Permethrin modulates cholinergic mini-synaptic currents by partially blocking the calcium channel

Toxicology Letters

Volumn 201, Issue 3, 2011, Pages 258-263

  Yan, Ying ^a   Yang, Ying ^a   You, Jing ^b   Yang, Guangxin ^a   Xu, Ye ^a   Huang, Naya ^a   Wang, Xutian ^a   Ran, Dongzhi ^a   Yuan, Xi ^a   Jin, Ying ^a   Fan, Yuting ^a   Lei, Jiayao ^a   Li, Weicong ^a   Gu, Huaiyu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU INSTITUTE OF GEOCHEMISTRY   (China)

Author keywords

Calcium channel; Cholinergic synaptic transmission; Drosophila; Neurotoxicity; Permethrin

Indexed keywords

CALCIUM CHANNEL; PERMETHRIN;

ARTICLE; BRAIN; CALCIUM CURRENT; CHOLINERGIC ACTIVITY; CHOLINERGIC TRANSMISSION; DROSOPHILA; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; DROSOPHILA; ELECTROPHYSIOLOGICAL PHENOMENA; EXCITATORY POSTSYNAPTIC POTENTIALS; INSECTICIDES; LYSINE; MICROSCOPY, FLUORESCENCE; NEURONS; PARASYMPATHETIC NERVOUS SYSTEM; PATCH-CLAMP TECHNIQUES; PERMETHRIN; PUPA; SODIUM CHANNELS; SOFTWARE; SYNAPSES; SYNAPTIC TRANSMISSION;

HEXAPODA; MAMMALIA;

EID: 79951771910     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.01.009     Document Type: Article

References (36)

1. Baines R.A., Bate M. Electrophysiological development of central neurons in the Drosophila embryo. J. Neurosci. 1998, 18:4673-4683.
2. Bekkers J., Stevens C. The nature of quantal transmission at central excitatory synapses. Adv. Second Messenger Phosphoprotein Res. 1994, 29:261.
3. Bloomquist J., Barlow R., Gillette J., Li W., Kirby M. Selective effects of insecticides on nigrostriatal dopaminergic nerve pathways. Neurotoxicology 2002, 23:537-544.
4. Catterall W. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol. 1980, 20:15.
5. 2+ channels. Annu. Rev. Cell Dev. Biol. 2000, 16:521-556.
6. Eells J., Dubocovich M. Pyrethroid insecticides evoke neurotransmitter release from rabbit striatal slices. J. Pharmacol. Exp. Ther. 1988, 246:514.
7. Eells J.T., Bandettini P.A., Holman P.A., Propp J.M. Pyrethroid insecticide-induced alterations in mammalian synaptic membrane potential. J. Pharmacol. Exp. Ther. 1992, 262:1173-1181.
8. Gu H., O'Dowd D.K. Cholinergic synaptic transmission in adult Drosophila Kenyon cells in situ. J. Neurosci. 2006, 26:265-272.
9. Gu H., O'Dowd D.K. Whole cell recordings from brain of adult Drosophila. J. Vis. Exp. 2007, 248.
10. v2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J. Neurophysiol. 2009, 101:42-53.
11. Haya K. Toxicity of pyrethroid insecticides to fish. Environ. Toxicol. Chem. 1989, 8:381-391.
12. Hildebrand M.E., McRory J.E., Snutch T.P., Stea A. Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin. J. Pharmacol. Exp. Ther. 2004, 308:805-813.
13. Kawasaki F., Zou B., Xu X., Ordway R.W. Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila. J. Neurosci. 2004, 24:282-285.
14. Kazama H., Wilson R. Homeostatic matching and nonlinear amplification at identified central synapses. Neuron 2008, 58:401-413.
15. Lee D., O'Dowd D. Fast excitatory synaptic transmission mediated by nicotinic acetylcholine receptors in Drosophila neurons. J. Neurosci. 1999, 19:5311.
16. Lee D., O'Dowd D.K. Fast excitatory synaptic transmission mediated by nicotinic acetylcholine receptors in Drosophila neurons. J. Neurosci. 1999, 19:5311-5321.
17. Linnett P.J. Permethrin toxicosis in cats. Aust. Vet. J. 2008, 86:32-35.
18. Lund A., Narahashi T. Kinetics of sodium channel modification as the basis for the variation in the nerve membrane effects of pyrethroids and DDT analogs. Pestic. Biochem. Physiol. 1983, 20:203-216.
19. Masse N.Y., Turner G.C., Jefferis G.S. Olfactory information processing in Drosophila. Curr. Biol. 2009, 19:R700-R713.
20. Meyer D., Shafer T. Permethrin, but not deltamethrin, increases spontaneous glutamate release from hippocampal neurons in culture. Neurotoxicology 2006, 27:594-603.
21. Ray D.E., Forshaw P.J. Pyrethroid insecticides: poisoning syndromes, synergies, and therapy. J. Toxicol. Clin. Toxicol. 2000, 38:95-101.
22. Restifo L., White K. Molecular and genetic approaches to neurotransmitter and neuromodulator systems in Drosophila. Adv. Insect Physiol. 1990, 22:115-219.
23. Rohrbough J., Broadie K. Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae. J. Neurophysiol. 2002, 88:847-860.
24. Shafer T.J., Meyer D.A. Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity. Toxicol. Appl. Pharmacol. 2004, 196:303-318.
25. Soderlund D., Clark J., Sheets L., Mullin L., Piccirillo V., Sargent D., Stevens J., Weiner M. Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology 2002, 171:3-59.
26. v2.2) voltage-sensitive calcium channels in rat brain. Pestic. Biochem. Physiol. 2005, 82:1-15.
27. Thompson M. Muscle relaxant drugs. Br. J. Hosp. Med. 1980, 23:153.
28. Trimble A., Weston D., Belden J., Lydy M. Identification and evaluation of pyrethroid insecticide mixtures in urban sediments. Environ. Toxicol. Chem. 2009, 28:1687-1695.
29. Verschoyle R., Aldridge W. Structure-activity relationships of some pyrethroids in rats. Arch. Toxicol. 1980, 45:325-329.
30. Wenningmann I., Dilger J. The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium. Mol. Pharmacol. 2001, 60:790.
31. Weston D., You J., Lydy M. Distribution and toxicity of sediment-associated pesticides in agriculture-dominated water bodies of California's Central Valley. Environ. Sci. Technol. 2004, 38:2752-2759.
32. Weston D., Holmes R., You J., Lydy M. Aquatic toxicity due to residential use of pyrethroid insecticides. Environ. Sci. Technol. 2005, 39:9778-9784.
33. Wilson R., Turner G., Laurent G. Transformation of olfactory representations in the Drosophila antennal lobe. Science 2004, 303:366.
34. 2+ currents in identified Drosophila motoneurons in situ. J. Neurophysiol. 2008, 100:868-878.
35. Yao W.D., Rusch J., Poo M., Wu C.F. Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: effects of cAMP-pathway mutations. J. Neurosci. 2000, 20:2626-2637.
36. Zlotkin E. The insect voltage-gated sodium channel as target of insecticides. Annu. Rev. Entomol. 1999, 44:429-455.