KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells

Endocrinology

Volumn 152, Issue 3, 2011, Pages 782-792

  Beyer, Sasha ^a   Lakshmanan, Aparna ^a   Liu, Yu Yu ^a   Zhang, Xiaoli ^a   Wapnir, Irene ^b   Smolenski, Albert ^c   Jhiang, Sissy ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; HYDROCORTISONE; KT 5823; RETINOIC ACID; SODIUM IODIDE SYMPORTER;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CELL MIGRATION; CELL SURFACE; DRUG ACTIVITY; GLYCOSYLATION; GOLGI COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID CANCER;

ANIMALS; BREAST NEOPLASMS; BREFELDIN A; CARBAZOLES; CELL LINE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOSYLATION; HUMANS; HYDROCORTISONE; IODIDES; PROTEIN KINASE INHIBITORS; PROTEIN SYNTHESIS INHIBITORS; RATS; SYMPORTERS; THYROID GLAND; THYROTROPIN; TRETINOIN;

EID: 79951890016     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0782     Document Type: Article

References (40)

1. Mazzaferri EL, Kloos RT 2001 Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab 86:1447-1463 (Pubitemid 32374886)
2. Tazebay UH, Wapnir IL, Levy O, Dohan O, Zuckier LS, Zhao QH, Deng HF, Amenta PS, Fineberg S, Pestell RG, Carrasco N 2000 The mammarygland iodide transporter is expressed during lactation and in breast cancer. Nat Med 6:871-878 (Pubitemid 30644744)
3. Wapnir IL, van de Rijn M, Nowels K, Amenta PS, Walton K, Montogomery K, Greco RS, Dohán R, Carrasco N 2003 Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast and other carcinomas using high density tissue microarray and conventional sections. J Clin Endocrinol Metab 88:1880-1888 (Pubitemid 36623418)
4. Renier C, Vogel H, Offor O, Yao C, Wapnir I 2010 Breast cancer brain metastases express the sodium iodide symporter. J Neurooncol 96:331-336
5. Renier C, Yao C, Goris M, Ghosh M, Katznelson L, Nowles K, Gambhir SS, Wapnir I 2009 Endogenous NIS expression in triple-negative breast cancers. Ann Surg Oncol 16:962-968
6. Wapnir IL, Goris M, Yudd A, Dohan O, Adelman D, Nowels K, Carrasco N 2004 The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. Clin Cancer Res 10:4294-4302 (Pubitemid 38878866)
7. Moon DH, Lee JL, Park KY, Park KK, Ahn SH, Pai MS, Chang H, Lee HK, Ahn IM 2001 Correlation between 99mTc-pertechnetate uptakes and expression of human sodium iodide symporter in breast tumor tissues. Nucl Med Biol 28:829-834 (Pubitemid 32900641)
8. Peyrottes I, Navarro V, Ondo-Mendez A, Marcellin D, Bellanger L, Marsault R, Lindenthal S, Ettore F, Darcourt J, Pourcher T 2009 Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers. Eur J Endocrinol 160:215-225
9. Kogai T, Schultz JJ, Johnson LS, Huang M, Brent GA 2000 Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. Proc Natl Acad Sci USA 97:8519-8524 (Pubitemid 30639705)
10. Kogai T, Kanamoto Y, Li AI, Che LH, Ohashi E, Taki K, Chandraratna RA, Saito T, Brent GA 2005 Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells. Endocrinology 146:3059-3069 (Pubitemid 41002815)
11. Unterholzner S, Willhauk MJ, Cengic N, Schütz M, Goke B, Morris JC, Spitzweg C 2006 Dexamethasone stimulation of retinoic acid-induced sodium iodide symporter expression and cytotoxicity of 131-I in breast cancer cells. J Clin Endocrinol Metab 91:69-78 (Pubitemid 43069120)
12. Willhauk MJ, Sharif-Samani B, Senekowitsch-Schmidtke R, Wunderlich N, Göke B, Morris JC, Spitzweg C 2008 Functional sodium iodide symporter expression in breast cancer xenografts in vivo after systemic treatment with retinoic acid and dexamethasone. Breast Cancer Res Treat 109:263-272
13. Dohán O, de la Vieja A, Carrasco N 2006 Hydrocortisone and purinergic signaling stimulate sodium/iodide symporter (NIS)-mediated iodide transport in breast cancer cells. Mol Endocrinol 20: 1121-1137
14. Weiss SJ, Philip NJ, Ambesi-Impiombato FS, Grollman EF 1984 Thyrotropin stimulated iodide transport mediated by adenosine 3′,5′- monophosphate and dependent on protein synthesis. Endocrinology 114:1099-1107 (Pubitemid 14134352)
15. Kaminsky SM, Levy O, Salvador C, Dai G, Carrasco N 1994 Na+ I- symporter activity is present in membrane vesicles from thyrotropin- deprived non-I(-)-transporting cultured thyroid cells. Proc Natl Acad Sci USA 91:3789-3793
16. Kogai T, Endo T, Saito T, Miyazaki A, Kawaguchi A, Onaya T 1997 Regulation by thyroid-stimulating hormone of sodium/iodide symporter gene expression and protein levels in FRTL-5 cells. Endocrinology 138:2227-2232 (Pubitemid 27215219)
17. Levy O, Dai G, Riedel C, Ginter CS, Paul EM, Lebowitz AN, Carrasco N 1997 Characterization of the thyroid Na+/I- symporter with an anti-COOH terminus antibody. Proc Natl Acad Sci USA 94:5568-5573 (Pubitemid 27241810)
18. Saito T, Endo T, Kawaguchi A, Ikeda M, Nakazato M, Kogai T, Onaya T 1997 Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab 82:3331-3336 (Pubitemid 27419082)
