Toll-like receptor 4 can recognize SapC-DOPS to stimulate macrophages to express several cytokines

Inflammation Research

Volumn 60, Issue 2, 2011, Pages 153-161

  Lu, Kaihua ^a   Zhao, Guangfeng ^a   Lu, Hongna ^a   Zhao, Shuli ^a   Song, Yuxian ^a   Qi, Xiaoyang ^b   Hou, Yayi ^a  

^a NANJING UNIVERSITY   (China)

^b Jiangsu Changzhou Changji Biotechnology Development Co Ltd   (China)

Author keywords

NF B; Raw264.7; SapC DOPS; TLRs

Indexed keywords

CYTOKINE; DIOLEOYLPHOSPHATIDYLSERINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; SAPOSIN C; SPHINGOLIPID ACTIVATOR PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CYTOKINES; FEMALE; MACROPHAGES; MICE; MICE, INBRED C57BL; PHOSPHATIDYLSERINES; SAPOSINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 79951723232     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0249-6     Document Type: Article

References (27)

1. T Nakano K Sandhoff J Stümper H Christomanou K Suzuki 1989 Structure of full-length cDNA coding for sulfatide activator, a co-beta-glucosidase and two other homologous proteins: two alternate forms of the sulfatide activator J Biochem 105 152 154 1:CAS:528:DyaL1MXlvVymsb4%3D 2498298 (Pubitemid 19059070)
2. EG Rorman GA Grabowski 1989 Molecular cloning of a human co-betaglucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats Genomics 5 486 492 1:CAS:528:DyaL1MXmt1Kgtbg%3D 10.1016/0888-7543(89)90014-1 2515150
3. S Fujibayashi DA Wenger 1986 Synthesis and processing of sphingolipid activator protein-2 (SAP-2) in cultured human fibroblasts J Biol Chem. 261 15339 15343 1:CAS:528:DyaL2sXhs1ahsw%3D%3D 3771578 (Pubitemid 17218116)
4. S Fujibayashi DA Wenger 1986 Biosynthesis of the sulfatide/GM1 activator protein (SAP-1) in control and mutant cultured skin fibroblasts Biochim Biophys Acta 875 554 562 1:CAS:528:DyaL28Xht1Olu74%3D 3081038 (Pubitemid 16073608)
5. T Leonova X Qi A Bencosme E Ponce Y Sun GA Grabowski 1996 Proteolytic processing patterns of prosaposin in insect and mammalian cells J Biol Chem. 271 17312 17320 1:CAS:528:DyaK28XksFamtL8%3D 10.1074/jbc.271.29.17312 8663398 (Pubitemid 26244290)
6. X Qi GA Grabowski 2001 Differential membrane interactions of saposin A and C: implications for the functional specificity J Biol Chem 276 27010 27017 1:CAS:528:DC%2BD3MXlsV2jt7c%3D 10.1074/jbc.M101075200 11356836
7. HX You L Yu X Qi 2001 Phospholipid membrane restructuring induced by saposin C: a topographic study using atomic force microscopy FEBS Lett 503 97 102 1:CAS:528:DC%2BD3MXmtFWitr4%3D 10.1016/S0014-5793(01)02700-4 11513862 (Pubitemid 32769963)
8. HX You X Qi GA Grabowski L Yu 2003 Phospholipid membrane interactions of saposin C: in situ atomic force microscopic study Biophys J 84 2043 2057 1:CAS:528:DC%2BD3sXit1ehtr0%3D 10.1016/S0006-3495(03)75012-7 12609906 (Pubitemid 36322966)
9. AM Vaccaro M Tatti F Ciaffoni R Salvioli A Serafino A Barca 1994 Saposin C induces pH-dependent destabilization and fusion of phosphatidylserine- containing vesicles FEBS Lett. 349 181 186 1:CAS:528:DyaK2cXmslCksLs%3D 10.1016/0014-5793(94)00659-8 8050562 (Pubitemid 24263258)
10. Y Wang GA Grabowski X Qi 2003 Phospholipid vesicle fusion induced by saposin C Arch Biochem Biophys 415 43 53 1:CAS:528:DC%2BD3sXksVaktbc%3D 10.1016/S0003-9861(03)00219-4 12801511 (Pubitemid 36687915)
11. X Qi Z Chu 2004 Fusogenic domain and lysines in saposin C Arch Biochem Biophys 424 210 218 1:CAS:528:DC%2BD2cXisVejtbo%3D 10.1016/j.abb.2004.02.023 15047193 (Pubitemid 38401954)
