메뉴 건너뛰기




Volumn 4, Issue 1, 2011, Pages 17-26

Iron chelation in thalassemia: Time to reconsider our comfort zones

Author keywords

compliance; deferasirox; deferiprone; desferrioxamine; endocrine dysfunction; iron chelation; magnetic resonance imaging; thalassemia; transfusion iron overload

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN; GLUCONATE ZINC; IRON; IRON CHELATING AGENT; TACHPYRIDINE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 79951776374     PISSN: 17474086     EISSN: None     Source Type: Journal    
DOI: 10.1586/ehm.10.74     Document Type: Review
Times cited : (26)

References (92)
  • 1
    • 59249101341 scopus 로고    scopus 로고
    • Hemoglobinopathies worldwide: Present and future
    • Weatherall DJ. Hemoglobinopathies worldwide: present and future. Curr. Mol. Med. 8, 592-599 (2008).
    • (2008) Curr. Mol. Med. , vol.8 , pp. 592-599
    • Weatherall, D.J.1
  • 2
    • 34247271478 scopus 로고    scopus 로고
    • Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective
    • DOI 10.2165/00019053-200725040-00005
    • Delea TE, Sofrygin O, Thomas SK, Baladi JF, Phatak PD, Coates TD. Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective. Pharmacoeconomics 25, 329-342 (2007). (Pubitemid 46607383)
    • (2007) PharmacoEconomics , vol.25 , Issue.4 , pp. 329-342
    • Delea, T.E.1    Sofrygin, O.2    Thomas, S.K.3    Baladi, J.-F.4    Phatak, P.D.5    Coates, T.D.6
  • 3
    • 0014685737 scopus 로고
    • Some clinical features of Cooleys anemia patients as related to transfusion schedules
    • Wolman IJ, Ortolani M. Some clinical features of Cooleys anemia patients as related to transfusion schedules. Ann. NY Acad. Sci. 165, 407-414 (1969).
    • (1969) Ann. NY Acad. Sci. , vol.165 , pp. 407-414
    • Wolman, I.J.1    Ortolani, M.2
  • 4
    • 0000390903 scopus 로고
    • Transfusion therapy in Cooleys anemia: Growth and health as related to long-range hemoglobin levels. A progress report
    • Wolman IJ. Transfusion therapy in Cooleys anemia: growth and health as related to long-range hemoglobin levels. A progress report. Ann. NY Acad. Sci. 119, 736-747 (1964).
    • (1964) Ann. NY Acad. Sci. , vol.119 , pp. 736-747
    • Wolman, I.J.1
  • 6
    • 0020034796 scopus 로고
    • Survival and desferrioxamine in thalassaemia major
    • Modell B, Letsky EA, Flynn DM, Peto R, Weatherall DJ. Survival and desferrioxamine in thalassaemia major. Br. Med. J. (Clin. Res. Ed.) 284, 1081-1084 (1982). (Pubitemid 12135972)
    • (1982) British Medical Journal , vol.284 , Issue.6322 , pp. 1081-1084
    • Modell, B.1    Letsky, E.A.2    Flynn, D.M.3
  • 7
    • 0034631379 scopus 로고    scopus 로고
    • Survival in β-thalassaemia major in the UK: Data from the UK thalassaesnia register
    • Modell B, Khan M, Darlison M. Survival in β-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet 355, 2051-2052 (2000). (Pubitemid 30339248)
    • (2000) Lancet , vol.355 , Issue.9220 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 9
    • 74049116227 scopus 로고    scopus 로고
    • Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major
    • Farmaki K, Tzoumari I, Pappa C, Chouliaras G, Berdoukas V. Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major. Br. J. Haematol. 148, 466-475 (2010).
