Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1414-1418

  Skerlj, Renato ^a   Bridger, Gary ^a   McEachern, Ernest ^a   Harwig, Curtis ^a   Smith, Chris ^a   Kaller, Alan ^a   Veale, Duane ^a   Yee, Helen ^a   Skupinska, Krystyna ^a   Wauthy, Rossana ^a   Wang, Letian ^a   Baird, Ian ^a   Zhu, Yongbao ^a   Burrage, Kate ^a   Yang, Wen ^a   Sartori, Michael ^a   Huskens, Dana ^b   Clercq, Erik De ^b   Schols, Dominique ^b  

^a GENZYME CORPORATION   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

AMD070; Chemokine receptor; CXCR4; HIV 1; Structure activity relationship

Indexed keywords

8 [(4 AMINOBUTYL)(2 BENZIMIDAZOLYLMETHYL)AMINO] 1,2,3,4 TETRAHYDROQUINOLINE; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST;

ANTIVIRAL ACTIVITY; ARTICLE; DOG; DRUG DESIGN; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; RAT; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; DNA REPLICATION; DOGS; DRUG DESIGN; HETEROCYCLIC COMPOUNDS, 1-RING; HIV-1; MOLECULAR STRUCTURE; RATS; RECEPTORS, CXCR4; VIRUS REPLICATION;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS 1; RATTUS;

EID: 79951721508     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.021     Document Type: Article

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