Enhancement of neurite outgrowth in PC12 cells stimulated with cyclic AMP and NGF by 6-acylated ascorbic acid 2-O-α-glucosides (6-Acyl-AA-2G), novel lipophilic ascorbate derivatives

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 3, 2003, Pages 341-346

  Zhou, Xiaohua ^a   Tai, Akihiro ^a   Yamamoto, Itaru ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Ascorbate; cAMP; Lipophilic ascorbate derivative; MAP kinase; Neurite outgrowth

Indexed keywords

ASCORBIC ACID DERIVATIVE; CASTANOSPERMINE; CYCLIC AMP; GLUCOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PROTEIN P42; PROTEIN P44; ASCORBIC ACID; ASCORBIC ACID 2 O GLUCOSIDE; ASCORBIC ACID 2-O-GLUCOSIDE; DRUG DERIVATIVE; ENZYME INHIBITOR; INDOLIZINE DERIVATIVE;

ACYLATION; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LEVEL; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG SCREENING; LIPOPHILICITY; NERVE FIBER GROWTH; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; STATISTICAL SIGNIFICANCE; ANIMAL; CELL COUNT; CELL LINE; CELL STRAIN; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; EXTRACELLULAR SPACE; METABOLISM; NEURITE; PHYSIOLOGY; WESTERN BLOTTING;

ACYLATION; ANIMALS; ASCORBIC ACID; BLOTTING, WESTERN; CELL COUNT; CELL LINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; EXTRACELLULAR SPACE; INDOLIZINES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NEURITES; PC12 CELLS; RATS;

EID: 0642318040     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.26.341     Document Type: Article

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