-
1
-
-
0024429141
-
A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease
-
Brynskov J, Freund L, Rasmussen SN, Lauritsen K, de Muckadell OS, Williams N, et al. A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease. N Engl J Med 1989;321:845-50. (Pubitemid 19238615)
-
(1989)
New England Journal of Medicine
, vol.321
, Issue.13
, pp. 845-850
-
-
Brynskov, J.1
Freund, L.2
Rasmussen, S.N.3
Lauritsen, K.4
De Schaffalitzky, M.O.5
Williams, N.6
MacDonald, A.S.7
Tanton, R.8
Molina, F.9
Campanini, M.C.10
Bianchi, P.11
Ranzi, T.12
Quarto, D.P.F.13
Malchow-Moller, A.14
Thomsen, O.O.15
Tage-Jensen, U.16
Binder, V.17
Riis, P.18
-
2
-
-
33747616250
-
2+/calcineurin signaling pathway
-
DOI 10.1038/sj.emboj.7601246, PII 7601246
-
Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, et al. Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J 2006;25:3714-24. (Pubitemid 44264881)
-
(2006)
EMBO Journal
, vol.25
, Issue.15
, pp. 3714-3724
-
-
Buchholz, M.1
Schatz, A.2
Wagner, M.3
Michl, P.4
Linhart, T.5
Adler, G.6
Gress, T.M.7
Ellenrieder, V.8
-
3
-
-
0026076395
-
The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats
-
Cho CH, Luk CT, Ogle CW. The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats. Life Sci 1991;49:189-94.
-
(1991)
Life Sci
, vol.49
, pp. 189-194
-
-
Cho, C.H.1
Luk, C.T.2
Ogle, C.W.3
-
4
-
-
4644369302
-
+ regulatory T cell function
-
DOI 10.1002/eji.200425274
-
de la Rosa M, Rutz S, Dorninger H, Scheffold A. Interleukin-2 is essential for CD4+CD25 + regulatory T cell function. Eur J Immunol 2004;34:2480-8. (Pubitemid 39302805)
-
(2004)
European Journal of Immunology
, vol.34
, Issue.9
, pp. 2480-2488
-
-
De La Rosa, M.1
Rutz, S.2
Dorninger, H.3
Scheffold, A.4
-
5
-
-
0031012926
-
T cell receptor-alphabeta-deficient mice fail to develop colitis in the absence of a microbial environment
-
Dianda L, Hanby AM, Wright NA, Sebesteny A, Hayday AC, Owen MJ. T cell receptoralpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol 1997;150:91-7. (Pubitemid 27027100)
-
(1997)
American Journal of Pathology
, vol.150
, Issue.1
, pp. 91-97
-
-
Dianda, L.1
Hanby, A.M.2
Wright, N.A.3
Sebesteny, A.4
Hayday, A.C.5
Owen, M.J.6
-
7
-
-
33749638414
-
Comparative proteomic studies on the pathogenesis of human ulcerative colitis
-
Hsieh SY, Shih TC, Yeh CY, Lin CJ, Chou YY, Lee YS. Comparative proteomic studies on the pathogenesis of human ulcerative colitis. Proteomics 2006;6:5322-31.
-
(2006)
Proteomics
, vol.6
, pp. 5322-5331
-
-
Hsieh, S.Y.1
Shih, T.C.2
Yeh, C.Y.3
Lin, C.J.4
Chou, Y.Y.5
Lee, Y.S.6
-
8
-
-
34547877600
-
Acetate inhibits NFAT activation in T cells via importin beta1 interference
-
DOI 10.1002/eji.200737180
-
Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Goto H. Acetate inhibits NFAT activation in T cells via importin beta1 interference. Eur J Immunol 2007;37:2309-16. (Pubitemid 47250222)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.8
, pp. 2309-2316
-
-
Ishiguro, K.1
Ando, T.2
Maeda, O.3
Ohmiya, N.4
Niwa, Y.5
Goto, H.6
-
10
-
-
0033698581
-
Manipulating immune responses with immunosuppressive agents that target NFAT
-
Kiani A, Rao A, Aramburu J. Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity 2000;12:359-72.
