SSTR2-based reporters for assessing gene transfer into non-small cell lung cancer: Evaluation using an intrathoracic mouse model

Human Gene Therapy

Volumn 22, Issue 1, 2011, Pages 55-64

  Singh, S P ^a   Han, L ^a   Murali, R ^a   Solis, L ^a   Roth, J ^a   Ji, L ^a   Wistuba, I ^a   Kundra, V ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; PENTETREOTIDE IN 111; SOMATOSTATIN RECEPTOR 2; VIRUS HEMAGGLUTININ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER MODEL; CONTROLLED STUDY; DRUG TUMOR LEVEL; EVALUATION; EX VIVO STUDY; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCINTILLATION CAMERA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ULTRASOUND;

ADENOCARCINOMA; ADENOVIRIDAE; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; GAMMA CAMERAS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; MODELS, ANIMAL; RECEPTORS, SOMATOSTATIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

ADENOVIRIDAE;

EID: 79951859670     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2010.109     Document Type: Article

References (43)

1. American Cancer Society. (2009). Cancer Facts & Figures 2009. (American Cancer Society, Atlanta, GA).
2. Bankson, J.A., Ji, L., Ravoori, M., Han, L., and Kundra, V. (2008). Echo-planar imaging for MRI evaluation of intrathoracic tumors in murine models of lung cancer. J. Magn. Reson. Imaging 27, 57-62.
3. Bell, G.I., and Reisine, T. (1993). Molecular biology of somato-statin receptors. Trends Neurosci. 16, 34-38.
4. Benamore, R., Shepherd, F.A., Leighl, N., Pintilie, M., Patel, M., Feld, R., and Herman, S. (2007). Does intensive follow-up alter outcome in patients with advanced lung cancer? J. Thorac. Oncol. 2, 273-281. (Pubitemid 47181708)
5. Cote, J., Bourget, L., Garnier, A., and Kamen, A. (1997). Study of adenovirus production in serum-free 293SF suspension culture by GFP-expression monitoring. Biotechnol. Prog. 13, 709-714. (Pubitemid 28022013)
6. Cross, D., and Burmester, J.K. (2006). Gene therapy for cancer treatment: past, present and future. Clin. Med. Res. 4, 218-227. (Pubitemid 44496015)
7. De Martin, R., Raidl, M., Hofer, E., and Binder, B.R. (1997). Adenovirus-mediated expression of green fluorescent protein. Gene Ther. 4, 493-495. (Pubitemid 27226594)
8. Dimitrakopoulou-Strauss, A., Georgoulias, V., Eisenhut, M., Herth, F., Koukouraki, S., Macke, H.R., Haberkorn, U., and Strauss, L.G. (2006). Quantitative assessment of SSTR2 expression in patients with non-small cell lung cancer using (68)Ga-DOTATOC PET and comparison with (18)F-FDG PET. Eur. J. Nucl. Med. Mol. Imaging 33, 823-830. (Pubitemid 43979691)
9. Fujita, T., Yamaji, Y., Sato, M., Murao, K., and Takahara, J. (1994). Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines. Life Sci. 55, 1797-1806.
10. Han, L., Yang, D., and Kundra, V. (2007). Signaling can be uncoupled from imaging of the somatostatin receptor type 2. Mol. Imaging 6, 427-437.
11. Hemminki, A., Belousova, N., Zinn, K.R., Liu, B., Wang, M., Chaudhuri, T.R., Rogers, B.E., Buchsbaum, D.J., Siegal, G.P., Barnes, M.N., Gomez-Navarro, J., Curiel, D.T., and Alvarez, R.D. (2001). An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression. Mol. Ther. 4, 223-231. (Pubitemid 32851286)
12. 99mTc-depreotide uptake in patients with non-small-cell lung cancer: immunohistochemical correlations. Acta Radiol 50, 902-908.
13. Jett, J.R. (1993). Current treatment of unresectable lung cancer. Mayo Clinic Proc. 68, 603-611. (Pubitemid 23160709)
14. Kirsch, C.M., Von Pawel, J., Grau, I., and Tatsch, K. (1994). Indium-111 pentetreotide in the diagnostic work-up of patients with bronchogenic carcinoma. Eur. J. Nucl. Med. 21, 1318-1325. (Pubitemid 24371005)
15. Kluxen, F.W., Bruns, C., and Lubbert, H. (1992). Expression cloning of a rat brain somatostatin receptor cDNA. Proc. Natl. Acad. Sci. U.S.A. 89, 4618-4622.
16. Kundra, V., Mannting, F., Jones, A.G., and Kassis, A.I. (2002). Noninvasive monitoring of somatostatin receptor type 2 chi-meric gene transfer. J. Nucl. Med. 43, 406-412. (Pubitemid 34208104)
17. Kwekkeboom, D.J., Kho, G.S., Lamberts, S.W., Reubi, J.C., Laissue, J.A., and Krenning, E.P. (1994). The value of octreo-tide scintigraphy in patients with lung cancer. Eur. J. Nucl. Med. 21, 1106-1113. (Pubitemid 24304437)
18. Lau, S.K., Johnson, D.S., and Coel, M.N. (2000). Imaging of non- small-cell lung cancer with indium-111 pentetreotide. Clin. Nucl. Med. 25, 24-28. (Pubitemid 30029915)
19. 111In-pentetreotide scintigraphy. J. Nucl. Med. 43, 889-895. (Pubitemid 34747811)
20. Liang, Q., Gotts, J., Satyamurthy, N., Barrio, J., Phelps, M.E., Gambhir, S.S., and Herschman, H.R. (2002). Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol. Ther. 6, 73-82. (Pubitemid 36124273)
