메뉴 건너뛰기




Volumn 77, Issue SUPPL.1, 2011, Pages

Can bisphosphonates improve outcomes in patients with newly diagnosed multiple myeloma?

Author keywords

Anticancer; Antimyeloma; Bisphosphonate; Clodronate; Myeloma; Skeletal related event; Survival; Zoledronic acid

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CLODRONIC ACID; CREATININE; DEXAMETHASONE; ETIDRONIC ACID; IBANDRONIC ACID; ISOPENTENYL DIPHOSPHATE; MELPHALAN; PAMIDRONIC ACID; PLACEBO; PREDNISONE; THALIDOMIDE; ZOLEDRONIC ACID;

EID: 79951843681     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1040-8428(11)70005-1     Document Type: Review
Times cited : (10)

References (42)
  • 2
    • 72949085546 scopus 로고    scopus 로고
    • Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines
    • Kumar SK, Mikhael JR, Buadi FK, Dingli D, Dispenzieri A, Fonseca R, et al. Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines. Mayo Clin Proc 2009, 84:1095-1110.
    • (2009) Mayo Clin Proc , vol.84 , pp. 1095-1110
    • Kumar, S.K.1    Mikhael, J.R.2    Buadi, F.K.3    Dingli, D.4    Dispenzieri, A.5    Fonseca, R.6
  • 3
    • 58249097191 scopus 로고    scopus 로고
    • Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma
    • Kyle RA, Rajkumar SV Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia 2009, 23:3-9.
    • (2009) Leukemia , vol.23 , pp. 3-9
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 4
    • 0035010803 scopus 로고    scopus 로고
    • Metastatic bone disease: clinical features, patho-physiology and treatment strategies
    • Coleman RE Metastatic bone disease: clinical features, patho-physiology and treatment strategies. Cancer Treat Rev 2001, 27:165-176.
    • (2001) Cancer Treat Rev , vol.27 , pp. 165-176
    • Coleman, R.E.1
  • 6
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappaB
    • Chauhan D, Uchiyama H, Akbarali Y, Urashima M, Yamamoto K, Libermann TA, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappaB. Blood 1996, 87:1104-1112.
    • (1996) Blood , vol.87 , pp. 1104-1112
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3    Urashima, M.4    Yamamoto, K.5    Libermann, T.A.6
  • 7
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: clinical applications
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC Advances in biology of multiple myeloma: clinical applications. Blood 2004, 104:607-618.
    • (2004) Blood , vol.104 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 8
    • 0036512435 scopus 로고    scopus 로고
    • Multiple myeloma: evolving genetic events and host interactions
    • Kuehl WM, Bergsagel PL Multiple myeloma: evolving genetic events and host interactions. Nat Rev Cancer 2002, 2:175-187.
    • (2002) Nat Rev Cancer , vol.2 , pp. 175-187
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 9
    • 79951821906 scopus 로고    scopus 로고
    • Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease
    • Terpos E, Dimopoulos MA, Berenson J Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease. Crit Rev Oncol Hematol 2011, 77(1):S13-S23.
    • (2011) Crit Rev Oncol Hematol , vol.77 , Issue.1
    • Terpos, E.1    Dimopoulos, M.A.2    Berenson, J.3
  • 10
    • 33846246666 scopus 로고    scopus 로고
    • Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma
    • Baulch-Brown C, Molloy TJ, Yeh SL, Ma D, Spencer A Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma. Leuk Res 2007, 31:341-352.
    • (2007) Leuk Res , vol.31 , pp. 341-352
    • Baulch-Brown, C.1    Molloy, T.J.2    Yeh, S.L.3    Ma, D.4    Spencer, A.5
  • 11
    • 0030931858 scopus 로고    scopus 로고
    • Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity
    • Shipman CM, Rogers MJ, Apperley JF, Russell RG, Croucher PI Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity. Br J Haematol 1997, 98:665-672.
    • (1997) Br J Haematol , vol.98 , pp. 665-672
    • Shipman, C.M.1    Rogers, M.J.2    Apperley, J.F.3    Russell, R.G.4    Croucher, P.I.5
  • 12
    • 0034055664 scopus 로고    scopus 로고
    • Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines
    • Tassone P, Forciniti S, Galea E, Morrone G, Turco MC, Martinelli Y, et al. Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines. Leukemia 2000, 14:841-844.
    • (2000) Leukemia , vol.14 , pp. 841-844
    • Tassone, P.1    Forciniti, S.2    Galea, E.3    Morrone, G.4    Turco, M.C.5    Martinelli, Y.6
  • 13
    • 0346848763 scopus 로고    scopus 로고
    • The bisphosphonate zoledronic acid induces cytotoxicity in human myeloma cell lines with enhancing effects of dexamethasone and thalidomide
    • Ural AU, Yilmaz MI, Aveu F, Pekel A, Zerman M, Nevruz O, et al. The bisphosphonate zoledronic acid induces cytotoxicity in human myeloma cell lines with enhancing effects of dexamethasone and thalidomide. Int J Hematol 2003, 78:443-449.
    • (2003) Int J Hematol , vol.78 , pp. 443-449
    • Ural, A.U.1    Yilmaz, M.I.2    Aveu, F.3    Pekel, A.4    Zerman, M.5    Nevruz, O.6
  • 14
    • 20544473523 scopus 로고    scopus 로고
    • Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: a possible mechanism for its antitumor effect
    • Corso A, Ferretti E, Lunghi M, Zappasodi P, Mangiacavalli S, De Amici M, et al. Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma: a possible mechanism for its antitumor effect. Cancer 2005, 104:118-125.
    • (2005) Cancer , vol.104 , pp. 118-125
    • Corso, A.1    Ferretti, E.2    Lunghi, M.3    Zappasodi, P.4    Mangiacavalli, S.5    De Amici, M.6
  • 15
    • 73949153315 scopus 로고    scopus 로고
    • Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines
    • Zwolak P, Manivel JC, Jasinski P, Kirstein MN, Dudek AZ, Fisher J, et al. Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines. J Bone Joint Surg Am 2010, 92:162-168.
    • (2010) J Bone Joint Surg Am , vol.92 , pp. 162-168
    • Zwolak, P.1    Manivel, J.C.2    Jasinski, P.3    Kirstein, M.N.4    Dudek, A.Z.5    Fisher, J.6
  • 17
    • 35048864309 scopus 로고    scopus 로고
    • Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells
    • Koizumi M, Nakaseko C, Ohwada C, Takeuchi M, Ozawa S, Shimizu N, et al. Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells. Eur J Haematol 2007, 79:382-391.
    • (2007) Eur J Haematol , vol.79 , pp. 382-391
    • Koizumi, M.1    Nakaseko, C.2    Ohwada, C.3    Takeuchi, M.4    Ozawa, S.5    Shimizu, N.6
  • 18
    • 33846547592 scopus 로고    scopus 로고
    • Gamma delta T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface
    • Uchida R, Ashihara E, Sato K, Kimura S, Kuroda J, Takeuchi M, et al. Gamma delta T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface. Biochem Biophys Res Commun 2007, 354:613-618.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 613-618
    • Uchida, R.1    Ashihara, E.2    Sato, K.3    Kimura, S.4    Kuroda, J.5    Takeuchi, M.6
  • 19
    • 0034660687 scopus 로고    scopus 로고
    • Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma
    • Kunzmann Y, Bauer E, Feurle J, Weissinger F, Tony HP, Wilhelm M Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 2000, 96:384-392.
    • (2000) Blood , vol.96 , pp. 384-392
    • Kunzmann, Y.1    Bauer, E.2    Feurle, J.3    Weissinger, F.4    Tony, H.P.5    Wilhelm, M.6
  • 20
    • 72449165023 scopus 로고    scopus 로고
    • Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma
    • Moschetta M, Di Pietro G, Ria R, Gnoni A, Mangialardi G, Guarini A, et al. Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma. Eur J Cancer 2010, 46:420-429.
    • (2010) Eur J Cancer , vol.46 , pp. 420-429
    • Moschetta, M.1    Di Pietro, G.2    Ria, R.3    Gnoni, A.4    Mangialardi, G.5    Guarini, A.6
  • 21
    • 0036181668 scopus 로고    scopus 로고
    • Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
    • Yaccoby S, Pearse RN, Johnson CL, Barlogie B, Choi Y, Epstein J Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol 2002, 116:278-290.
    • (2002) Br J Haematol , vol.116 , pp. 278-290
