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Volumn 37, Issue 3, 2011, Pages 202-207

Asparaginase in the management of adult acute lymphoblastic leukaemia: Is it used appropriately?

Author keywords

Acute lymphoblastic leukaemia; Asparaginase; Asparagine; L asparaginase; Leukaemia

Indexed keywords

ASPARAGINASE; DOXORUBICIN; PREDNISOLONE; VINCRISTINE;

EID: 79952006939     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2010.08.002     Document Type: Review
Times cited : (24)

References (45)
  • 1
    • 0000917445 scopus 로고
    • Desamidation enzymatique de l'asparagine
    • Clementi A. Desamidation enzymatique de l'asparagine. Arch Internat Physiol 1922, 19:369.
    • (1922) Arch Internat Physiol , vol.19 , pp. 369
    • Clementi, A.1
  • 2
    • 84965111634 scopus 로고
    • Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum - course of transplanted cancers of various kinds in mice and rats given guinea pig serum or rabbit serum
    • Kidd J.G. Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum - course of transplanted cancers of various kinds in mice and rats given guinea pig serum or rabbit serum. J Exp Med 1953, 98:565-582.
    • (1953) J Exp Med , vol.98 , pp. 565-582
    • Kidd, J.G.1
  • 3
    • 75449142384 scopus 로고
    • Evidence that the l-asparaginase of guinea pig serum is responsible for its anti-lymphoma effects
    • Broome J.D. Evidence that the l-asparaginase of guinea pig serum is responsible for its anti-lymphoma effects. J Exp Med 1963, 118:99-120.
    • (1963) J Exp Med , vol.118 , pp. 99-120
    • Broome, J.D.1
  • 4
    • 0014169820 scopus 로고
    • Inhibition of leukemias in man by l-asparaginase
    • Oettgen H.F., Old L.J., Boyse E.A. Inhibition of leukemias in man by l-asparaginase. Cancer Res 1967, 27:2619-2631.
    • (1967) Cancer Res , vol.27 , pp. 2619-2631
    • Oettgen, H.F.1    Old, L.J.2    Boyse, E.A.3
  • 5
    • 0014218895 scopus 로고
    • L-asparaginase therapy for leukemia and other malignant neoplasms
    • Hill J.M., Roberts J., Loeb E. l-asparaginase therapy for leukemia and other malignant neoplasms. J Am Med Assoc 1967, 202:882-888.
    • (1967) J Am Med Assoc , vol.202 , pp. 882-888
    • Hill, J.M.1    Roberts, J.2    Loeb, E.3
  • 6
    • 0014668523 scopus 로고
    • Effects of l-asparaginase in acute myelocytic leukemia
    • Ohnuma T., Holland J.F., Nagal G. Effects of l-asparaginase in acute myelocytic leukemia. J Am Med Assoc 1969, 210:1919-1921.
    • (1969) J Am Med Assoc , vol.210 , pp. 1919-1921
    • Ohnuma, T.1    Holland, J.F.2    Nagal, G.3
  • 7
    • 33749332107 scopus 로고    scopus 로고
    • Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients
    • Caruso V., Lacoviello L., Di Castelnuovo A. Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients. Blood 2006, 108:2216-2222.
    • (2006) Blood , vol.108 , pp. 2216-2222
    • Caruso, V.1    Lacoviello, L.2    Di Castelnuovo, A.3
  • 8
    • 34447305168 scopus 로고    scopus 로고
    • Thrombosis and acute lymphoblastic leukaemia
    • Payne J.H., Vora A.J. Thrombosis and acute lymphoblastic leukaemia. Br J Haematol 2007, 138:430-445.
    • (2007) Br J Haematol , vol.138 , pp. 430-445
    • Payne, J.H.1    Vora, A.J.2
  • 9
    • 0024374609 scopus 로고
    • In vitro and in vivo killing of acute lymphoblastic leukemia cells by l-asparaginase
    • Asselin B.L., Ryan D., Frantz C.N., et al. In vitro and in vivo killing of acute lymphoblastic leukemia cells by l-asparaginase. Cancer Res 1989, 49:4363-4368.
    • (1989) Cancer Res , vol.49 , pp. 4363-4368
    • Asselin, B.L.1    Ryan, D.2    Frantz, C.N.3
  • 10
    • 0035881515 scopus 로고    scopus 로고
    • Multiple adaptive mechanisms affect asparagine synthase substrate availability in asparaginase-resistant MOLT-4 leukemia cells
    • Aslanian A.M., Kilberg M.S. Multiple adaptive mechanisms affect asparagine synthase substrate availability in asparaginase-resistant MOLT-4 leukemia cells. Biochem J 2001, 358:59-67.
