Application of melt granulation technology to enhance tabletting properties of poorly compactible high-dose drugs

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1553-1565

  Lakshman, Jay P ^a   Kowalski, James ^a   Vasanthavada, Madhav ^a   Tong, Wei Qin ^a,b   Joshi, Yatindra M ^a,c   Serajuddin, Abu T M ^a,d  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Teva Pharmaceuticals   (United States)

^c TEVA PHARMACEUTICALS   (Israel)

^d ST JOHN'S UNIVERSITY   (United States)

Author keywords

Extrusion; Formulation; Granulation; Solid dosage form; Tableting; Water in solids

Indexed keywords

HYDROXYPROPYLCELLULOSE; METFORMIN; ANTIDIABETIC AGENT; CELLULOSE; EXCIPIENT; TABLET; WATER;

ARTICLE; BULK DENSITY; CONTROLLED STUDY; DRUG GRANULATION; DRUG SOLUBILITY; DRUG STORAGE; GLASS TRANSITION TEMPERATURE; MELT GRANULATION; MELTING POINT; MOISTURE; PARTICLE SIZE; PHYSICAL CHEMISTRY; TABLET COMPRESSION; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TABLET MANUFACTURE; TABLET PROPERTY; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG FORMULATION; HARDNESS; PROCEDURES; TABLET; TRANSITION TEMPERATURE;

CELLULOSE; DRUG COMPOUNDING; EXCIPIENTS; HARDNESS; HYPOGLYCEMIC AGENTS; METFORMIN; TABLETS; TRANSITION TEMPERATURE; WATER;

EID: 79951862692     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22369     Document Type: Article

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