    • Yaccoby, S.1    Pearse, R.N.2    Johnson, C.L.3    Barlogie, B.4    Choi, Y.5    Epstein, J.6
  • 22
    • 0242308942 scopus 로고    scopus 로고
    • Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival
    • Croucher PI, De Hendrik R, Perry MJ, Hijzen A, Shipman CM, Lippitt J, et al. Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival. J Bone Miner Res 2003, 18:482-492.
    • (2003) J Bone Miner Res , vol.18 , pp. 482-492
    • Croucher, P.I.1    De Hendrik, R.2    Perry, M.J.3    Hijzen, A.4    Shipman, C.M.5    Lippitt, J.6
  • 23
    • 73449128342 scopus 로고    scopus 로고
    • The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation
    • Guenther A, Gordon S, Tiemann M, Burger R, Bakker F, Green JR, et al. The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation. Int J Cancer 2010, 126:239-246.
    • (2010) Int J Cancer , vol.126 , pp. 239-246
    • Guenther, A.1    Gordon, S.2    Tiemann, M.3    Burger, R.4    Bakker, F.5    Green, J.R.6
  • 25
    • 78049376262 scopus 로고    scopus 로고
    • Mature results from ABCSG-12: adjuvant ovarian suppression combined with tamoxifen or anastro-zole, alone or in combination with zoledronic acid, in premenopausal women with endocrine-responsive early breast cancer
    • [abstract 533].
    • Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Poestlberger S, Dubsky PC, et al. Mature results from ABCSG-12: adjuvant ovarian suppression combined with tamoxifen or anastro-zole, alone or in combination with zoledronic acid, in premenopausal women with endocrine-responsive early breast cancer. J Clin Oncol 2010, 28(Suppl):75s. [abstract 533].
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Gnant, M.1    Mlineritsch, B.2    Stoeger, H.3    Luschin-Ebengreuth, G.4    Poestlberger, S.5    Dubsky, P.C.6
  • 26
    • 69149084971 scopus 로고    scopus 로고
    • Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials
    • Dearnaley DP, Mason MD, Parmar MK, Sanders K, Sydes MR Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials. Lancet Oncol 2009, 10:872-876.
    • (2009) Lancet Oncol , vol.10 , pp. 872-876
    • Dearnaley, D.P.1    Mason, M.D.2    Parmar, M.K.3    Sanders, K.4    Sydes, M.R.5
  • 27
    • 36248938315 scopus 로고    scopus 로고
    • Antitumor effect of zoledronic acid in previously untreated patients with multiple myeloma
    • Aviles A, Nambo MJ, Neri N, Castaneda C, Cleto S, Huerta-Guzman J Antitumor effect of zoledronic acid in previously untreated patients with multiple myeloma. Med Oncol 2007, 24:227-230.
    • (2007) Med Oncol , vol.24 , pp. 227-230
    • Aviles, A.1    Nambo, M.J.2    Neri, N.3    Castaneda, C.4    Cleto, S.5    Huerta-Guzman, J.6
  • 28
    • 79951838858 scopus 로고    scopus 로고
    • Improved survival in patients with multiple myeloma and high BALP levels treated with zoledronic acid compared with pamidronate: univariate and multivariate models of hazard ratios. Presented at 48th ASH Annual Meeting and Exposition, 2006 [abstract 3589].
    • Berenson J, Dimopoulos M, Chen Y-M. Improved survival in patients with multiple myeloma and high BALP levels treated with zoledronic acid compared with pamidronate: univariate and multivariate models of hazard ratios. Presented at 48th ASH Annual Meeting and Exposition, 2006 [abstract 3589].
    • Berenson, J.1    Dimopoulos, M.2    Chen, Y.-M.3
  • 29
    • 0034937438 scopus 로고    scopus 로고
    • Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma
    • McCloskey EV, Dunn JA, Kanis JA, MacLennan IC, Drayson MT Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma. Br J Haematol 2001, 113:1035-1043.
    • (2001) Br J Haematol , vol.113 , pp. 1035-1043
    • McCloskey, E.V.1    Dunn, J.A.2    Kanis, J.A.3    MacLennan, I.C.4    Drayson, M.T.5
  • 30
    • 6844252283 scopus 로고    scopus 로고
    • Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group
    • Berenson JR, Lichtenstein A, Porter L, Dimopoulos MA, Bordoni R, George S, et al. Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group. J Clin Oncol 1998, 16:593-602.
