The association between serotonin-related gene polymorphisms and panic disorder

Journal of Anxiety Disorders

Volumn 22, Issue 8, 2008, Pages 1529-1534

  Yoon, Ho Kyoung ^a   Yang, Jong Chul ^b   Lee, Heon Jeong ^a,c   Kim, Yong Ku ^a,c  

^a Korea University College of Medicine   (South Korea)

^b Chonbuk National University   (South Korea)

^c Korea University   (South Korea)

Author keywords

Panic disorder; Polymorphism; Serotonin 2A receptor; Tryptophan hydroxylase

Indexed keywords

SEROTONIN 2A RECEPTOR; TRYPTOPHAN HYDROXYLASE;

ACUTE PANIC INVENTORY; ADULT; ANXIETY SENSITIVITY INDEX; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PANIC; PANIC DISORDER SEVERITY SCALE; SCORING SYSTEM; SEROTONIN 2A RECEPTOR GENE; SEROTONINERGIC SYSTEM; SPIELBERGER STATE-TRAIT ANXIETY INVENTORY; SYMPTOM; TRYPTOPHAN HYDROXYLASE GENE;

ADULT; CATECHOL O-METHYLTRANSFERASE; CONTROL GROUPS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; PANIC DISORDER; PERSONALITY INVENTORY; PHENOTYPE; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN HYDROXYLASE;

EID: 53149149825     PISSN: 08876185     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.janxdis.2008.03.006     Document Type: Article

References (47)

