Prostaglandin E2 and the protein kinases A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells

British Journal of Cancer

Volumn 82, Issue 12, 2000, Pages 2000-2006

  Chen, Y ^a   Hughes Fulford, M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Arachidonic acid; c fos; EP4; Gene expression; Prostaglandin E2; Prostaglandin receptor; Prostate cancer; Protein kinase

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ARACHIDONIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; FLURBIPROFEN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; PROTEIN KINASE C INHIBITOR; ISOQUINOLINE DERIVATIVE; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2 RECEPTOR, EP4 SUBTYPE; SULFONAMIDE;

ARTICLE; CANCER GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; ONCOGENE C FOS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; CELL CULTURE; MALE; METABOLISM; NASA DISCIPLINE CELL BIOLOGY; NASA PROGRAM FUNDAMENTAL SPACE BIOLOGY; NON-NASA CENTER; ONCOGENE; PROSTATE TUMOR;

NASA DISCIPLINE CELL BIOLOGY; NASA PROGRAM FUNDAMENTAL SPACE BIOLOGY; NON-NASA CENTER;

ARACHIDONIC ACID; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; FLURBIPROFEN; GENE EXPRESSION; GENES, FOS; HUMANS; ISOQUINOLINES; MALE; PROSTATIC NEOPLASMS; RECEPTORS, PROSTAGLANDIN E; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONAMIDES; TUMOR CELLS, CULTURED;

EID: 0033623858     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Angel P and Karin M (1991) The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072: 129-157
2. Buscher M, Rahmsdorf HJ, Litfin M, Karin M and Herrlich P (1988) Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene 3: 301-311
3. Chaudry AA, Wahle KW, McClinton S and Moffat LE (1994) Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: effects of fatty acids and cyclooxygenase inhibitors. Int J Cancer 57: 176-180
4. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K. Toshioka T and Hidaka H (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase. N-[2-(p-bromocinnamylamino)ethy 1]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265: 5267-5272
5. Chilton FH, Fonteh AN, Surette ME, Triggiani M and Winkler JD (1996) Control of arachidonate levels within inflammatory cells. Biochim Biophys Acta 1299: 1-15
6. Coleman RA and Kennedy I (1985) Characterisation of the prostanoid receptors mediating contraction of guinea-pig isolated trachea. Prostaglandins, 29: 363-375
7. Connolly JM, Coleman M and Rose DP (1997) Effects of dietary fatty acids on DU145 human prostate cancer cell growth in athymic nude mice. Nutr Cancer 29: 114-119
8. Danesch U, Weber PC and Sellmayer A (1994) Arachidonic acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin E2 and activation of protein kinase C. J Biol Chem 269: 27258-27263
9. 2-induced upregulation of c -fos mRNA is primarily mediated by cAMP in MC3T3-E1 osteoblasts. Endocrinology 141: 291-298
10. Geuskens M, Torres JM, Esteban C and Uriel J (1994) Endocytosis of three serum proteins of a multigene family and of arachidonic acid in human lectin-stimulated T lymphocytes. Microsc Res Tech 28: 297-307
11. Gilman MZ (1988) The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP. Genes Dev 2: 394-402
12. Habenicht AJ, Salbach P, Goerig M, Zeh W, Janssen-Timmen U, Blattner C, King WC and Glomset JA (1990) The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor. Nature 345: 634-636
13. Iturralde M, Alava MA, Gonzalez B, Anel A and Pineiro A (1991) Effect of alpha-fetoprotein and albumin on the uptake of polyunsaturated fatty acids by rat hepatoma cells and fetal rat hepatocytes. Biochim Biophys Acta 1086: 81-88
14. Juzan M, Hostein I and Gualde N (1992) Role of thymus-eicosanoids in the immune response. Prostaglandins Leukot Essent Fatty Acids 46: 247-255
15. Kacich RL, Williams LT and Coughlin SR (1988) Arachidonic acid and cyclic adenosine monophosphate stimulation of c-fos expression by a pathway independent of phorbol ester-sensitive protein kinase C. Mol Endocrinol 2: 73-77
16. Lau LF and Nathans D (1987) Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 84: 1182-1186
17. Liu XH, Yao S, Kirschenbaum A and Levine AC (1998) NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells. Cancer Res 58: 4245-1249
18. Marnett LJ (1992) Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 52: 5575-5589
19. Mehmet H, Millar JB, Lehmann W, Higgins T and Rozengurt E (1990) Bombesín stimulation of c-fos expression and mitogenesis in Swiss 3T3 cells: the role of prostaglandin E2-mediated cyclic AMP accumulation. Exp Cell Res 190: 265-270
20. Monick M, Glazier J and Hunninghake GW (1987) Human alveolar macrophages suppress interleukin-1 (IL-1) activity via the secretion of prostaglandin E2. Am Rev Respir Dis 135: 72-77
21. Negishi M, Sugimoto Y and Ichikawa A (1995) Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1259: 109-119
22. O'Neill GP and Ford-Hutchinson AW (1993) Expression of mRNA for cyclooxgygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 330: 156-160
23. Pilbeam CC, Raisz LG, Voznesensky O, Alander CB, Delman BN and Kawaguchi H (1995) Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. J Bone Mineral Res 10: 406-414
24. Raisz LG, Pilbeam CC and Fall PM (1993) Prostaglandins: mechanisms of action and regulation of production in bone. Osteoporos Int 3 (Suppl 1): 136-140
25. Rao GN, Lassegue B, Griendling KK, Alexander RW and Berk BC (1993) Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C. Nucleic Acids Res 21: 1259-1263
26. Rose DP (1997) Dietary fatty acids and cancer. Am J Clin Nutr 66(Suppl) 998S-1003S
27. Rose DP and Connolly JM (1991) Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. Prostate 18. 243-254
28. Smith WL (1989) The eicosanoids and their biochemical mechanisms of action. Biochem J 259: 315-324
29. Tjandrawinata RR, Dahiya R and Hughes-Fulford M (1997) Induction of cyclooxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. Br J Cancer 75: 1111-1118
30. Toullec D, Pianetli P, Toste H, Bellevergue P, Grand Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamel L, Charon D and Kirilovsky J (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266: 1577I-15781
31. Uriel J, Torres JM and Anel A (1994) Carrier-protein mediated enhancement of fatty-acid binding and internalization in human T-lymphocytes. Biochim Biophys Acta 1220: 231-240
32. Weinreb M, Grosskopf A and Shir N (1999) The anabolic effect of PGE2 in rat bone marrow cultures is mediated via the EP4 receptor subtype. Am J Physiol 276: E376-383