Anemia correction by erythropoietin reduces BNP levels, hospitalization rate, and NYHA class in patients with cardio-renal anemia syndrome

Clinical and Experimental Medicine

Volumn 11, Issue 1, 2011, Pages 43-48

  Palazzuoli, Alberto ^a   Quatrini, Ilaria ^a   Calabrò, Anna ^a   Antonelli, Giovanni ^a   Caputo, Maria ^a   Campagna, Maria S ^a   Franci, Beatrice ^a   Nuti, Ranuccio ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Anemia; B type natriuretic peptide; Cardio renal syndrome; Erythropoietin; Heart failure

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; ERYTHROPOIETIN; FERROUS GLUCONATE; HEMOGLOBIN;

ANEMIA; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERYTHROCYTE; FOLLOW UP; HEMATOCRIT; HOSPITALIZATION; HUMAN; IRON THERAPY; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

ADMINISTRATION, ORAL; ANEMIA; ERYTHROPOIETIN; HEART FAILURE; HEMOGLOBINS; HOSPITALIZATION; HUMANS; INJECTIONS, SUBCUTANEOUS; IRON; KIDNEY DISEASES; NATRIURETIC PEPTIDE, BRAIN; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 79951950401     PISSN: 15918890     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10238-010-0100-y     Document Type: Article

References (30)

