The effect of the expression of vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 on the clinical outcome in patients with gastric carcinoma

European Journal of Surgical Oncology

Volumn 36, Issue 12, 2010, Pages 1172-1179

  Han, F H ^a   Li, H M ^a   Zheng, D H ^a   He, Y L ^a   Zhan, W H ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Gastric carcinoma; Lymphatic metastasis; Prognosis; VEGF C; VEGFR 3

Indexed keywords

VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3; TUMOR MARKER;

ADULT; AGE; AGED; ARTICLE; BLOOD TRANSFUSION; CANCER INVASION; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CANCER TISSUE; CARCINOMA CELL; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; FEMALE; GASTRECTOMY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; LYMPH VESSEL ENDOTHELIUM; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETROSPECTIVE STUDY; STOMACH CARCINOMA; SURVIVAL RATE; GENE EXPRESSION REGULATION; LYMPH NODE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; STOMACH TUMOR; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; STOMACH NEOPLASMS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 79952048861     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2010.09.002     Document Type: Article

References (34)

1. Hölscher AH, Drebber U, Mönig SP, et al. Early gastric cancer: lymph node metastasis starts with deep mucosal infiltration. Ann Surg 2009; 250(5):791-7.
2. Nesi G, Basili G, Girardi LR, et al. Pathological predictors of lymph node involvement in submucosal gastric carcinoma: a retrospective analysis of long-term outcome. In Vivo 2009;23(2):337-41.
3. del Casar JM, Corte MD, Alvarez A, et al. Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance. J Cancer Res Clin Oncol 2008;134:153-61. (Pubitemid 350234059)
4. Hyung WJ, Lee JH, Choi SH, Min JS, Noh SH. Prognostic impact of lymphatic and/or blood vessel invasion in patients with node-negative advanced gastric cancer. Ann Surg Oncol 2002;9(6):562-7. (Pubitemid 34774417)
5. Kitadai Y, Kodama M, Cho S, et al. Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes. Int J Cancer 2005;115:388-92. (Pubitemid 40663742)
6. Shimizu K, Kubo H, Yamaguchi K, et al. Suppression of VEGFR-3 signaling inhibits lymph node metastasis in gastric cancer. Cancer Sci 2004;95(4):328-33. (Pubitemid 38519473)
7. Shida A, Fujioka S, Kobayashi K, et al. Expression of vascular endothelial growth factor (VEGF)-C and eD in gastric carcinoma. Int J Clin Oncol 2006;11:38-43. (Pubitemid 43320325)
8. Joukov V, Pajusola K, Kaipainen A, et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996;15(7):1751. (Pubitemid 26112397)
9. Paavonen K, Horelli-Kuitunen N, Chilov D, et al. Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively. Circulation 1996;93(6):1079-82. (Pubitemid 26089805)
10. Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 2004;387-95. (Pubitemid 38780956)
11. Dumont DJ, Jussila L, Taipale J, et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998;282:946-9. (Pubitemid 28507528)
12. Karkkainen MJ, Ferrell RE, Lawrence EC, et al. Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema. Nat Genet 2000;25(2):153-9. (Pubitemid 30394984)
13. Saaristo A, Partanen TA, Arola J, et al. Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors. Am J Pathol 2000;157(1):7-14. (Pubitemid 30641718)
14. Mylona E, Alexandrou P, Mpakali A, et al. Clinicopathological and prognostic significance of vascular endothelial growth factors (VEGF)-C and -D and VEGF receptor 3 in invasive breast carcinoma. Eur J Surg Oncol 2007;33:294-300. (Pubitemid 46508645)
15. Takizawa H, Kondo K, Fujino H, et al. The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer. Br J Cancer 2006;95:75-9. (Pubitemid 43980557)
16. Schoppmann SF, Birner P, Stockl J, et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 2002;161:947-56. (Pubitemid 34988382)
17. He Y, Rajantie I, Pajusola K, et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005;65:4739-46. (Pubitemid 40740810)
18. Sayegh ME, Sano T, Dexter S, Katai H, Fukagawa T, Sasako M. TNM and Japanese staging systems for gastric cancer: how do they coexist? Gastric Cancer 2004;7:140-8. (Pubitemid 39314355)
19. Nakamura Y, Yasuoka H, Tsujimoto M, et al. Clinicopathological significance of vascular endothelial growth factor-C in breast carcinoma with long-term follow-up. Mod Pathol 2003;16:309-14. (Pubitemid 36443979)
20. Asoglu O, Karanlik H, Parlak M, et al. Metastatic lymph node ratio is an independent prognostic factor in gastric cancer. Hepatogastroenterology 2009;56(91-92):908-13.
21. Miyahara M, Tanuma J, Sugihara K, Semba I. Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma. Cancer 2007;110(6):1287-94. (Pubitemid 47435600)
22. Mumprecht V, Detmar M. Lymphangiogenesis and cancer metastasis. J Cell Mol Med 2009;13(8A):1405-16.
23. Cunnick GH, Jiang WG, Douglas-Jones T, et al. Lymphangiogenesis and lymph node metastasis in breast cancer. Mol Cancer 2008;7:23.
24. Jeltsch M, Kaipainen A, Joukov V, et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 1997;276(5317):1423-5. (Pubitemid 27235412)
25. Saaristo A, Veikkola T, Enholm B, et al. Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. FASEB J 2002;16(9):1041-9. (Pubitemid 34753510)
26. Achen MG, Stacker SA. The vascular endothelial growth factor family; proteins which guide the development of the vasculature. Int J Exp Pathol 1998;79(5):255-65. (Pubitemid 28481534)
27. Marconcini L, Marchio S, Morbidelli L, et al. c-fos-Induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro. Proc Natl Acad Sci U S A 1999;96(17):9671-6. (Pubitemid 29398790)
28. Karpanen T, Alitalo K. Lymphatic vessels as targets of tumor therapy? J Exp Med 2001;194(6):F37-42. (Pubitemid 32983007)
29. Yonemura Y, Endo Y, Fujita H, et al. Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer. Clin Cancer Res 1999;5(7):1823-9. (Pubitemid 29334464)
30. Kajita T, Ohta Y, Kimura K, et al. The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer. Br J Cancer 2001;85(2):255-60. (Pubitemid 32695748)
31. Kaio E, Tanaka S, Kitadai Y, et al. Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma. Oncology 2003;64(1):61-73. (Pubitemid 35477956)
32. Des Guetz G, Uzzan B, Nicolas P, et al. Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Metaanalysis of the literature. Br J Cancer 2006;94:1823-32. (Pubitemid 43882572)
33. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 1996; 77(5):858-63. (Pubitemid 26061277)
34. Kabashima A, Maehara Y, Kakeji Y, Sugimachi K. Overexpression of vascular endothelial growth factor C is related to lymphogenous metastasis in early gastric carcinoma. Oncology 2001;60(2):146-50. (Pubitemid 32245333)