    • (2010) Br. J. Haematol. , vol.148 , pp. 466-475
    • Farmaki, K.1    Tzoumari, I.2    Pappa, C.3    Chouliaras, G.4    Berdoukas, V.5
  • 11
    • 1442307460 scopus 로고    scopus 로고
    • Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease
    • DOI 10.1182/blood-2003-06-1919
    • Wood JC, Tyszka JM, Carson S, Nelson MD, Coates TD. Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood 103, 1934-1936 (2004). (Pubitemid 38268994)
    • (2004) Blood , vol.103 , Issue.5 , pp. 1934-1936
    • Wood, J.C.1    Tyszka, J.M.2    Carson, S.3    Nelson, M.D.4    Coates, T.D.5
  • 12
    • 23744459788 scopus 로고    scopus 로고
    • MRI R2 and R2*mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
    • DOI 10.1182/blood-2004-10-3982
    • Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2*mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106, 1460-1465 (2005). (Pubitemid 41129616)
    • (2005) Blood , vol.106 , Issue.4 , pp. 1460-1465
    • Wood, J.C.1    Enriquez, C.2    Ghugre, N.3    Tyzka, J.M.4    Carson, S.5    Nelson, M.D.6    Coates, T.D.7
  • 13
    • 29744439189 scopus 로고    scopus 로고
    • Measurement and mapping of liver iron concentrations using magnetic resonance imaging
    • DOI 10.1196/annals.1345.046
    • St Pierre TG, Clark PR, Chua-Anusorn W. Measurement and mapping of liver iron concentrations using magnetic resonance imaging. Ann. NY Acad. Sci. 1054, 379-385 (2005). (Pubitemid 43031045)
    • (2005) Annals of the New York Academy of Sciences , vol.1054 , pp. 379-385
    • St. Pierre, T.G.1    Clark, P.R.2    Chua-Anusorn, W.3
  • 14
    • 38549150853 scopus 로고    scopus 로고
    • A T2*magnetic resonance imaging study of pancreatic iron overload in thalassemia major
    • DOI 10.3324/haematol.11768
    • Au WY, Lam WW, Chu W, et al. A T2*magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Haematologica 93, 116-119 (2008). (Pubitemid 351156159)
    • (2008) Haematologica , vol.93 , Issue.1 , pp. 116-119
    • Au, W.-Y.1    Lam, W.W.-M.2    Chu, W.3    Tam, S.4    Wong, W.-K.5    Liang, R.6    Ha, S.-Y.7
  • 15
    • 77950442762 scopus 로고    scopus 로고
    • Pancreatic iron loading predicts cardiac iron loading in thalassemia major
    • Noetzli LJ, Papudesi J, Coates TD, Wood JC. Pancreatic iron loading predicts cardiac iron loading in thalassemia major. Blood 114, 4021-4026 (2009).
    • (2009) Blood , vol.114 , pp. 4021-4026
    • Noetzli, L.J.1    Papudesi, J.2    Coates, T.D.3    Wood, J.C.4
  • 16
    • 0032470850 scopus 로고    scopus 로고
    • MR imaging technique for the diagnosis of pituitary iron overload in patients with transfusion-dependent β-thalassemia major
    • Sparacia G, Banco A, Midiri M, Iaia A. MR imaging technique for the diagnosis of pituitary iron overload in patients with transfusion-dependent β-thalassemia major. AJNR Am. J. Neuroradiol. 19, 1905-1907 (1998). (Pubitemid 30409978)
    • (1998) American Journal of Neuroradiology , vol.19 , Issue.10 , pp. 1905-1907
    • Sparacia, G.1    Banco, A.2    Midiri, M.3    Iaia, A.4
  • 17
    • 46849083909 scopus 로고    scopus 로고
    • One-stop measurement of iron deposition in the anterior pituitary, liver, and heart in thalassemia patients
    • DOI 10.1002/jmri.21433
    • Lam WW, Au WY, Chu WC, Tam S, Ha SY, Pennell DJ. One-stop measurement of iron deposition in the anterior pituitary, liver, and heart in thalassemia patients. J. Magn. Reson. Imaging. 28, 29-33 (2008). (Pubitemid 351956462)
    • (2008) Journal of Magnetic Resonance Imaging , vol.28 , Issue.1 , pp. 29-33
    • Lam, W.W.M.1    Au, W.Y.2    Chu, W.C.W.3    Tam, S.4    Ha, S.Y.5    Pennell, D.J.6
  • 18
    • 0022974645 scopus 로고
    • Plasma ferritin determination as a diagnostic tool
    • Finch CA, Bellotti V, Stray S, et al. Plasma ferritin determination as a diagnostic tool. West. J. Med. 145, 657-663 (1986). (Pubitemid 17196113)
    • (1986) Western Journal of Medicine , vol.145 , Issue.5 , pp. 657-663
    • Finch, C.A.1    Bellotti, V.2    Stray, S.3
  • 19
    • 0018557558 scopus 로고
    • Chelation therapy and ferritin levels in patients with homozygous β-thalassemia
    • Kattamis C, Lagos P, Langona E. Chelation therapy and ferritin levels in patients with homozygous β-thalassemia. Prog. Clin. Biol. Res. 34, 351-359 (1979).
