Cell based therapy for the management of chronic pain

Korean Journal of Anesthesiology

Volumn 60, Issue 1, 2011, Pages 3-7

  Jeon, Younghoon ^a  

^a Kyungpook National University   (South Korea)

Author keywords

Cell therapy; Chronic pain; Encapsulated cells; Gene therapy; Genetically modified cells

Indexed keywords

4 AMINOBUTYRIC ACID; CATECHOLAMINE; INTERLEUKIN 1BETA; METENKEPHALIN; NEUROPEPTIDE; NEUROTRANSMITTER; OPIATE; PREPROENKEPHALIN;

ANALGESIA; CELL ACTIVATION; CELL ENCAPSULATION; CELL FUSION; CELL LINE; CELL THERAPY; CELL TRANSPLANTATION; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHROMAFFIN CELL; CHRONIC PAIN; GRAFT REJECTION; HUMAN; IN VITRO STUDY; MESENCHYMAL STEM CELL; MICROENCAPSULATION; NERVE CELL; NOCICEPTION; NONHUMAN; ORGAN TRANSPLANTATION; REVIEW; STEM CELL;

EID: 79951907044     PISSN: 20056419     EISSN: 20057563     Source Type: Journal    
DOI: 10.4097/kjae.2011.60.1.3     Document Type: Review

References (39)