1. Arranz M.J., Munro J., Owen M.J., Spurlock G., Sham P.C., Zhao J., et al. Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine. Molecular Psychiatry 3 (1998) 61-66
2. Azmitia E.C. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Research Bulletin 56 (2001) 413-424
3. Bondy B., Spaeth M., Offenbaecher M., Glatzeder K., Stratz T., Schwarz M., et al. The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiology of Disease 6 (1999) 433-439
4. Chee I.S., Lee S.W., Kim J.L., Wang S.K., Shin Y.O., Shin S.C., et al. 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder. Psychiatric Genetics 11 (2001) 111-114
5. Crowe R.R., Noyes R., Pauls D.L., and Slymen D. A family study of panic disorder. Archives of General Psychiatry 40 (1983) 1065-1069
6. de Angelis L. 5-HT2A antagonists in psychiatric disorders. Current Opinion in Investigational drugs (London, England: 2000) 3 (2002) 106-112
7. de Bortoli V.C., Nogueira R.L., and Zangrossi H. Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray. Psychopharmacology 183 (2006) 422-428
8. Dillon D.J., Gorman J.M., Liebowitz M.R., Fyer A.J., and Klein D.F. Measurement of lactate-induced panic and anxiety. Psychiatry Research 20 (1987) 97-105
9. Du L., Bakish D., Lapierre Y.D., Ravindran A.V., and Hrdina P.D. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. American Journal of Medical Genetics 96 (2000) 56-60
10. Enoch M.A., Kaye W.H., Rotondo A., Greenberg B.D., Murphy D.L., and Goldman D. 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet 351 (1998) 1785-1786
11. Fehr C., Schleicher A., Szegedi A., Anghelescu I., Klawe C., Hiemke C., et al. Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Progress in Neuro-Psychopharmacology and Biological Psychiatry 25 (2001) 965-982
12. First M., Spitzer R.L., Gibbon M., and William J.B. Structured clinical interview for DSM-IV axis I disorder-patient edition (SCID-I/P, version 2.0) (1998), American Psychiatric Publishing, Inc., New York
13. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry 23 (1960) 56-62
14. Han L., Nielsen D.A., Rosenthal N.E., Jefferson K., Kaye W., Murphy D., et al. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biological Psychiatry 45 (1999) 615-619
15. Hemrick-Luecke S.K., and Evans D.C. Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis. Neuropharmacology 42 (2002) 162-169
16. Hettema J.M., Neale M.C., and Kendler K.S. A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry 158 (2001) 1568-1578
17. Inada Y., Yoneda H., Koh J., Sakai J., Himei A., Kinoshita Y., et al. Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene. Psychiatry Research 118 (2003) 25-31
18. Kendler K.S., Neale M.C., Kessler R.C., Heath A.C., and Eaves L.J. Panic disorder in women: a population-based twin study. Psychological Medicine 23 (1993) 397-406
19. Kendler K.S., Walters E.E., Neale M.C., Kessler R.C., Heath A.C., and Eaves L.J. The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry 52 (1995) 374-383
20. Kessler R. Review: major anxiety disorders all have substantive familial aggregation. Evidence-Based Mental Health 5 (2002) 92
21. Kim W., Choi Y.H., Yoon K.S., Cho D.Y., Pae C.U., and Woo J.M. Tryptophan hydroxylase and serotonin transporter gene polymorphism does not affect the diagnosis, clinical features and treatment outcome of panic disorder in the Korean population. Progress in Neuro-Psychopharmacology and Biological Psychiatry 30 (2006) 1413-1418
22. Lander E.S., and Schork N.J. Genetic dissection of complex traits. Science 265 (1994) 2037-2048
23. Lim Y.J., Yu B.H., and Kim J.H. Korean Panic Disorder Severity Scale: construct validity by confirmatory factor analysis. Depression and Anxiety 24 (2007) 95-102
24. Maier W., Lichtermann D., Minges J., Oehrlein A., and Franke P. A controlled family study in panic disorder. Journal of Psychiatric Research 27 Suppl. 1 (1993) 79-87
25. Maron E., Lang A., Tasa G., Liivlaid L., Töru I., Must A., et al. Associations between serotonin-related gene polymorphisms and panic disorder. The International Journal of Neuropsychopharmacology/Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 8 (2005) 261-266
26. Maron E., Nikopensius T., Köks S., Altmäe S., Heinaste E., Vabrit K., et al. Association study of 90 candidate gene polymorphisms in panic disorder. Psychiatric Genetics 15 (2005) 17-24
27. Martinez-Barrondo S., Saiz P.A., Morales B., Garcia-Portilla M.P., Coto E., Alvarez V., et al. Serotonin gene polymorphisms in patients with panic disorder. Actas Espa Psiquiatr 33 (2005) 210-215
28. Nielsen D.A., Jenkins G.L., Stefanisko K.M., Jefferson K.K., and Goldman D. Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Brain Research. Molecular Brain Research 45 (1997) 145-148
29. Noyes R.J., Crowe R.R., Harris E.L., Hamra B.J., McChesney C.M., and Chaudhry D.R. Relationship between panic disorder and agoraphobia. A family study. Archives of General Psychiatry 43 (1986) 227-232
30. Nutt D.J. Antidepressants in panic disorder: clinical and preclinical mechanisms. Journal of Clinical Psychiatry 59 Suppl. 8 (1998) 24-28 discussion 29
31. Papp L.A., Martinez J.M., Klein D.F., Coplan J.D., Norman R.G., Cole R., et al. Respiratory psychophysiology of panic disorder: three respiratory challenges in 98 subjects. The American Journal of Psychiatry 154 (1997) 1557-1565
32. Reiss S., Peterson R.A., Gursky D.M., and McNally R.J. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behaviour Research and Therapy 24 (1986) 1-8
33. Rothe C., Koszycki D., Bradwejn J., King N., De Luca V., Shaikh S., et al. Association study of serotonin-2A receptor gene polymorphism and panic disorder in patients from Canada and Germany. Neuroscience Letters 363 (2004) 276-279
34. In: Sadock B.J., and Sadock V.A. (Eds). Synopsis of psychiatry (2007), Lippincott Williams and Wilkins, Philadelphia
35. Schruers K., Klaassen T., Pols H., Overbeek T., Deutz N.E., and Griez E. Effects of tryptophan depletion on carbon dioxide provoked panic in panic disorder patients. Psychiatry Research 93 (2000) 179-187
36. Schruers K., van Diest R., Overbeek T., and Griez E. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Research 113 (2002) 237-243
37. Shear M.K., Brown T.A., Barlow D.H., Money R., Sholomskas D.E., Woods S.W., et al. Multicenter collaborative Panic Disorder Severity Scale. The American Journal of Psychiatry 154 (1997) 1571-1575
38. Shear M.K., Rucci P., Williams J., Frank E., Grochocinski V., Vander Bilt J., et al. Reliability and validity of the Panic Disorder Severity Scale: replication and extension. Journal of Psychiatric Research 35 (2001) 293-296
39. Spielberger C.D. STAI: Manual for the Stait-Trait Anxiety Inventory (1983), Consulting Psychologists Press, Palo Alto, CA
40. Taylor S., Koch W.J., and Crockett D.J. Anxiety sensitivity, trait anxiety, and the anxiety disorders. Journal of Anxiety Disorders 5 (1991) 293-311
41. Telch M.J., Shermis M.D., and Lucas J.A. Anxiety sensitivity: unitary personality trait or domain-specific appraisals?. Journal of Anxiety Disorders 3 (1989) 25-32
42. Tsuang M.T., Faraone S.V., and Lyons M.J. Identification of the phenotype in psychiatric genetics. European Archives of Psychiatry and Clinical Neuroscience 243 (1993) 131-142
43. Walitza S., Wewetzer C., Warnke A., Gerlach M., Geller F., Gerber G., et al. 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders. Molecular Psychiatry 7 (2002) 1054-1057
44. Walther D.J., Peter J.U., Bashammakh S., Hörtnagl H., Voits M., Fink H., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
45. Yamauchi M., Miyara T., Matsushima T., and Imanishi T. Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors. Brain Research 1067 (2006) 164-169
46. Zanoveli J.M., Nogueira R.L., and Zangrossi H. Chronic imipramine treatment sensitizes 5-HT1A and 5-HT 2 A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety. Behavioural Pharmacology 16 (2005) 543-552
47. Zill P., Büttner A., Eisenmenger W., Bondy B., and Ackenheil M. Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains. European Neuropsychopharmacology 14 (2004) 282-284