    • (2001) Biochem J , vol.358 , pp. 59-67
    • Aslanian, A.M.1    Kilberg, M.S.2
  • 11
    • 33744497255 scopus 로고    scopus 로고
    • Up-regulation of asparagine synthetase expression is not linked to the clinical response to l-asparaginase in pediatric acute lymphoblastic leukemia
    • Appel I.M., den Boer M., Meijerink J.P.P., Veerman A.J., Reniers N.C., Pieters R. Up-regulation of asparagine synthetase expression is not linked to the clinical response to l-asparaginase in pediatric acute lymphoblastic leukemia. Blood 2006, 107:4244-4249.
    • (2006) Blood , vol.107 , pp. 4244-4249
    • Appel, I.M.1    den Boer, M.2    Meijerink, J.P.P.3    Veerman, A.J.4    Reniers, N.C.5    Pieters, R.6
  • 12
    • 0037089437 scopus 로고    scopus 로고
    • Comparison of Escherichia coli-asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of randomized European Organisation for Research and Treatment of Cancer - Children's Leukemia Group phase 3 trial
    • Duval M., Suciu S., Ferster A., et al. Comparison of Escherichia coli-asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of randomized European Organisation for Research and Treatment of Cancer - Children's Leukemia Group phase 3 trial. Blood 2002, 99:2734-2739.
    • (2002) Blood , vol.99 , pp. 2734-2739
    • Duval, M.1    Suciu, S.2    Ferster, A.3
  • 13
    • 0027197614 scopus 로고
    • Comparative pharmacokinetic studies of three asparaginase preparations
    • Asselin B.L., Whitin J.C., Coppola D.J., et al. Comparative pharmacokinetic studies of three asparaginase preparations. J Clin Oncol 1993, 11:1780-1786.
    • (1993) J Clin Oncol , vol.11 , pp. 1780-1786
    • Asselin, B.L.1    Whitin, J.C.2    Coppola, D.J.3
  • 14
    • 0032945308 scopus 로고    scopus 로고
    • Cerebrospinal fluid asparagine concentrations after Escherichia coli asparaginase in children with acute lymphoblastic leukemia
    • Woo M., Hak L., Storm M., et al. Cerebrospinal fluid asparagine concentrations after Escherichia coli asparaginase in children with acute lymphoblastic leukemia. J Clin Oncol 1999, 17:1568-1573.
    • (1999) J Clin Oncol , vol.17 , pp. 1568-1573
    • Woo, M.1    Hak, L.2    Storm, M.3
  • 15
    • 0028878135 scopus 로고
    • Levels of l-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia
    • Dibenedetto S., Cataldo A., Ragusa R., Meli C., Nigro L. Levels of l-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia. J Clin Oncol 1995, 13:339-344.
    • (1995) J Clin Oncol , vol.13 , pp. 339-344
    • Dibenedetto, S.1    Cataldo, A.2    Ragusa, R.3    Meli, C.4    Nigro, L.5
  • 16
    • 9044226139 scopus 로고    scopus 로고
    • Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia
    • Smith M., Arthur C., Camitta B., et al. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol 1996, 14:18-24.
    • (1996) J Clin Oncol , vol.14 , pp. 18-24
    • Smith, M.1    Arthur, C.2    Camitta, B.3
  • 17
    • 31544475922 scopus 로고    scopus 로고
    • In adult ALL, less is now more
    • Weiss M.A., Lamanna N. In adult ALL, less is now more. Blood 2006, 107:852-853.
    • (2006) Blood , vol.107 , pp. 852-853
    • Weiss, M.A.1    Lamanna, N.2
  • 18
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • Pui C.H., Evans W.E. Treatment of acute lymphoblastic leukemia. N Eng J Med 2006, 354:166-178.
    • (2006) N Eng J Med , vol.354 , pp. 166-178
    • Pui, C.H.1    Evans, W.E.2
  • 19
    • 47849108085 scopus 로고    scopus 로고
    • What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of children's cancer group and cancer and leukemia group b studies
    • Stock W., La M., Sanford B., et al. What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of children's cancer group and cancer and leukemia group b studies. Blood 2008, 112:1646-1654.
