Review: Effects of PPAR activation in the placenta and the fetus: Implications in maternal diabetes

Placenta

Volumn 32, Issue SUPPL. 2, 2011, Pages

  Jawerbaum, A ^a   Capobianco, E ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Diabetes; Fetus; Peroxisome proliferator activated receptors; Placenta; Pregnancy

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ARACHIDONIC ACID; ARACHIDONIC ACID DERIVATIVE; CARBACYCLIN; DOCOSAHEXAENOIC ACID; FIBRIC ACID DERIVATIVE; GLITAZONE DERIVATIVE; ICOSAPENTAENOIC ACID; ILOPROST; LEUKOTRIENE; LINOLEIC ACID; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN;

ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; DEVELOPMENTAL DISORDER; DNA POLYMORPHISM; EMBRYO DEVELOPMENT; FETOPLACENTAL UNIT; FETUS; FETUS DEVELOPMENT; HUMAN; LIPID METABOLISM; LIPID PEROXIDATION; MATERNAL DIABETES MELLITUS; NONHUMAN; PLACENTA; PLACENTA DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; DIABETES, GESTATIONAL; FEMALE; FETUS; HUMANS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PLACENTA; PREGNANCY; PREGNANCY IN DIABETICS;

EID: 79952002653     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2010.12.002     Document Type: Conference Paper

References (60)

1. Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 2008;454:470-7.
2. Wieser F, Waite L, Depoix C, Taylor RN. PPAR action in human placental development and pregnancy and its complications. PPAR Res 2008;2008:527048.
3. Jawerbaum A, Gonzalez E. Diabetic pregnancies: the challenge of developing in a pro-inflammatory environment. Curr Med Chem 2006;13:2127-38. (Pubitemid 44132605)
4. Herrera E, Ortega-Senovilla H. Disturbances in lipid metabolism in diabetic pregnancy - Are these the cause of the problem? Best Pract Res Clin Endocrinol Metab 2010;24:515-25.
5. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res 2006;45:120-59. (Pubitemid 43248732)
6. Kersten S, Wahli W. Peroxisome proliferator activated receptor agonists. Exs 2000;89:141-51.
7. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 1996; 384:39-43.
8. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995;83:803-12. (Pubitemid 3006324)
9. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999;103:1489-98.
10. Desvergne B, Michalik L, Wahli W. Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol 2004;18:1321-32. (Pubitemid 38692172)
11. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, et al. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 2002;99:303-8. (Pubitemid 34060358)
12. Lim H, Dey SK. PPAR delta functions as a prostacyclin receptor in blastocyst implantation. Trends Endocrinol Metab 2000;11:137-42. (Pubitemid 30238546)
13. Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999;4:585-95. (Pubitemid 29531138)
14. Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 2000;16:145-71. (Pubitemid 32037503)
15. Szanto A, Nagy L. The many faces of PPARgamma: anti-inflammatory by any means? Immunobiology 2008;213:789-803.
16. Rosmond R, Chagnon M, Bouchard C. The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men. Diabetes Metab Res Rev 2003;19:159-63. (Pubitemid 36417201)
17. Hocher B, Schlemm L, Haumann H, Poralla C, Chen YP, Li J, et al. Interaction of maternal peroxisome proliferator-activated receptor gamma2 Pro12Ala polymorphism with fetal sex affects maternal glycemic control during pregnancy. Pharmacogenet Genomics 2010;20:139-42.
18. Tok EC, Ertunc D, Bilgin O, Erdal EM, Kaplanoglu M, Dilek S. PPAR-gamma2 Pro12Ala polymorphism is associated with weight gain in women with gestational diabetes mellitus. Eur J Obstet Gynecol Reprod Biol 2006;129:25-30. (Pubitemid 44633493)
19. Braissant O, Wahli W. Differential expression of peroxisome proliferatoractivated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 1998;139:2748-54.
20. Abbott BD, Wood CR, Watkins AM, Das KP, Lau CS. Peroxisome proliferatoractivated receptors alpha, beta, and gamma mRNA and protein expression in human fetal tissues. PPAR Res 2010;2010:690907.
21. Yessoufou A, Hichami A, Besnard P, Moutairou K, Khan NA. Peroxisome proliferator-activated receptor alpha deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: Modulation of T cell differentiation. Endocrinology 2006;147:4410-8. (Pubitemid 44268392)
22. Ringseis R, Gutgesell A, Dathe C, Brandsch C, Eder K. Feeding oxidized fat during pregnancy up-regulates expression of PPARalpha-responsive genes in the liver of rat fetuses. Lipids Health Dis 2007;6:6.
23. Lindegaard ML, Nielsen LB. Maternal diabetes causes coordinated downregulation of genes involved with lipid metabolism in the murine fetal heart. Metabolism 2008;57:766-73. (Pubitemid 351697907)
24. Martinez N, White V, Kurtz M, Higa R, Capobianco E, Jawerbaum A. Activation of the nuclear receptor PPARalfa regulates lipid metabolism in fetal liver from diabetic rats: implications in diabetes-induced fetal overgrowth. Diabetes Metab Res Rev; 2010. Epub DOI: 10.1012/dmrr1151.
25. Lehman JJ, Kelly DP. Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol 2002;29:339-45. (Pubitemid 34227071)
26. Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005;135:1382-6. (Pubitemid 40799599)
27. Peters JM, Lee SS, Li W, Ward JM, Gavrilova O, Everett C, et al. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol Cell Biol 2000;20:5119-28. (Pubitemid 30431565)
28. Barak Y, Sadovsky Y, Shalom-Barak T. PPAR signaling in placental development and function. PPAR Res 2008;2008:142082.
29. Schaiff WT, Knapp Jr FF, Barak Y, Biron-Shental T, Nelson DM, Sadovsky Y. Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice. Endocrinology 2007;148:3625-34. (Pubitemid 47105868)
30. Asami-Miyagishi R, Iseki S, Usui M, Uchida K, Kubo H, Morita I. Expression and function of PPARgamma in rat placental development. Biochem Biophys Res Commun 2004;315:497-501. (Pubitemid 38185851)
31. Lappas M, Permezel M, Georgiou HM, Rice GE. Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone. J Clin Endocrinol Metab 2002;87:4667-72. (Pubitemid 35247059)
32. Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Trono D, et al. Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol 2006;26:3266-81.
33. Martinez N, Capobianco E, White V, Pustovrh MC, Higa R, Jawerbaum A. Peroxisome proliferator-activated receptor alpha activation regulates lipid metabolism in the feto-placental unit from diabetic rats. Reproduction 2008;136:95-103. (Pubitemid 351984723)
34. Hashimoto F, Oguchi Y, Morita M, Matsuoka K, Takeda S, Kimura M, et al. PPARalpha agonists clofibrate and gemfibrozil inhibit cell growth, downregulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells. Biochem Pharmacol 2004;68:313-21. (Pubitemid 38757700)