19. Schmutzler C, Winzer R, Meissner-Weigl J, Köhrle J 1997 Retinoic acid increases sodium/iodide symportermRNAlevels in human thyroid cancer cell lines and suppresses expression of functional symporter in non-transformed FRTL-5 rat thyroid cells. Biochem Biophys Res Commun 240:832-838 (Pubitemid 28271806)
20. Kogai T, Ohashi E, Jacobs MS, Sajid-Crockett S, Fisher ML, Kanamoto Y, Brent GA 2008 Retinoic acid stimulation of the sodium/ iodide symporter in MCF-7 breast cancer cells is meditated by the insulin growth factor-I/ phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways. J Clin Endocrinol Metab 93:1884-1892 (Pubitemid 351656534)
21. Knauf JA, Kuroda H, Basu S, Fagin JA 2003 RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase. Oncogene 22:4406-4412 (Pubitemid 36897971)
22. Vadysirisack DD, Venkateswaran A, Zhang Z, Jhiang SM 2007 MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner. Endocr Relat Cancer 14:421-432 (Pubitemid 47242640)
23. Fozzatti L, Vélez ML, LuceroAM,Nicola JP, Mascanfroni ID, Macció DR,Pellizas CG, Roth GA Masini-Repiso AM 2007 Endogenous thyrocyte-produced nitric oxide inhibits iodide uptake and thyroid-specific gene expression in FRTL-5 thyroid cells. J Endocrinol 192: 627-637 (Pubitemid 46455965)
24. Smanik PA, Liu Q, Furminger TL, Ryu K, Xing S, Mazzaferri EL, Jhiang SM 1996 Cloning of the human sodium iodide symporter. Biochem Biophys Res Commun 226:339-345 (Pubitemid 26331906)
25. Knostman KA, Cho JY, Ryu KY, Lin X, McCubrey JA, Hla T, Liu CH, Di Carlo E, Keri R, Zhang M, Hwang DY, Kisseberth WC, Capen CC, Jhiang SM 2004 Signaling through 3′,5′-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/ iodide symporter expression in breast cancer. J Clin Endocrinol Metab 89:5196-5203 (Pubitemid 39391469)
26. Jhiang SM, Cho JY, Ryu KY, DeYoung BR, Smanik PA, McGaughy VR, Fischer AH, Mazzaferri EL 1998 An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues. Endocrinology 139:4416-4419 (Pubitemid 28513732)
27. Smolenski A, Bachmann C, Reinhard K, Hönig-Liedl P, Jarchau T, Hoschuetzky H, Walter U 1998 Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. J Biol Chem 273:20029-20035
28. Marsee DK, Venkateswaran A, Tao H, Vadysirisack D, Zhang Z, Vandre DD, Jhiang SM 2004 Inhibition of heat shock protein 90, a novel RET/PTC1-associated protein, increases radioiodide accumulation in thyroid cells. J Biol Chem 279:43990-43997 (Pubitemid 39390707)
29. Burkhardt M, Glazova M, Gambaryan S, Vollkommer T, Butt E, Bader B, Heermeier K, Lincoln TM, Walter U, Palmetshofer A 2000 KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J BiolChem 275:33536-33541
30. Levy O, De la Vieja A, Ginter CS, Riedel C, Dai G, Carrasco N 1998 N-linked glycosylation of the thyroid Na+/I- symporter (NIS). J Biol Chem 273:22657-22663
31. Vadysirisack DD, Shen DH, Jhiang SM 2006 Correlation of Na+/I- symporter expression and activity: implications of Na+/I- symporter as an imaging reporter gene. J Nucl Med 47:182-190 (Pubitemid 46768528)
32. Riedel C, Levy O, Carrasco N 2001 Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. J Biol Chem 276: 21458-21463
33. Kogai T, Kanamoto Y, Che LH, Taki K, Moatamed F, Schultz JJ, Brent GA 2004 Systemic retinoic acid treatment induces sodium/ iodide symporter expression and radioiodide uptake in mouse breast cancer models. Cancer Res 64:415-422 (Pubitemid 38114126)
34. Arturi F, Ferretti E, Presta I, Mattei T, Scipioni A, Scarpelli D, Bruno R, Lacroix L, Tosi E, Gulino A, Russo D, Filetti S 2005 Regulation of iodide uptake and sodium/iodide symporter expression in the MCF-7 human breast cancer cell line. J Clin Endocrinol Metab 90: 2321-2326 (Pubitemid 40586280)
35. Osborne CK, Hobbs K, Trent JM 1987 Biological differences among MCF-7 human breast cancer cell lines from different laboratories. Breast Cancer Res Treat 9:111-121 (Pubitemid 17114724)
36. Resnicoff M, Medrano EE, Podhajcer OL, Bravo AI, Bover L, Mordoh J 1987 Subpopulations of MCF7 cells separated by Percoll gradient centrifugation: a model to analyze the heterogeneity of human breast cancer. Proc Natl Acad Sci USA 84:7295-7299 (Pubitemid 18017335)
37. Vadysirisack DD, Chen ES, Zhang Z, Tsai MD, Chang GD, Jhiang SM 2007 Identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter. J Biol Chem 282:36820-36828
38. Suzuki N, Lee YC 2004 Site-specific N-glycosylation of chicken serum IgG. Glycobiology 14:275-292 (Pubitemid 38324943)
39. Bolander Jr FF 2000 Rapid hormonal regulation of N-acetylglucosamine transferase I. J Mol Endocrinol 24:377-382
40. Smolenski A, Burkhardt AM, Eigenthaler M, Butt E, Gambaryan S, Lohmann SM, Walter U 1998 Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch Pharmacol 358:134-139 (Pubitemid 28365970)