    • (2008) Blood , vol.112 , pp. 1646-1654
    • Stock, W.1    La, M.2    Sanford, B.3
  • 20
    • 60949101218 scopus 로고    scopus 로고
    • Pediatric-inspired therapy in adults with Philadelphia-chromosome negative acute lymphoblastic leukemia: the GRAALL-2003 study
    • Huguet F., Raffoux E., Thomas X., et al. Pediatric-inspired therapy in adults with Philadelphia-chromosome negative acute lymphoblastic leukemia: the GRAALL-2003 study. J Clin Oncol 2009, 27(6):911-918.
    • (2009) J Clin Oncol , vol.27 , Issue.6 , pp. 911-918
    • Huguet, F.1    Raffoux, E.2    Thomas, X.3
  • 21
    • 67049098987 scopus 로고    scopus 로고
    • Treatment of adults with BCR-ABL negative acute lymphoblastic leukemia (ALL) with a modified Paediatric Regimen
    • Storring J.M., Brandwein J., Gupta V., et al. Treatment of adults with BCR-ABL negative acute lymphoblastic leukemia (ALL) with a modified Paediatric Regimen. Br J Haematol 2009, 146:76-85.
    • (2009) Br J Haematol , vol.146 , pp. 76-85
    • Storring, J.M.1    Brandwein, J.2    Gupta, V.3
  • 22
    • 10044259800 scopus 로고    scopus 로고
    • Long-term follow up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone (Hyper-CVAD), a dose intensive regimen, in adult acute lymphocytic leukemia
    • Kantarjian H., Thomas D., O'Brien S., et al. Long-term follow up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone (Hyper-CVAD), a dose intensive regimen, in adult acute lymphocytic leukemia. Cancer 2004, 101:2788-2801.
    • (2004) Cancer , vol.101 , pp. 2788-2801
    • Kantarjian, H.1    Thomas, D.2    O'Brien, S.3
  • 23
    • 7044263031 scopus 로고    scopus 로고
    • Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial
    • Thomas X., Boiron J.M., Huguet F., et al. Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial. J Clin Oncol 2004, 22:4075-4086.
    • (2004) J Clin Oncol , vol.22 , pp. 4075-4086
    • Thomas, X.1    Boiron, J.M.2    Huguet, F.3
  • 24
    • 0017662049 scopus 로고
    • Optimal use of l-asparaginase (NSC-109229) in acute lymphocytic leukemia
    • Jones B., Holland J.F., Glidewell O., et al. Optimal use of l-asparaginase (NSC-109229) in acute lymphocytic leukemia. Med Pediatr Oncol 1977, 3:387-400.
    • (1977) Med Pediatr Oncol , vol.3 , pp. 387-400
    • Jones, B.1    Holland, J.F.2    Glidewell, O.3
  • 25
    • 0021032126 scopus 로고
    • Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia
    • Sallan S.E., Hitchcock-Bryan S., Gelber R., et al. Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia. Cancer Res 1983, 43:5601-5607.
    • (1983) Cancer Res , vol.43 , pp. 5601-5607
    • Sallan, S.E.1    Hitchcock-Bryan, S.2    Gelber, R.3
  • 26
    • 0035283163 scopus 로고    scopus 로고
    • Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01
    • Silverman L.B., Gelber R.D., Dalton V.K., et al. Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01. Blood 2001, 97:1211-1218.
    • (2001) Blood , vol.97 , pp. 1211-1218
    • Silverman, L.B.1    Gelber, R.D.2    Dalton, V.K.3
  • 27
    • 0037085747 scopus 로고    scopus 로고
    • A randomised comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study
    • Avramis V.I., Sencer S., Periclou A.P., et al. A randomised comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study. Blood 2002, 99:1986-1994.
    • (2002) Blood , vol.99 , pp. 1986-1994
    • Avramis, V.I.1    Sencer, S.2    Periclou, A.P.3
  • 28
    • 0034284267 scopus 로고    scopus 로고
    • Weekly polyethylene glycol conjugated l-asparaginase compared to biweekly dosing production superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a pediatric oncology group study
    • Abshire T., Pollock B., Billett A., Bradley P., Buchanan G. Weekly polyethylene glycol conjugated l-asparaginase compared to biweekly dosing production superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a pediatric oncology group study. Blood 2000, 96:1709-1715.
    • (2000) Blood , vol.96 , pp. 1709-1715
    • Abshire, T.1    Pollock, B.2    Billett, A.3    Bradley, P.4    Buchanan, G.5
  • 29
    • 0030731212 scopus 로고    scopus 로고
    • Intensification of treatment for adults with acute lymphoblastic leukaemia: results of U.K. Medical Research Council randomized trial UKALL XA
    • Durrant I.J., Prentice H.G., Richards S.M. Intensification of treatment for adults with acute lymphoblastic leukaemia: results of U.K. Medical Research Council randomized trial UKALL XA. Br J Haematol 1997, 99:84-92.
