Functional sodium iodide symporter expression in breast cancer xenografts in vivo after systemic treatment with retinoic acid and dexamethasone

Breast Cancer Research and Treatment

Volumn 109, Issue 2, 2008, Pages 263-272

  Willhauck, Michael J ^a   Sharif Samani, Bibi ^a   Senekowitsch Schmidtke, Reingard ^b   Wunderlich, Nathalie ^a   Göke, Burkhard ^a   Morris, John C ^c   Spitzweg, Christine ^a,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c MAYO CLINIC   (United States)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Breast cancer; Dexamethasone; Radioiodine therapy; Retinoic acid; Sodium iodide symporter

Indexed keywords

DEXAMETHASONE; IODINE 123; IODINE 131; RETINOIC ACID; SODIUM IODIDE SYMPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER SURGERY; CELL STRAIN MCF 7; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; EX VIVO STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MONOTHERAPY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; SCINTILLATION CAMERA; XENOGRAFT;

EID: 43149109505     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-007-9646-0     Document Type: Article

References (53)

1. 1. C Spitzweg JC Morris 2002 The sodium iodide symporter: its pathophysiological and therapeutic implications Clin Endocrinol 57 559 574 10.1046/j.1365-2265.2002.01640.x 1:CAS:528:DC%2BD38XptVGgtLY%3D Spitzweg C, Morris JC (2002) The sodium iodide symporter: its pathophysiological and therapeutic implications. Clin Endocrinol 57:559–574
2. 2. O Dohan A la Vieja De V Paroder C Riedel M Artani M Reed CS Ginter N Carrasco 2003 The sodium/iodide symporter (NIS): characterization, regulation, and medical significance Endocrine Rev 24 48 77 10.1210/er.2001-0029 1:CAS:528:DC%2BD3sXhslOgsb0%3D Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N (2003) The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocrine Rev 24:48–77
3. 3. N Carrasco 1993 Iodide transport in the thyroid gland Biochem Biophys Acta 1154 65 82 8507647 1:CAS:528:DyaK3sXksVGrurY%3D Carrasco N (1993) Iodide transport in the thyroid gland. Biochem Biophys Acta 1154:65–82
4. 4. UH Tazebay IL Wapnir O Levy O Dohan LS Zuckier QH Zhao HF Deng PS Amenta S Fineberg RG Pestell N Carrasco 2000 The mammary gland iodide transporter is expressed during lactation and in breast cancer Nature Med 6 871 878 10932223 10.1038/78630 1:CAS:528:DC%2BD3cXlsFamt7o%3D Tazebay UH, Wapnir IL, Levy O, Dohan O, Zuckier LS, Zhao QH, Deng HF, Amenta PS, Fineberg S, Pestell RG, Carrasco N (2000) The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nature Med 6:871–878
5. 5. JM Strum 1978 Site of iodination in rat mammary gland Anat Rec 192 235 244 717798 10.1002/ar.1091920204 1:STN:280:DyaE1M%2FmtVaqsA%3D%3D Strum JM (1978) Site of iodination in rat mammary gland. Anat Rec 192:235–244
6. 6. JM Strum PC Phelps MM McAtee 1983 Resting human female breast tissue produces iodinated proteins J Ultrastruct Res 84 130 139 6632051 10.1016/S0022-5320(83)90124-7 1:STN:280:DyaL2c%2Fjs1emsQ%3D%3D Strum JM, Phelps PC, McAtee MM (1983) Resting human female breast tissue produces iodinated proteins. J Ultrastruct Res 84:130–139
