Naturally occurring organic osmolytes: From cell physiology to disease prevention

IUBMB Life

Volumn 62, Issue 12, 2010, Pages 891-895

  Khan, Shagufta H ^a   Ahmad, Nihal ^b   Ahmad, Faizan ^c   Kumar, Raj ^a  

^a PA Professor of Surgery Department of Clinical Sciences The Geisinger Commonwealth Medical College Scranton   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

aggregation; cell homeostasis; disease prevention; intrinsically disordered proteins; misfolding; osmolyte; protein folding; transcription factors

Indexed keywords

ORGANIC COMPOUND; OSMOLYTE; UNCLASSIFIED DRUG;

CELL FUNCTION; HUMAN; PROPHYLAXIS; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; PROTEIN STABILITY; REVIEW;

AMINO ACIDS; AMYLOID; ANIMALS; CARBOHYDRATES; HUMANS; METHYLAMINES; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEURODEGENERATIVE DISEASES; OSMOSIS; PROTEIN FOLDING; PROTEIN STABILITY; PROTEINS; THERMODYNAMICS;

EID: 79952023953     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.406     Document Type: Review

References (38)

1. Závodszky, P., Kardos, J., Svingor, A., and, Petsko, G. A., (1998) Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins. Proc. Natl. Acad. Sci. USA 95, 7406-7411. (Pubitemid 28293265)
2. Yancey, P. H., Clark, M. E., Hand, S. C., Bowlus, R. D., and, Somero, G. N., (1982) Living with water stress: evolution of osmolyte systems. Science 217, 1214-1222. (Pubitemid 13283134)
3. Boggess, S. F., (1976) Contribution of arginine to proline accumulation in water-stressed barley leaves. Plant Physiol. 58, 796-797.
4. Bolen, D. W., and, Baskakov, I. V., (2001) The osmophobic effect: natural selection of a thermodynamic force in protein folding. J. Mol. Biol. 310, 955-963. (Pubitemid 32738368)
5. Lamitina, T., Huang, C. G., and, Strange, K., (2006) Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression. Proc. Natl. Acad. Sci. USA 103, 12173-12178. (Pubitemid 44215830)
6. Diamant, S., Eliahu, N., Rosenthal, D., and, Goloubinoff, P., (2001) Chemical chaperones regulate molecular chaperones in vitro and in cells under combined salt and heat stresses. J. Biol. Chem. 276, 39586-39591.
7. Tarczynski, M. C., Jensen, R. G., and, Bohnert, H. J., (1993) Stress protection of transgenic tobacco by production of the osmolyte mannitol. Science 259, 508-510. (Pubitemid 23058706)
8. Yancey, P. H., (2004) Compatible and counteracting solutes: protecting cells from the dead sea to the deep sea. Sci. Progress 87, 1-24.
9. Garcia-Perez, A., and, Burg, M. B., (1990) Importance of organic osmolytes for osmoregulation by renal medullary cells. Hypertension 16, 595-602.
10. Burg, M. B., (1996) Coordinate regulation of organic osmolytes in renal cells. Kidney Int. 49, 1684-1685. (Pubitemid 26188064)
11. Wang, A., and, Bolen, D. W., (1997) A naturally occurring protective system in urea rich cells: mechanism of osmolyte protection of protein against urea denaturation. Biochemistry 36, 9101-9108. (Pubitemid 27329494)
12. Burg, M. B., Kwon, E. D., and, Kultz, D., (1996) Osmotic regulation of gene expression. FASEB J. 10, 1598-1606. (Pubitemid 27043776)
13. MacMillen, R. E., and, Lee, A. K., (1967) Australian desert mice: independence of exogenous water. Science 158, 383-385.
14. Wang, A., and, Bolen, D. W., (1996) Effect of proline on lactate dehydrogenase activity: testing the generality and scope of the compatibility paradigm. Biophys. J. 71, 2117-2122. (Pubitemid 26325990)
15. Baldwin, R. L., and, Rose, G. D., (1999) Is protein folding hierarchic? II. Folding intermediates and transition states. Trends Biochem. Sci. 24, 77-83. (Pubitemid 29346578)
16. Street, T. O., Bolen, D. W., and, Rose, G. D., (2006) A molecular mechanism for osmolyte-induced protein stability. Proc. Natl. Acad. Sci. USA 103, 13997-14002. (Pubitemid 44488414)
17. Holthauzen, L. M., Rösgen, J., and, Bolen, D. W., (2010) Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes. Biochemistry 49, 1310-1318.