    • (1979) Prog. Clin. Biol. Res. , vol.34 , pp. 351-359
    • Kattamis, C.1    Lagos, P.2    Langona, E.3
  • 22
    • 33745892383 scopus 로고    scopus 로고
    • Myocardial iron loading in patients with thalassemia major on deferoxamine chelation
    • Tanner MA, Galanello R, Dessi C, et al. Myocardial iron loading in patients with thalassemia major on deferoxamine chelation. J. Cardiovasc. Magn. Reson. 8, 543-547 (2006).
    • (2006) J. Cardiovasc. Magn. Reson. , vol.8 , pp. 543-547
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3
  • 24
    • 20344381825 scopus 로고    scopus 로고
    • Lack of correlation between iron overload cardiac dysfunction and needle liver biopsy iron concentration
    • Berdoukas V, Dakin C, Freema A, Fraser I, Aessopos A, Bohane T. Lack of correlation between iron overload cardiac dysfunction and needle liver biopsy iron concentration. Haematologica 90, 685-686 (2005). (Pubitemid 40780888)
    • (2005) Haematologica , vol.90 , Issue.5 , pp. 685-686
    • Berdoukas, V.1    Dakin, C.2    Freeman, A.3    Fraser, I.4    Aessopos, A.5    Bohane, T.6
  • 25
    • 0038187626 scopus 로고    scopus 로고
    • Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
    • Piga A, Gaglioti C, Fogliacco E, Tricta F. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica 88, 489-496 (2003). (Pubitemid 36648438)
    • (2003) Haematologica , vol.88 , Issue.5 , pp. 489-496
    • Piga, A.1    Gaglioti, C.2    Fogliacco, E.3    Tricta, F.4
  • 29
    • 0024566311 scopus 로고
    • Myocardial iron grading by endomyocardial biopsy. A clinico-pathologic study on iron overloaded patients
    • Barosi G, Arbustini E, Gavazzi A, Grasso M, Pucci A. Myocardial iron grading by endomyocardial biopsy. A clinico-pathologic study on iron overloaded patients. Eur. J. Haematol. 42, 382-388 (1989). (Pubitemid 19131449)
    • (1989) European Journal of Haematology , vol.42 , Issue.4 , pp. 382-388
    • Barosi, G.1    Arbustini, E.2    Gavazzi, A.3    Grasso, M.4    Pucci, A.5
  • 30
    • 0026680591 scopus 로고
    • Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia
    • Olivieri NF, Koren G, Matsui D, et al. Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia. Blood 79, 2741-2748 (1992).
    • (1992) Blood , vol.79 , pp. 2741-2748
    • Olivieri, N.F.1    Koren, G.2    Matsui, D.3
  • 31
    • 72449177984 scopus 로고    scopus 로고
    • Cardiac T2*magnetic resonance for prediction of cardiac complications in thalassemia major
    • Kirk P, Roughton M, Porter JB, et al. Cardiac T2*magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation 120, 1961-1968 (2009).
    • (2009) Circulation , vol.120 , pp. 1961-1968
    • Kirk, P.1    Roughton, M.2    Porter, J.B.3
  • 34
    • 36348940441 scopus 로고    scopus 로고
    • Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: A T2 relaxometry study
    • DOI 10.1007/s00330-007-0683-1
    • Argyropoulou MI, Kiortsis DN, Astrakas L, Metafratzi Z, Chalissos N, Efremidis SC. Liver, bone marrow, pancreas and pituitary gland iron overload in young and adult thalassemic patients: a T2 relaxometry study. Eur. Radiol. 17, 3025-3030 (2007). (Pubitemid 350142326)
    • (2007) European Radiology , vol.17 , Issue.12 , pp. 3025-3030
    • Argyropoulou, M.I.1    Kiortsis, D.N.2    Astrakas, L.3    Metafratzi, Z.4    Chalissos, N.5    Efremidis, S.C.6
  • 35
    • 38049113365 scopus 로고    scopus 로고
    • The heart in transfusion dependent homozygous thalassaemia today-prediction, prevention and management
    • Aessopos A, Berdoukas V, Tsironi M. The heart in transfusion dependent homozygous thalassaemia today-prediction, prevention and management. Eur. J. Haematol. 80, 93-106 (2008).
    • (2008) Eur. J. Haematol. , vol.80 , pp. 93-106
    • Aessopos, A.1    Berdoukas, V.2    Tsironi, M.3
  • 36
    • 0015947937 scopus 로고
    • Long-term chelation therapy in thalassaemia major: Effect on liver iron concentration, liver histology, and clinical progress
    • Barry M, Flynn DM, Letsky EA, Risdon RA. Long-term chelation therapy in thalassaemia major: effect on liver iron concentration, liver histology, and clinical progress. Br. Med. J. 2, 16-20 (1974).