7. 7. L Rudnicka A Sinczak P Szybinski B Huszno J Stachura 2003 Expression of the Na(+)/I(-) symporter in invasive ductal breast cancer Folia Histochem Cytobiol 41 37 40 12705478 1:CAS:528:DC%2BD3sXjsVOktrg%3D Rudnicka L, Sinczak A, Szybinski P, Huszno B, Stachura J (2003) Expression of the Na(+)/I(-) symporter in invasive ductal breast cancer. Folia Histochem Cytobiol 41:37–40
8. 8. DH Moon SJ Lee KY Park KK Park SH Ahn MS Pai H Chang HK Lee I-M Ahn 2001 Correlation between 99mTc-pertechnetate uptakes and expressions of human sodium iodide symporter gene in breast tumor tissues Nucl Med Biol 28 829 834 11578905 10.1016/S0969-8051(01)00243-8 1:CAS:528:DC%2BD3MXntV2htbw%3D Moon DH, Lee SJ, Park KY, Park KK, Ahn SH, Pai MS, Chang H, Lee HK, Ahn I-M (2001) Correlation between 99mTc-pertechnetate uptakes and expressions of human sodium iodide symporter gene in breast tumor tissues. Nucl Med Biol 28:829–834
9. 9. T Kogai J Schultz L Johnson M Huang G Brent 2000 Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line Proc Natl Acad Sci USA 97 8519 8524 10890895 10.1073/pnas.140217197 1:CAS:528:DC%2BD3cXlt1Gnsrw%3D Kogai T, Schultz J, Johnson L, Huang M, Brent G (2000) Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. Proc Natl Acad Sci USA 97:8519–8524
10. 10. T Kogai Y Kanamoto LH Che K Taki F Moatamed JJ Schultz GA Brent 2004 Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodine uptake in mouse breast cancer models Cancer Res 64 415 422 14729653 10.1158/0008-5472.CAN-03-2285 1:CAS:528:DC%2BD2cXkslyqtg%3D%3D Kogai T, Kanamoto Y, Che LH, Taki K, Moatamed F, Schultz JJ, Brent GA (2004) Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodine uptake in mouse breast cancer models. Cancer Res 64:415–422
11. 11. S Tanosaki T Ikezoe A Heaney JW Said K Dan M Akashi P Koeffler 2003 Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cacner cells Breast Cancer Res Treat 79 335 345 12846418 10.1023/A:1024064424855 1:CAS:528:DC%2BD3sXktlahu7Y%3D Tanosaki S, Ikezoe T, Heaney A, Said JW, Dan K, Akashi M, Koeffler P (2003) Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cacner cells. Breast Cancer Res Treat 79:335–345
12. 12. T Kogai Y Kanamoto AI Li LH Che E Ohashi K Taki RA Chandraratna T Saito GA Brent 2005 Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells Endocrinology 146 3059 3069 15817668 10.1210/en.2004-1334 1:CAS:528:DC%2BD2MXlslGhsbk%3D Kogai T, Kanamoto Y, Li AI, Che LH, Ohashi E, Taki K, Chandraratna RA, Saito T, Brent GA (2005) Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells. Endocrinology 146:3059–3069
13. 13. O Dohan A la Vieja De N Carrasco 2006 Hydrocortisone and purinergic signaling stimulate NIS-mediated iodide transport in breast cancer cells Mol Endocrinol 20 1121 1137 16439463 10.1210/me.2005-0376 1:CAS:528:DC%2BD28XksleqsLs%3D Dohan O, De la Vieja A, Carrasco N (2006) Hydrocortisone and purinergic signaling stimulate NIS-mediated iodide transport in breast cancer cells. Mol Endocrinol 20:1121–1137
14. 14. S Unterholzner MJ Willhauck N Cengic M Schütz B Göke JC Morris C Spitzweg 2006 Dexamethasone stimulation of retinoic acid-induced sodium iodide symporter expression and cytotoxicity of 131-I in breast cancer cells J Clin Endocrinol Metab 91 69 78 16234306 10.1210/jc.2005-0779 1:CAS:528:DC%2BD28Xms1ahtQ%3D%3D Unterholzner S, Willhauck MJ, Cengic N, Schütz M, Göke B, Morris JC, Spitzweg C (2006) Dexamethasone stimulation of retinoic acid-induced sodium iodide symporter expression and cytotoxicity of 131-I in breast cancer cells. J Clin Endocrinol Metab 91:69–78
