeptides of the OATP/ SLC21 family: Phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pfluegers Arch. 2004, 447, 653-665.
    • (2004) Pfluegers Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 47
    • 1242295189 scopus 로고    scopus 로고
    • Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
    • Reimer, R.J.; Edwards, R.H. Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. Pfluegers Arch. 2004, 447, 629-635.
    • (2004) Pfluegers Arch , vol.447 , pp. 629-635
    • Reimer, R.J.1    Edwards, R.H.2
  • 50
    • 1442351172 scopus 로고    scopus 로고
    • Peptide transporters: Structure, function, regulation and application for drug delivery
    • Terada, T.; Inui, K. Peptide transporters: structure, function, regulation and application for drug delivery. Curr. Drug Metab. 2004, 5, 85-94.
    • (2004) Curr. Drug Metab , vol.5 , pp. 85-94
    • Terada, T.1    Inui, K.2
  • 51
    • 0025007511 scopus 로고
    • Pharmacology of drugs that alter multidrug resistance in cancer
    • Ford, J.M.; Hait, W.N. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev. 1990, 42, 155-199.
    • (1990) Pharmacol. Rev , vol.42 , pp. 155-199
    • Ford, J.M.1    Hait, W.N.2
  • 52
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman, M.M.; Fojo, T.; Bates, S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer. 2002, 2, 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 54
    • 12144269640 scopus 로고    scopus 로고
    • Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    • Smeets, P.H.; van Aubel, R.A.; Wouterse, A.C.; van den Heuvel, J.J.; Russel, F.G. Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J. Am. Soc. Nephrol. 2004, 15, 2828-2835.
    • (2004) J. Am. Soc. Nephrol , vol.15 , pp. 2828-2835
    • Smeets, P.H.1    van Aubel, R.A.2    Wouterse, A.C.3    van den Heuvel, J.J.4    Russel, F.G.5
  • 55
    • 12144257103 scopus 로고    scopus 로고
    • Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    • van Aubel, R.A.; Smeets, P.H.; van den Heuvel, J.J.; Russel, F.G. Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am. J. Physiol. Renal Physiol. 2005, 288, F327-F333.
    • (2005) Am. J. Physiol. Renal Physiol , vol.288
    • van Aubel, R.A.1    Smeets, P.H.2    van den Heuvel, J.J.3    Russel, F.G.4
  • 56
    • 70349088929 scopus 로고    scopus 로고
    • Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics
    • Ishikawa, T.; Nakagawa, H. Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics. J. Exp. Ther. Oncol. 2009, 8, 5-24.
    • (2009) J. Exp. Ther. Oncol , vol.8 , pp. 5-24
    • Ishikawa, T.1    Nakagawa, H.2
  • 62
    • 79952090833 scopus 로고    scopus 로고
    • Ochratoxin A transport mediated by a novel human voltage-driven organic anion transporter hOATv1
    • Jutabha, P.; Anzai, N.; Thammapratip, T.; Endou, H.; Sakurai, H. Ochratoxin A transport mediated by a novel human voltage-driven organic anion transporter hOATv1. J. Tox. Sci. 2010, 35 (Suppl. 1), S219.
    • (2010) J. Tox. Sci , vol.35 , Issue.SUPPL. 1
    • Jutabha, P.1    Anzai, N.2    Thammapratip, T.3    Endou, H.4    Sakurai, H.5
  • 63
    • 0034812634 scopus 로고    scopus 로고
    • Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2
    • Takeuchi, A.; Masuda, S.; Saito, H.; Abe, T.; Inui, K. Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2. J. Pharmacol. Exp. Ther. 2001, 299, 261-267.
    • (2001) J. Pharmacol. Exp. Ther , vol.299 , pp. 261-267
    • Takeuchi, A.1    Masuda, S.2    Saito, H.3    Abe, T.4    Inui, K.5
  • 64
    • 0034083906 scopus 로고    scopus 로고
    • ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2
    • Leier, I.; Hummel-Eisenbeiss, J.; Cui, Y.; Keppler, D. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000, 57, 1636-1642.
    • (2000) Kidney Int , vol.57 , pp. 1636-1642
    • Leier, I.1    Hummel-Eisenbeiss, J.2    Cui, Y.3    Keppler, D.4
  • 65
    • 33645885302 scopus 로고    scopus 로고
    • Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells
    • Schrickx, J.; Lektarau, Y.; Fink-Gremmels, J. Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells. Arch. Toxicol. 2006, 80, 243-249.
    • (2006) Arch. Toxicol , vol.80 , pp. 243-249
    • Schrickx, J.1    Lektarau, Y.2    Fink-Gremmels, J.3
  • 66
    • 0037432669 scopus 로고    scopus 로고
    • Interaction of ochratoxin A with human intestinal Caco-2 cells: Possible implication of a multidrug resistance-associated protein (MRP2)
    • Berger, V.; Gabriel, A.F.; Sergent, T.; Trouet, A.; Larondelle, Y.; Schneider, Y.J. Interaction of ochratoxin A with human intestinal Caco-2 cells: Possible implication of a multidrug resistance-associated protein (MRP2). Toxicol. Lett. 2003, 140-141, 465-476.
    • (2003) Toxicol. Lett , vol.140-141 , pp. 465-476
    • Berger, V.1    Gabriel, A.F.2    Sergent, T.3    Trouet, A.4    Larondelle, Y.5    Schneider, Y.J.6
  • 67
    • 0030437929 scopus 로고    scopus 로고
    • Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide
    • Kontaxi, M.; Echkardt, U.; Hagenbuch, B.; Stieger, B.; Meier, P.J.; Petzinger, E. Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 1996, 279, 1507-1513.
    • (1996) J. Pharmacol. Exp. Ther , vol.279 , pp. 1507-1513
    • Kontaxi, M.1    Echkardt, U.2    Hagenbuch, B.3    Stieger, B.4    Meier, P.J.5    Petzinger, E.6
  • 68
    • 73149094513 scopus 로고    scopus 로고
    • Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier
    • Ose, A.; Kusuhara, H.; Endo, C.; Tohyama, K.; Miyajima, M.; Kitamura, S.; Sugiyama, Y. Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier. Drug Metab. Dispos. 2010, 38, 168-176.
    • (2010) Drug Metab. Dispos , vol.38 , pp. 168-176
    • Ose, A.1    Kusuhara, H.2    Endo, C.3    Tohyama, K.4    Miyajima, M.5    Kitamura, S.6    Sugiyama, Y.7
  • 70
    • 0032856603 scopus 로고    scopus 로고
    • The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
    • Cihlar, T.; Lin, D.C.; Pritchard, J.B.; Fuller, M.D.; Mendel, D.B.; Sweet, D.H. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol. Pharmacol. 1999, 56, 570-580.
    • (1999) Mol. Pharmacol , vol.56 , pp. 570-580
    • Cihlar, T.1    Lin, D.C.2    Pritchard, J.B.3    Fuller, M.D.4    Mendel, D.B.5    Sweet, D.H.6
  • 71
    • 0031716603 scopus 로고    scopus 로고
    • Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys
    • Lacy, S.A.; Hitchcock, M.J.; Lee, W.A.; Tellier, P.; Cundy, K.C. Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys. Toxicol. Sci. 1998, 44, 97-106.
    • (1998) Toxicol. Sci , vol.44 , pp. 97-106
    • Lacy, S.A.1    Hitchcock, M.J.2    Lee, W.A.3    Tellier, P.4    Cundy, K.C.5


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