1. Baliki MN, Geha PY, Apkarian AV, Chialvo DR. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci 2008; 28: 1398-403. (Pubitemid 351231512)
2. Pruimboom L, van Dam AC. Chronic pain: a non-use disease. Med Hypotheses 2007; 68: 506-11. (Pubitemid 46037984)
3. Gureje O, Von Korff M, Simon GE, Gater R. Persistent pain and well-being: a World Health Organization Study in Primary Care. JAMA1998; 280: 147-51.
4. Siegan JB, Sagen J. Attenuation of formalin pain responses in the rat by adrenal medullary transplants in the spinal subarachnoid space. Pain 1997; 70: 279-85. (Pubitemid 27179639)
5. Baek WY, Kim HG, Kim YM, Lim JO, Jeon YH. Microencapsulated bovine adrenal medullary chromaffin cells transplanted into rat spinal cord alleviated cold allodynia. Korean J Anesthesiol 2004; 46: 354-9.
6. Jeon Y, Kwak K, Kim S, Kim Y, Lim J, Baek W. Intrathecal implants of microencapsulated xenogenic chromaffin cells provide a long-term source of analgesic substances. Transplant Proc 2006; 38: 3061-5. (Pubitemid 44737899)
7. Kim YM, Jeon YH, Jin GC, Lim JO, Baek WY. Immunoisolated chromaffin cells implanted into the subarachnoid space of rats reduce cold allodynia in a model of neuropathic pain: a novel application of microencapsulation technology. Artif Organs 2004; 28: 1059-66.
8. Zieglgänsberger W, Tulloch IF. The effects of methionine- and leucine-enkephalin on spinal neurons of the cat. Brain Res 1979; 167: 53-64. (Pubitemid 9154140)
9. Reddy SV, Maderdrut JL, Yaksh TL. Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J Pharmacol Exp Ther 1980; 213: 525-33. (Pubitemid 10085156)
10. Mukhida K, Mendez I, McLeod M, Kobayashi N, Haughn C, Milne B, et al. Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain. Stem Cells 2007; 25: 2874-85. (Pubitemid 350127872)
11. Sugaya I, Qu T, Sugaya K, Pappas GD. Genetically engineered human mesenchymal stem cells produce met-enkephalin at augmented higher levels in vitro. Cell Transplant 2006; 15: 225-30. (Pubitemid 43726181)
12. Eaton MJ, Plunkett JA, Martinez MA, Lopez T, Karmally S, Cejas P, et al. Transplants of neuronal cells bioengineered to synthesize GABA alleviate chronic neuropathic pain. Cell Transplant 1999; 8: 87-101. (Pubitemid 29408774)
13. Décosterd I, Buchser E, Gilliard N, Saydoff J, Zurn AD, Aebischer P. Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain. Pain 1998; 76: 159-66. (Pubitemid 28304952)
14. Park JM, Kim SJ, Kwak KH, Jeon YH, Baek WY. Quantitative analysis of secreted catecholamines from chromaffin cells in vitro and in vivo. Korean J Anesthesiol 2005; 49: 235-40.
15. Hentall ID, Sagen J. Spinal CSF from rats with painful peripheral neuropathy evokes catecholamine release from chromaffin cells in vitro. Neurosci Lett 2000; 286: 95-8. (Pubitemid 30312898)
16. Lu Y, Jing R, Yeomans DC, Pappas GD. Porcine chromaffin cells, culture, and transplant for antinociceptive effects in rodents and primates. Neurol Res 2004; 26: 707-12. (Pubitemid 39552711)
17. Sol JC, Li RY, Sallerin B, Jozan S, Zhou H, Lauwers-Cances V, et al. Intrathecal grafting of porcine chromaffin cells reduces formaline-voked c-Fos expression in the rat spinal cord. Cell Transplant 2005; 14: 353-65. (Pubitemid 41324366)
18. Zhou H, Aziza J, Sol JC, Courtade-Saïdi M, Chatelin S, Evra C, et al. Cell therapy of pain: characterization of human fetal chromaffin cells at early adrenal medulla development. Exp Neurol 2006; 198: 370-81.
19. Jozan S, Aziza J, Châtelin S, Evra C, Courtade-Saïdi M, Parant O, et al. Human fetal chromaffin cells: a potential tool for cell pain therapy. Exp Neurol 2007; 205: 525-35. (Pubitemid 46755773)
20. Mayer DJ, Price DD, Becker DP. Neurophysiological characterization of the anterolateral spinal cord neurons contributing to pain perception in man. Pain 1975; 1: 51-8.
21. Woolf CJ; American College of Physicians; American Physiological Society. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med 2004; 140: 441-51.
22. Short B, Brouard N, Occhiodoro-Scott T, Ramakrishnan A, Simmons PJ. Mesenchymal stem cells. Arch Med Res 2003; 34: 565-71. (Pubitemid 38084710)
23. Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature 2006; 441: 1094-6. (Pubitemid 43990722)
24. Cao Q, Benton RL, Whittemore SR. Stem cell repair of central nervous system injury. J Neurosci Res 2002; 68: 501-10. (Pubitemid 34575616)
25. Siniscalco D, Rossi F, Maione S. Molecular approaches for neuropathic pain treatment. Curr Med Chem 2007; 14: 1783-7. (Pubitemid 47163416)
26. Siniscalco D, Giordano C, Galderisi U, Luongo L, Alessio N, Di Bernardo G, et al. Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice. Cell Mol Life Sci 2010; 67: 655-69.
27. Shi G, Ma K, Pappas GD, Qu T. Phenotypic characteristics of hybrid cells produced by cell fusion of porcine adrenal chromaffin cells with human mesenchymal stem cells: a preliminary study. Neurol Res 2008; 30: 217-22. (Pubitemid 351769411)
28. Pfragner R, Behmel A, Smith DP, Ponder BA, Wirnsberger G, Rinner I, et al. First continuous human pheochromocytoma cell line: KNA. Biological, cytogenetic and molecular characterization of KNA cells. J Neurocytol 1998; 27: 175-86. (Pubitemid 28253068)
29. Greene LA, Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 1976; 73: 2424-8.
30. Venihaki M, Gravanis A, Margior is AN. KAT45 human pheochromacytoma cell line. A new model for the in vitro study of neuro-immuno-hormonal interactions. Ann N Y Acad Sci 1998; 840: 425-33.
31. Powers JF, Evinger MJ, Tsokas P, Bedri S, Alroy J, Shahsavari M, et al. Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice. Cell Tissue Res 2000; 302: 309-20.
32. Obinata M. Conditionally immortalized cell lines with differentiated functions established from temperature-sensitive T-antigen transgenic mice. Genes Cells 1997; 2: 235-44. (Pubitemid 127688575)
33. Eaton MJ. Emerging cell and molecular strategies for the study and treatment of painful peripheral neuropathies. J Peripher Nerv Syst 2000; 5: 59-74. (Pubitemid 30451708)
34. Eaton MJ, Herman JP, Jullien N, Lopez TL, Martinez M, Huang J. Immortalized chromaffin cells disimmortalized with Cre/lox site-directed recombination for use in cell therapy for pain after partial nerve injury. Exp Neurol 2002; 175: 49-60. (Pubitemid 34507909)
35. De la Calle JL, Mena MA, González-Escalada JR, Paíno CL. Intrathecal transplantation of neuroblastoma cells decreases heat hyperalgesia and cold allodynia in a rat model of neuropathic pain. Brain Res Bull 2002; 59: 205-11. (Pubitemid 35300456)
36. Duplan H, Li RY, Vue C, Zhou H, Emorine L, Herman JP, et al. Grafts of immortalized chromaffin cells bio-engineered to improve metenkephalin release also reduce formalin-evoked c-fos expression in rat spinal cord. Neurosci Lett 2004; 370: 1-6. (Pubitemid 39369846)
37. Hino M, Ogata T, Morino T, Horiuchi H, Yamamoto H. Intrathecal transplantation of autologous macrophages genetically modified to secrete proenkephalin ameliorated hyperalgesia and allodynia following peripheral nerve injury in rats. Neurosci Res 2009; 64: 56-62.
38. Bés JC, Tkaczuk J, Czech KA, Tafani M, Bastide R, Caratero C, et al. One-year chromaffin cell allograft survival in cancer patients with chronic pain: morphological and functional evidence. Cell Transplant 1998; 7: 227-38. (Pubitemid 28280851)
39. Lazorthes Y, Sagen J, Sallerin B, Tkaczuk J, Duplan H, Sol JC, et al. Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study. Pain 2000; 87: 19-32. (Pubitemid 30345658)