Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats

Life Sciences

Volumn 88, Issue 9-10, 2011, Pages 392-399

  Grover, Gary J ^a,b   Koetzner, Lee ^a   Wicks, Joan ^c   Gahler, Roland J ^d   Lyon, Michael R ^e,f   Reimer, Raylene A ^g   Wood, Simon ^e  

^a EurofinsUS ^*  (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c Histo Scientific Research Laboratories   (United States)

^d Factors Group of Nutritional Studies Inc R 1 D   (Canada)

^e Canadian Centre for Functional Medicine   (Canada)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^g UNIVERSITY OF CALGARY   (Canada)

Author keywords

Diabetes; Dietary fiber; GLP 1; Glucose; Insulin; Inulin; Obesity; PGX

Indexed keywords

CELLULOSE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; COMPLEX FORMATION; CONTROLLED STUDY; DIETARY FIBER; FOOD INTAKE; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN BLOOD LEVEL; RAT; ZUCKER DIABETIC FATTY RAT;

ALGINATES; ANIMAL FEED; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CELLULOSE; DIABETES MELLITUS, TYPE 2; DRUG COMBINATIONS; EATING; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HYPERGLYCEMIA; INSULIN; MALE; POLYSACCHARIDES, BACTERIAL; RATS; RATS, ZUCKER;

ANIMALIA; RATTUS; RODENTIA;

EID: 79951883370     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.11.014     Document Type: Article

References (47)

