Neurotrophic effects of a cyanine dye via the PI3K-AKt pathway: Attenuation of motor discoordination and neurodegeneration in an ataxic animal model

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Ohta, Hitomi ^a   Arai, Shigeyuki ^a   Akita, Kenji ^a   Ohta, Tsunetaka ^a   Fukuda, Shigeharu ^a  

^a HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYANINE DYE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NK 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE A RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; CARBOCYANINE; COLORING AGENT; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; NEUROTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATAXIA; BRAIN ATROPHY; CELL COUNT; CELL DAMAGE; CELL STRAIN; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PURKINJE CELL; RAT; SIGNAL TRANSDUCTION; ANIMAL; ATROPHY; CELL PROLIFERATION; CEREBELLAR ATAXIA; DISEASE MODEL; HAMSTER; INTRACELLULAR SPACE; METABOLISM; MUTATION; NEURITE; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOMOTOR PERFORMANCE;

ANIMALIA; CRICETINAE;

ANIMALS; ATROPHY; CARBOCYANINES; CELL PROLIFERATION; CEREBELLAR ATAXIA; COLORING AGENTS; CRICETINAE; DISEASE MODELS, ANIMAL; FEMALE; INTRACELLULAR SPACE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MUTATION; NEURITES; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NEUROTOXINS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PSYCHOMOTOR PERFORMANCE; PURKINJE CELLS; RATS; SIGNAL TRANSDUCTION;

EID: 79951837880     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017137     Document Type: Article

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