    • (1974) Br. Med. J. , vol.2 , pp. 16-20
    • Barry, M.1    Flynn, D.M.2    Letsky, E.A.3    Risdon, R.A.4
  • 37
    • 0017622851 scopus 로고
    • Continuous subcutaneous administration of deferoxamine in patients with iron overload
    • Propper RD, Cooper B, Rufo RR, et al. Continuous subcutaenous administration of deferoxamine in patients with iron overload. N. Engl. J. Med. 297, 418-423 (1977). (Pubitemid 8197453)
    • (1977) New England Journal of Medicine , vol.297 , Issue.8 , pp. 418-423
    • Propper, R.D.1    Cooper, B.2    Rufo, R.R.3
  • 38
    • 84920215033 scopus 로고
    • Subcutaneous infusion and intramuscular injection of desferrioxamine in patients with transfusional iron overload
    • Hussain MA, Green N, Flynn DM, Hussein S, Hoffbrand AV. Subcutaneous infusion and intramuscular injection of desferrioxamine in patients with transfusional iron overload. Lancet 2, 1278-1280 (1976).
    • (1976) Lancet , vol.2 , pp. 1278-1280
    • Hussain, M.A.1    Green, N.2    Flynn, D.M.3    Hussein, S.4    Hoffbrand, A.V.5
  • 39
    • 0021833690 scopus 로고
    • Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major
    • Wolfe L, Olivieri N, Sallan D, et al. Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. N. Engl. J. Med. 312, 1600-1603 (1985). (Pubitemid 15062652)
    • (1985) New England Journal of Medicine , vol.312 , Issue.25 , pp. 1600-1603
    • Wolfe, L.1    Olivieri, N.2    Sallan, D.3
  • 41
    • 14644393678 scopus 로고    scopus 로고
    • Liver iron concentration and fibrosis in a cohort of transfusion- dependent patients on long-term desferrioxamine therapy
    • DOI 10.1038/sj.thj.6200569
    • Berdoukas V, Bohane T, Tobias V, et al. Liver iron concentration and fibrosis in a cohort of transfusion-dependent patients on long-term desferrioxamine therapy. Hematol. J. 5, 572-578 (2005). (Pubitemid 40309622)
    • (2005) Hematology Journal , vol.5 , Issue.7 , pp. 572-578
    • Berdoukas, V.1    Bohane, T.2    Tobias, V.3    De Silva, K.4    Fraser, I.5    Aessopos, A.6    Lindeman, R.7
  • 44
    • 0025569760 scopus 로고
    • Current therapy for thalassemia in Italy
    • Gabutti V. Current therapy for thalassemia in Italy. Ann. NY Acad. Sci. 612, 268-274 (1990).
    • (1990) Ann. NY Acad. Sci. , vol.612 , pp. 268-274
    • Gabutti, V.1
  • 46
    • 0023812748 scopus 로고
    • Hearing loss and desferrioxamine in homozygous β-thalassemia
    • Albera R, Pia F, Morra B, et al. Hearing loss and desferrioxamine in homozygous β-thalassemia. Audiology 27, 207-214 (1988).
    • (1988) Audiology , vol.27 , pp. 207-214
    • Albera, R.1    Pia, F.2    Morra, B.3
  • 47
    • 0023930820 scopus 로고
    • Electroretinographic and visual-evoked potential abnormalities in patients with beta-thalassemia major
    • Gelmi C, Borgna-Pignatti C, Franchin S, Tacchini M, Trimarchi F. Electroretinographic and visual-evoked potential abnormalities in patients with β-thalassemia major. Ophthalmologica 196, 29-34 (1988). (Pubitemid 18041342)
    • (1988) Ophthalmologica , vol.196 , Issue.1 , pp. 29-34
    • Gelmi, C.1    Borgna-Pignatti, C.2    Franchin, S.3    Tacchini, M.4    Trimarchi, F.5
  • 48
    • 0034783438 scopus 로고    scopus 로고
    • Chelation therapy in β-thalassemia: An optimistic update
    • Giardina PJ, Grady RW. Chelation therapy in β-thalassemia: an optimistic update. Semin. Hematol. 38, 360-366 (2001). (Pubitemid 32995605)
    • (2001) Seminars in Hematology , vol.38 , Issue.4 , pp. 360-366
    • Giardina, P.J.1    Grady, R.W.2
  • 49
    • 70350701847 scopus 로고    scopus 로고
    • Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
    • Chan GC, Chan S, Ho PL, Ha SY. Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients. Hemoglobin 33, 352-360 (2009).
