Eye tracking performance and the boundaries of the schizophrenia spectrum

Psychiatry Research

Volumn 186, Issue 1, 2011, Pages 18-22

  Mitropoulou, Vivian ^a   Friedman, Lee ^a   Zegarelli, Gayle ^a   Wajnberg, Sarah ^a   Meshberg, Justin ^a   Silverman, Jeremy M ^a   Siever, Larry J ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Clinical symptoms; Endophenotype; Motion detection; Quantitative measures; Temporal lobe; Velocity sensitivity

Indexed keywords

ADULT; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DEMOGRAPHY; EYE TRACKING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SCHIZOPHRENIC REACTION; SCHIZOTYPAL PERSONALITY DISORDER; TASK PERFORMANCE; VELOCITY;

ADULT; ANALYSIS OF VARIANCE; EYE MOVEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; OCULAR MOTILITY DISORDERS; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; STATISTICS AS TOPIC;

EID: 79951953908     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2010.08.004     Document Type: Article

References (51)

1. Abel L.A., Friedman L., Jesberger J., Malki A., Meltzer H.Y. Quantitative assessment of smooth pursuit gain and catch-up saccades in schizophrenia and affective disorders. Biological Psychiatry 1991, 29(11):1063-1072.
2. Avila M.T., Adami H.M., McMahon R.P., Thaker G.K. Using neurophysiological markers of genetic risk to define the boundaries of the schizophrenia spectrum phenotype. Schizophrenia Bulletin 2003, 29(2):299-309.
3. Barch D.M., Mitropoulou V., Harvey P.D., New A.S., Silverman J.M., Siever L.J. Context-processing deficits in schizotypal personality disorder. Journal of Abnormal Psychology 2004, 113(4):556-568.
4. Beck A.T., Beamesderfer A. Assessment of depression: the depression inventory. Modern Problems of Pharmacopsychiatry 1974, 7:151-169.
5. Bergman A.J., Harvey P.D., Mitropoulou V., Aronson A., Marder D., Silverman J., Trestman R., Siever L.J. The factor structure of schizotypal symptoms in a clinical population. Schizophrenia Research 1996, 22(3):501-509.
6. Cadenhead K.S., Geyer M.A., Braff D.L. Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. The American Journal of Psychiatry 1993, 150(12):1862-1867.
7. Cannon T.D., Keller M.C. Endophenotypes in the genetic analyses of mental disorders. Annual Review of Clinical Psychology 2006, 2:267-290.
8. Chen Y., Grossman E.D., Bidwell L.C., Yurgelun-Todd D., Gruber S.A., Levy D.L., Nakayama K., Holzman P.S. Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains. Cognitive, Affective & Behavioral Neuroscience 2008, 8(3):293-303.
9. Clementz B.A., Sweeney J.A., Hirt M., Haas G. Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia. Journal of Abnormal Psychology 1990, 99(4):327-335.
10. Clementz B.A., McDowell J.E., Zisook S. Saccadic system functioning among schizophrenia patients and their first-degree biological relatives. Journal of Abnormal Psychology 1994, 103(2):277-287.
11. Clementz B.A., Reid S.A., McDowell J.E., Cadenhead K.S. Abnormality of smooth pursuit eye movement initiation: specificity to the schizophrenia spectrum?. Psychophysiology 1995, 32(2):130-134.
12. Endicott R., Spitzer E. Schedule for affective disorders and schizophrenia (SADS). The American Journal of Psychiatry 1978, 35(7):837-844.
13. Friedman L., Jesberger J.A., Meltzer H.Y. A model of smooth pursuit performance illustrates the relationship between gain, catch-up saccade rate, and catch-up saccade amplitude in normal controls and patients with schizophrenia. Biological Psychiatry 1991, 30(6):537-556.
14. Friedman L., Abel L.A., Jesberger J.A., Malki A., Meltzer H.Y. Saccadic intrusions into smooth pursuit in patients with schizophrenia or affective disorder and normal controls. Biological Psychiatry 1992, 31(11):1110-1118.