1. Abdelhameed AS, Ang A, Morris GA, Smith I, Lawson C, Gahler R, et al. An analytical ultracentrifuge study on ternary mixtures of konjac glucomannan supplemented with sodium alginate and xanthan gum. Carbohydr Polym 2010;81:141-8.
2. Anderson JW, Jones AE, Riddell-Mason S. Ten different dietary fibers have significantly different effects on serum and liver lipids of cholesterol-fed rats. J Nutr 1994;124:78-83. (Pubitemid 24057439)
3. Anderson JW, Allgodd LD, Turner J, Oeltgen RR, Daggy BP. Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes. Am J Clin Nutr 1999;70:466-73. (Pubitemid 29463439)
4. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131-57. (Pubitemid 46711096)
5. Blackwood AD, Salter J, Dettmar PW, Chaplin MF. Dietary fiber, physicochemical properties and their relationship to health. J R Soc Promot Health 2000;120:242-7. (Pubitemid 32058565)
6. Cani PD, Neyrinck AM, Delzenne NM. Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like petide-1. Obes Res 2005;13:1000-7.
7. Carabin IG, Lyon MR, Wood S, Pelletier X, Donazzolo Y, Burdock GA. Supplementation of the diet with the functional fiber PolyGlycopleX® is well tolerated by healthy subjects in a clinical trial. J Nutr 2007;5:8-9.
8. Currie PJ, Mirza A, Fuld R, Park D, Vassselli JR. Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei. Am J Physiol 2005;289:R353-8.
9. Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, Declerck B, et al. Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Nutr 2002;132:967-73. (Pubitemid 34493561)
10. Gee JM, Johnson IT. Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans. Nutrition 2005;21:1036-43. (Pubitemid 41266995)
11. Grover GJ, Mellstrom K, Ye L, Malm J, Li Y, Bladh L, et al. Selective thyroid hormone receptor subtype-β activation: a strategy for weight reduction with reduced cardiovascular liabilities. Proc Natl Acad Sci USA 2003;100:10067-72. (Pubitemid 37098262)
12. Grunberger G, Jen K-L Catherine, Artiss JD. The benefits of early intervention in obese diabetic patients with FBCX. Diab/Metab Res Rev 2006;23:56-62.
13. Halem HA, Tahlor JE, Dong JZ, Shen Y, Datta R, Abizaid A, et al. Novel analogs of ghrelin: physiological and clinical implications. Eur J Endocrinol 2004;151:S71-5.
14. Harding SE, Smith IH, Lawson CJ, Gahler RJ, Wood S. Studies on macromolecular interactions in ternary mixtures of konjac glucomannan, xanthan gum and sodium alginate. J Carbpol 2010;10:1016-20.
15. Horvath TL, Diano S, Stonyi P, Heiman M, Tschop M. Ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 2001;142:4163-9. (Pubitemid 32907040)
16. Howarth NC, Salzman E, Roberts SB. Dietary fiber and weight regulation. Nutr Rev 2001;59:163-9.
17. Jenkins DJA, Kendal CWC, Axelson M, Augustin LSA, Vuksan V. Viscous and nonviscous fibers, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 2000;11:49-56. (Pubitemid 30148198)
18. Kim W, Egan JM. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev 2008;60:470-412.
19. Kim S-J, Nian Nian C, Doudet DJ, McIntosh CHS. Inhibition of dipeptidyl peptidase IV with sitagliptin prolongs graft survival in streptozotocin-induced diabetic mice. Diabetes 2007;57:1331-9.
20. Kok NN, Morgan LM, Williams CM, Roberfroid MB, Thissen J-P, Delzenne NM. Insulin, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. J Nutr 1998;128:1099-103. (Pubitemid 28317672)
21. Massimino SP, McBurney MI, Field CJ, Thomson ABR, Keelan M, Hayek MG, et al. Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. J Nutr 1998;128:1786-93. (Pubitemid 28452866)
22. Matulka RA, Lyon MR, Wood S, Marone PA, Merkel DJ, Burdock GA. The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study. Nutr J 2009;8:1-11.
23. Maurer AD, Chen AD, McPherson C, Reimer RA. Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned on a diet high in fiber or protein reflect susceptibility to increased fat mass in adulthood. J Physiologyt Lond 2009;587:679-91.
24. Morgan LM, Tredger JA, Wright J, Marks V. The effect of soluble- and insoluble-fiber supplementation on post-prandial glucose tolerance, insulin and gastric inhibitory polypeptide secretion in healthy subjects. Br J Nutr 1990;64:103-10. (Pubitemid 20261539)
25. Murphy KG, Dhillo WS, Bloom SR. Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 2006;27:719-27. (Pubitemid 44936055)
26. Nielson LL, Young AA, Parkes DG. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regul Pept 2004;117:77-88. (Pubitemid 38045329)
27. Nishina PM, Schneeman BO, Freedland RA. Effects of dietary fibers on nonfasting plasma lipoprotein and apolipoprotein levels in rats. J Nutr 1991;121:431-7.
28. Nonaka K, Kakikawa T, Sato A, Okuyama K, Fujimoto G, Kato N, et al. Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes. Diab Res Clin Pract 2007;79:291-8.
29. Panahi S, Exatagha A, Temelli F, Vasanthan T, Vuksan V. Glucan from two sources of oat concentrates affect postprandial glycemia in relation to the level of viscosity. J Am Coll Nutr 2007;26:639-44.
30. Parnell JA, Reimer RA. Effect of prebiotic fiber supplementation on hepatic gene expression and serum lipids: a dose-response study in JCR: LA-cp rats. Br J Nutr 2010;103:1577-84.
31. Pospisilik JA, Stafford SG, Denmuth H-U, McIntosh CHS, Dederson RA. Long term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat. Diabetes 2002;51:2677-83. (Pubitemid 34970918)
32. Ramberg J, Murray RK, Vennum E, McAnalley B. Dietary carbohydrates in the human GI tract: the established and emerging science. Glycosci Nutr 2005;6:1-10.
33. Reimer RA, McBurney MI. Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology 1996;137:3948-56. (Pubitemid 26284671)
34. Reimer RA, Russell JC. Glucose tolerance, lipids and GLP-1 secretion in JCR:LA-cp rats fed a high protein fiber diet. Obesity 2008;16:40-6. (Pubitemid 351271948)
35. Reimer RA, Pelletier IG, CarabinM, Gahler R, Lyon M, Parnell JA, et al. Increased plasma PYY levels following supplementation with the functional fiber PolyGlycoplexX in healthy adults. Eur J Clin Nutr 2010, doi:10.1038/ejcn.2010. 141 Electronic copy before print.
36. Rozan P, Nejdi A, Hidalgo S, Bisson J-F, Desor D. Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan. Br J Nutr 2008;99:1-8.
37. Sandberg A-S, Andersson H, Bosaeus I, Carlsson N-G, Hasselblad K, Harrod M. Alginate, small bowel sterol excretion and absorption of nutrients in ileostomy patients. Am J Clin Nutr 1994;51:751-6. (Pubitemid 24327874)
38. Schneeman BO. Effects of nutrients and nonnutrients on food intake. Am J Clin Nutr 1985;42:966-72. (Pubitemid 16148048)
39. Stevens J, Levitsky DA, VanSoest PJ, Robertson JB, Kalkwarf HJ, Roe DA. Effect of psyllium gum and wheat bran on spontaneous energy intake. Am J Clin Nutr 1987;46:812-7. (Pubitemid 18004865)
40. Sugatani J, Osabe M, Wada T, Yamakawa K, Yamazaki Y, Takahashi T, et al. Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet. Eur J Nutr 2008;47:192-200.
41. Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M. (R)-8-(3-Amino-piperidin-1-yl)-7-ynyl-3-methyl-1-(4-methyl-quinazolin-2- ylmethyl)-3, 7-dihydro-purine-2, 6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther 2008;325:175-82. (Pubitemid 351439162)
42. Torsdottir I, Alpsten M, Holm G, Sandberg A-S, Tolli J. A small dose of soluble alginate-fiber affects postprandial glycemia and gastric emptying in humans with diabetes. J Nutr 1991;121:795-9.
43. Viljanen A, Iozzo P, Borra R, Kankaanpaa, Karmie A, Lautamaki R, et al. Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. J Clin Endocrinol Metab 2009;94:50-5.
44. Wang ZQ, Zuberi AR, Zhang XH, Macgowan J, Qin J, Ye X, et al. Effects of dietary fibers on weight gain, carbohydrate metabolism and gastric ghrelin gene expression in mice fed a high fat diet. Metab Clin Exp 2007;56:1635-42. (Pubitemid 350060930)
45. Wiekert MO, Pfeiffer AF. Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr 2008;138:439-42. (Pubitemid 351355237)
46. Wilson JN, Wilson SP, Eaton RP. Dietary fiber and lipoprotein metabolism in the genetically obese Zucker rat. Arteriosclerosis 1984;4:147-53. (Pubitemid 14152893)
47. Zerilli T, Pyon E. Sitagligpin Phosphate. A DPP-4 inhibitor for the treatment of type 2 diabetes mellitus. Clin Ther 2007;29:2612-34.