35. Balsells M, Garcia-Patterson A, Gich I, Corcoy R. Maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: a systematic review and metaanalysis. J Clin Endocrinol Metab 2009;94:4284-91.
36. Melamed N, Hod M. Perinatal mortality in pregestational diabetes. Int J Gynaecol Obstet 2009;104(Suppl. 1):S20-4.
37. Reece EA, Leguizamon G, Wiznitzer A. Gestational diabetes: the need for a common ground. Lancet 2009;373:1789-97.
38. Arck P, Toth B, Pestka A, Jeschke U. Nuclear receptors of the peroxisome proliferator-activated receptor (PPAR) family in gestational diabetes: from animal models to clinical trials. Biol Reprod 2010;83:168-76.
39. Jawerbaum A, Capobianco E, Pustovrh C, White V, Baier M, Salzberg S, et al. Influence of peroxisome proliferator-activated receptor gamma activation by its endogenous ligand 15-deoxy Delta12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women. Mol Hum Reprod 2004;10:671-6. (Pubitemid 39341588)
40. Holdsworth-Carson SJ, Lim R, Mitton A, Whitehead C, Rice GE, Permezel M, et al. Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia. Placenta 2010;31:222e9.
41. Lappas M, Permezel M, Rice GE. 15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. Placenta 2006;27:1060-72.
42. Kossenjans W, Eis A, Sahay R, Brockman D, Myatt L. Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia. Am J Physiol Heart Circ Physiol 2000;278:H1311-9.
43. Higa R, Gonzalez E, Pustovrh MC, White V, Capobianco E, Martinez N, et al. PPARdelta and its activator PGI2 are reduced in diabetic embryopathy: involvement of PPARdelta activation in lipid metabolic and signalling pathways in rat embryo early organogenesis. Mol Hum Reprod 2007;13:103-10. (Pubitemid 46152596)
44. Eriksson UJ, Cederberg J, Wentzel P. Congenital malformations in offspring of diabetic mothers - animal and human studies. Rev Endocr Metab Disord 2003;4:79-93. (Pubitemid 36182153)
45. Jawerbaum A, Gonzalez E. The role of alterations in arachidonic acid metabolism and nitric oxide homeostasis in rat models of diabetes during early pregnancy. Curr Pharm Des 2005;11:1327-42. (Pubitemid 40458277)
46. Sivan E, Reece EA, Wu YK, Homko CJ, Polansky M, Borenstein M. Dietary vitamin E prophylaxis and diabetic embryopathy: morphologic and biochemical analysis. Am J Obstet Gynecol 1996;175:793-9. (Pubitemid 26357931)
47. Min Y, Lowy C, Ghebremeskel K, Thomas B, Bitsanis D, Crawford MA. Fetal erythrocyte membrane lipids modification: preliminary observation of an early sign of compromised insulin sensitivity in offspring of gestational diabetic women. Diabet Med 2005;22:914-20. (Pubitemid 40942590)
48. Ortega-Senovilla H, Alvino G, Taricco E, Cetin I, Herrera E. Gestational diabetes mellitus impairs the proportion of fatty acids in umbilical artery but not in umbilical vein plasma. Diabetes Care 2009;32:120-2.
49. Bordoni A, Di Nunzio M, Danesi F, Biagi PL. Polyunsaturated fatty acids: from diet to binding to ppars and other nuclear receptors. Genes Nutr 2006;1:95-106.
50. Higa R, White V, Martinez N, Kurtz M, Capobianco E, Jawerbaum A. Safflower and olive oil dietary treatments rescue aberrant embryonic arachidonic acid and nitric oxide metabolism and prevent diabetic embryopathy in rats. Mol Hum Reprod 2010;16:286-95.
51. Pustovrh MC, Capobianco E, Martinez N, Higa R, White V, Jawerbaum A. MMP/TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats. Eur J Clin Invest 2009;39:1082-90.
52. Capobianco E, Martinez N, Higa R, White V, Jawerbaum A. The effects of maternal dietary treatments with natural PPAR ligands on lipid metabolism in fetuses from control and diabetic rats. Prostaglandins Leukot Essent Fatty Acids 2008;79:191-9.
53. Soulimane-Mokhtari NA, Guermouche B, Yessoufou A, Saker M, Moutairou K, Hichami A, et al. Modulation of lipid metabolism by n-3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring. Clin Sci (Lond) 2005;109:287-95. (Pubitemid 41337133)
54. Capobianco E, Jawerbaum A, Romanini MC, White V, Pustovrh C, Higa R, et al. 15-Deoxy-Delta(12,14)-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. Reprod Fertil Dev 2005;17:423-33.
55. Kurtz M, Capobianco E, Martinez N, Fernandez J, Higa R, White V, et al. Carbaprostacyclin, a PPARdelta agonist, ameliorates excess lipid accumulation in diabetic rat placentas. Life Sci 2010;86:781-90.
56. Suwaki N, Masuyama H, Masumoto A, Takamoto N, Hiramatsu Y. Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy. Placenta 2007;28:315-23. (Pubitemid 46505940)
57. White V, Capobianco E, Higa R, Martinez N, Sosa M, Pustovrh MC, et al. Increased nitration and diminished activity of copper/zinc superoxide dismutase in placentas from diabetic rats. Free Radic Res 2010;44:1407-15.
58. Pustovrh MC, Jawerbaum A, White V, Capobianco E, Higa R, Martinez N, et al. The role of nitric oxide on matrix metalloproteinase 2 (MMP2) and MMP9 in placenta and fetus from diabetic rats. Reproduction 2007;134:605-13. (Pubitemid 47555054)
59. Capobianco E, White V, Higa R, Martinez N, Jawerbaum A. Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. Mol Hum Reprod 2008;14:491-9.
60. Feig DS, Briggs GG, Koren G. Oral antidiabetic agents in pregnancy and lactation: a paradigm shift? Ann Pharmacother 2007;41:1174-80.