12. Z Chu Y Sun CY Kuan GA Grabowski X Qi 2005 Saposin C: neuronal Effect and CNS Delivery by Liposomes Ann N Y Acad Sci 1053 237 246 1:CAS:528: DC%2BD28XotlKrsQ%3D%3D 10.1196/annals.1344.021 16179529 (Pubitemid 43031103)
13. X Qi Z Chu YY Mahller KF Stringer DP Witte TP Cripe 2009 Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein Clin Cancer Res 15 18 5840 5851 1:CAS:528:DC%2BD1MXhtFars73E 10.1158/1078-0432.CCR-08-3285 19737950
14. R Medzhitov P Preston-Hurlburt CA Janeway Jr 1997 A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 394 397 1:CAS:528:DyaK2sXkvVChurc%3D 10.1038/41131 9237759 (Pubitemid 27334820)
15. T Kawai S Akira 2006 TLR signaling Cell Death Differ 13 816 825 1:CAS:528:DC%2BD28XjsFWisbo%3D 10.1038/sj.cdd.4401850 16410796
16. T Chen XY Zhao Y Liu Q Shi ZC Hua PP Shen 2004 Analysis of immunomodulating nitric oxide, iNOS and cytokines mRNA in mouse macrophages induced by microcystin-LR Toxicology 197 67 77 1:CAS:528:DC%2BD2cXhs12htbg%3D 10.1016/j.tox.2003.12.013 15003335 (Pubitemid 38299215)
17. E Schreiber K Harshman I Kemler U Malipiero W Schaffner A Fontana, et al. 1990 Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins Nucleic Acids Res 18 5495 5503 1:CAS:528:DyaK3cXmt1yhur0%3D 10.1093/nar/18.18. 5495 2216722
18. S Lemay TV Lebedeva AK Singh 1999 Inhibition of cytokine gene expression by sodium salicylate in a macrophage cell line through an NFkappaB-independent mechanism Clin Diagn Lab Immunol 6 567 572 1:CAS:528:DyaK1MXkvV2lt7o%3D 10391864 (Pubitemid 29330744)
19. GR Stark IM Kerr BR Williams RH Silverman RD Schreiber 1998 How cells respond to interferons Annu Rev Biochem 67 227 264 1:CAS:528:DyaK1cXlsFOmsLo%3D 10.1146/annurev.biochem.67.1.227 9759489 (Pubitemid 28411130)
20. VED Barros BR Ferreira M Livonesi LTM Figueiredo 2009 Cytokine and nitric oxide production by mouse macrophages infected with brazilian flaviviruses Rev Inst Med Trop Sao Paulo 51 3 141 147 19551288
21. YC Lu WC Yeh PS Ohashi 2008 LPS/TLR4 signal transduction pathway Cytokine 42 145 151 1:CAS:528:DC%2BD1cXlslynt7c%3D 10.1016/j.cyto.2008.01.006 18304834
22. J Cuschieri J Billigren RV Maier 2006 Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation J Leukoc Biol 80 1289 1297 1:CAS:528:DC%2BD28XhtlSisLnP 10.1189/jlb.0106053 16959900 (Pubitemid 44911046)
23. VN Bochkov A Kadl J Huber F Gruber BR Binder N Leitinger 2002 Protective role of phospholipids oxidation products in endotoxin-induced tissue damage Nature 419 77 81 1:CAS:528:DC%2BD38Xmslahurc%3D 10.1038/nature01023 12214235 (Pubitemid 34987873)
24. ML Schmitz S Bacher M Kracht 2001 IκB-independent control of NF-κB activity by modulatory phosphorylations Trends Biochem Sci 26 186 190 1:CAS:528:DC%2BD3MXhs1els7w%3D 10.1016/S0968-0004(00)01753-9 11246025 (Pubitemid 32197579)
25. HA Young JH Bream 2007 IFN-γ: recent advances in understanding regulation of expression, biological functions, and clinical applications Curr Top Microbiol Immunol 316 97 117 1:CAS:528:DC%2BD1cXhs12rt7g%3D 10.1007/978-3-540-71329-6-6 17969445
26. H Sawada Y Mitani J Maruyama BH Jiang Y Ikeyama FA Dida, et al. 2007 a nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats Orig Res 132 1265 1274 1:CAS:528: DC%2BD2sXhtlaqur7L (Pubitemid 47621003)
27. T Kawai O Takeuchi T Fujita J Inoue PF Mühlradt S Sato, et al. 2001 Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes J Immunol 167 5887 5894 1:CAS:528: DC%2BD3MXotlamurc%3D 11698465 (Pubitemid 33062783)