Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours: Correlation with preoperative octreotide scintigraphy

Virchows Archiv

Volumn 439, Issue 6, 2001, Pages 787-797

  Papotti, Mauro ^a   Croce, Sabrina ^a   Bellò, Marilena ^a   Bongiovanni, Massimo ^a   Allìa, Elena ^a   Schindler, Marcus ^b,c   Bussolati, Gianni ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Immunohistochemistry; Lung; Octreotide scintigraphy; Somatostatin receptors; Tumors

Indexed keywords

MEMBRANE PROTEIN; OCTREOTIDE; RECEPTOR SUBTYPE; SOMATOSTATIN RECEPTOR; TRACER;

ADULT; AGED; ARTICLE; AUTORADIOGRAPHY; CANCER SURGERY; CELL MEMBRANE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLOGY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERMETHOD COMPARISON; LUNG TUMOR; MALE; NEUROENDOCRINE TUMOR; NUCLEIC ACID ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR BIOPSY; TUMOR NECROSIS; TUMOR SCINTISCANNING;

EID: 0035212220     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280100494     Document Type: Article

References (49)

1. Somatostatin receptor imaging in small cell lung cancer
2. Somatostatin receptor imaging of small cell lung cancer (SCLC) by means of 111 In-DTPA octreotide scintigraphy
3. Isolation of biologically active RNA from sources enriched in ribonuclease
4. Tumour uptake of the radiolabelled somatostatin analogue [DOTA0 TYR3]octreotide is dependent on the peptide amount
5. Expression of somatostatin receptors in peritumoral veins of human tumors
6. Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines
7. The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit
8. Development of selective antibodies against the human somatostatin receptor subtypes sst1-sst5
9. Immunohistochemical detection of somatostatin receptor subtypes sst1 and sst2A in human somatostatin receptor positive tumors
10. A comparison between the efficacy of somatostatin receptor scintigraphy and that of in situ hybridization for somatostatin receptor subtype 2 messenger RNA to predict therapeutic outcome in car-cinoid patients
11. Determination of Somatostatin receptors subtype 2 in carci-noid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies
12. Nuclear localisation of 111-In after intravenous injection of [111In-DTPA-D-Phe1]-octreotide in patients with neu-roendocrine tumors
13. Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine tumors
14. Indium-111 pentetreotide in the diagnostic work-up of patients with bron-chogenic carcinoma
15. Expression of the five somatostatin receptors (SSTR1-5) subtypes in rat pituitary somatotrophes: Quantitative analysis by double-label immunofluorescence confocal microscopy
16. Comparison of 111In-DOTA-TYR3-octreotide and 111In-DTPA-octreotide in the same patients: Biodistribution, kinetics, organ and tumor uptake
17. Avoiding false positives with PCR
18. Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: Consequences with regard to diagnosis, localization and therapy
19. Imaging of non-small-cell lung cancer with indium-111 pentetreotide
20. Somatostatin and somatostatin receptor subtype gene expression in medullary thyroid carcinoma
21. Comparative studies on the expression of somatostatin receptor subtypes, outcome of octreotide scintigraphy and response to octreotide treatment in patients with carcinoid tumours
22. Somatostatin receptor expression in lung cancer
23. Correlative study on neuroendocrine differentiation and presence of so-matostatin receptors in breast carcinomas
24. Quantitation of somatostatin receptor type 2 in neuroendocrine (Merkel cell) carcinoma of the skin by competitive RT-PCR
25. Correlative immunohisto-chemical and reverse transcriptase-polymerase chain reaction analysis of somatostatin receptor type 2 in neuroendocrine tumors of the lung
26. Somatostatin receptor scintigraphy in small-cell lung cancer: Results of a multicenter study
27. What is a false-positive somatostatin receptor scintigraphy?
28. Somatostatin receptors in human endocrine tumors
29. So-matostatin receptors are present in small-cell but not in non-small-cell primary lung carcinomas: Relationship to EGF receptors
30. In vitro autoradiographic and in vivo scintigraphic localisation of so-matostatin receptors in human lymphatic tissues
31. Expression and localization of somatostatin receptors SSTR1, SSTR2, SSTR3 messenger RNA in primary human tumors using in situ hybridisation
32. Immunohistochemical localization of somatostatin receptors sst2A in human tumors
33. sst3-selective potent peptidic somatostatin receptor antagonists
34. Subcellular distribution of somatostatin sst2A receptors in human tumors of the nervous and neuroendocrine systems: Membranous versus intracellular location
35. Affinity profiles for human so-matostatin receptor subtypes sst1-sst5 of somatostatin radio-tracers selected for scintigraphic and radiotherapeutic use
36. Immunohistochemical localization of the somatostatin sst2(A) receptor in the rat brain and spinal cord
37. Localization of the somatostatin sst2a receptor in human cerebral cortex, hippocampus and cerebellum
38. 3 in paraffin-embedded breast cancer tissue Resusing subtype-specific antibodies
39. 111 In-octreotide scintigraphy in small cell lung cancer
40. Quantification of Somatostatin receptor type 2 gene expression in neuroblastoma cell lines and primary tumors using competitive reverse transcription-polymerase chain reaction
41. Somatostatin receptor imaging, therapy and new strategies in patients with neuroen-docrine tumors
42. Increased uptake of indium-111 pente-treotide up to ten years after external thoracic irradiation: Report of two cases
43. Imaging and staging of small-cell lung cancer: Is there a future role for octreo-tide scintigraphy?
44. Detection of somatostatin receptor subtype 2 (SSTR2) in established tumors and tumor cell lines: Evidence for sst2 heterogeneity
45. Clinical diagnostic application of 111In-DTPA-octreotide scintigraphy in small cell lung cancer
46. Post-incubation heating significantly improves tyramide signal amplification
47. Point mutation of the somatosta-tin receptor 2 gene in the human small cell lung cancer cell line COR-L103