The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation

Biomaterials

Volumn 32, Issue 13, 2011, Pages 3395-3403

  Gittens, Rolando A ^a,b   McLachlan, Taylor ^a   Olivares Navarrete, Rene ^b,d   Cai, Ye ^a   Berner, Simon ^c   Tannenbaum, Rina ^a   Schwartz, Zvi ^b,d   Sandhage, Kenneth H ^a,b   Boyan, Barbara D ^a,b,d  

^a Georgia Institute of Technology   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c INSTITUT STRAUMANN AG   (Switzerland)

^d Emory University   (United States)

Author keywords

Bone; Implant; Nanotopography; Osteoblasts; Surface roughness; Titanium oxide

Indexed keywords

CELL RESPONSE; ELEMENTAL COMPOSITIONS; IMPLANT; IN-VIVO; MG63 CELLS; MODIFIED SURFACES; NANO-SCALE ROUGHNESS; NANOSCALE FEATURES; NANOSCALE STRUCTURE; NANOSCALE TOPOGRAPHY; NANOTOPOGRAPHIES; ORTHOPEDIC IMPLANT; OSSEOINTEGRATION; OSTEOBLAST DIFFERENTIATION; OXIDATION TREATMENTS; SUBMICRON SCALE; SURFACE CRYSTALS; SURFACE FEATURE; SURFACE MODIFICATION; TI SUBSTRATES;

BONE; CELL PROLIFERATION; CONTACT ANGLE; CRYSTAL STRUCTURE; DENTAL PROSTHESES; METAL ANALYSIS; NANOSTRUCTURED MATERIALS; OSTEOBLASTS; SURFACE PROPERTIES; SURFACE STRUCTURE; SURFACE TREATMENT; TITANIUM; TITANIUM OXIDES;

SURFACE ROUGHNESS;

TITANIUM;

ARTICLE; BONE REGENERATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTACT ANGLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; NANOANALYSIS; OSTEOBLAST; OXIDATION; PRIORITY JOURNAL; SURFACE PROPERTY;

CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, TRANSMISSION; OSTEOBLASTS; SURFACE PROPERTIES; TITANIUM; X-RAY DIFFRACTION;

EID: 79952009295     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.01.029     Document Type: Article

References (54)