-
(2000)
Immunity
, vol.12
, pp. 359-372
-
-
Kiani, A.1
Rao, A.2
Aramburu, J.3
-
12
-
-
24744464406
-
Increased expression of calcineurin in human colorectal adenocarcinomas
-
DOI 10.1002/jcb.20437
-
Lakshmikuttyamma A, Selvakumar P, Kanthan R, Kanthan SC, Sharma RK. Increased expression of calcineurin in human colorectal adenocarcinomas. J Cell Biochem 2005;95:731-9. (Pubitemid 41420160)
-
(2005)
Journal of Cellular Biochemistry
, vol.95
, Issue.4
, pp. 731-739
-
-
Lakshmikuttyamma, A.1
Selvakumar, P.2
Kanthan, R.3
Kanthan, S.C.4
Sharma, R.K.5
-
13
-
-
33748297537
-
Regulation of NFAT activation: A potential therapeutic target for immunosuppression
-
Lee M, Park J. Regulation of NFAT activation: a potential therapeutic target for immunosuppression. Mol Cells 2006;22:1-7. (Pubitemid 44323038)
-
(2006)
Molecules and Cells
, vol.22
, Issue.1
, pp. 1-7
-
-
Lee, M.1
Park, J.2
-
15
-
-
0018159318
-
Ionomycin, a new polyether antibiotic
-
Liu WC, Slusarchyk DS, Astle G, Trejo WH, Brown WE, Meyers E. Ionomycin, a new polyether antibiotic. J Antibiot Tokyo 1978;31:815-9. (Pubitemid 9040535)
-
(1978)
Journal of Antibiotics
, vol.31
, Issue.9
, pp. 815-819
-
-
Liu, W.C.1
Smith, S.D.2
Astle, G.3
-
16
-
-
15844416253
-
Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
-
DOI 10.1074/jbc.271.18.10884
-
Loh C, Shaw KT, Carew J, Viola JP, Luo C, Perrino BA, et al. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J Biol Chem 1996;271:10884-91. (Pubitemid 26145827)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.18
, pp. 10884-10891
-
-
Loh, C.1
Shaw, K.T.-Y.2
Carew, J.3
Viola, J.P.B.4
Luo, C.5
Perrino, B.A.6
Rao, A.7
-
17
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
DOI 10.1038/nri1435
-
Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004;4:665-74. (Pubitemid 39223073)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.9
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
18
-
-
0034219226
-
Applicability of zinc complex of L-carnosine for medical use
-
Matsukura T, Tanaka H. Applicability of zinc complex of L-carnosine for medical use. Biochem Mosc 2000;65:817-23.
-
(2000)
Biochem Mosc
, vol.65
, pp. 817-823
-
-
Matsukura, T.1
Tanaka, H.2
-
19
-
-
0032563244
-
A viral mechanism for inhibition of the cellular phosphatase calcineurin
-
Miskin JE, Abrams CC, Goatley LC, Dixon LK. A viral mechanism for inhibition of the cellular phosphatase calcineurin. Science 1998;281:562-5.
-
(1998)
Science
, vol.281
, pp. 562-565
-
-
Miskin, J.E.1
Abrams, C.C.2
Goatley, L.C.3
Dixon, L.K.4
-
20
-
-
0024552818
-
Hapten-induced model of chronic inflammation and ulceration in the rat colon
-
Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989;96:795-803. (Pubitemid 19057602)
-
(1989)
Gastroenterology
, vol.96
, Issue.3
, pp. 795-803
-
-
Morris, G.P.1
Beck, P.L.2
Herridge, M.S.3
Depew, W.T.4
Szewczuk, M.R.5
Wallace, J.L.6
-
21
-
-
0034772988
-
Review article: The treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine
-
DOI 10.1046/j.1365-2036.2001.01102.x
-
Nielsen OH, Vainer B, Rask-Madsen J. Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Aliment Pharmacol Ther 2001;15:1699-708. (Pubitemid 33001133)
-
(2001)
Alimentary Pharmacology and Therapeutics
, vol.15
, Issue.11
, pp. 1699-1708
-
-
Nielsen, O.H.1
Vainer, B.2
Rask-Madsen, J.3
-
22
-
-
33750503155
-
Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation
-
