Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot

Molecular Pharmacology

Volumn 79, Issue 3, 2011, Pages 461-471

  Levitt, Erica S ^a   Purington, Lauren C ^a   Traynor, John R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; ADENYLATE CYCLASE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CLONIDINE; CP 559140; CYCLIC AMP; DELTA OPIATE RECEPTOR; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; G PROTEIN COUPLED RECEPTOR; MU OPIATE RECEPTOR; NOCICEPTIN; NOCICEPTIN RECEPTOR; OPIATE; OPIATE AGONIST; SEROTONIN 1A RECEPTOR; UK 14301; UNCLASSIFIED DRUG; CNR1 PROTEIN, RAT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NARCOTIC ANALGESIC AGENT;

ARTICLE; CELL COMPARTMENTALIZATION; HUMAN; HUMAN CELL; INCUBATION TIME; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NEUROBLASTOMA; PHYSIOLOGY; RADIOASSAY; TUMOR CELL LINE; WESTERN BLOTTING;

ADENYLATE CYCLASE; ANALGESICS, OPIOID; BLOTTING, WESTERN; CELL LINE, TUMOR; CYCLIC AMP; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; NEUROBLASTOMA; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION;

EID: 79952001514     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.064816     Document Type: Article

References (40)

1. Aghajanian GK (1978) Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine. Nature 276:186-188.
2. Allen JA, Halverson-Tamboli RA, and Rasenick MM (2007) Lipid raft microdomains and neurotransmitter signalling. Nat Rev Neurosci 8:128-140. (Pubitemid 46146951)
3. Alt A, Clark MJ, Woods JH, and Traynor JR (2002) Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells. Br J Pharmacol 135:217-225. (Pubitemid 34102115)
4. 35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of mu-opioid receptors and G protein. J Pharmacol Exp Ther 298:116-121.
5. Aston-Jones G, Hirata H, and Akaoka H (1997) Local opiate withdrawal in locus coeruleus in vivo. Brain Res 765:331-336. (Pubitemid 27397631)
6. Beedle AM, McRory JE, Poirot O, Doering CJ, Altier C, Barrere C, Hamid J, Nargeot J, Bourinet E, and Zamponi GW (2004) Agonist-independent modulation of N-type calcium channels by ORL1 receptors. Nat Neurosci 7:118-125. (Pubitemid 38129787)
7. Brinkerhoff CJ, Traynor JR, and Linderman JJ (2008) Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results? J Theor Biol 255:278-286.
8. Chabre M, Deterre P, and Antonny B (2009) The apparent cooperativity of some GPCRs does not necessarily imply dimerization. Trends Pharmacol Sci 30:182-187.
9. Christie MJ, Williams JT, Osborne PB, and Bellchambers CE (1997) Where is the locus in opioid withdrawal? Trends Pharmacol Sci 18:134-140. (Pubitemid 27168256)
10. Connor M, Vaughan CW, Chieng B, and Christie MJ (1996) Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro. Br J Pharmacol 119:1614-1618. (Pubitemid 27019536)
11. 2+ channel Cav1.2. Science 293: 98-101.
12. George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, and O'Dowd BF (2000) Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem 275:26128-26135.
13. Gold MS, Redmond DE Jr, and Kleber HD (1978) Clonidine blocks acute opiate-withdrawal symptoms. Lancet 2:599-602. (Pubitemid 9009208)
14. Gomes I, Gupta A, Filipovska J, Szeto HH, Pintar JE, and Devi LA (2004) A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci USA 101: 5135-5139. (Pubitemid 38469214)
15. Graeser D and Neubig RR (1993) Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors. Mol Pharmacol 43:434-443. (Pubitemid 23082000)
16. Hall RA and Lefkowitz RJ (2002) Regulation of G protein-coupled receptor signaling by scaffold proteins. Circ Res 91:672-680. (Pubitemid 35204949)
17. Hine B, Friedman E, Torrelio M, and Gershon S (1975) Morphine-dependent rats: blockade of precipitated abstinence by tetrahydrocannabinol. Science 187: 443-445.
18. Hur EM and Kim KT (2002) G protein-coupled receptor signalling and cross-talk: achieving rapidity and specificity. Cell Signal 14:397-405.
