Seizures during pegylated interferon and ribavirin therapy for chronic hepatitis C: Observations from the WIN-R trial

Journal of Clinical Gastroenterology

Volumn 45, Issue 3, 2011, Pages 286-292

  Ahmed, Furqaan ^a   Jacobson, Ira M ^b   Herrera, Jorge L ^c   Brand, Myron ^d   Wasserman, Ronald B ^e   Fixelle, Alan M ^f   Rustgi, Vinod K ^g   Albert, Clive ^h   Brown, Robert ⁱ   Brass, Clifford ^j  

^a AGA KHAN UNIVERSITY   (Pakistan)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

^d Gastroenterology Consultants of Connecticut   (United States)

^e Infectious Disease Doctors   (United States)

^f Gastroenterology Consultants   (United States)

^g GEORGETOWN UNIVERSITY   (United States)

^h Northside Forsyth Drive ^*  (United States)

ⁱ Columbia University College of Physicians and Surgeons ^*  (United States)

^j MERCK RESEARCH LABORATORIES   (United States)

more..

Author keywords

adverse event; hepatitis C; peginterferon; ribavirin; seizure

Indexed keywords

ALANINE AMINOTRANSFERASE; AMFEBUTAMONE; ANTICONVULSIVE AGENT; BUSPIRONE; CITALOPRAM; ETIRACETAM; PAROXETINE; PEGINTERFERON ALPHA2B; PHENYTOIN; RIBAVIRIN; SERTRALINE; VENLAFAXINE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ANTICONVULSANT THERAPY; ANTIVIRAL THERAPY; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; DEPRESSION; DRUG DOSE REDUCTION; DRUG INDUCED DISEASE; DRUG OVERDOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; FEMALE; FOLLOW UP; GENETIC VARIABILITY; GRAND MAL SEIZURE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HYPONATREMIA; MALE; MEDICAL HISTORY; NEUROIMAGING; NEUTROPENIA; PATIENT COMPLIANCE; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; SEIZURE; SIDE EFFECT; SODIUM BLOOD LEVEL;

ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2B; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RIBAVIRIN; SEIZURES; TREATMENT OUTCOME;

EID: 79951809620     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3181f656fb     Document Type: Article

References (42)

1. Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358:958-965. (Pubitemid 32913521)
2. Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa- 2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 2002;347:975-982.
3. Wong VK, Cheong-Lee C, Ford JAE, et al. Acute sensorineural hearing loss associated with peginterferon and ribavirin combination therapy during hepatitis C treatment: outcome after resumption of therapy. World J Gastroenterol. 2005;11: 5392-5393. (Pubitemid 41410314)
4. Russo MW, Fried MW. Side effects of therapy for chronic hepatitis C. Gastroenterology. 2003;124:1711-1719. (Pubitemid 36617688)
5. Fried MW. Side effects of therapy of hepatitis C and their management. Hepatology. 2002;36:S237-S244. (Pubitemid 35253486)
6. Rohatiner AZS, Prior PF, Burton AC, et al. Central nervous system toxicity of interferon. Br J Cancer. 1983;47:419-422. (Pubitemid 13117150)
7. Dieperink E, Willenbring M, Ho SB. Neuropsychiatric symptoms associated with hepatitis C and interferon alpha: a review. Am J Psychiatry. 2000;157:867-876. (Pubitemid 30412335)
8. Fattovich G, Giustina G, Favarato S, et al.; Investigators of the Italian Association for the Study of the Liver. A survey of adverse events in 11,241 patients with chronic viral hepatitis treated with alfa interferon. J Hepatol. 1996;24:38-47.
9. Dierckx RA, Michotte A, Schmedding E, et al. Unilateral seizures in a patient with hairy cell leukemia treated with interferon. Clin Neurol Neurosurg. 1985;87:209-212. (Pubitemid 16226431)
10. Munschauer FE III, Kinkel RP. Managing side effects of interferon-beta in patients with relapsing-remitting multiple sclerosis. Clin Ther. 1997;19:883-893. (Pubitemid 27508924)
11. Kirkwood JM, Ernstoff MS, Davis CA, et al. Comparison of intramuscular and intravenous recombinant alpha-2 interferon in melanoma and other cancers. Ann Intern Med. 1985;103:32-36. (Pubitemid 15068495)
12. Ameen M, Russell-Jones R. Seizures associated with interferon- alpha treatment of cutaneous malignancies. Br J Dermatol. 1999;141:386-387. (Pubitemid 29398039)
13. Brouwers PJAM, Bosker RJI, Schaafsma MR, et al. Photosensitive seizures associated with interferon alfa-2a. Ann Pharmacother. 1999;33:113-114. (Pubitemid 29056569)
14. Dubisar BM, Stoner SC, Khan R, et al. Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. Pharmacotherapy. 2002;22:1504-1507. (Pubitemid 35266388)
15. Janssen HLA, Berk L, Vermeulen M, et al. Seizures associated with low-dose alpha-interferon. Lancet. 1990;336:1580.
16. Shakil AO, Di Bisceglie AM, Hoofnagle JH. Seizures during alpha interferon therapy. J Hepatol. 1996;24:48-51. (Pubitemid 26037205)
17. Calvet MC, Gresser I. Interferon enhances the excitability of cultured neurones. Nature. 1979;278:558-560. (Pubitemid 9146520)
18. Arenzana-Seisdedos F, Virelizier JL. Interferons as macrophage- activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide-stimulated human monocytes. Eur J Immunol. 1983;13:437-440. (Pubitemid 13060105)
19. Blalock JE, Smith EM. Human leukocyte interferon (HuIFNalpha): potent endorphin-like opioid activity. Biochem Biophys Res Commun. 1981;101:472-478. (Pubitemid 12251615)
20. Guyer DR, Tiedeman J, Yannuzzi LA, et al. Interferon- associated retinopathy. Arch Ophthalmol. 1993;111: 350-356.
21. Seno H, Inagaki T, Itoga M, et al. A case of seizures 1 week after the cessation of interferon-alpha therapy. Psychiatry Clin Neurosci. 1999;53:417-420. (Pubitemid 29333971)
22. Anton C, Trifan A, Stanciu C, et al. Seizures during the treatment with interferon for chronic C hepatitis. Rev Med Chir Soc Med Nat Iasi. 2000;104:135-137.
23. Verger P, De Monredon J, Blais J. Convulsive seizure during a treatment with interferon alpha for chronic viral hepatitis C. Gastroenterol Clin Biol. 1997;21:902-903. (Pubitemid 27522810)
24. Kraus MR, Schafer A, Faller H, et al. Paroxetine for the treatment of interferon-a-induced depression in chronic hepatitis C. Aliment Pharmacol Ther. 2002;16:1091-1099. (Pubitemid 34680751)
25. Jacobson IM, Brown RS Jr, Freilich B, et al. Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial. Hepatology. 2007;46: 971-981. (Pubitemid 350144761)
26. Jacobson IM, Brown RS Jr, McCone J, et al. Impact of weightbased ribavirin with peginterferon alfa-2b in African Americans with hepatitis C virus genotype 1. Hepatology. 2007; 46:982-990. (Pubitemid 350144762)
27. Annegers JF. The epidemiology of epilepsy. In: Wyllie E, ed. The Treatment of Epilepsy: Principles and Practice. Philadelphia: Lea and Febiger; 1993:157-164.
28. Valentini P, Mariotti P, Ngalikpima CJ, et al. Seizures in an interferon-treated child. Dig Liver Dis. 2001;33: 363-365. (Pubitemid 32537025)
29. Woynarowski M, Socha J. Seizures in children during interferon alpha therapy. J Hepatol. 1997;26:956-957. (Pubitemid 27145726)
30. Cunha JM, Carlini EA, Pereira AE, et al. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology. 1980;21:175-185. (Pubitemid 10039764)
31. Consroe PF, Wood GC, Buchsbaum H. Anticonvulsant nature of marihuana smoking. JAMA. 1975;234:306-307.
32. Brust JCM. Seizures and substance abuse: treatment considerations. Neurology. 2006;67:S45-S48. (Pubitemid 44967997)
33. Hauser P, Khosla J, Aurora H, et al. A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C. Mol Psychiatry. 2002;7:942-947. (Pubitemid 35333048)
34. Hauser P. Neuropsychiatric side effects of HCV therapy and their treatment: focus on IFN alpha-induced depression. Gastroenterol Clin North Am. 2004;33:S35-S50.
35. Musselman DL, Lawson DH, Gumnick JF, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N Engl J Med. 2001;344:961-966. (Pubitemid 32240314)
36. Zdilar D, Franco-Bronson K, Buchler N, et al. Hepatitis C, interferon alfa, and depression. Hepatology. 2000;31: 1207-1211. (Pubitemid 30351279)
37. Rosenstein DL, Nelson JC, Jacobs SC. Seizures associated with antidepressants: a review. J Clin Psychiatry. 1993;54: 289-299. (Pubitemid 23273945)
38. Seethalakshmi R, Krishnamoorthy ES. Depression in epilepsy: phenomenology, diagnosis and management. Epileptic Disord. 2007;9:1-10. (Pubitemid 46396670)
39. Barry JJ, Huynh N, Lembke A. Depression in individuals with epilepsy. Curr Treat Options Neurol. 2000;2:571-585.
40. Lee KC, Finley PR, Alldredge BK. Risk of seizures associated with psychotropic medications: emphasis on new drugs and new findings. Expert Opin Drug Saf. 2003;2:233-247.
41. Davidson J. Seizures and bupropion: a review. J Clin Psychiatry. 1989;50:256-261. (Pubitemid 19193449)
42. Belson MG, Kelley TR. Bupropion exposures: clinical manifestations and medical outcome. J Emerg Med. 2002;23: 223-230. (Pubitemid 35300241)