18. Timasheff, S. N., (2002) Protein-solvent preferential interactions, protein hydration and the modulation of biochemical reactions by solvent components. Proc. Natl. Acad. Sci. USA 99, 9721-9726. (Pubitemid 34831114)
19. Singh, R., Haque, I., and, Ahmad, F., (2005) Counteracting osmolyte trimethylamine N-oxide destabilizes proteins at pH below its pKa. Measurements of thermodynamic parameters of proteins in the presence and absence of trimethylamine N-oxide. J. Biol. Chem. 280, 1035-1042.
20. Kaushik, J. K., and, Bhat, R., (1998) Thermal stability of proteins in aqueous polyol solutions: role of the surface tension of water in the stabilizing effect of polyols. J. Phys. Chem. 102, 7058-7066. (Pubitemid 128611750)
21. Gekko, K., and, Timasheff, S. N., (1981) Thermodynamic and kinetic examination of protein stabilization by glycerol. Biochemistry 20, 4677-4686.
22. Kumar, R., (2009) Role of naturally occurring osmolytes on the protein folding and stability. Arch. Biochem. Biophys. 491, 1-6.
23. Lang, F., (2007) Mechanisms and significance of cell volume regulation. J. Am. Coll. Nutr. 26, 613S-623S. (Pubitemid 47512057)
24. Steeves, C. L., Hammer, M. A., Walker, G. B., Rae, D., Stewart, N. A., and, Baltz, J. M., (2003) The glycine neurotransmitter transporter GLYT1 is an organic osmolyte transporter regulating cell volume in cleavage-stage embryos. Proc. Natl. Acad. Sci. USA 100, 13982-13987. (Pubitemid 37499177)
25. Andrew, T. R., Rösgen, J., and, Bolen, D. W., (2003) Osmolyte effects on kinetics of FKBP12 C22A folding coupled with prolyl isomerization. J. Mol. Biol. 330, 851-866.
26. Dyson, H. J., and, Wright, P. E., (2005) Intrinsically unstructured proteins and their functions. Nat. Rev. 6, 197-208. (Pubitemid 40314921)
27. Liu, J., Perumal, N. B., Oldfield, C. J., Su, E. W., Uversky, V. N., and, Dunker, A. K., (2006) Intrinsic disorder in transcription factors. Biochemistry 45, 6873-6888. (Pubitemid 43856673)
28. Kumar, R., and, Thompson, E. B., (2003) Transactivation functions of the N-terminal domains of nuclear hormone receptors: protein folding and coactivator interactions. Mol. Endocrinol. 17, 1-10. (Pubitemid 36132655)
29. Spolar, R. S., and, Record, M. T., Jr., (1994) Coupling of local folding to site-specific binding of proteins to DNA. Science 263, 777-784. (Pubitemid 24093205)
30. Kumar, R., Lee, J. C., Bolen, D. W., and, Thompson, E. B., (2001) The osmolyte-induced conformation of the glucocorticoid receptor AF1/tau1 domain binds coregulators. J. Biol. Chem. 276, 18146-18152.
31. Reid, J., Kelly, S. M., Watt, K., Price, N. C., and, McEwan, I. J., (2002) Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions. J. Biol. Chem. 277, 20079-20086. (Pubitemid 34975644)
32. Soto, C., (2001) Protein misfolding and disease: protein refolding and therapy. FEBS Lett. 498, 204-207. (Pubitemid 32539204)
33. Powers, E. T., Morimoto, R. I., Dillin, A., Kelly, J. W., and, Balch, W. E., (2009) Biological and chemical approaches to diseases of proteostasis deficiency. Annu. Rev. Biochem. 78, 959-991.
34. Warrick, J. M., Paulson, H. L., Gray-Board, G. L., Bui, Q. T., Fischbeck, K. H., Pittman, R. N., and, Bonini, N. M., (1998) Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in drosophila. Cell 93, 939-949. (Pubitemid 28280788)
35. Chow, M. K., Devlin, G. L., and, Bottomley, S. P., (2001) Osmolytes as modulators of conformational changes in serpins. J. Biol. Chem. 382, 1593-1599. (Pubitemid 33107701)
36. Samuel, D., Kumar, T. K., Ganesh, G., Jayaraman, G., Yang, P. W., Chang, M. M., Trivedi, V. O., Wang, S. L., Hwang, K. C., Chang, D. K., and, Yu, C., (2000) Proline inhibits aggregation during protein refolding. Protein Sci. 9, 344-352. (Pubitemid 30127007)
37. Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N. R., Doi, H., Kurosawa, M., Nekooki, M., and, Nukina, N., (2004) Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat. Med. 10, 148-154. (Pubitemid 38524884)
38. Balch, W. E., Morimoto, R. I., Dillin, A., and, Kelly, J. F., (2008) Adapting proteostasis for disease intervention. Science 319, 916-919. (Pubitemid 351263754)