Tunable physiologic interactions of adhesion molecules for inflamed cell-selective drug delivery

Biomaterials

Volumn 32, Issue 13, 2011, Pages 3487-3498

  Kang, Sungkwon ^a   Park, Taehyun ^a   Chen, Xiaoyue ^a   Dickens, Greg ^a   Lee, Brian ^a   Lu, Kevin ^a   Rakhilin, Nikolai ^a   Daniel, Susan ^a   Jin, Moonsoo M ^a  

^a Cornell University   (United States)

Author keywords

Avidity; Celastrol; Drug delivery; ICAM 1; Inflammation; Integrin

Indexed keywords

AVIDITY; CELASTROL; ICAM-1; INFLAMMATION; INTEGRINS;

ADHESION; CELL PROLIFERATION; DRUG DELIVERY; DRUG DOSAGE; ENDOTHELIAL CELLS; MOLECULES; PATHOLOGY; PHYSIOLOGY; TOXICITY;

DRUG INTERACTIONS;

CELASTROL; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; LIPOSOME; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; CELL FUNCTION; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG TARGETING; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATION; MICROVASCULAR ENDOTHELIAL CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION;

CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; DRUG DELIVERY SYSTEMS; ENDOTHELIUM; FLOW CYTOMETRY; HUMANS; INFLAMMATION; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; LIPOSOMES; MONOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRITERPENES;

EID: 79952002733     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.01.046     Document Type: Article

References (48)