    • (1998) J Clin Oncol , vol.16 , pp. 593-602
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3    Dimopoulos, M.A.4    Bordoni, R.5    George, S.6
  • 31
    • 78650174738 scopus 로고    scopus 로고
    • First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial
    • Morgan GJ, Davies FE, Gregory WM, Cocks K, Bell SE, Szubert AJ, et al. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet 2010, 376:1989-1999.
    • (2010) Lancet , vol.376 , pp. 1989-1999
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3    Cocks, K.4    Bell, S.E.5    Szubert, A.J.6
  • 32
    • 79951819023 scopus 로고    scopus 로고
    • Optimising bone disease in myeloma; zoledronic acid plus thalidomide combinations improve survival and bone endpoints: results of the Myeloma IX trial. Presented at 52nd ASH Annual Meeting and Exposition, 2010 [abstract 311].
    • Morgan GJ, Davies FE, Gregory WM, Bell SE, Szubert AJ, Drayson MT, et al. Optimising bone disease in myeloma; zoledronic acid plus thalidomide combinations improve survival and bone endpoints: results of the Myeloma IX trial. Presented at 52nd ASH Annual Meeting and Exposition, 2010 [abstract 311].
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3    Bell, S.E.4    Szubert, A.J.5    Drayson, M.T.6
  • 34
    • 44449153039 scopus 로고    scopus 로고
    • Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates
    • Hoff AO, Toth BB, Altundag K, Johnson MM, Warneke CL, Hu M, et al. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res 2008, 23:826-836.
    • (2008) J Bone Miner Res , vol.23 , pp. 826-836
    • Hoff, A.O.1    Toth, B.B.2    Altundag, K.3    Johnson, M.M.4    Warneke, C.L.5    Hu, M.6
  • 35
    • 35048875471 scopus 로고    scopus 로고
    • Pathologic fractures correlate with reduced survival in patients with malignant bone disease
    • Saad F, Lipton A, Cook R, Chen YM, Smith M, Coleman R Pathologic fractures correlate with reduced survival in patients with malignant bone disease. Cancer 2007, 110:1860-1867.
    • (2007) Cancer , vol.110 , pp. 1860-1867
    • Saad, F.1    Lipton, A.2    Cook, R.3    Chen, Y.M.4    Smith, M.5    Coleman, R.6
  • 38
    • 21044454594 scopus 로고    scopus 로고
    • ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of multiple myeloma
    • Harrouseau JL, Greil R, Kloke O ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of multiple myeloma. Ann Oncol 2005, 16(Suppl l):i45-i47.
    • (2005) Ann Oncol , vol.16 , Issue.SUPPL 1
    • Harrouseau, J.L.1    Greil, R.2    Kloke, O.3
  • 39
    • 34347260332 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma
    • Kyle RA, Yee GC, Somerfield MR, Flynn PJ, Halabi S, Jagannath S, et al. American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma. J Clin Oncol 2007, 25:2464-2472.
    • (2007) J Clin Oncol , vol.25 , pp. 2464-2472
    • Kyle, R.A.1    Yee, G.C.2    Somerfield, M.R.3    Flynn, P.J.4    Halabi, S.5    Jagannath, S.6
  • 41
    • 67649804881 scopus 로고    scopus 로고
    • Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results
    • Brufsky AM, Bosserman LD, Caradonna RR, Haley BB, Jones CM, Moore HC, et al. Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results. Clin Breast Cancer 2009, 9:77-85.
    • (2009) Clin Breast Cancer , vol.9 , pp. 77-85
    • Brufsky, A.M.1    Bosserman, L.D.2    Caradonna, R.R.3    Haley, B.B.4    Jones, C.M.5    Moore, H.C.6
  • 42
    • 79951822723 scopus 로고    scopus 로고
    • Comparative effectiveness of bisphosphonates in multiple myeloma. Presented at 52nd ASH Annual Meeting and Exposition, 2010 [abstract 3028].
    • Mhaskar R, Redzepovic J, Wheatley K, Clark O, Glasmacher A, Miladinovic B, et al. Comparative effectiveness of bisphosphonates in multiple myeloma. Presented at 52nd ASH Annual Meeting and Exposition, 2010 [abstract 3028].
    • Mhaskar, R.1    Redzepovic, J.2    Wheatley, K.3    Clark, O.4    Glasmacher, A.5    Miladinovic, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.