How coenzyme B12-dependent ethanolamine ammonia-lyase deals with both enantiomers of 2-amino-1-propanol as substrates: Structure-based rationalization

Biochemistry

Volumn 50, Issue 4, 2011, Pages 591-598

  Shibata, Naoki ^a,b   Higuchi, Yoshiki ^a,b   Toraya, Tetsuo ^c  

^a UNIVERSITY OF HYOGO   (Japan)

^b SPring 8 Center ^*  (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1-PROPANOL; ABSOLUTE CONFIGURATION; CONFORMATIONAL CHANGE; DERIVED PRODUCTS; ENZYME ACTIVE SITES; ETHANOLAMINES; HYDROGEN ATOMS; INVERSION OF CONFIGURATION; ROTAMERS; SIDE CHAINS; STEREOSPECIFICITY; STERIC REPULSIONS; STRUCTURE-BASED; X-RAY STRUCTURE;

ABSTRACTING; AMMONIA; CHIRALITY; ENZYMES; HYDROGEN; PROPANOL; SUBSTRATES;

ENANTIOMERS;

AMINOPROPANOL; COBAMAMIDE; CYANOCOBALAMIN; ETHANOLAMINE AMMONIA LYASE; HYDROGEN; PROPANOL; UNCLASSIFIED DRUG; 2-AMINOPROPANOL; ESCHERICHIA COLI PROTEIN; PROPANOLAMINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DEAMINATION; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; STEREOCHEMISTRY; STEREOSPECIFICITY; X RAY ANALYSIS; CHEMISTRY; COMPARATIVE STUDY; ENZYME SPECIFICITY; METABOLISM; PREDICTIVE VALUE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; COBAMIDES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; ETHANOLAMINE AMMONIA-LYASE; PREDICTIVE VALUE OF TESTS; PROPANOLAMINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 79952083423     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101696h     Document Type: Article

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