1. TB Horwich GC Fonarow MA Hamilton, et al. 2002 Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure J Am Coll Cardiol 39 178 (Pubitemid 34595288)
2. D Mozaffarian R Nye WC Levy 2003 Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE) J Am Coll Cardiol 41 1933 1939 10.1016/S0735-1097(03)00425-X 12798560 (Pubitemid 36677110)
3. GM Felker KF Adams Jr WA Gattis CM O'Connor 2004 Anemia as a risk factor and therapeutic target in heart failure J Am Coll Cardiol 44 959 966 10.1016/j.jacc.2004.05.070 15337204 (Pubitemid 39165127)
4. JA Ezekowitz FA McAlister PW Armstrong 2003 Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure Circulation 107 223 225 10.1161/01.CIR.0000052622.51963.FC 12538418 (Pubitemid 36135214)
5. JE Mitchell 2007 Emerging role of anemia an heart failure Am J Cardiol 99 15D 20D 10.1016/j.amjcard.2006.12.015 17378990 (Pubitemid 46427803)
6. A Palazzuoli M Gallotta F Iovine R Nuti DS Silverberg 2008 Anaemia in heart failure: a common interaction with chronic renal insufficiency called the cardio renal anaemia syndrome Int J Clin Pract 62 281 286 1:STN:280: DC%2BD1c%2FksFCisw%3D%3D 10.1111/j.1742-1241.2007.01650.x 18081797
7. Y-D Tang S Katz 2008 The prevalence of anemia in chronic heart failure and its impact on the clinical outcomes Heart Failure Rev 13 387 392 10.1007/s10741-008-9089-7
8. HF Groenveld JL Januzzi K Damman 2008 Anemia and mortality in heart failure patients: a systematic review and meta-analysis J Am Coll Cardiol 52 818 827 10.1016/j.jacc.2008.04.061 18755344
9. DS Silverberg D Wexler A Iaina D Schwartz 2008 The role of anaemia in patients with congestive heart failure: a short review Eur J Heart Failure 10 819 823 10.1016/j.ejheart.2008.06.015
10. IS Anand 2008 Anemia and chronic heart failure J Am Coll Cardiol 52 501 511 10.1016/j.jacc.2008.04.044 18687241
11. DS Silverberg D Wexler M Blum, et al. 2000 The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, congestive heart failure improves cardiac and renal function, functional cardiac class, and markedly reduces hospitalizations J Am Coll Cardiol 35 1737 1744 1:CAS:528:DC%2BD3cXktlGlt7Y%3D 10.1016/S0735-1097(00)00613-6 10841219 (Pubitemid 30342851)
12. DS Silverberg D Wexler D Sheps, et al. 2001 The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study J Am Coll Cardiol 37 1775 1780 1:CAS:528:DC%2BD3MXltVGhsL8%3D 10.1016/S0735-1097(01)01248- 7 11401110 (Pubitemid 32499958)
13. DM Mancini SD Katz CC Lang, et al. 2003 Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure Circulation 21 294 299 10.1161/01.CIR.0000044914.42696.6A (Pubitemid 36135227)
14. K Kourea JT Parissis D Farmakis F Panou I Paraskevaidis, et al. 2008 Effect of darbepoetin-alfa on plasma pro-inflammatory cytokines, anti-inflammatory cytokines interleukin-10 and soluble Fas/fas ligand system in anemic patients with chronic heart failure Atherosclerosis 199 215 221 1:CAS:528:DC%2BD1cXns1SnsL8%3D 10.1016/j.atherosclerosis.2007.09.039 17991471 (Pubitemid 351842695)
15. K Kourea JT Parissis D Farmakis, et al. 2008 Effects of darbepoetin-alfa on quality of life and emotional stress in anemic patients with chronic heart failure Eur J Cardiovascular Prev Rehabil 15 365 369 10.1097/HJR. 0b013e3282f849d0
16. JT Parissis K Kourea F Panou, et al. 2008 Effect of darbepoetin alpha on right and left ventricular systolic and diastolic function in an anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy Am Heart J 155 751e1 751e7 10.1016/j.ahj.2008.01.016
17. A Palazzuoli DS Silverberg F Iovine, et al. 2006 Erythropoietin improves anemia, exercise tolerance, and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia Am Heart J 152 1096e9 1096e15 10.1016/j.ahj.2006.08.005 (Pubitemid 44854798)
18. A Palazzuoli DS Silverberg F Iovine, et al. 2007 Effects of -erythropoietin treatment on left ventricular remodelling systolic function and B-type natriuretic peptide levels in patients with cardiorenal anemia syndrome Am Heart J 645 e10 e15
19. DJ Van Veldhuisen K Dickstein A Cohen-Solal, et al. 2007 Randomized double blind placebo- controlled trial to evaluate the effect of two dosing regimens of darbepoetin alpha in patients with heart failure and anaemia Eur Heart J 28 2208 2216 10.1093/eurheartj/ehm328 17681958 (Pubitemid 47428946)
20. P Ponikowski SD Anker J Szachniewicz, et al. 2007 Effect of darbepoetin alpha on exercise tolerance in anemic patients with symptomatic chronic heart failure J Am Coll Cardiol 49 753 762 1:CAS:528:DC%2BD2sXhvVyhsbg%3D 10.1016/j.jacc.2006.11.024 17306703 (Pubitemid 46240705)
21. European Society of Cardiology, Heart Failure Association of the ESC (HFA), European Society of Intensive Care Medicine (ESICM), Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Strömberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Tendera M, Auricchio A, Bax J, Böhm M, Corrà U, della Bella P, Elliott PM, Follath F, Gheorghiade M, Hasin Y, Hernborg A, Jaarsma T, Komajda M, Kornowski R, Piepoli M, Prendergast B, Tavazzi L, Vachiery JL, Verheugt FW, Zamorano JL, Zannad F (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 29:2388-2442
22. G Rostoker P Andrivet I Pham M Griuncelli S Adnot 2007 A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate J Nephrol 20 576 585 17918143
23. C Ronco M Haapio AA House N Anavekar R Bellomo 2008 Cardiorenal syndrome J Am Coll Cardiol 52 1527 1529 10.1016/j.jacc.2008.07.051 19007588
24. JK Ghali IS Anand WT Abraham, et al. 2008 Randomized double-blind trial of darbepoietin alfa in patients with symptomatic heart failure and anemia Circulation 117 526 535 1:CAS:528:DC%2BD1cXotlCrtw%3D%3D 10.1161/CIRCULATIONAHA. 107.698514 18195176
25. AK Singh L Szczcech KL Tang, et al. 2006 Correction of anemia with epoietin alfa in chronic kidney disease New Engl J Med 355 2085 2098 1:CAS:528:DC%2BD28Xht1Wqt7fN 10.1056/NEJMoa065485 17108343 (Pubitemid 44749317)
26. TB Drueke F Locatelli N Clyne, et al. 2006 Normalization of haemoglobin level in patients with chronic kidney disease and anemia New Eng J Med 355 2071 2084 1:CAS:528:DC%2BD28Xht1Wqt7fM 10.1056/NEJMoa062276 17108342 (Pubitemid 44749316)
27. SD Anand J Comin Colet G Filippatos, et al. 2009 Ferric carboxymaltose in patients with heart failure and iron deficiency New Engl J Med 361 2436 2448 10.1056/NEJMoa0908355
28. GL Wright P Hanlon K Amin, et al. 2004 Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury FASEB J 25 285 291
29. P Van der Meer E Lipsic RH Henning, et al. 2005 Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction J Am Coll Cardiol 46 125 133 10.1016/j.jacc.2005.03. 044 15992646 (Pubitemid 40905140)
30. E Lipsic BD Westenbrink P van der Meer, et al. 2008 Low dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit Eur J Heart Fail 10 22 29 1:CAS:528: DC%2BD1cXisl2jsg%3D%3D 10.1016/j.ejheart.2007.10.008 18077209