DOI 10.1016/j.lfs.2006.07.032, PII S0024320506005753
-
Odashima M, Otaka M, Jin M, Wada I, Horikawa Y, Matsuhashi T, et al. Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation. Life Sci 2006;79:2245-50. (Pubitemid 44666062)
-
(2006)
Life Sciences
, vol.79
, Issue.24
, pp. 2245-2250
-
-
Odashima, M.1
Otaka, M.2
Jin, M.3
Wada, I.4
Horikawa, Y.5
Matsuhashi, T.6
Ohba, R.7
Hatakeyama, N.8
Oyake, J.9
Watanabe, S.10
-
23
-
-
27844543768
-
Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice
-
DOI 10.1080/00365520510023530
-
Ohkawara T, Takeda H, Kato K, Miyashita K, Kato M, Iwanaga T, et al. Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice. Scand J Gastroenterol 2005;40:1321-7. (Pubitemid 41658731)
-
(2005)
Scandinavian Journal of Gastroenterology
, vol.40
, Issue.11
, pp. 1321-1327
-
-
Ohkawara, T.1
Takeda, H.2
Kato, K.3
Miyashita, K.4
Kato, M.5
Iwanaga, T.6
Asaka, M.7
-
24
-
-
0029062389
-
Proliferative activity in colonic adenomas as a predictor of metachronous adenomas as assessed by proliferating cell nuclear antigen immunohistochemistry
-
Paspatis GA, Karamanolis DG, Vasilakaki T, Zizi A, Xourgias V, Elemenoglou I, et al. Proliferative activity in colonic adenomas as a predictor of metachronous adenomas as assessed by proliferating cell nuclear antigen immunohistochemistry. Am J Gastroenterol 1995;90:597-602.
-
(1995)
Am J Gastroenterol
, vol.90
, pp. 597-602
-
-
Paspatis, G.A.1
Karamanolis, D.G.2
Vasilakaki, T.3
Zizi, A.4
Xourgias, V.5
Elemenoglou, I.6
-
25
-
-
0025856744
-
Onset of ulcerative colitis in a cyclosporin-treated patient
-
Passfall J, Distler A, Riecken EO, Zeitz M. Onset of ulcerative colitis in a cyclosporin-treated patient. Lancet 1991;338:9.
-
(1991)
Lancet
, vol.338
, pp. 9
-
-
Passfall, J.1
Distler, A.2
Riecken, E.O.3
Zeitz, M.4
-
26
-
-
0037043658
-
Inflammatory bowel disease
-
DOI 10.1056/NEJMra020831
-
Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347:417-29. (Pubitemid 34851835)
-
(2002)
New England Journal of Medicine
, vol.347
, Issue.6
, pp. 417-429
-
-
Podolsky, D.K.1
-
27
-
-
0030973579
-
Transcription factors of the NFAT family: Regulation and function
-
DOI 10.1146/annurev.immunol.15.1.707
-
Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997;15:707-47. (Pubitemid 27169297)
-
(1997)
Annual Review of Immunology
, vol.15
, pp. 707-747
-
-
Rao, A.1
Luo, C.2
Hogan, P.G.3
-
28
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
DOI 10.1016/0092-8674(93)80067-O
-
Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993;75:253-61. (Pubitemid 23320289)
-
(1993)
Cell
, vol.75
, Issue.2
, pp. 253-261
-
-
Sadlack, B.1
Merz, H.2
Schorle, H.3
Schimpl, A.4
Feller, A.C.5
Horak, I.6
-
29
-
-
0029761681
-
Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
-
DOI 10.1038/382370a0
-
Shibasaki F, Price ER, Milan D, McKeon F. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 1996;382:370-3. (Pubitemid 26260467)
-
(1996)
Nature
, vol.382
, Issue.6589
, pp. 370-373
-
-
Shibasaki, F.1
Price, E.R.2
Milan, D.3
McKeon, F.4
-
30
-
-
41849111995
-
Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis
-
Shih TC, Hsieh SY, Hsieh YY, Chen TC, Yeh CY, Lin CJ, et al. Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis. World J Gastroenterol 2008;14:1759-67.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 1759-1767
-
-
Shih, T.C.1
Hsieh, S.Y.2
Hsieh, Y.Y.3
Chen, T.C.4
Yeh, C.Y.5
Lin, C.J.6