    • (2009) Hemoglobin , vol.33 , pp. 352-360
    • Chan, G.C.1    Chan, S.2    Ho, P.L.3    Ha, S.Y.4
  • 52
    • 0032466964 scopus 로고    scopus 로고
    • Infection due to Yersinia enterocolitica in a series of patients with β-thalassemia: Incidence and predisposing factors
    • Adamkiewicz TV, Berkovitch M, Krishnan C, Polsinelli C, Kermack D, Olivieri NF. Infection due to Yersinia enterocolitica in a series of patients with β-thalassemia: incidence and predisposing factors. Clin. Infect. Dis. 27, 1362-1366 (1998). (Pubitemid 29242403)
    • (1998) Clinical Infectious Diseases , vol.27 , Issue.6 , pp. 1362-1366
    • Adamkiewicz, T.V.1    Berkovitch, M.2    Krishnan, C.3    Polsinelli, C.4    Kermack, D.5    Olivieri, N.F.6
  • 53
    • 0026722799 scopus 로고
    • Yersinia infections in patients with homozygous β-thalassemia associated with iron overload and its treatment
    • Green NS. Yersinia infections in patients with homozygous β-thalassemia associated with iron overload and its treatment. Pediatr. Hematol. Oncol. 9, 247-254 (1992).
    • (1992) Pediatr. Hematol. Oncol. , vol.9 , pp. 247-254
    • Green, N.S.1
  • 54
    • 29844457587 scopus 로고    scopus 로고
    • The evolution of iron chelators for the treatment of iron overload disease and cancer
    • DOI 10.1124/pr.57.4.2
    • Kalinowski DS, Richardson DR. The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol. Rev. 57, 547-583 (2005). (Pubitemid 43036441)
    • (2005) Pharmacological Reviews , vol.57 , Issue.4 , pp. 547-583
    • Kalinowski, D.S.1    Richardson, D.R.2
  • 55
    • 33745542268 scopus 로고    scopus 로고
    • Liver fibrosis and iron levels during long-term deferiprone treatment of thalassemia major patients
    • Wu SF, Peng CT, Wu KH, Tsai CH. Liver fibrosis and iron levels during long-term deferiprone treatment of thalassemia major patients. Hemoglobin 30, 215-218 (2006).
    • (2006) Hemoglobin , vol.30 , pp. 215-218
    • Wu, S.F.1    Peng, C.T.2    Wu, K.H.3    Tsai, C.H.4
  • 56
    • 0028898064 scopus 로고
    • Iron-chelation therapy with oral deferipronein patients with thalassemia major
    • Olivieri NF, Brittenham GM, Matsui D, et al. Iron-chelation therapy with oral deferipronein patients with thalassemia major. N. Engl. J. Med. 332, 918-922 (1995).
    • (1995) N. Engl. J. Med. , vol.332 , pp. 918-922
    • Olivieri, N.F.1    Brittenham, G.M.2    Matsui, D.3
  • 57
    • 33646387405 scopus 로고    scopus 로고
    • Randomized controlled trial of deferiprone or deferoxamine in β-thalassemia major patients with asymptomatic myocardial siderosis
    • Pennell DJ, Berdoukas V, Karagiorga M, et al. Randomized controlled trial of deferiprone or deferoxamine in β-thalassemia major patients with asymptomatic myocardial siderosis. Blood 107, 3738-3744 (2006).
    • (2006) Blood , vol.107 , pp. 3738-3744
    • Pennell, D.J.1    Berdoukas, V.2    Karagiorga, M.3
  • 58
    • 0037125595 scopus 로고    scopus 로고
    • Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia
    • DOI 10.1016/S0140-6736(02)09740-4
    • Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, Pennell DJ. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in β-thalassaemia. Lancet 360, 516-520 (2002). (Pubitemid 35232104)
    • (2002) Lancet , vol.360 , Issue.9332 , pp. 516-520
    • Anderson, L.J.1    Wonke, B.2    Prescott, E.3    Holden, S.4    Walker, J.M.5    Pennell, D.J.6
  • 59
    • 33646407268 scopus 로고    scopus 로고
    • Cardiac morbidity and mortality in deferoxamine-or deferiprone-treated patients with thalassemia major
    • Borgna-Pignatti C, Cappellini MD, De Stefano P, et al. Cardiac morbidity and mortality in deferoxamine-or deferiprone-treated patients with thalassemia major. Blood 107, 3733-3737 (2006).
