Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family

FEBS Journal

Volumn 278, Issue 5, 2011, Pages 793-808

  Stern, Ana L ^a   Naworyta, Agata ^a   Cazzulo, Juan J ^b   Mowbray, Sherry L ^a,c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Chagas disease; enzyme specificity; pentose phosphate pathway; type B ribose 5 phosphate isomerase (RpiB); X ray crystallography

Indexed keywords

4 PHOSPHO DEXTRO ERYTHRONOHYDROXAMIC ACID; ALANINE; CYSTEINE; DEXTRO ALLOSE 6 PHOSPHATE; HYDROXAMIC ACID DERIVATIVE; ISOMERASE; MUTANT PROTEIN; PHOSPHATE; RIBOSE 5 PHOSPHATE; SUGAR; TYPE B RIBOSE 5 PHOSPHATE ISOMERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ISOMERIZATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN FAMILY; TRYPANOSOMA CRUZI; WILD TYPE;

ALDOSE-KETOSE ISOMERASES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTOZOAN PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA CRUZI;

ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; PROTOZOA; TRYPANOSOMA CRUZI;

EID: 79951955143     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07999.x     Document Type: Article

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