15. Friedman L., Jesberger J.A., Siever L.J., Thompson P., Mohs R., Meltzer H.Y. Smooth pursuit performance in patients with affective disorders or schizophrenia 413 and normal controls: analysis with specific oculomotor measures, RMS error and 414 qualitative ratings. Psychological Medicine 1995, 25(11):387-403.
16. Gooding D.C., Iacono W.G., Beiser M. Temporal stability of smooth-pursuit eye tracking in first episode psychosis. Psychophysiology 1994, 31(1):62-67.
17. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. The American Journal of Psychiatry 2003, 160(4):636-645.
18. Holzman P.S. Recent studies of psychophysiology in schizophrenia. Schizophrenia Bulletin 1987, 13(1):49-75.
19. Holzman P.S. Eye movements and the search for the essence of schizophrenia. Brain Research. Brain Research Reviews 2000, 31(2-3):350-356.
20. Holzman P.S., Proctor L.R., Hughes D.W. Eye-tracking patterns in schizophrenia. Science 1973, 181(95):179-181.
21. Holzman P.S., Proctor L.R., Levy D.L., Yasillo N.J., Meltzer H.Y., Hurt S.W. Eye-tracking dysfunctions in schizophrenic patients and their relatives. Archives of General Psychiatry 1974, 31(2):143-151.
22. Hong L.E., Mitchell B.D., Avila M.T., Adami H., McMahon R.P., Thaker G.K. Familial aggregation of eye-tracking endophenotypes in families of schizophrenic patients. Archives of General Psychiatry 2006, 63(3):259-264.
23. Hong L.E., Turano K.A., O'Neill H., Hao L., Wonodi I., McMahon R.P., Elliot A., Thaker G.K. Refining the predictive pursuit endophenotype in schizophrenia. Biological Psychiatry 2008, 63(5):458-464.
24. Kathmann N., Hochrein A., Uwer R., Bondy B. Deficits in gain of smooth pursuit eye movements in schizophrenia and affective disorder patients and their unaffected relatives. The American Journal of Psychiatry 2003, 160(4):696-702.
25. Keefe R.S., Silverman J.M., Mohs R.C., Siever L.J., Harvey P.D., Friedman L., Roitman S.E., DuPre R.L., Smith C.J., Schmeidler J., Davis K.L. Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Archives of General Psychiatry 1997, 54(2):169-176.
26. Kendler K.S., Gardner C.O. The risk for psychiatric disorders in relatives of schizophrenic and control probands: a comparison of three independent studies. Psychological Medicine 1997, 27(2):411-419.
27. Lencer R., Trillenberg-Krecker K., Schwinger E., Arolt V. Schizophrenia spectrum disorders and eye tracking dysfunction in singleton and multiplex schizophrenia families. Schizophrenia Research 2003, 60(1):33-45.
28. Lenzenweger M.F., O'Driscoll G.A. Smooth pursuit eye movement and schizotypy in the community. Journal of Abnormal Psychology 2006, 115(4):779-786.
29. Levy D.L., Holzman P.S., Matthysse S., Mendell N.R. Eye tracking dysfunction and schizophrenia: a critical perspective. Schizophrenia Bulletin 1993, 19(3):461-536.
30. McDowell J.E., Brown G.G., Paulus M., Martinez A., Stewart S.E., Dubowitz D.J., Braff D.L. Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biological Psychiatry 2002, 51(3):216-223.
31. Mitropoulou V., Harvey P., Maldari L., Moriarty P., New A., Silverman J., Siever L.J. Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity. Biological Psychiatry 2002, 52(12):1175-1182.
32. Mitropoulou V., Harvey P.D., Zegarelli G., New A., Silverman J., Siever L. Neuropsychological performance in schizotypal personality disorder: importance of working memory. The American Journal of Psychiatry 2005, 162(10):1896-1903.
33. O'Driscoll G.A., Callahan B.L. Smooth pursuit in schizophrenia: a meta-analytic review of research since 1993. Brain and Cognition 2008, 68:359-370.
