Gene fusions find an ERG-way to tumor inflammation

Cancer Biology and Therapy

Volumn 11, Issue 4, 2011, Pages 418-420

  Martin, Sarah K ^a   Kyprianou, Natasha ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Fusion genes; Hydroxy prostaglandin dehydrogenase; Prostaglandins; Prostate cancer

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; ANDROGEN RECEPTOR; CYCLOOXYGENASE 2; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN; TRANSCRIPTION FACTOR ERG; UVOMORULIN;

5' UNTRANSLATED REGION; CANCER CELL; CARCINOGENESIS; CASTRATION RESISTANT PROSTATE CANCER; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; DOUBLE STRANDED DNA BREAK; EARLY DIAGNOSIS; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; HUMAN; INFLAMMATION; NOTE; PROGNOSIS; PROMOTER REGION; PROSTAGLANDIN SIGNALING; PROSTATE CANCER; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

HUMANS; INFLAMMATION; MALE; ONCOGENE FUSION; ONCOGENE PROTEINS, FUSION; PROSTATIC NEOPLASMS;

EID: 79951846237     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.11.4.14499     Document Type: Note

References (15)

1. Esgueva R, Perner S, Lafargue C, Scheble V, Stephan C, Lein M, et al. Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. Mod Pathol 2010; 23:539-46.
2. Petrovics G, Aijun L, Shaheduzzaman S, Furasato B, Sun C, Chen Y, et al. Frequent overexpression of ETS-related gene-1 (ERG) in prostate cancer transcriptome. Oncogene 2005; 24:3847-52. (Pubitemid 40826884)
3. Klezovitch O, Risk M, Coleman I. A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Scie USA 2008; 105:2105-10. (Pubitemid 351439472)
4. Tomlins SA, Laxman B, Varambally S, Cao X, Yu J, Helgeson BE, et al. Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia 2008; 10:177-88. (Pubitemid 351240884)
5. Mani RS, Tomlins SA, Callahan K, Ghosh A, Nyati MK, Varambally S, et al. Induced chromosomal proximity and the genesis of gene fusions in prostate cancer. Science 2009; 326:5957.
6. Rostad K, Mannelqvist M, Halvorsen OJ, Oyan AM, Bo TH, Stordgrange L, et al. ERG upregulation and related ETS transcription factors in prostate cancer. International J Oncol 2007; 30:19-32.
7. Hermans KG, van Marion R, van Dekken H, Jenster G, van Weeden WM, Trapman J. TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen dependent prostate cancer. Cancer Res 2006; 66:10658-63.
8. Shroder F. Progress in understanding androgen-independent prostate cancer (AIPC): A review of potential endocrine-mediated mechanisms. Eur Urol 2008; 53:1129-37.
9. Perner S, Mosquera JM, Demichelis F, Hofer MD, Simko J, Collins C, et al. TMPRSS2-ERG Fusion prostate cancer: An early molecular even associated with invasion. Am J Surg Pathol 2007; 31:882-8. (Pubitemid 47165141)
10. Mohamed AA, Tan SH, Sun C, Shaheduzzaman S, Hu Y, Petrovics G, et al. ERG oncogene modulates prostaglandin signaling in prostate cancer cells. Cancer Biol Ther 2011;11: 410-7.
11. Kirschenbaum A, Liu XH, Yao S, Levine AC. The role of cyclooxygenase-2 in prostate cancer. Urology 2001; 58:127-31. (Pubitemid 32743428)
12. Chen Y, Hughes-Fulford M. Prostaglandin E2 and the protein kinase A pathway mediate arachadonic acid induction of c-fos in human prostate cells. Br J Cancer 2000; 82:2000-6. (Pubitemid 30326462)
13. Liu XH, Kirschenbaum A, Yao S, Lee R, Holland JF, Levine AC. Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo. J Uro 2000; 164:820-5. (Pubitemid 30637640)
14. Gupta S, Iljin K. FZD4 as a mediator of ERG oncogene induced WNT signaling and epithelial to mesenchymal transition in human prostate cancer cells. Cancer Res 2010; 70:6735-45.
15. Lee LM, Pan CC, Cheng CJ, Chi CW, Liu TY. Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. Anticancer Res 2001; 21:1291-4.