Functional characterization of Wilms tumor-suppressor WTX and tumor-associated mutants

Oncogene

Volumn 30, Issue 7, 2011, Pages 832-842

  Kim, M K H ^a   Min, D J ^a   Rabin, M ^a   Licht, J D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

G0 G1 arrest; microarray; p21; tumor suppressor; WT1; WTX

Indexed keywords

PROTEIN P21;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE INDUCTION; GENE WTX; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NEPHROBLASTOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CELL LINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY; KIDNEY NEOPLASMS; PROTO-ONCOGENE PROTEINS P21(RAS); SEQUENCE DELETION; TUMOR SUPPRESSOR PROTEINS; WILMS TUMOR;

EID: 79951813486     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.452     Document Type: Article

References (30)

1. Bardeesy N, Beckwith JB, Pelletier J. (1995). Clonal expansion and attenuated apoptosis in Wilm's tumors are associated with p53 gene mutations. Cancer Res 55: 215-219.
2. Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD et al. (2005). Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci USA 102: 3324-3329. (Pubitemid 40328044)
3. Chung NG, Kim MS, Chung YJ, Yoo NJ, Lee SH. (2008). Tumor suppressor WTX gene mutation is rare in acute leukemias. Leuk Lymphoma 49: 1616-1617.
4. Englert C, Maheswaran S, Garvin AJ, Kreidberg J, Haber DA. (1997). Induction of p21 by the Wilm's tumor suppressor gene WT1. Cancer Res 57: 1429-1434. (Pubitemid 27175555)
5. Grohmann A, Tanneberger K, Alzner A, Schneikert J, Behrens J. (2007). AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane. J Cell Sci 120: 3738-3747. (Pubitemid 350187356)
6. Huff V. (1998). Characterization of a wilms tumor in a 9-year-old girl with trisomy 18. Am J Med Genet 79: 260-267.
7. Jenkins ZA, van Kogelenberg M, Morgan T, Jeffs A, Fukuzawa R, Pearl E et al. (2009). Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nat Genet 41: 95-100.
8. Kim MK,Mason JM, Li CM, Berkofsky-Fessler W, Jiang L, Choubey D et al. (2008). A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16. Neoplasia 10: 69-78. (Pubitemid 351170714)
9. Kim MK, McGarry TJ, Obroin .P, Flatow JM, Golden AA, Licht JD. (2009). An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1. Proc Natl Acad Sci USA 106: 11154-11159.
10. Koesters R, Ridder R, Kopp-Schneider A, Betts D, Adams V, Niggli F et al. (1999). Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilm's tumors. Cancer Res 59: 3880-3882. (Pubitemid 29393544)
11. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D et al. (1993). WT-1 is required for early kidney development. Cell 74: 679-691. (Pubitemid 23259748)
12. Li CM, Kim CE, Margolin AA, Guo M, Zhu J, Mason JM et al. (2004). CTNNB1 mutations and overexpression of Wnt/betacatenin target genes in WT1-mutant Wilm's tumors. Am J Pathol 165: 1943-1953. (Pubitemid 39578373)
13. Maiti S, Alam R, Amos CI, Huff V. (2000). Frequent association of beta-catenin and WT1 mutations in Wilms tumors. Cancer Res 60: 6288-6292.
14. Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C et al. (2007). Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 316: 1043-1046. (Pubitemid 46799493)
15. Morrison DJ, Kim MK, Berkofsky-Fessler W, Licht JD. (2008). WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression. Mol Cancer Res 6: 1225-1231.
16. Morvan F, Boulukos K, Clement-Lacroix P, Roman Roman S, Suc-Royer I, Vayssiere B et al. (2006). Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 21: 934-945. (Pubitemid 43788000)
17. Ogawa O, Eccles MR, Szeto J, McNoe LA, Yun K, Maw MA et al. (1993). Relaxation of insulin-like growth factor II gene imprinting implicated in Wilm's tumour. Nature 362: 749-751. (Pubitemid 23125978)
18. Ohlsson R, Nystrom A, Pfeifer-Ohlsson S, Tohonen V, Hedborg F, Schofield P et al. (1993). IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome. Nat Genet 4: 94-97. (Pubitemid 23165921)
19. Owen C, Virappane P, Alikian M, Stasevich I, Summers K, Lillington D et al. (2008). WTX is rarely mutated in acute myeloid leukemia. Haematologica 93: 947-948. (Pubitemid 351821739)
20. Park JS, Valerius MT, McMahon AP. (2007). Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development 134: 2533-2539. (Pubitemid 47074147)
21. Perotti D, Gamba B, Sardella M, Spreafico F, Terenziani M, Collini P et al. (2008). Functional inactivation of the WTX gene is not a frequent event in Wilm's tumors. Oncogene 27: 4625-4632.
22. Rivera MN, Haber DA. (2005). Wilm's tumour: connecting tumorigenesis and organ development in the kidney. Nat Rev Cancer 5: 699-712. (Pubitemid 41486363)
23. Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M et al. (2007). An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science 315: 642-645. (Pubitemid 46214707)
24. Rivera MN, Kim WJ, Wells J, Stone A, Burger A, Coffman EJ et al. (2009). The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity. Proc Natl Acad Sci USA 106: 8338-8343.
25. Ruteshouser EC, Robinson SM, Huff V. (2008). Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors. Genes Chromosomes Cancer 47: 461-470. (Pubitemid 351657181)
26. Schmidt-Ott KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J et al. (2007). beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors. Development 134: 3177-3190. (Pubitemid 47506156)
27. Strathdee CA, McLeod MR, Hall JR. (1999). Efficient control of tetracycline-responsive gene expression from an autoregulated bidirectional expression vector. Gene 229: 21-29. (Pubitemid 29148303)
28. Wegert J, Wittmann S, Leuschner I, Geissinger E, Graf N, Gessler M. (2009). WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact. Genes Chromosomes Cancer 48: 1102-1111.
29. Weksberg R, Shen DR, Fei YL, Song QL, Squire J. (1993). Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome. Nat Genet 5: 143-150. (Pubitemid 23293449)
30. Yoo NJ, Kim S, Lee SH. (2009). Mutational analysis of WTX gene in Wnt/ beta-catenin pathway in gastric, colorectal, and hepatocellular carcinomas. Dig Dis Sci 54: 1011-1014.