19. Ivanov A and Aston-Jones G (2001) Local opiate withdrawal in locus coeruleus neurons in vitro. J Neurophysiol 85:2388-2397. (Pubitemid 32525517)
20. Jordan BA, Gomes I, Rios C, Filipovska J, and Devi LA (2003) Functional interactions between mu opioid and alpha 2A-adrenergic receptors. Mol Pharmacol 64:1317-1324. (Pubitemid 37532221)
21. Kotlińska J, Suder P, Legowska A, Rolka K, and Silberring J (2000) Orphanin FQ/nociceptin inhibits morphine withdrawal. Life Sci 66:PL119-PL123.
22. Kotlinska J, Wichmann J, Rafalski P, Talarek S, Dylag T, and Silberring J (2003) Non-peptidergic OP4 receptor agonist inhibits morphine antinociception but does not influence morphine dependence. Neuroreport 14:601-604. (Pubitemid 36528998)
23. Lameh J, Eiger S, and Sadée W (1992) Interaction among mu-opioid receptors and alpha 2-adrenoceptors on SH-SY5Y human neuroblastoma cells. Eur J Pharmacol 227:19-24.
24. Lee PH, McNutt RW, and Chang KJ (1993) A nonpeptidic delta opioid receptor agonist, BW373U86, attenuates the development and expression of morphine abstinence precipitated by naloxone in rat. J Pharmacol Exp Ther 267:883-887. (Pubitemid 23352551)
25. Rios C, Gomes I, and Devi LA (2004) Interactions between delta opioid receptors and alpha-adrenoceptors. Clin Exp Pharmacol Physiol 31:833-836. (Pubitemid 39556863)
26. Rios C, Gomes I, and Devi LA (2006) mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol 148:387-395. (Pubitemid 43882074)
27. Saulière A, Gaibelet G, Millot C, Mazères S, Lopez A, and Salomé L (2006) Diffusion of the mu opioid receptor at the surface of human neuroblastoma SH-SY5Y cells is restricted to permeable domains. FEBS Lett 580:5227-5231.
28. Scavone JL, Mackie K, and Van Bockstaele EJ (2010) Characterization of cannabinoid-1 receptors in the locus coeruleus: relationship with mu-opioid receptors. Brain Res 1312:18-31.
29. Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, and Basbaum AI (2009) Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 137:1148-1159.
30. Shapira M, Vogel Z, and Sarne Y (2000) Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors. Cell Mol Neurobiol 20:291-304. (Pubitemid 30228222)
31. Smith CB, Moises HC, Spengler RN, and Hollingsworth PJ (1989) Changes in alpha 2-adrenoceptor number and function in brains of morphine-dependent rats. Eur J Pharmacol 161: 111-119. (Pubitemid 19080493)
32. Stickle D and Barber R (1992) The encounter coupling model for beta-adrenergic receptor/GTP-binding protein interaction in the S49 cell. Calculation of the encounter frequency. Biochem Pharmacol 43:2015-2028.
33. Tallarida RJ (2006) An overview of drug combination analysis with isobolograms. J Pharmacol Exp Ther 319:1-7.
34. Tolkovsky AM and Levitzki A (1978) Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochemistry 17:3795.
35. Traynor J (2010) Regulator of G protein-signaling proteins and addictive drugs. Ann NY Acad Sci 1187:341-352.
36. Wang HL, Hsu CY, Huang PC, Kuo YL, Li AH, Yeh TH, Tso AS, and Chen YL (2005) Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of mu receptor agonist. J Neurochem 92:1285-1294. (Pubitemid 40389199)
37. Watts VJ (2002) Molecular mechanisms for heterologous sensitization of adenylate cyclase. J Pharmacol Exp Ther 302:1-7.
38. Yu E, Miotto K, Akerele E, Montgomery A, Elkashef A, Walsh R, Montoya I, Fischman MW, Collins J, McSherry F, et al. (2008) A phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal. Drug Alcohol Depend 97:158-168.
39. Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, and Nestler EJ (2008) Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biol Psychiatry 63:1013-1021.
40. Zadina JE, Harrison LM, Ge LJ, Kastin AJ, and Chang SL (1994) Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther 270:1086-1096.