1. Kieswetter K., Schwartz Z., Dean D.D., Boyan B.D. The role of implant surface characteristics in the healing of bone. Crit Rev Oral Biol Med 1996, 7(4):329-345.
2. Schwartz Z., Boyan B.D. Underlying mechanisms at the bone-biomaterial interface. J Cell Biochem 1994, 56:340-347.
3. Martin J.Y., Schwartz Z., Hummert T.W., Schraub D.M., Simpson J., Lankford J., et al. Effect of titanium surface-roughness on proliferation, differentiation, and protein-synthesis of human osteoblast-like cells (mg63). J Biomed Mater Res 1995, 29(3):389-401.
4. Boyan B.D., Bonewald L.F., Paschalis E.P., Lohmann C.H., Rosser J., Cochran D.L., et al. Osteoblast-mediated mineral deposition in culture is dependent on surface microtopography. Calcif Tissue Int 2002, 71(6):519-529.
5. Sul Y.T., Johansson C., Wennerberg P., Cho L.R., Chang B.S., Albrektsson P. Optimum surface properties of oxidized implants for reinforcement of osseointegration: surface chemistry, oxide thickness, porosity, roughness, and crystal structure. Int J Oral Maxillofac Implants 2005, 20(3):349-359.
6. Buser D., Broggini N., Wieland M., Schenk R.K., Denzer A.J., Cochran D.L., et al. Enhanced bone apposition to a chemically modified sla titanium surface. J Dent Res 2004, 83(7):529-533.
7. Liu X., Lim J.Y., Donahue H.J., Dhurjati R., Mastro A.M., Vogler E.A. Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hfob 1.19: phenotypic and genotypic responses observed in vitro. Biomaterials 2007, 28(31):4535-4550.
8. Rupp F., Scheideler L., Olshanska N., deWild M., Wieland M., Geis-Gerstorfer J. Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater Res 2006, 76A:323-334.
9. Zhao G., Schwartz Z., Wieland M., Rupp F., Geis-Gerstorfer J., Cochran D.L., et al. High surface energy enhances cell response to titanium substrate microstructure. J Biomed Mater Res 2005, 74A:49-58.
10. Schwartz Z., Raz P., Zhao G., Barak Y., Tauber M., Yao H., et al. Effect of micrometer-scale roughness of the surface of ti6al4v pedicle screws in vitro and in vivo. J Bone Joint Surg Am 2008, 90A(11):2485-2498.
11. Att W., Tsukimura N., Suzuki T., Ogawa T. Effect of supramicron roughness characteristics produceed by 1-and 2-step acid etching on the osseointegration capability of titanium. Int J Oral Maxillofac Implants 2007, 22(5):719-728.
12. Zhao G., Zinger O., Schwartz Z., Wieland M., Landolt D., Boyan B.D. Osteoblast-like cells are sensitive to submicron-scale surface structure. Clin Oral Implants Res 2006, 17(3):258-264.
13. Kubo K., Tsukimura N., Iwasa F., Ueno T., Saruwatari L., Aita H., et al. Cellular behavior on tio2 nanonodular structures in a micro-to-nanoscale hierarchy model. Biomaterials 2009, 30(29):5319-5329.
14. Mendonca G., Mendonca D.B.S., Aragao F.J.L., Cooper L.F. The combination of micron and nanotopography by h2so4/h2o2 treatment and its effects on osteoblast-specific gene expression of hmscs. J Biomed Mater Res 2010, 94A(1):169-179.
15. Schwartz Z., Lohmann C.H., Wieland M., Cochran D.L., Dean D.D., Textor M., et al. Osteoblast proliferation and differentiation on dentin slices are modulated by pretreatment of the surface with tetracycline or osteoclasts. J Periodontol 2000, 71(4):586-597.
16. Mulari M.T.K., Qu Q., Harkonen P.L., Vaananen H.K. Osteoblast-like cells complete osteoclastic bone resorption and form new mineralized bone matrix in vitro. Calcif Tissue Int 2004, 75(3):253-261.
17. Mori S., Burr D.B. Increased intracortical remodeling following fatigue damage. Bone 1993, 14(2):103-109.
18. Baron R., Neff L., Louvard D., Courtoy P.J. Cell-mediated extracellular acidification and bone-resorption - evidence for a low ph in resorbing lacunae and localization of a 100-kd lysosomal membrane-protein at the osteoclast ruffled border. J Cell Biol 1985, 101(6):2210-2222.
19. Chambers T.J., Revell P.A., Fuller K., Athanasou N.A. Resorption of bone by isolated rabbit osteoclasts. J Cell Sci 1984, 66(MAR):383-399.
20. Rho J.Y., Kuhn-Spearing L., Zioupos P. Mechanical properties and the hierarchical structure of bone. Med Eng Phys 1998, 20(2):92-102.
21. Boyde A., Ali N.N., Jones S.J. Optical and scanning electron-microscopy in the single osteoclast resorption assay. Scan Electron Microsc 1985, 1259-1271.
22. Boyan B.D., Schwartz Z., Lohmann C.H., Sylvia V.L., Cochran D.L., Dean D.D., et al. Pretreatment of bone with osteoclasts affects phenotypic expression of osteoblast-like cells. J Orthop Res 2003, 21(4):638-647.
23. Teitelbaum S.L., Ross F.P. Genetic regulation of osteoclast development and function. Nat Rev Genet 2003, 4(8):638-649.
24. Kieswetter K., Schwartz Z., Hummert T.W., Cochran D.L., Simpson J., Dean D.D., et al. Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like mg-63 cells. J Biomed Mater Res 1996, 32(1):55-63.
25. Raines A.L., Olivares-Navarrete R., Wieland M., Cochran D.L., Schwartz Z., Boyan B.D. Regulation of angiogenesis during osseointegration by titanium surface microstructure and energy. Biomaterials 2010, 31(18):4909-4917.
26. Buser D., Schenk R.K., Steinemann S., Fiorellini J.P., Fox C.H., Stich H. Influence of surface characteristics on bone integration of titanium implants - a histomorphometric study in miniature pigs. J Biomed Mater Res 1991, 25(7):889-902.