    • (2006) Blood , vol.107 , pp. 3733-3737
    • Borgna-Pignatti, C.1    Cappellini, M.D.2    De Stefano, P.3
  • 60
    • 38349157810 scopus 로고    scopus 로고
    • Effect of transfusional iron intake on response to chelation therapy in β-thalassemia major
    • Cohen AR, Glimm E, Porter JB. Effect of transfusional iron intake on response to chelation therapy in β-thalassemia major. Blood 111, 583-587 (2008).
    • (2008) Blood , vol.111 , pp. 583-587
    • Cohen, A.R.1    Glimm, E.2    Porter, J.B.3
  • 61
    • 0031784438 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and desferrioxamine
    • DOI 10.1046/j.1365-2141.1998.01002.x
    • Wonke B, Wright C, Hoffbrand AV. Combined therapy with deferiprone and desferrioxamine. Br. J. Haematol. 103, 361-364 (1998). (Pubitemid 28522439)
    • (1998) British Journal of Haematology , vol.103 , Issue.2 , pp. 361-364
    • Wonke, B.1    Wright, C.2    Hoffbrand, A.V.3
  • 62
    • 0003305345 scopus 로고    scopus 로고
    • Optimising chelation therapy: Combining deferiprone and deferoxamine
    • Grady RW, Rachmielewitz EA, Giardina PJ. Optimising chelation therapy: combining deferiprone and deferoxamine. Blood 96, 604a (2000).
    • (2000) Blood , vol.96 , pp. 604
    • Grady, R.W.1    Rachmielewitz, E.A.2    Giardina, P.J.3
  • 63
    • 64849100325 scopus 로고    scopus 로고
    • Improving survival with deferiprone treatment in patients with thalassemia major: A prospective multicenter randomized clinical trial under the auspices of the Italian Society for Thalassemia and Hemoglobinopathies
    • Maggio A, Vitrano A, Capra M, et al. Improving survival with deferiprone treatment in patients with thalassemia major: a prospective multicenter randomized clinical trial under the auspices of the Italian Society for Thalassemia and Hemoglobinopathies. Blood Cells Mol. Dis. 42, 247-251 (2009).
    • (2009) Blood Cells Mol. Dis. , vol.42 , pp. 247-251
    • Maggio, A.1    Vitrano, A.2    Capra, M.3
  • 64
    • 33748783066 scopus 로고    scopus 로고
    • A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia
    • Galanello R, Kattamis A, Piga A, et al. A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia. Haematologica 91, 1241-1243 (2006). (Pubitemid 44408435)
    • (2006) Haematologica , vol.91 , Issue.9 , pp. 1241-1243
    • Galanello, R.1    Kattamis, A.2    Piga, A.3    Fischer, R.4    Leoni, G.5    Ladis, V.6    Voi, V.7    Lund, U.8    Tricta, F.9
  • 65
    • 44049102508 scopus 로고    scopus 로고
    • Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction
    • Tanner MA, Galanello R, Dessi C, et al. Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction. J. Cardiovasc. Magn. Reson. 10, 12 (2008).
    • (2008) J. Cardiovasc. Magn. Reson. , vol.10 , pp. 12
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3
  • 66
    • 34247103036 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
    • DOI 10.1161/CIRCULATIONAHA.106.648790
    • Tanner MA, Galanello R, Dessi C, et al. A randomized, placebo-controlled, double-βlind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation 115, 1876-1884 (2007). (Pubitemid 46598901)
    • (2007) Circulation , vol.115 , Issue.14 , pp. 1876-1884
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3    Smith, G.C.4    Westwood, M.A.5    Agus, A.6    Roughton, M.7    Assomull, R.8    Nair, S.V.9    Walker, J.M.10    Pennell, D.J.11
  • 68
    • 33749344185 scopus 로고    scopus 로고
    • Successful recovery of acute hemosiderotic heart failure in β-thalassemia major treated with a combined regimen of desferrioxamine and deferiprone
    • Tavecchia L, Masera N, Russo P, et al. Successful recovery of acute hemosiderotic heart failure in β-thalassemia major treated with a combined regimen of desferrioxamine and deferiprone. Haematologica 91(Suppl. 6), ECR19 (2006).
    • (2006) Haematologica , vol.91 , Issue.SUPPL. 6
    • Tavecchia, L.1    Masera, N.2    Russo, P.3
  • 69
    • 3042777499 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and desferrioxamine successfully regresses severe heart failure in patients with β-thalassemia major
    • DOI 10.1007/s00277-003-0820-0
    • Wu KH, Chang JS, Tsai CH, Peng CT. Combined therapy with deferiprone and desferrioxamine successfully regresses severe heart failure in patients with β-thalassemia major. Ann. Hematol. 83, 471-473 (2004). (Pubitemid 38877974)
    • (2004) Annals of Hematology , vol.83 , Issue.7 , pp. 471-473
    • Wu, K.H.1    Chang, J.S.2    Tsai, C.H.3    Peng, C.T.4
  • 70
    • 33646414765 scopus 로고    scopus 로고
    • A Phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia
    • Cappellini MD, Cohen A, Piga A, et al. A Phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia. Blood 107, 3455-3462 (2006).
