MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner

Endocrine-Related Cancer

Volumn 14, Issue 2, 2007, Pages 421-432

  Vadysirisack, Douangsone D ^a   Venkateswaran, Anjli ^a   Zhang, Zhaoxia ^a   Jhiang, Sissy M ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); IODINE 125; MITOGEN ACTIVATED PROTEIN KINASE; OUABAIN; PROTEIN RET; RADIOACTIVE IODINE; SODIUM IODIDE SYMPORTER;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; NONHUMAN; PAPILLARY CARCINOMA; RAT; THYROID CARCINOMA; THYROID CELL;

ADENOVIRIDAE; ANIMALS; CELL LINE, TUMOR; FLAVONOIDS; IODIDES; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OUABAIN; PROTEIN KINASE INHIBITORS; RATS; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE; SYMPORTERS; THYROID GLAND;

EID: 34547808829     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.1.01263     Document Type: Article

References (31)

1. Al-Alawi N, Rose DW, Buckmaster C, Ann N, Rapp U, Meinkoth J & Feramisco JR 1995 Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade. Molecular and Cellular Biology 15 1162-1168.
2. Alessi DR, Cuenda A, Cohen P, Dudley DT & Saltiel AR 1995 PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. Journal of Biological Chemistry 270 27489-27494.
3. Arturi F, Russo D, Schlumberger M, du Villard JA, Caillou B, Vigneri P, Wicker R, Chiefari E, Suarez HG & Filetti S 1998 Iodide symporter gene expression in human thyroid tumors. Journal of Clinical Endocrinology and Metabolism 83 2493-2496.
4. Arturi F, Russo D, Giuffrida D, Schlumberger M & Filetti S 2000 Sodium-iodide symporter (NIS) gene expression in lymph-node metastases of papillary thyroid carcinomas. European Journal of Endocrinology 143 623-627.
5. Buckwalter TL, Venkateswaran A, Lavender M, La Perle KM, Cho JY, Robinson ML & Jhiang SM 2002 The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation. Oncogene 21 8166-8172.
6. Cass LA & Meinkoth JL 2000 Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation. Oncogene 19 924-932.
7. Cho JY, Sagartz JE, Capen CC, Mazzaferri EL & Jhiang SM 1999 Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. Oncogene 18 3659-3665.
8. Ciullo I, Diez-Roux G, Di Domenico M, Migliaccio A & Avvedimento EV 2001 cAMP signaling selectively influences Ras effectors pathways. Oncogene 20 1186-1192.
9. -) symporter activity requires a small and uncharged amino acid residue at position 395. Molecular Endocrinology 16 1893-1902.
10. +/I symporter. Mechanism, stoichiometry, and specificity. Journal of Biological Chemistry 272 27230-27238.
11. + pump involves the phosphatidyl-inositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways in vascular smooth muscle cells. Endocrinology 145 1151-1160.
12. Jhiang SM 2000 The RET proto-oncogene in human cancers. Oncogene 19 5590-5597.
13. Jhiang SM, Cho JY, Furminger TL, Sagartz JE, Tong Q, Capen CC & Mazzaferri EL 1998 Thyroid carcinomas in RET/PTC transgenic mice. Recent Results in Cancer Research 154 265-270.
14. +)-I-symport activity is present in membrane vesicles from thyrotropin-deprived non-I(-)-transporting cultured thyroid cells. PNAS 91 3789-3793.
15. +-ATPase in response to parathyroid hormone requires ERK-dependent phosphorylation of Ser-11 within the alpha1-subunit. Journal of Biological Chemistry 279 17418-17427.
16. +-ATPase requires ERK-dependent translocation of protein kinase Calpha. Journal of Biological Chemistry 280 8705-8713.
17. Knauf JA, Kuroda H, Basu S & Fagin JA 2003 RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase. Oncogene 22 4406-4412.
18. Kogai T, Endo T, Saito T, Miyazaki A, Kawaguchi A & Onaya T 1997 Regulation by thyroid-stimulating hormone of sodium/iodide symporter gene expression and protein levels in FRTL-5 cells. Endocrinology 138 2227-2232.
19. Kupperman E, Wofford D, Wen W & Meinkoth JL 1996 Ras inhibits thyroglobulin expression but not cyclic adenosine monophosphate-mediated signaling in Wistar rat thyrocytes. Endocrinology 137 96-104.
20. - symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. Journal of Clinical Endocrinology and Metabolism 84 3228-3234.
21. - symporter with an anti-COOH terminus antibody. PNAS 94 5568-5573.
22. Marsee DK, Venkateswaran A, Tao H, Vadysirisack D, Zhang Z, Vandre DD & Jhiang SM 2004 Inhibition of heat shock protein 90, a novel RET/PTC1-associated protein,increases radioiodide accumulation in thyroid cells. Journal of Biological Chemistry 279 43990-43997.
23. Miller MJ, Rioux L, Prendergast GV, Cannon S, White MA & Meinkoth JL 1998 Differential effects of protein kinase A on Ras effector pathways. Molecular and Cellular Biology 18 3718-3726.
24. Missero C, Pirro MT & Di Lauro R 2000 Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1. Molecular and Cellular Biology 20 2783-2793.
25. Riedel C, Levy O & Carrasco N 2001 Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. Journal of Biological Chemistry 276 21458-21463.
26. - targeting to the membrane. Endocrine-Related Cancer 13 257-269.
27. - symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. Journal of Clinical Endocrinology and Metabolism 82 3331-3336.
28. Trapasso F, Iuliano R, Chiefari E, Arturi F, Stella A, Filetti S, Fusco A & Russo D 1999 Iodide symporter gene expression in normal and transformed rat thyroid cells. European Journal of Endocrinology 140 447-451.
29. Venkateswaran A, Marsee DK, Green SH & Jhiang SM 2004 Forskolin, 8-Br-3′,5′-cyclic adenosine 5′-monophosphate, and catalytic protein kinase A expression in the nucleus increase radioiodide uptake and sodium/iodide symporter protein levels in RET/PTC1-expressing cells. Journal of Clinical Endocrinology and Metabolism 89 6168-6172.
30. Weiss SJ, Philip NJ, Ambersi-Impiombato FS & Grollman EF 1984 Thyrotropin-stimulated iodide transport mediated by adenosine 3′,5′-monophosphate and dependent on protein synthesis. Endocrinology 114 1099-1107.
31. +-ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells. Cellular and Molecular Life Sciences 61 2782-2790.