Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults

European Journal of Clinical Nutrition

Volumn 64, Issue 10, 2010, Pages 1186-1191

  Reimer, R A ^a   Pelletier, X ^b   Carabin, I G ^c   Lyon, M ^d,e   Gahler, R ^f   Parnell, J A ^g   Wood, S ^d  

^a UNIVERSITY OF CALGARY   (Canada)

^b OPTIMED Clinical Research   (France)

^c Burdock Group   (United States)

^d Canadian Centre for Functional Medicine   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f Factors Group of Nutritional Studies Inc R 1 D   (Canada)

^g MOUNT ROYAL UNIVERSITY   (Canada)

Author keywords

functional fiber; GLP 1; peptide YY; satiety hormones; viscosity

Indexed keywords

GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; PEPTIDE YY; PLACEBO; POLYGLYCOPLEX; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY FIBER; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MILK; NORMAL HUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM;

ADOLESCENT; ADULT; ALGINATES; BODY MASS INDEX; DIETARY FIBER; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; GHRELIN; GLUCAGON-LIKE PEPTIDE 1; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OVERWEIGHT; PEPTIDE YY; POLYSACCHARIDES, BACTERIAL; TIME FACTORS; YOUNG ADULT;

EID: 77957827886     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2010.141     Document Type: Article

References (24)

1. Adam TC, Westererp-Plantenga RS (2005). Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects. Br J Nutr 93, 845-851.
2. Batterham RL, Cowley MA, Small CJ, Heshka S, Cohen MA, Dakin CL et al. (2002). Gut hormone PYY (3-36) physiologically inhibits food intake. Nature 418, 650-654.
3. Cani PD, Dewever C, Delzenne NM (2004). Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92, 521-526.
4. Cani PD, Lecourt E, Dewulf EM, Sohet FM, Pachikian BD, Naslain D et al. (2009). Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with conse-quences for appetite sensation and glucose response after a meal. Am J Clin Nutr 90, 1236-1243.
5. Carabin IG, Lyon MR, Wood S, Pelletier X, Donazzolo Y, Burdock GA (2009). Supplementation of the diet with the functional fiber Poly GlycopleX is well tolerated by healthy subjects in a clinical trial. Nutr J 8, 1-11.
6. Castaneda TR, Tong J, Datta R, Culler M, Tschop MH (2010). Ghrelin in the regulation of body weight and metabolism. Frontiers Neuroendocrinol 31, 44-60.
7. Chen HL, Cheng HC, Wu WT, Liu YJ, Liu SY (2008). Supplementa-tion of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial. J Am Coll Nutr 27, 102-108.
8. Dumoulin V, Moro F, Barcelo A, Dakka T, Cuber J-C (1998). Peptide YY, glucagon-like peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused frat ileum. Endocrinology 139, 3780-3786.
9. Juntunen KS, Laaksonen DE, Autio K, Niskanen LK, Holst JJ, Savolainen KE et al. (2003). Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread. Am J Clin Nutr 78, 957-964.
10. Marone PA, Lyon MR, Gahler R, Donath C, Hofman-Huther H, Wood S (2009). Genotoxicity studies of Poly Glycoplex (PGX): a novel dietary fiber. Int J Toxicol 28, 318-331.
11. Matulka RA, Lyon MR, Wood S, Marone PA, Merkel DJ, Burdock GA (2009). The safety of Poly GlycopleX (PGX) as shown in a 90-day rodent feeding study. Nutr J 8, 1-11.
12. Overduin J, Frayo RS, Grill HJ, Kaplan JM, Cummings DE (2005). Role of the duodenum and macronutrient type in ghrelin regulation. Endocrinology 146, 845-850.
13. Parnell JA, Reimer RA (2009). Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 89, 1751-1759.
14. Reimer RA, McBurney MI (1996). Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secre-tion of glucagon-like peptide-1 and insulin in rats. Endocrinology 137, 3948-3956.
15. Reimer RA, Russell JC (2008). Glucose tolerance, lipids and GLP-1 secretion inJCR:LA-cp rats fed a high protein fiber diet. Obesity 16, 40-46.
16. Reimer RA, Thomson ABR, Rajotte R, Basu TK, Ooraikul B, McBurney MI (1997). A physiological level of rhubarb fiber increases proglucagon gene expression and modulates intestinal glucose uptake in rats. J Nutr 127, 1923-1928.
17. St-Pierre DH, Rabasa-Lhoret R, Lavoie M-E, Karelis AD, Strychar I, Doucet E et al. (2009). Fiber intake predicts ghrelin levels in overweight and obese postmenopausal women. Eur J Endocrinol 161, 65-72.
18. Tschop M, Smiley DL, Heiman ML (2000). Ghrelin induces adiposity in rodents. Nature 407, 908-913.
19. Vuksan V, Panda D, Lyon MR, Rogovik AL, Jenkins AL, Leiter LA (2009). Viscosity of fiber preloads affects food intake in adoles-cents. Nutr Metabol Cardiovasc Dis 19, 498-503.
20. Weickert MO, Mohlig M, Schofl C, Arafat AM, Otto B, Viehoff H et al. (2006a). Cereal fiber improves whole-body insulin sensitivity in overweight and obese women. Diabetes Care 29, 775-780.
21. Weickert MO, Spranger J, Holst JJ, Otto B, Koebnick C, Mohlig M et al. (2006b). Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety. Br J Nutr 96, 795-798.
22. Wren AM, Bloom SR (2007). Gut hormones and appetite control. Gastroenterology 132, 2116-2130.
23. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG et al. (2001). Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86, 5992-5995.
24. Zhou J, Martin RJ, Tulley RT, Raggio AM, McCutcheon KL, Shen L et al. (2008). Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol Metab 295, E1160-E1166.