    • (1997) Br J Haematol , vol.99 , pp. 84-92
    • Durrant, I.J.1    Prentice, H.G.2    Richards, S.M.3
  • 30
    • 41349100708 scopus 로고    scopus 로고
    • In adults with standard risk acute lymphoblastic leukaemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: the final results of the international ALL trial (MRC UKALLXII/ECOG E2993)
    • Goldstone A.H., Richards S.M., Lazarus H.M., et al. In adults with standard risk acute lymphoblastic leukaemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: the final results of the international ALL trial (MRC UKALLXII/ECOG E2993). Blood 2008, 111:1827-1833.
    • (2008) Blood , vol.111 , pp. 1827-1833
    • Goldstone, A.H.1    Richards, S.M.2    Lazarus, H.M.3
  • 31
    • 0028938844 scopus 로고
    • A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and Leukemia Group B study 8811
    • Larson R.A., Dodge R.K., Burns C.P., et al. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and Leukemia Group B study 8811. Blood 1995, 85:2025-2037.
    • (1995) Blood , vol.85 , pp. 2025-2037
    • Larson, R.A.1    Dodge, R.K.2    Burns, C.P.3
  • 32
    • 0021265295 scopus 로고
    • Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by Cancer and Leukemia Group B
    • Gottlieb A.J., Weinberg V., Ellison R.R., et al. Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by Cancer and Leukemia Group B. Blood 1984, 64:267-274.
    • (1984) Blood , vol.64 , pp. 267-274
    • Gottlieb, A.J.1    Weinberg, V.2    Ellison, R.R.3
  • 33
    • 34248325307 scopus 로고    scopus 로고
    • Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukaemia: Cancer and Leukemia Group B Study 9511
    • Wetzler M., Sanford B., Kurtzberg J. Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukaemia: Cancer and Leukemia Group B Study 9511. Blood 2007, 109:4164-4169.
    • (2007) Blood , vol.109 , pp. 4164-4169
    • Wetzler, M.1    Sanford, B.2    Kurtzberg, J.3
  • 34
    • 3042777511 scopus 로고    scopus 로고
    • Thromboembolism in adults with acute lymphoblastic leukemia during induction with l-asparaginase containing multi-agent regimens: Incidence, risk factors and possible role of antithrombin
    • Elliott M., Wolf R., Hook C., Pruthi R., Heit J., Letendre L. Thromboembolism in adults with acute lymphoblastic leukemia during induction with l-asparaginase containing multi-agent regimens: Incidence, risk factors and possible role of antithrombin. Leuk Lymph 2004, 45:1545-1551.
    • (2004) Leuk Lymph , vol.45 , pp. 1545-1551
    • Elliott, M.1    Wolf, R.2    Hook, C.3    Pruthi, R.4    Heit, J.5    Letendre, L.6
  • 35
    • 0030094888 scopus 로고    scopus 로고
    • Management of l-asparaginase induced prothrombotic state in acute lymphoblastic leukemia
    • Parma M., Belotti D., Pogliani E. Management of l-asparaginase induced prothrombotic state in acute lymphoblastic leukemia. Haematologica 1996, 81:191.
    • (1996) Haematologica , vol.81 , pp. 191
    • Parma, M.1    Belotti, D.2    Pogliani, E.3
  • 36
    • 33947600985 scopus 로고    scopus 로고
    • Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukaemia
    • Douer D., Yampolsky H., Cohen L., et al. Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukaemia. Blood 2007, 109:2744-2750.
    • (2007) Blood , vol.109 , pp. 2744-2750
    • Douer, D.1    Yampolsky, H.2    Cohen, L.3
  • 37
    • 0030218821 scopus 로고    scopus 로고
    • Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations
    • Boos J., Werber G., Ahilke E., et al. Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations. Eur J Cancer 1996, 32A:1544-1550.