15. 15. F Berdichevsky D Alford B D’Souza J Taylor-Papadimitriou 1994 Branching morphogenesis of human mammary epithelial cells in collagen gels J Cell Sci 107 3557 3568 7535787 1:CAS:528:DyaK2MXivFyrtLo%3D Berdichevsky F, Alford D, D’Souza B, Taylor-Papadimitriou J (1994) Branching morphogenesis of human mammary epithelial cells in collagen gels. J Cell Sci 107:3557–3568
16. 16. MR Castro ER Bergert TG Beito PC Roche SC Ziesmer SM Jhiang JR Goellner JC Morris 1999 Monoclonal antibodies against the human sodium iodide symporter: utility for immunocytochemistry of thyroid cancer J Endocrinol 163 495 504 10588823 10.1677/joe.0.1630495 1:CAS:528:DC%2BD3cXks1anug%3D%3D Castro MR, Bergert ER, Beito TG, Roche PC, Ziesmer SC, Jhiang SM, Goellner JR, Morris JC (1999) Monoclonal antibodies against the human sodium iodide symporter: utility for immunocytochemistry of thyroid cancer. J Endocrinol 163:495–504
17. 17. SJ Weiss NJ Philip EF Grollmann 1984 Iodine transport in a continous line of cultured cells from rat thyroid Endocrinology 114 1090 1098 6705729 1:CAS:528:DyaL2cXhsFCmtL4%3D 10.1210/endo-114-4-1090 Weiss SJ, Philip NJ, Grollmann EF (1984) Iodine transport in a continous line of cultured cells from rat thyroid. Endocrinology 114:1090–1098
18. 18. SM Kaminsky O Levy C Salvador G Dai N Carrasco 1994 Na +-I − symport activity is present in membrane vesicles from thyrotropin-deprived non-I-transporting cultured thyroid cells Proc Natl Acad Sci USA 91 3789 3793 8170988 10.1073/pnas.91.9.3789 1:CAS:528:DyaK2cXivFSntro%3D Kaminsky SM, Levy O, Salvador C, Dai G, Carrasco N (1994) Na +-I − symport activity is present in membrane vesicles from thyrotropin-deprived non-I-transporting cultured thyroid cells. Proc Natl Acad Sci USA 91:3789–3793
19. 19. C Spitzweg MK O’Connor ER Bergert DJ Tindall CYF Young JC Morris 2000 Treatment of prostate cancer by radioiodine therapy after tissue-specific expression of the sodium iodide symporter Cancer Res 60 6526 6530 11103823 1:CAS:528:DC%2BD3cXos1Sktbk%3D Spitzweg C, O’Connor MK, Bergert ER, Tindall DJ, Young CYF, Morris JC (2000) Treatment of prostate cancer by radioiodine therapy after tissue-specific expression of the sodium iodide symporter. Cancer Res 60:6526–6530
20. 20. PA Smanik Q Liu TL Furminger K Ryu S Xing EL Mazzaferri SM Jhiang 1996 Cloning of the human sodium iodide symporter Biochem Biophys Res Commun 226 339 345 8806637 10.1006/bbrc.1996.1358 1:CAS:528:DyaK28Xls1yis7g%3D Smanik PA, Liu Q, Furminger TL, Ryu K, Xing S, Mazzaferri EL, Jhiang SM (1996) Cloning of the human sodium iodide symporter. Biochem Biophys Res Commun 226:339–345
21. 21. G Dai O Levy N Carrasco 1996 Cloning and characterization of the thyroid iodide transporter Nature 379 458 460 8559252 10.1038/379458a0 1:CAS:528:DyaK28XovVagtw%3D%3D Dai G, Levy O, Carrasco N (1996) Cloning and characterization of the thyroid iodide transporter. Nature 379:458–460
22. 22. PA Smanik K-Y Ryu KS Theil EL Mazzaferri SM Jhiang 1997 Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter Endocrinology 138 3555 3558 9231811 10.1210/en.138.8.3555 1:CAS:528:DyaK2sXkslSnsL0%3D Smanik PA, Ryu K-Y, Theil KS, Mazzaferri EL, Jhiang SM (1997) Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter. Endocrinology 138:3555–3558
