Loss-of-function mutations in the transcription factor 7 (T cell factor-1) gene in hepatogastrointestinal cancers

Molecular and Cellular Toxicology

Volumn 6, Issue 3, 2010, Pages 271-278

  Jung, Kwang Hwa ^a   Yoon, Kang Jun ^a   Song, Jae Hwi ^a   Lee, Sung Hak ^a   Eun, Jung Woo ^a   Noh, Ji Heon ^a   Kim, Jeong Kyu ^a   Bae, Hyun Jin ^a   Lee, Jang Eun ^a   Kim, Sang Woo ^a   Choi, Myung Gyu ^a   Kim, Su Young ^a   Park, Won Sang ^a   Nam, Suk Woo ^a   Lee, Jung Young ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Alimentary tract cancers; Loss of heterozygosity; Somatic mutations; TCF7; Wnt signaling pathway

Indexed keywords

EID: 79951895134     PISSN: 1738642X     EISSN: 20928467     Source Type: Journal    
DOI: 10.1007/s13273-010-0037-y     Document Type: Article

References (21)

1. Tetsu, O. & McCormick, F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398:422-426 (1999). (Pubitemid 29180374)
2. Hurlstone, A. & Clevers, H. T-cell factors: turn-ons and turn-offs. EMBO J 21:2303-2311 (2002). (Pubitemid 34546703)
3. Satoh, S. et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 24:245-250 (2000). (Pubitemid 30132191)
4. Klaus, A. & Birchmeier, W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8:387-398 (2008). (Pubitemid 351589714)
5. Park, W. S. et al. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Cancer Res 59:4257-4260 (1999). (Pubitemid 29418739)
6. Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87:159-170 (1996). (Pubitemid 26358996)
7. Wang, S. S. et al. Alterations of the PPP2R1B gene in human lung and colon cancer. Science 282:284-287 (1998). (Pubitemid 28487198)
8. He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512 (1998).
9. Chen, G., Fernandez, J., Mische, S. & Courey, A. J. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev 13:2218-2230 (1999). (Pubitemid 29426727)
10. van de Wetering, M., Castrop, J., Korinek, V. & Clevers, H. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol Cell Biol 16:745-752 (1996). (Pubitemid 26061643)
11. Waterman, M. L. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev 23:41-52 (2004). (Pubitemid 38228369)
12. Roose, J. et al. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science 285:1923-1926 (1999).
13. Najdi, R. et al. A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer. Oncogene 28:4133-4146 (2009).
14. Veien, E. S., Grierson, M. J., Saund, R. S. & Dorsky, R. I. Expression pattern of zebrafish tcf7 suggests unexplored domains of Wnt/beta-catenin activity. Dev Dyn 233:233-239 (2005). (Pubitemid 40548042)
15. Daniels, D. L. & Weis, W. I. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wntmediated transcription activation. Nat Struct Mol Biol 12:364-371 (2005). (Pubitemid 43093092)
16. Brantjes, H., Roose, J., van De Wetering, M. & Clevers, H. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res 29:1410-1419 (2001). (Pubitemid 32288486)
17. Arce, L., Pate, K. T. & Waterman, M. L. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. BMC Cancer 9:159 (2009).
18. Roose, J. et al. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395:608-612 (1998). (Pubitemid 28475715)
19. Lee, J. Y. et al. A simple, precise and economical microdissection technique for analysis of genomic DNA from archival tissue sections. Virchows Arch 433:305-309 (1998). (Pubitemid 28477030)
20. van de Wetering, M. et al. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. J Biol Chem 267:8530-8536 (1992).
21. Tetsuka, T. et al. Inhibition of nuclear factor-kappaB-mediated transcription by association with the aminoterminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J Biol Chem 275:4383-4390 (2000). (Pubitemid 30094681)