    • (2006) Blood , vol.107 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3
  • 71
    • 77950682176 scopus 로고    scopus 로고
    • Tailoring iron chelation by iron intake and serum ferritin: The prospective EPIC study of deferasirox in 1744 patients with transfusion- dependent anemias
    • Cappellini MD, Porter J, El-Beshlawy A, et al. Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias. Haematologica 95, 557-566 (2010).
    • (2010) Haematologica , vol.95 , pp. 557-566
    • Cappellini, M.D.1    Porter, J.2    El-Beshlawy, A.3
  • 72
    • 77749317208 scopus 로고    scopus 로고
    • Update on the use of deferasirox in the management of iron overload
    • Taher A, Cappellini MD. Update on the use of deferasirox in the management of iron overload. Ther. Clin. Risk Manag. 5, 857-868 (2009).
    • (2009) Ther. Clin. Risk Manag. , vol.5 , pp. 857-868
    • Taher, A.1    Cappellini, M.D.2
  • 73
    • 70449403619 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload
    • Taher A, Cappellini MD, Vichinsky E, et al. Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload. Br. J. Haematol. 147, 752-759 (2009).
    • (2009) Br. J. Haematol. , vol.147 , pp. 752-759
    • Taher, A.1    Cappellini, M.D.2    Vichinsky, E.3
  • 74
    • 65349152022 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with β-thalassaemia: The ESCALATOR study
    • Taher A, El-Beshlawy A, Elalfy MS, et al. Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with β-thalassaemia: the ESCALATOR study. Eur. J. Haematol. 82, 458-465 (2009).
    • (2009) Eur. J. Haematol. , vol.82 , pp. 458-465
    • Taher, A.1    El-Beshlawy, A.2    Elalfy, M.S.3
  • 75
    • 77950617863 scopus 로고    scopus 로고
    • Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia
    • Pennell DJ, Porter JB, Cappellini MD, et al. Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia. Blood 115, 2364-2371 (2010).
    • (2010) Blood , vol.115 , pp. 2364-2371
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3
  • 76
    • 77953779950 scopus 로고    scopus 로고
    • The effect of deferasirox on cardiac iron in thalassemia major: Impact of total body iron stores
    • Wood JC, Kang BP, Thompson A, et al. The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood 116(4), 537-543 (2010).
    • (2010) Blood , vol.116 , Issue.4 , pp. 537-543
    • Wood, J.C.1    Kang, B.P.2    Thompson, A.3
  • 77
    • 77955891235 scopus 로고    scopus 로고
    • Retrospective study on the combination of desferrioxamine and deferasirox for treatment of iron-overloaded thalassemic patients: First evidence of more than 2 years
    • Jetsrisuparb A, Komvilaisak P, Wiangnon S, Jetsrisuparb C. Retrospective study on the combination of desferrioxamine and deferasirox for treatment of iron-overloaded thalassemic patients: first evidence of more than 2 years. J. Pediatr. Hematol. Oncol. 32(5), 400-403 (2010).
    • (2010) J. Pediatr. Hematol. Oncol. , vol.32 , Issue.5 , pp. 400-403
    • Jetsrisuparb, A.1    Komvilaisak, P.2    Wiangnon, S.3    Jetsrisuparb, C.4
  • 78
    • 77953069934 scopus 로고    scopus 로고
    • Daily alternating deferasirox and deferiprone therapy for hard-to-chelate β-thalassemia major patients
    • Balocco M, Carrara P, Pinto V, Forni GL. Daily alternating deferasirox and deferiprone therapy for hard-to-chelate β-thalassemia major patients. Am. J. Hematol. 85, 460-461 (2010).
    • (2010) Am. J. Hematol. , vol.85 , pp. 460-461
    • Balocco, M.1    Carrara, P.2    Pinto, V.3    Forni, G.L.4
  • 79
    • 77956962957 scopus 로고    scopus 로고
    • Combining two orally active iron chelators for thalassemia
    • Berdoukas V, Carson S, Nord A, et al. Combining two orally active iron chelators for thalassemia. Ann. Hematol. 89, 1177-1178 (2010).