21. 111In-pente-treotide. Mol. Ther. 10, 553-561. (Pubitemid 39186116)
22. Meyer, K., Irminger, J.C., Moss, L.G., De Vargas, L.M., Ober-holzer, J., Bosco, D., Morel, P., and Halban, P.A. (1998). Sorting human beta-cells consequent to targeted expression of green fluorescent protein. Diabetes 47, 1974-1977. (Pubitemid 28549209)
23. Nesbitt, J.C., Putnam, J.B., Jr., Walsh, G.L., Roth, J.A., and Mountain, C.F. (1995). Survival in early-stage non-small cell lung cancer. Ann. Thorac. Surg. 60, 466-472.
24. O'Carroll A.M., Lolait, S.J., König, M., and Mahan, L.C. (1992). Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. Mol. Pharmacol. 42, 939-946. (Pubitemid 23028826)
25. Panetta R., Greenwood, M.T., Warszynska, A., Demchyshyn, L.L., Day, R., Niznik, H.B., Srikant, C.B., and Patel, Y.C. (1994). Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. Mol. Pharmacol. 45, 417-427. (Pubitemid 24094930)
26. Papotti, M., Croce, S., Bellò, M., Bongiovanni, M., Allia, E., Schindler, M., and Bussolati, G. (2001). Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours. Correlation with preop-erative octreotide scintigraphy. Virchows Arch. 439, 787-797. (Pubitemid 33141324)
27. Parry, J.J., Eiblmaier, M., Andrews, R., Meyer, L.A., Higa-shikubo, R., Anderson, C.J., and Rogers, B.E. (2007). Characterization of somatostatin receptor subtype 2 expression in stably transfected A-427 human cancer cells. Mol. Imaging 6, 56-67. (Pubitemid 46642491)
28. Reubi, J.C., Waser, B., Sheppard, M., and Macaulay, V. (1990). Somatostatin receptors are present in small-cell but not in non-small-cell primary lung carcinomas: relationship to EGF-receptors. Int. J. Cancer 45, 269-274. (Pubitemid 20061380)
29. Rogers, B.E., Zinn, K.R., and Buchsbaum, D.J. (2000). Gene transfer strategies for improving radiolabeled peptide imaging and therapy. Q. J. Nucl. Med. 44, 208-223.
30. Rogers, B.E., Chaudhuri, T.R., Reynolds, P.N., Della Manna, D., and Zinn, K.R. (2003). Non-invasive gamma camera imaging of gene transfer using an adenoviral vector encoding an epi-tope-tagged receptor as a reporter. Gene Ther. 10, 105-114. (Pubitemid 36582582)
31. 94mTc-Demotate 1. J. Nucl. Med. 46, 1889-1897. (Pubitemid 46196652)
32. Scagliotti, G. (2007). Multimodality approach to early-stage non- small cell lung cancer. Lung Cancer 57 (Suppl. 2), S6-S11. (Pubitemid 47193234)
33. Singh, S.P., Yang, D., Ravoori, M., Han, L., and Kundra, V. (2009). In vivo functional and anatomic imaging for assessment of in vivo gene transfer. Radiology 252, 763-771.
34. Stables, J., Scott, S., Brown, S., Roelant, C., Burns, D., Lee, M.G., and Rees, S. (1999). Development of a dual glow-signal firefly and Renilla luciferase assay reagent for the analysis of G-protein coupled receptor signalling. J. Receptor Signal Transduct. Res. 19, 395-410. (Pubitemid 29152197)
35. Sun, X., Annala, A.J., Yaghoubi, S.S., Barrio, J.R., Nguyen, K.N., Toyokuni, T., Satyamurthy, N., Namavari, M., Phelps, M.E., Herschman, H.R., and Gambhir, S.S. (2001). Quantitative imaging of gene induction in living animals. Gene Ther. 8, 1572-1579. (Pubitemid 33061896)
36. Tjuvajev, J.G., Joshi, A., Callegari, J., Lindsley, L., Joshi, R., Ba-latoni, J., Finn, R., Larson, S.M., Sadelain, M., and Blasberg, R.G. (1999). A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia 1, 315-320.
37. Vattemi, E., and Claudio, P.P. (2004). Gene therapy for lung cancer: practice and promise. Ann. Ital. Chir. 75, 279-289.
38. 99mTc-P829. Cancer Res. 58, 1850-1859. (Pubitemid 28217458)
39. Yaghoubi, S.S., Wu, L., Liang, Q., Toyokuni, T., Barrio, J.R., Namavari, M., Satyamurthy, N., Phelps, M.E., Herschman, H.R., and Gambhir, S.S. (2001). Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Ther. 8, 1072-1080. (Pubitemid 32970375)
40. Yamada, Y., Reisine, T., Law, S.F., Ihara, Y., Kubota, A., Kagi-moto, S., Seino, M., Seino, Y., Bell, G.I., and Seino, S. (1992). Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. Mol. Endocrinol. 6, 2136-2142. (Pubitemid 23021563)
41. Yang, D., Han, L., and Kundra, V. (2005). Exogenous gene expression in tumors: noninvasive quantification with functional and anatomic imaging in a mouse model. Radiology 235, 950-958. (Pubitemid 40695894)
42. 188Re. J. Nucl. Med. 41, 887-895. (Pubitemid 30266035)
43. Zinn, K.R., Chaudhuri, T.R., Krasnykh, V.N., Buchsbaum, D.J., Belousova, N., Grizzle, W.E., Curiel, D.T., and Rogers, B.E. (2002). Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicis-tronic adenovirus in mice. Radiology 223, 417-425. (Pubitemid 34454320)