    • (1996) Eur J Cancer , vol.32 A , pp. 1544-1550
    • Boos, J.1    Werber, G.2    Ahilke, E.3
  • 38
    • 56649104441 scopus 로고    scopus 로고
    • Failure of asparagine (ASN) depletion, not inadequate asparaginase (ASNase) activity, predicts relapse in standard risk (SR) childhood acute lymphoblastic leukemia (ALL): A Children's Oncology Group (COG) report
    • [abstract 588]
    • Avramis V.I., Holcenberg J.S., Ettinger A.G., Stork L.C., La M., Gaynon P.S. Failure of asparagine (ASN) depletion, not inadequate asparaginase (ASNase) activity, predicts relapse in standard risk (SR) childhood acute lymphoblastic leukemia (ALL): A Children's Oncology Group (COG) report. Blood 2007, 110. [abstract 588].
    • (2007) Blood , vol.110
    • Avramis, V.I.1    Holcenberg, J.S.2    Ettinger, A.G.3    Stork, L.C.4    La, M.5    Gaynon, P.S.6
  • 39
    • 0031049365 scopus 로고    scopus 로고
    • Dose reduction of asparaginase under pharmacokinetic and pharmacodynamic control during induction therapy in children with acute lymphoblastic leukaemia
    • Ahlke E., Nowak-Gottl U., Schulze-Westhoff P., et al. Dose reduction of asparaginase under pharmacokinetic and pharmacodynamic control during induction therapy in children with acute lymphoblastic leukaemia. Br J Hematol 1997, 96:675-681.
    • (1997) Br J Hematol , vol.96 , pp. 675-681
    • Ahlke, E.1    Nowak-Gottl, U.2    Schulze-Westhoff, P.3
  • 40
    • 0014737061 scopus 로고
    • Toxicity of E. coli asparaginase in man
    • Oettgen H., Stephenson P., Schwartz M. Toxicity of E. coli asparaginase in man. Cancer 1970, 15:253-278.
    • (1970) Cancer , vol.15 , pp. 253-278
    • Oettgen, H.1    Stephenson, P.2    Schwartz, M.3
  • 41
    • 0017253880 scopus 로고
    • Hypersensitivity reactions and antibody formation during l-asparaginase treatment of children and adults with acute leukemia
    • Killander D., Dohlwitz A., Engstedt L., et al. Hypersensitivity reactions and antibody formation during l-asparaginase treatment of children and adults with acute leukemia. Cancer 1976, 37:220-228.
    • (1976) Cancer , vol.37 , pp. 220-228
    • Killander, D.1    Dohlwitz, A.2    Engstedt, L.3
  • 42
    • 0036255941 scopus 로고    scopus 로고
    • Antibody formation during intravenous and intramuscular therapy with Erwinia asparaginase
    • Albertsen B., Schroder H., Jakobsen P., et al. Antibody formation during intravenous and intramuscular therapy with Erwinia asparaginase. Med Pediatr Oncol 2002, 38:310-316.
    • (2002) Med Pediatr Oncol , vol.38 , pp. 310-316
    • Albertsen, B.1    Schroder, H.2    Jakobsen, P.3
  • 43
    • 2442496750 scopus 로고    scopus 로고
    • Asparaginase antibody and asparaginase activity in children with high-risk acute lymphoblastic leukemia
    • Panosyan E., Seibel N., Martin-Aragon S., et al. Asparaginase antibody and asparaginase activity in children with high-risk acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2004, 26:217-226.
    • (2004) J Pediatr Hematol Oncol , vol.26 , pp. 217-226
    • Panosyan, E.1    Seibel, N.2    Martin-Aragon, S.3
  • 44
    • 0041520550 scopus 로고    scopus 로고
    • Evaluation of immunological cross reaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma patients
    • Wang B., Relling M., Storm M., et al. Evaluation of immunological cross reaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma patients. Leukemia 2003, 17:1583-1588.
    • (2003) Leukemia , vol.17 , pp. 1583-1588
    • Wang, B.1    Relling, M.2    Storm, M.3
  • 45
    • 34547444893 scopus 로고    scopus 로고
    • The anti-asparaginase antibodies correlate with l-asparaginase activity and may affect clinical outcome of childhood acute lymphoblastic leukemia
    • Zalewska-Szewczyk B., Anderzejewski W., Mlynarski W., Jedrychowska-Danska K., Witas H., Bodalski J. The anti-asparaginase antibodies correlate with l-asparaginase activity and may affect clinical outcome of childhood acute lymphoblastic leukemia. Leuk Lymph 2007, 48(5):931-936.
    • (2007) Leuk Lymph , vol.48 , Issue.5 , pp. 931-936
    • Zalewska-Szewczyk, B.1    Anderzejewski, W.2    Mlynarski, W.3    Jedrychowska-Danska, K.4    Witas, H.5    Bodalski, J.6


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