23. 23. C Spitzweg KJ Harrington LA Pinke RG Vile JC Morris 2001 The sodium iodide symporter and its potential in cancer therapy J Clin Endocrinol Metab 86 3327 3335 11443208 10.1210/jc.86.7.3327 1:CAS:528:DC%2BD3MXlt1Gjur4%3D Spitzweg C, Harrington KJ, Pinke LA, Vile RG, Morris JC (2001) The sodium iodide symporter and its potential in cancer therapy. J Clin Endocrinol Metab 86:3327–3335
24. 24. C Spitzweg S Zhang ER Bergert MR Castro BD McIver DJ Tindall CYF Young JC Morris 1999 Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines Cancer Res 59 2136 2141 10232600 1:CAS:528:DyaK1MXjtVWjsbo%3D Spitzweg C, Zhang S, Bergert ER, Castro MR, McIver BD, Tindall DJ, Young CYF, Morris JC (1999) Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines. Cancer Res 59:2136–2141
25. 25. C Spitzweg AB Dietz MK O’Connor ER Bergert DJ Tindall CYF Young JC Morris 2001 In vivo sodium iodide symporter gene therapy of prostate cancer Gene Ther 8 1524 1531 11704812 10.1038/sj.gt.3301558 1:CAS:528:DC%2BD3MXotVWisLY%3D Spitzweg C, Dietz AB, O’Connor MK, Bergert ER, Tindall DJ, Young CYF, Morris JC (2001) In vivo sodium iodide symporter gene therapy of prostate cancer. Gene Ther 8:1524–1531
26. 26. H Kakinuma ER Bergert C Spitzweg JC Cheville MM Lieber JC Morris 2003 Probasin promoter (ARR2PB)-driven, prostate-specific expression of h-NIS for targeted radioiodine therapy of prostate cancer Cancer Res 63 7840 7844 14633711 1:CAS:528:DC%2BD3sXptFOlt74%3D Kakinuma H, Bergert ER, Spitzweg C, Cheville JC, Lieber MM, Morris JC (2003) Probasin promoter (ARR2PB)-driven, prostate-specific expression of h-NIS for targeted radioiodine therapy of prostate cancer. Cancer Res 63:7840–7844
27. 27. C Spitzweg IV Scholz ER Bergert DJ Tindall CYF Young B Göke JC Morris 2003 Retinoic acid-induced stimulation of sodium iodide symporter (NIS) expression and cytotoxicity of radioiodine in prostate cancer cells Endocrinology 144 3423 3432 12865321 10.1210/en.2002-0206 1:CAS:528:DC%2BD3sXlslGjsbk%3D Spitzweg C, Scholz IV, Bergert ER, Tindall DJ, Young CYF, Göke B, Morris JC (2003) Retinoic acid-induced stimulation of sodium iodide symporter (NIS) expression and cytotoxicity of radioiodine in prostate cancer cells. Endocrinology 144:3423–3432
28. 28. N Cengic CH Baker M Schutz B Göke JC Morris C Spitzweg 2005 A novel therapeutic strategy for medullary thyroid cancer based on radioiodine therapy following tissue-specific sodium iodide symporter gene expression J Clin Endocrinol Metab 90 4457 4464 15941870 10.1210/jc.2004-2140 1:CAS:528:DC%2BD2MXnvVWltL4%3D Cengic N, Baker CH, Schutz M, Göke B, Morris JC, Spitzweg C (2005) A novel therapeutic strategy for medullary thyroid cancer based on radioiodine therapy following tissue-specific sodium iodide symporter gene expression. J Clin Endocrinol Metab 90:4457–4464
29. 29. IV Scholz N Cengic CH Baker KJ Harrington K Maletz ER Bergert R Vile B Göke JC Morris C Spitzweg 2005 Radioiodine therapy of colon cancer following tissue-specific sodium iodide symporter gene transfer Gene Ther 12 272 280 15510175 10.1038/sj.gt.3302410 1:CAS:528:DC%2BD2MXmtlOhug%3D%3D Scholz IV, Cengic N, Baker CH, Harrington KJ, Maletz K, Bergert ER, Vile R, Göke B, Morris JC, Spitzweg C (2005) Radioiodine therapy of colon cancer following tissue-specific sodium iodide symporter gene transfer. Gene Ther 12:272–280