1. Nathan C., Ding A. Nonresolving inflammation. Cell 2010, 140(6):871-882.
2. Libby P. Inflammation in atherosclerosis. Nature 2002, 420(6917):868-874.
3. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444(7121):860-867.
4. Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 140(6):918-934.
5. Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420(6917):860-867.
6. FitzGerald G.A., Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 2001, 345(6):433-442.
7. Jain M.K., Ridker P.M. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov 2005, 4(12):977-987.
8. Patrono C., Garcia Rodriguez L.A., Landolfi R., Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 2005, 353(22):2373-2383.
9. Rhen T., Cidlowski J.A. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005, 353(16):1711-1723.
10. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., Hennekens C.H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997, 336(14):973-979.
11. Schacke H., Docke W.D., Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002, 96(1):23-43.
12. Fitzgerald G.A. Coxibs and cardiovascular disease. N Engl J Med 2004, 351(17):1709-1711.
13. Hanai J., Cao P., Tanksale P., Imamura S., Koshimizu E., Zhao J., et al. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest 2007, 117(12):3940-3951.
14. Allen T.M., Cullis P.R. Drug delivery systems: entering the mainstream. Science 2004, 303(5665):1818-1822.
15. Muzykantov V.R. Targeting of superoxide dismutase and catalase to vascular endothelium. J Control Release 2001, 71(1):1-21.
16. Muro S., Dziubla T., Qiu W.N., Leferovich J., Cui X., Berk E., et al. Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to intercellular adhesion molecule 1. J Pharmacol Exp Ther 2006, 317(3):1161-1169.
17. Kelly K.A., Allport J.R., Tsourkas A., Shinde-Patil V.R., Josephson L., Weissleder R. Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res 2005, 96(3):327-336.
18. Voinea M., Manduteanu I., Dragomir E., Capraru M., Simionescu M. Immunoliposomes directed toward VCAM-1 interact specifically with activated endothelial cells-a potential tool for specific drug delivery. Pharm Res 2005, 22(11):1906-1917.
19. Kozower B.D., Christofidou-Solomidou M., Sweitzer T.D., Muro S., Buerk D.G., Solomides C.C., et al. Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury. Nat Biotechnol 2003, 21(4):392-398.
20. Spragg D.D., Alford D.R., Greferath R., Larsen C.E., Lee K.D., Gurtner G.C., et al. Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system. Proc Natl Acad Sci USA 1997, 94(16):8795-8800.
21. Ehrhardt C., Kneuer C., Bakowsky U. Selectins-an emerging target for drug delivery. Adv Drug Deliv Rev 2004, 56(4):527-549.
22. Arap W., Pasqualini R., Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 1998, 279(5349):377-380.
23. Sugahara K.N., Teesalu T., Karmali P.P., Kotamraju V.R., Agemy L., Girard O.M., et al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 2009, 16(6):510-520.
24. Dustin M.L., Rothlein R., Bhan A.K., Dinarello C.A., Springer T.A. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986, 137(1):245-254.
25. Marlin S.D., Springer T.A. Purified intercellular-adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen-1 (LFA-1). Cell 1987, 51(5):813-819.
26. Dunehoo A.L., Anderson M., Majumdar S., Kobayashi N., Berkland C., Siahaan T.J. Cell adhesion molecules for targeted drug delivery. J Pharm Sci 2006, 95(9):1856-1872.
27. Simone E., Ding B.S., Muzykantov V. Targeted delivery of therapeutics to endothelium. Cell Tissue Res 2009, 335(1):283-300.
28. Jin M., Song G., Carman C.V., Kim Y.S., Astrof N.S., Shimaoka M., et al. Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad Sci USA 2006, 103(15):5758-5763.
29. Phan U.T., Waldron T., Springer T.A. Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Nat Immunol 2006, 7(8):883-889.
30. Park S., Kang S., Veach A.J., Vedvyas Y., Zarnegar R., Kim J.Y., et al. Self-assembled nanoplatform for targeted delivery of chemotherapy agents via affinity-regulated molecular interactions. Biomaterials 2010, 31(30):7766-7775.
31. Almenarqueralt A., Duperray A., Miles L.A., Felez J., Altieri D.C. Apical topography and modulation of ICAM-1 expression on activated endothelium. Am J Pathol 1995, 147(5):1278-1288.
32. Lee J.H., Koo T.H., Yoon H., Jung H.S., Jin H.Z., Lee K., et al. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem Pharmacol 2006, 72(10):1311-1321.
33. Yang H.J., Chen D., Cui Q.Z.C., Yuan X., Dou Q.P. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 2006, 66(9):4758-4765.
34. Mu T.W., Ong D.S.T., Wang Y.J., Balch W.E., Yates J.R., Segatori L., et al. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 2008, 134(5):769-781.
35. Hu X., Kang S., Lefort C., Kim M., Jin M.M. Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies. Proc Natl Acad Sci USA 2010, 107(14):6252-6257.
36. Szoka F., Olson F., Heath T., Vail W., Mayhew E., Papahadjopoulos D. Preparation of unilamellar liposomes of intermediate size (0.1-0.2 mumol) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes. Biochim Biophys Acta 1980, 601(3):559-571.
37. Chow J.C., Young D.W., Golenbock D.T., Christ W.J., Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999, 274(16):10689-10692.
38. Diamond M.S., Staunton D.E., Marlin S.D., Springer T.A. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 1991, 65(6):961-971.
39. Xie J., Li R., Kotovuori P., Vermot-Desroches C., Wijdenes J., Arnaout M.A., et al. Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain. J Immunol 1995, 155(7):3619-3628.
40. Lupher M.L., Harris E.A.S., Beals C.R., Sui L.M., Liddington R.C., Staunton D.E. Cellular activation of leukocyte function-associated antigen-1 and its affinity are regulated at the I domain allosteric site. J Immunol 2001, 167(3):1431-1439.
41. Takashiba S., Van Dyke T.E., Amar S., Murayama Y., Soskolne A.W., Shapira L. Differentiation of monocytes to macrophages primes cells for lipopolysaccharide stimulation via accumulation of cytoplasmic nuclear factor kappa B. Infect Immun 1999, 67(11):5573-5578.
42. Penn M.S., Chisolm G.M. Relation between lipopolysaccharide-induced endothelial-cell injury and entry of macromolecules into the rat aorta in vivo. Circ Res 1991, 68(5):1259-1269.
43. Stewart M., Hogg N. Regulation of leukocyte integrin function: affinity vs avidity. J Cell Biochem 1996, 61(4):554-561.
44. Subauste M.C., Jacoby D.B., Richards S.M., Proud D. Infection of a human respiratory epithelial-cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 1995, 96(1):549-557.
45. Johnson J.L.H., He Y., Yalkowsky S.H. Prediction of precipitation-induced phlebitis: a statistical validation of an in vitro model. J Pharm Sci 2003, 92(8):1574-1581.
46. Muro S., Wiewrodt R., Thomas A., Koniaris L., Albelda S.M., Muzykantov V.R., et al. A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1. J Cell Sci 2003, 116(8):1599-1609.
47. Staunton D.E., Dustin M.L., Springer T.A. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 1989, 339(6219):61-64.
48. Weber C., Fraemohs L., Dejana E. The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol 2007, 7(6):467-477.