-
31
-
-
21744455700
-
Review article: Practical management of inflammatory bowel disease patients taking immunomodulators
-
DOI 10.1111/j.1365-2036.2005.02520.x
-
Siegel CA, Sands BE. Review article: practical management of inflammatory bowel disease patients taking immunomodulators. Aliment Pharmacol Ther 2005;22:1-16. (Pubitemid 40943869)
-
(2005)
Alimentary Pharmacology and Therapeutics
, vol.22
, Issue.1
, pp. 1-16
-
-
Siegel, C.A.1
Sands, B.E.2
-
32
-
-
0024457565
-
Cyclosporin A treatment in inflammatory bowel disease
-
Stange EF, Fleig WE, Rehklau E, Ditschuneit H. Cyclosporin A treatment in inflammatory bowel disease. Dig Dis Sci 1989;34:1387-92. (Pubitemid 19247395)
-
(1989)
Digestive Diseases and Sciences
, vol.34
, Issue.9
, pp. 1387-1392
-
-
Stange, E.F.1
Fleig, W.E.2
Rehklau, E.3
Ditschuneit, H.4
-
33
-
-
0038049535
-
Zinc inhibits calcineurin activity in vitro by competing with nickel
-
DOI 10.1016/S0006-291X(03)01122-7
-
Takahashi K, Akaishi E, Abe Y, Ishikawa R, Tanaka S, Hosaka K, et al. Zinc inhibits calcineurin activity in vitro by competing with nickel. Biochem Biophys Res Commun 2003;307:64-8. (Pubitemid 36808536)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.307
, Issue.1
, pp. 64-68
-
-
Takahashi, K.1
Akaishi, E.2
Abe, Y.3
Ishikawa, R.4
Tanaka, S.5
Hosaka, K.6
Kubohara, Y.7
-
34
-
-
55349125318
-
The effect of tacrolimus (FK-506) on Japanese patients with refractory Crohn's disease
-
Tamaki H, Nakase H, Matsuura M, Inoue S, Mikami S, Ueno S, et al. The effect of tacrolimus (FK-506) on Japanese patients with refractory Crohn's disease. J Gastroenterol 2008;43:774-9.
-
(2008)
J Gastroenterol
, vol.43
, pp. 774-779
-
-
Tamaki, H.1
Nakase, H.2
Matsuura, M.3
Inoue, S.4
Mikami, S.5
Ueno, S.6
-
35
-
-
25144477033
-
Zinc ions suppress mitogen-activated interleukin-2 production in Jurkat cells
-
DOI 10.1016/j.bbrc.2005.07.059, PII S0006291X05015366
-
Tanaka S, Akaishi E, Hosaka K, Okamura S, Kubohara Y. Zinc ions suppress mitogen-activated interleukin-2 production in Jurkat cells. Biochem Biophys Res Commun 2005;335:162-7. (Pubitemid 41350776)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.335
, Issue.1
, pp. 162-167
-
-
Tanaka, S.1
Akaishi, E.2
Hosaka, K.3
Okamura, S.4
Kubohara, Y.5
-
36
-
-
0024584951
-
Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease
-
Wallace JL, MacNaughton WK, Morris GP, Beck PL. Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease. Gastroenterology 1989;96:29-36. (Pubitemid 19046263)
-
(1989)
Gastroenterology
, vol.96
, Issue.1
, pp. 29-36
-
-
Wallace, J.L.1
MacNaughton, W.K.2
Morris, G.P.3
Beck, P.L.4
-
37
-
-
51049089284
-
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis
-
Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, et al. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J Exp Med 2008;205:2099-110.
-
(2008)
J Exp Med
, vol.205
, pp. 2099-2110
-
-
Weigmann, B.1
Lehr, H.A.2
Yancopoulos, G.3
Valenzuela, D.4
Murphy, A.5
Stevens, S.6
-
38
-
-
0030747182
-
Effect of Z-103 on TNB-induced colitis in rats
-
Yoshikawa T, Yamaguchi T, Yoshida N, Yamamoto H, Kitazumi S, Takahashi S, et al. Effect of Z-103 on TNB-induced colitis in rats. Digestion 1997;58:464-8. (Pubitemid 27445615)
-
(1997)
Digestion
, vol.58
, Issue.5
, pp. 464-468
-
-
Yoshikawa, T.1
Yamaguchi, T.2
Yoshida, N.3
Yamamoto, H.4
Kitazumi, S.5
Takahashi, S.6
Naito, Y.7
Kondo, M.8
|