30. 30. RM Dwyer ER Bergert MK O’Connor SJ Gendler JC Morris 2005 In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter Clin Cancer Res 11 1483 1489 15746050 10.1158/1078-0432.CCR-04-1636 1:CAS:528:DC%2BD2MXhvVSrsb0%3D Dwyer RM, Bergert ER, O’Connor MK, Gendler SJ, Morris JC (2005) In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter. Clin Cancer Res 11:1483–1489
31. 31. K Brown-Grant 1957 The iodide concentrating mechanism of the mammary gland J Physiol 135 644 654 13417128 1:CAS:528:DyaG2sXot1CgsQ%3D%3D Brown-Grant K (1957) The iodide concentrating mechanism of the mammary gland. J Physiol 135:644–654
32. 32. C Spitzweg W Joba K Schriever JR Goellner JC Morris AE Heufelder 1999 Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands J Clin Endocrinol Metab 84 4178 4184 10566669 10.1210/jc.84.11.4178 1:CAS:528:DyaK1MXntlOqu7c%3D Spitzweg C, Joba W, Schriever K, Goellner JR, Morris JC, Heufelder AE (1999) Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands. J Clin Endocrinol Metab 84:4178–4184
33. 33. C Spitzweg W Joba W Eisenmenger AE Heufelder 1998 Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa J Clin Endocrinol Metab 83 1746 1751 9589686 10.1210/jc.83.5.1746 1:CAS:528:DyaK1cXjtF2gsL8%3D Spitzweg C, Joba W, Eisenmenger W, Heufelder AE (1998) Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa. J Clin Endocrinol Metab 83:1746–1751
34. 34. C Spitzweg CM Dutton MR Castro ER Bergert JR Goellner AE Heufelder JC Morris 2001 Expression of the sodium iodide symporter in human kidney Kidney Int 59 1013 1023 11231356 10.1046/j.1523-1755.2001.0590031013.x 1:CAS:528:DC%2BD3MXitlOmsbs%3D Spitzweg C, Dutton CM, Castro MR, Bergert ER, Goellner JR, Heufelder AE, Morris JC (2001) Expression of the sodium iodide symporter in human kidney. Kidney Int 59:1013–1023
35. 35. IL Wapnir M Rijn K Nowels PS Amenta K Walton K Montgomery RS Greco O Dohan N Carrasco 2003 Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections J Clin Endocrinol Metab 88 1880 1888 12679487 10.1210/jc.2002-021544 1:CAS:528:DC%2BD3sXjtFCltLk%3D Wapnir IL, Rijn M, Nowels K, Amenta PS, Walton K, Montgomery K, Greco RS, Dohan O, Carrasco N (2003) Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab 88:1880–1888
36. 36. SM Jhiang J-Y Cho K-Y Ryu BR Young De PA Smanik VR McGaughy AH Fischer EL Mazzaferri 1998 An immunohistochemical study of Na+/I-symporter in human thyroid tissues and salivary gland tissues Endocrinology 139 4416 4419 9751526 10.1210/en.139.10.4416 1:CAS:528:DyaK1cXmsVGmsL8%3D Jhiang SM, Cho J-Y, Ryu K-Y, De Young BR, Smanik PA, McGaughy VR, Fischer AH, Mazzaferri EL (1998) An immunohistochemical study of Na+/I-symporter in human thyroid tissues and salivary gland tissues. Endocrinology 139:4416–4419
37. 37. BA Eskin JA Parker JG Bassett DL George 1974 Human breast uptake of radioactive iodine Obstet Gynecol 44 398 402 4852305 1:STN:280:DyaE2czgt1eqsQ%3D%3D Eskin BA, Parker JA, Bassett JG, George DL (1974) Human breast uptake of radioactive iodine. Obstet Gynecol 44:398–402
38. 38. BA Eskin 1977 Iodine and mammary cancer Adv Exp Med Biol 91 293 304 343535 1:STN:280:DyaE1c7itVOhtA%3D%3D Eskin BA (1977) Iodine and mammary cancer. Adv Exp Med Biol 91:293–304