34. Pfohl B., Blum N., Zimmerman M. A structured interview for the DSM-III-R personality disorders 1989, Dept of Psychiatry, University of Iowa.
35. Roitman S.E., Cornblatt B.A., Bergman A., Obuchowski M., Mitropoulou V., Keefe R.S., Silverman J.M., Siever L.J. Attentional functioning in schizotypal personality disorder. The American Journal of Psychiatry 1997, 154(5):655-660.
36. Rosenberg D.R., Sweeney J.A., Squires-Wheeler E., Keshavan M.S., Cornblatt B.A., Erlenmeyer-Kimling L. Eye-tracking dysfunction in offspring from the New York high-risk project: diagnostic specificity and the role of attention. Psychiatry Research 1997, 7(66(2-3)):121-130.
37. Ross R.G., Olincy A., Mikulich S.K., Radant A.D., Harris J.G., Waldo M., Compagnon N., Heinlein S., Leonard S., Zerbe G.O., Adler L., Freedman R. Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes. Psychophysiology 2002, 39(6):809-819.
38. Shagass C., Amadeo M., Overton D.A. Eye tracking performance in psychiatric patients. Biological Psychiatry 1974, 9(3):245-260.
39. Siever L.J., Davis K.L. A psychobiological perspective on the personality disorders. The American Journal of Psychiatry 1991, 148:1647-1658.
40. Siever L.J., Davis K.L. The pathophysiology of schizophrenia disorders: perspectives from the spectrum. The American Journal of Psychiatry 2004, 161:398-413.
41. Siever L.J., Kalus O.F., Keefe R.S. The boundaries of schizophrenia. The Psychiatric Clinics of North America 1993, 16(2):217-244.
42. Siever L.J., Friedman L., Moskowitz J., Mitropoulou V., Keefe R., Roitman S.L., Merhige D., Trestman R., Silverman J., Mohs R. Eye movement impairment and schizotypal psychopathology. The American Journal of Psychiatry 1994, 151(8):1209-1215.
43. Sweeney J.A., Luna B., Keedy S.K., McDowell J.E., Clementz B.A. fMRI studies of eye movement control: investigating the interaction of cognitive and sensorimotor brain systems. Neuroimage 2007, 36(Suppl 2):T54-T60.
44. Sweeney J.A., Luna B., Srinivasagam N.M., Keshavan M.S., Schooler N.R., Haas G.L., Carl J.R. Eye tracking abnormalities in schizophrenia: evidence for dysfunction in the frontal eye fields. Biological Psychiatry 1998, 44(8):698-708.
45. Thaker G.K., Cassady S., Adami H., Moran M., Ross D.E. Eye movements in spectrum personality disorders: comparison of community subjects and relatives of schizophrenic patients. The American Journal of Psychiatry 1996, 153(3):362-368.
46. Thaker G.K., Ross D.E., Cassady S.L., Adami H.M., LaPorte D., Medoff D.R., Lahti A. Smooth pursuit eye movements to extraretinal motion signals: deficits in relatives of patients with schizophrenia. Archives of General Psychiatry 1998, 55(9):830-836.
47. Thaker G.K., Ross D.E., Buchanan R.W., Adami H.M., Medoff D.R. Smooth pursuit eye movements to extra-retinal motion signals: deficits in patients with schizophrenia. Psychiatry Research 1999, 29(88(3)):209-219.
48. Thaker G.K., Wonodi I., Avila M.T., Hong L.E., Stine O.C. Catechol O-methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary report. The American Journal of Psychiatry 2004, 161(12):2320-2322.
49. Tregellas J.R., Tanabe J.L., Miller D.E., Ross R.G., Olincy A., Freedman R. Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an fMRI study. The American Journal of Psychiatry 2004, 161(2):315-321.
50. Voglmaier M.M., Seidman L.J., Salisbury D., McCarley R.W. Neuropsychological dysfunction in schizotypal personality disorder: a profile analysis. Biological Psychiatry 1997, 41(5):530-540.
51. Voglmaier M.M., Seidman L.J., Niznikiewicz M.A., Dickey C.C., Shenton M.E., McCarley R.W. Verbal and nonverbal neuropsychological test performance in subjects with schizotypal personality disorder. The American Journal of Psychiatry 2000, 157(5):787-793.