27. Cochran D.L., Schenk R.K., Lussi A., Higginbottom F.L., Buser D. Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible. J Biomed Mater Res 1998, 40(1):1-11.
28. Cochran D.L. A comparison of endosseous dental implant surfaces. J Periodontol 1999, 70(12):1523-1539.
29. Cochran D.L., Buser D., ten Bruggenkate C.M., Weingart D., Taylor T.M., Bernard J.P., et al. The use of reduced healing times on iti (r) implants with a sandblasted and acid-etched (sla) surface: early results from clinical trials on iti (r) sla implants. Clin Oral Implants Res 2002, 13(2):144-153.
30. Lipski A.M., Pino C.J., Haselton F.R., Chen I.W., Shastri V.P. The effect of silica nanoparticle-modified surfaces on cell morphology, cytoskeletal organization and function. Biomaterials 2008, 29(28):3836-3846.
31. Curtis A.S.G., Gadegaard N., Dalby M.J., Riehle M.O., Wilkinson C.D.W., Aitchison G. Cells react to nanoscale order and symmetry in their surroundings. IEEE Trans Nanobioscience 2004, 3(1):61-65.
32. Riehle M.O., Dalby M.J., Johnstone H., MacIntosh A., Affrossman S. Cell behaviour of rat calvaria bone cells on surfaces with random nanometric features. Mater Sci Eng C Biomimetic Supramol Syst 2003, 23(3):337-340.
33. Ward B.C., Webster T.J. Increased functions of osteoblasts on nanophase metals. Mater Sci Eng C Biomimetic Supramol Syst 2007, 27(3):575-578.
34. Biggs M.J.P., Richards R.G., Gadegaard N., McMurray R.J., Affrossman S., Wilkinson C.D.W., et al. Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage. J Biomed Mater Res Part A 2009, 91A(1):195-208.
35. Palin E., Liu H.N., Webster T.J. Mimicking the nanofeatures of bone increases bone-forming cell adhesion and proliferation. Nanotechnology 2005, 16(9):1828-1835.
36. Dalby M.J., McCloy D., Robertson M., Wilkinson C.D.W., Oreffo R.O.C. Osteoprogenitor response to defined topographies with nanoscale depths. Biomaterials 2006, 27(8):1306-1315.
37. Webster T.J., Ergun C., Doremus R.H., Siegel R.W., Bizios R. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials 2000, 21(17):1803-1810.
38. Webster T.J., Ejiofor J.U. Increased osteoblast adhesion on nanophase metals: Ti, ti6al4v, and cocrmo. Biomaterials 2004, 25(19):4731-4739.
39. Washburn N.R., Yamada K.M., Simon C.G., Kennedy S.B., Amis E.J. High-throughput investigation of osteoblast response to polymer crystallinity: influence of nanometer-scale roughness on proliferation. Biomaterials 2004, 25(7-8):1215-1224.
40. Cai K.Y., Bossert J., Jandt K.D. Does the nanometre scale topography of titanium influence protein adsorption and cell proliferation?. Colloids Surf B Biointerfaces 2006, 49(2):136-144.
41. Zinger O., Zhao G., Schwartz Z., Simpson J., Wieland M., Landolt D., et al. Differential regulation of osteoblasts by substrate microstructural features. Biomaterials 2005, 26(14):1837-1847.
42. Guo J., Padilla R.J., Ambrose W., De Kok I.J., Cooper L.F. The effect of hydrofluoric acid treatment of tio2 grit blasted titanium implants on adherent osteoblast gene expression in vitro and in vivo. Biomaterials 2007, 28(36):5418-5425.
43. Mendonca G., Mendonca D.B.S., Simoes L.G.P., Araujo A.L., Leite E.R., Duarte W.R., et al. The effects of implant surface nanoscale features on osteoblast-specific gene expression. Biomaterials 2009, 30(25):4053-4062.
44. Zhao L., Mei S., Chu P.K., Zhang Y., Wu Z. The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions. Biomaterials 2010, 31(19):5072-5082.
45. Mendes V.C., Moineddin R., Davies J.E. The effect of discrete calcium phosphate nanocrystals on bone-bonding to titanium surfaces. Biomaterials 2007, 28(32):4748-4755.
46. Gittens RA, Sandhage KH, Schwartz Z, Tannenbaum R, Boyan BD. Surface modification under controlled oxidative environment. U.S. patent application no. 61/299,433, 2010.
47. Bretaudiere J.P., Spillman T. Alkaline phosphatases. Methods of enzymatic analysis. Verlag Chemica 1984, 75-92.
48. Boyan B.D., Batzer R., Kieswetter K., Liu Y., Cochran D.L., Szmuckler-Moncler S., et al. Titanium surface roughness alters responsiveness of mg63 osteoblast-like cells to 1 alpha,25-(oh)(2)d-3. J Biomed Mater Res 1998, 39(1):77-85.
49. Murray J.L., Wriedt H.A. Phase diagrams of binary titanium alloys 1987, ASM International, Metals Park, OH.
50. Unnam J., Clark R.K. Oxidation of commercial purity titanium. Oxid Met 1986, 26(3-4):231-252.
51. Lian J.B., Stein G.S., Bortell R., Owen T.A. Phenotype suppression - a postulated molecular mechanism for mediating the relationship of proliferation and differentiation by fos/jun interactions at ap-1 sites in steroid responsive promoter elements of tissue-specific genes. J Cell Biochem 1991, 45(1):9-14.
52. Stein G.S., Lian J.B. Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 1993, 14(4):424-442.
53. Stein G.S., Lian J.B., Stein J.L., VanWijnen A.J., Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiol Rev 1996, 76(2):593-629.
54. Lian J.B., Stein G.S. Concepts of osteoblast growth and differentiation - basis for modulation of bone cell-development and tissue formation. Crit Rev Oral Biol Med 1992, 3(3):269-305.