39. 39. ET Cancroft SJ Goldsmith 1973 99mTc-pertechnetate scintigraphy as an aid in the diagnosis of breast masses Radiology 106 441 444 4684490 1:STN:280:DyaE3s%2FosFCmsA%3D%3D Cancroft ET, Goldsmith SJ (1973) 99mTc-pertechnetate scintigraphy as an aid in the diagnosis of breast masses. Radiology 106:441–444
40. 40. IL Wapnir M Goris A Yudd O Dohan D Adelman K Nowels N Carrasco 2004 The Na+/I-symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid Clin Cancer Res 10 4294 4302 15240514 10.1158/1078-0432.CCR-04-0074 1:CAS:528:DC%2BD2cXlsVWlsrY%3D Wapnir IL, Goris M, Yudd A, Dohan O, Adelman D, Nowels K, Carrasco N (2004) The Na+/I-symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. Clin Cancer Res 10:4294–4302
41. 41. M Dentice C Luongo A Elefante R Romino R Ambrosio M Vitale G Rossi G Fenzi D Salvatore 2004 Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid-and lactation-induced transcription in mammary cells Mol Cell Biol 24 7863 7877 15340050 10.1128/MCB.24.18.7863-7877.2004 1:CAS:528:DC%2BD2cXnslCrsrc%3D Dentice M, Luongo C, Elefante A, Romino R, Ambrosio R, Vitale M, Rossi G, Fenzi G, Salvatore D (2004) Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid-and lactation-induced transcription in mammary cells. Mol Cell Biol 24:7863–7877
42. 42. E Czeczuga-Semeniuk S Wolczynski J Dzieciol M Dabrowska T Anchim I Tomaszewska 2001 13-cis retinoic acid and all-trans retinoic acid in the regulation of the proliferation and survival of human breast cancer cell line MCF-7 Cell Mol Biol Lett 6 925 939 11753438 1:CAS:528:DC%2BD38XhtVyrtrY%3D Czeczuga-Semeniuk E, Wolczynski S, Dzieciol J, Dabrowska M, Anchim T, Tomaszewska I (2001) 13-cis retinoic acid and all-trans retinoic acid in the regulation of the proliferation and survival of human breast cancer cell line MCF-7. Cell Mol Biol Lett 6:925–939
43. 43. J Heusden Van W Wouters FC Ramaekers MD Krekels L Dillen M Borgers G Smets 1998 All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitro Br J Cancer 77 26 32 Van Heusden J, Wouters W, Ramaekers FC, Krekels MD, Dillen L, Borgers M, Smets G (1998) All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitro. Br J Cancer 77:26–32
44. 44. R Mangiarotti M Danova R Alberici C Pellicciari 1998 All-trans retinoic acid (ATRA)-induced apoptosis is preceded by G1 arrest in human MCF-7 breast cancer cells Br J Cancer 77 186 191 9460987 1:CAS:528:DyaK1cXoslCitw%3D%3D Mangiarotti R, Danova M, Alberici R, Pellicciari C (1998) All-trans retinoic acid (ATRA)-induced apoptosis is preceded by G1 arrest in human MCF-7 breast cancer cells. Br J Cancer 77:186–191
45. 45. HP Rutz JB Little 1989 Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid Int J Radiat Oncol Biol Phys 16 1285 1288 2715081 1:CAS:528:DyaL1MXktlGqsrs%3D Rutz HP, Little JB (1989) Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid. Int J Radiat Oncol Biol Phys 16:1285–1288
46. 46. S Carlin SH Cunningham M Boyd AG McCluskey RJ Mairs 2000 Experimental targeted radioiodide therapy following transfection of the sodium iodide symporter gene: effect on clonogenicity in both two-and three-dimensional models Cancer Gene Ther 7 1529 1536 11228531 10.1038/sj.cgt.7700264 1:CAS:528:DC%2BD3MXkvVSjtQ%3D%3D Carlin S, Cunningham SH, Boyd M, McCluskey AG, Mairs RJ (2000) Experimental targeted radioiodide therapy following transfection of the sodium iodide symporter gene: effect on clonogenicity in both two-and three-dimensional models. Cancer Gene Ther 7:1529–1536