    • (2010) Ann. Hematol. , vol.89 , pp. 1177-1178
    • Berdoukas, V.1    Carson, S.2    Nord, A.3
  • 81
    • 63149177947 scopus 로고    scopus 로고
    • Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: A randomized clinical trial
    • Maggio A, Vitrano A, Capra M, et al. Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: a randomized clinical trial. Br. J. Haematol. 145, 245-254 (2009).
    • (2009) Br. J. Haematol. , vol.145 , pp. 245-254
    • Maggio, A.1    Vitrano, A.2    Capra, M.3
  • 82
    • 57049104663 scopus 로고    scopus 로고
    • Cardiac iron across different transfusion-dependent diseases
    • Wood JC. Cardiac iron across different transfusion-dependent diseases. Blood Rev. 22(Suppl. 2), S14-S21 (2008).
    • (2008) Blood Rev. , vol.22 , Issue.SUPPL. 2
    • Wood, J.C.1
  • 83
    • 3042758517 scopus 로고    scopus 로고
    • Complications of β-thalassemia major in North America
    • DOI 10.1182/blood-2003-09-3167
    • Cunningham MJ, Macklin EA, Neufeld EJ, Cohen AR. Complications of β-thalassemia major in North America. Blood 104, 34-39 (2004). (Pubitemid 38879833)
    • (2004) Blood , vol.104 , Issue.1 , pp. 34-39
    • Cunningham, M.J.1    Macklin, E.A.2    Neufeld, E.J.3    Cohen, A.R.4
  • 84
    • 0023607725 scopus 로고
    • Hearing loss attributed to desferrioxamine in patients with beta-thalassaemia major
    • Barratt PS, Toogood IR. Hearing loss attributed to desferrioxamine in patients with β-thalassaemia major. Med. J. Aust. 147, 177-179 (1987). (Pubitemid 18047066)
    • (1987) Medical Journal of Australia , vol.147 , Issue.4 , pp. 177-179
    • Barratt, P.S.1    Toogood, I.R.G.2
  • 85
    • 0024292744 scopus 로고
    • Hearing loss attributed to desferrioxamine in patients with β-thalassaemia major
    • Schindlery C. Hearing loss attributed to desferrioxamine in patients with β-thalassaemia major. Med. J. Aust. 148, 662-663 (1988).
    • (1988) Med. J. Aust. , vol.148 , pp. 662-663
    • Schindlery, C.1
  • 86
    • 0141705304 scopus 로고    scopus 로고
    • Labile plasma iron in iron overload: Redox activity and susceptibility to chelation
    • DOI 10.1182/blood-2003-03-0807
    • Esposito BP, Breuer W, Sirankapracha P, Pootrakul P, Hershko C, Cabantchik ZI. Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood 102, 2670-2677 (2003). (Pubitemid 37193611)
    • (2003) Blood , vol.102 , Issue.7 , pp. 2670-2677
    • Esposito, B.P.1    Breuer, W.2    Sirankapracha, P.3    Pootrakul, P.4    Hershko, C.5    Cabantchik, Z.I.6
  • 87
    • 65349110837 scopus 로고    scopus 로고
    • Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with β-thalassaemia
    • Daar S, Pathare A, Nick H, et al. Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with β-thalassaemia. Eur. J. Haematol. 82, 454-457 (2009).
    • (2009) Eur. J. Haematol. , vol.82 , pp. 454-457
    • Daar, S.1    Pathare, A.2    Nick, H.3
  • 88
    • 4444274916 scopus 로고    scopus 로고
    • Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded β-thalassemia/HbE patients treated with an oral chelator
    • DOI 10.1182/blood-2004-02-0630
    • Pootrakul P, Breuer W, Sametband M, Sirankapracha P, Hershko C, Cabantchik ZI. Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded β-thalassemia/HbE patients treated with an oral chelator. Blood 104, 1504-1510 (2004). (Pubitemid 39166531)
    • (2004) Blood , vol.104 , Issue.5 , pp. 1504-1510
    • Pootrakul, P.1    Breuer, W.2    Sametband, M.3    Sirankapracha, P.4    Hershko, C.5    Cabantchik, Z.I.6
  • 90
    • 0026252025 scopus 로고
    • Hemochromatosis: Diagnosis and treatment
    • Flexner JM. Hemochromatosis: diagnosis and treatment. Compr. Ther. 17, 7-9 (1991).
    • (1991) Compr. Ther. , vol.17 , pp. 7-9
    • Flexner, J.M.1
  • 92
    • 79951795869 scopus 로고    scopus 로고
    • FBS0701 program
    • FBS0701 program www. ferrokin. com/fbs0701-program. Html


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.