Flight behaviour in humans is intensified by a candidate genetic risk factor for panic disorder: Evidence from a translational model of fear and anxiety

Molecular Psychiatry

Volumn 16, Issue 3, 2011, Pages 242-244

  Perkins, A M ^a   Ettinger, U ^b   Williams, S C R ^a   Reuter, M ^c   Hennig, J ^d   Corr, P J ^e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN 2A RECEPTOR;

ALLELE; ANXIETY; CHROMOSOME 13Q; CONTROLLED STUDY; ELECTROSTIMULATION; FEAR; FEMALE; FLIGHT; GENE EXPRESSION; GENETIC RISK; HUMAN; HUMAN EXPERIMENT; LETTER; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; NORMAL HUMAN; PANIC; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RISK FACTOR; RNA TRANSLATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANXIETY; ESCAPE REACTION; FEAR; GENE FREQUENCY; HUMANS; PANIC DISORDER; POLYMORPHISM, GENETIC; PSYCHOMOTOR PERFORMANCE; RECEPTOR, SEROTONIN, 5-HT2A; RISK FACTORS;

EID: 79951813582     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2010.2     Document Type: Letter

References (11)

1. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 593-603.
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. (DSM-IV) American Psychiatric Association: Washington, DC, USA, 1994.
3. Gorman JM, Kent JM, Sullivan GM, Coplan JD. Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 2000; 157: 493-505. (Pubitemid 30191187)
4. Griebel G, Blanchard DC, Agnes RS, Blanchard RJ. Differential modulation of antipredator defensive behavior in Swiss-Webster mice following acute or chronic administration of imipramine and fluoxetine. Psychopharmacology 1995; 120: 57-66.
5. Perkins AM, Ettinger U, Davis R, Foster R, Williams SCR, Corr PJ. Effects of Lorazepam and citalopram on human defensive reactions: ethopharmacological differentiation of fear and anxiety. J Neurosci 2009; 29: 12617-12624.
6. Maron E, Nikopensius T, Kõks S, Altmäe S, Heinaste E, Vabrit K et al. Association study of 90 candidate gene polymorphisms in panic disorder. Psychiatr Genet 2005; 15: 17-24. (Pubitemid 40411566)
7. Yoon HK, Yang JC, Lee HJ, Kim YK. The association between serotonin-related gene polymorphisms and panic disorder. J Anxiety Disord 2008; 22: 1529-1534.
8. Barnes LLB, Harp D, Jung WS. Educ Psychol Meas 2002; 62: 603-618.
9. Serretti A, Calati R, Giegling I, Hartmann AM, Möller HJ, Colombo C et al. 5-HT2A SNPs and the Temperament and Character Inventory. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1275-1281. (Pubitemid 47081316)
10. Serretti A, Drago A, De Ronchi D. HTR2A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies. Curr Med Chem 2007; 14: 2053-2069. (Pubitemid 47578163)
11. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645. (Pubitemid 41079594)