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Volumn 303, Issue 5656, 2004, Pages 366-370

Transformation of Olfactory Representations in the Drosophila Antennal Lobe

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; NEUROLOGY;

EID: 0345742615     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090782     Document Type: Article
Times cited : (438)

References (35)
  • 1
    • 0035831042 scopus 로고    scopus 로고
    • K. Scott et al., Cell 104, 661 (2001).
    • (2001) Cell , vol.104 , pp. 661
    • Scott, K.1
  • 11
    • 0037168107 scopus 로고    scopus 로고
    • M. Ng et al., Neuron 36, 463 (2002).
    • (2002) Neuron , vol.36 , pp. 463
    • Ng, M.1
  • 18
    • 0346952971 scopus 로고    scopus 로고
    • note
    • Materials and methods are available as supporting material on Science Online.
  • 20
    • 0348213729 scopus 로고    scopus 로고
    • note
    • Subtle differences across PNs in the same glomerulus may reflect true differences among the three to five PNs innervating each glomerulus, differences among individual flies, or variability across preparations.
  • 23
    • 0347584011 scopus 로고    scopus 로고
    • note
    • We noted a weak PN response to the small mechanical component of the stimulus (which was generally the same as the response to paraffin oil, bottom row, Fig. 3) to which the OSNs did not respond. This result suggests that PNs may also receive indirect input from mechanosensory antennal afferents, which terminate immediately posterior to the olfactory glomeruli.
  • 26
    • 0348213726 scopus 로고    scopus 로고
    • note
    • Lifetime sparseness, S, ranges from 0 (for a neuron that responds equally to all stimuli) to 1 (for a neuron that is excited by one stimulus and shows zero response to all others).
  • 27
    • 0347584012 scopus 로고    scopus 로고
    • note
    • One connection was detected in nine paired recordings. No inhibitory connections were detected in these pairs, which may reflect a low LN to PN connectivity or a unitary conductance that is too small or electrotonically distant to be detected in the soma. Also, we cannot exclude the possibility that the effect of picrotoxin on PN odor responses may be indirect, reflecting disinhibition of lateral excitatory inputs.
  • 32
    • 0346952970 scopus 로고    scopus 로고
    • note
    • One study has described a strong correlation between OSN- and PN-derived signals in the same glomerulus, but only when the OSN map was visualized using a higher odor concentration than that used to visualize the PN map (12). The necessity for this higher stimulus concentration was attributed to a weak OSN Gal4-driver but may also reflect a genuine difference between OSN and PN odor responses, as we show here.
  • 35
    • 0348213727 scopus 로고    scopus 로고
    • note
    • We thank L. Luo, L. Vosshall, R. Stocker, and S. Benzer for fly lines, E. Buchner and A. Hofbauer for nc82 antibody, D. Darcy and M. Dickinson of the Caltech Biological Imaging center for technical assistance, and J. R. Carlson and W. van der Goes van Naters for sharing methods and flies. We thank M. Stopfer, W. D. Tracey, and members of the Laurent lab for helpful discussions. This work was supported by the Helen Hay Whitney Foundation (R.I.W.), the Jane Coffin Childs Foundation (G.C.T.), the McKnight and Keck Foundations, the National Science Foundation, and the National Institute on Deafness and Other Communication Disorders (G.L.).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.