47. 47. E Mitrofanova C Hagan J Qi T Seregina C Link 2003 Sodium iodide symporter/radioactive iodine system has more efficient antitumor effect in three-dimensional spheroids Anticancer Res 23 2397 2404 12894520 1:CAS:528:DC%2BD3sXmsFyrtLs%3D Mitrofanova E, Hagan C, Qi J, Seregina T, Link C (2003) Sodium iodide symporter/radioactive iodine system has more efficient antitumor effect in three-dimensional spheroids. Anticancer Res 23:2397–2404
48. 48. E Dadachova B Bouzahzah LS Zuckier RG Pestell 2002 Rhenium-188 as an alternative to iodine-131 for treatment of breast tumors expressing the sodium/iodide symporter (NIS) Nucl Med Biol 29 13 18 11786271 10.1016/S0969-8051(01)00279-7 1:CAS:528:DC%2BD38XitlajsA%3D%3D Dadachova E, Bouzahzah B, Zuckier LS, Pestell RG (2002) Rhenium-188 as an alternative to iodine-131 for treatment of breast tumors expressing the sodium/iodide symporter (NIS). Nucl Med Biol 29:13–18
49. 49. E Dadachova A Nguyen EY Lin L Gnatovskiy P Lu JW Pollard 2005 Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth Nucl Med Biol 32 695 700 16243644 10.1016/j.nucmedbio.2005.05.007 1:CAS:528:DC%2BD2MXhtFKhsLfF Dadachova E, Nguyen A, Lin EY, Gnatovskiy L, Lu P, Pollard JW (2005) Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth. Nucl Med Biol 32:695–700
50. 50. S Carlin G Akabani MR Zalutsky 2003 In vitro cytotoxicity of 211At-Astatide and 131I-Iodide to glioma tumor cells expressing the sodium/iodide symporter J Nucl Med 44 1827 1838 14602867 1:CAS:528:DC%2BD3sXpslCgtLk%3D Carlin S, Akabani G, Zalutsky MR (2003) In vitro cytotoxicity of 211At-Astatide and 131I-Iodide to glioma tumor cells expressing the sodium/iodide symporter. J Nucl Med 44:1827–1838
51. 51. T Petrich H-J Helmeke GJ Meyer WH Knapp E Pötter 2002 Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter Eur J Nucl Med Mol Imaging 29 842 854 12111124 10.1007/s00259-001-0745-6 1:CAS:528:DC%2BD38XkvFSns70%3D Petrich T, Helmeke H-J, Meyer GJ, Knapp WH, Pötter E (2002) Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter. Eur J Nucl Med Mol Imaging 29:842–854
52. 52. T Petrich L Quintanilla-Martinez Z Korkmaz E Samson HJ Helmeke GJ Meyer WH Knapp E Pötter 2006 Effective cancer therapy with the a-particle emitter [211-At]astatine in a mouse model of genetically modified sodium/iodide symporter-expressing tumors Clin Cancer Res 12 1342 1348 16489092 10.1158/1078-0432.CCR-05-1576 1:CAS:528:DC%2BD28XhsFalur8%3D Petrich T, Quintanilla-Martinez L, Korkmaz Z, Samson E, Helmeke HJ, Meyer GJ, Knapp WH, Pötter E (2006) Effective cancer therapy with the a-particle emitter [211-At]astatine in a mouse model of genetically modified sodium/iodide symporter-expressing tumors. Clin Cancer Res 12:1342–1348
53. 53. S Carlin RJ Mairs P Welsh MR Zalutsky 2002 Sodium-iodide symporter (NIS)-mediated accumulation of (211At)astatide in NIS-transfected human cancer cells Nucl Med Biol 29 729 739 12381453 10.1016/S0969-8051(02)00332-3 1:CAS:528:DC%2BD38XnvVKmtrc%3D Carlin S, Mairs RJ, Welsh P, Zalutsky MR (2002) Sodium-iodide symporter (NIS)-mediated accumulation of (211At)astatide in NIS-transfected human cancer cells. Nucl Med Biol 29:729–739