HY251, a novel decahydrocyclopenta[a]indene analog, from Aralia continentalis induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1347-1349

  Oh, Ha Lim ^a   Lee, Chul Hoon ^b  

^a Hanyang University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Androgen receptor; Apoptotic induction; Aralia continentalis; LNCaP cells

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANTIANDROGEN; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; HY 251; INDENE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARALIA; ARALIA CONTINENTALIS; ARTICLE; CELL STRAIN LNCAP; DOWN REGULATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; NICK END LABELING; PROSTATE CANCER; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; ARALIA; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; INDENES; MALE; PLANT EXTRACTS; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; VINYL COMPOUNDS;

ARALIA CONTINENTALIS;

EID: 79951721262     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.045     Document Type: Article

References (23)

1. R.J. Bold, P.M. Termuhlen, and D.J. McConkey Surg. Oncol. 6 1997 133
2. S. Fulda, and K.M. Debatin Oncogene 25 2006 4798
3. M.K. Kim, J. Min, B.Y. Choi, H. Lim, Y.H. Cho, and C.H. Lee J. Microbiol. Biotechnol. 17 2007 1712
4. J. Kang, D.K. Lee, and C.H. Lee J. Microbiol. Biotechnol. 20 2010 433
5. H. Lim, H.L. Oh, and C.H. Lee J. Microbiol. Biotechnol. 16 2006 1399
6. S. Bracarda, O. de Cobelli, C. Greco, T. Prayer-Galetti, R. Valdagni, G. Gatta, F. de Braud, and G. Bartsch Crit. Rev. Oncol. Hematol. 56 2005 379
7. M.M. Bhuiyan, Y. Li, S. Banerjee, F. Ahmed, Z. Wang, S. Ali, and F.H. Sarkar Cancer Res. 66 2006 10064
8. R. Lieberman Am. J. Ther. 11 2004 501
9. C.D. Chen, D.S. Welsbie, C. Tran, S.H. Baek, R. Chen, R. Vessella, M.G. Rosenfeld, and C.L. Sawyers Nat. Med. 10 2004 33
10. L.G. Wang, L. Ossowski, and A.C. Ferrari Cancer Res. 61 2001 7544
11. B.H. Han, Y.N. Han, K.A. Han, M.H. Park, and E.O. Lee Arch. Pharm. Res. 6 1983 17
12. B.H. Han, M.H. Park, Y.N. Han, and J.B. Manalo Arch. Pharm. Res. 6 1983 75
13. S.Y. Ryu Arch. Pharm. Res. 19 1996 77
14. H.L. Oh, H. Lim, Y.H. Cho, H.C. Koh, H. Kim, Y. Lim, and C.H. Lee Bioorg. Med. Chem. Lett. 19 2009 959
15. H.L. Oh, H. Lim, Y. Park, Y. Lim, H.C. Koh, Y.H. Cho, and C.H. Lee Bioorg. Med. Chem. Lett. 19 2009 797
16. H.L. Oh, D.K. Lee, H. Lim, and C.H. Lee J. Ethnopharmacol. 129 2010 135
17. 23 House-keeping gene GAPDH was used to confirm the homogeneity of the DNA products.
18. C. Chang, A. Saltzman, S. Yeh, W. Young, E. Keller, H.J. Lee, C. Wang, and A. Mizokami Crit. Rev. Eukaryot. Gene Expr. 5 1995 97
19. J. Gobinet, N. Poujol, and C.H. Sultan Mol. Cell. Endocrinol. 198 2002 15
20. C. Huggins, and C.V. Hodges J. Urol. 168 2002 9
21. H.S. Moon, H. Lim, S. Moon, H.L. Oh, Y. Kim, M.K. Kim, and C.H. Lee Bioorg. Med. Chem. Lett. 19 2009 742
22. D.L. Marrocco, W.D. Tilley, T. Bianco-Miotto, A. Evdokiou, H.I. Scher, R.A. Rifkind, P.A. Marks, V.M. Richon, and L.M. Butler Mol. Cancer Ther. 6 2007 51
23. J.L. Kenneth, and D.S. Thomas Methods 25 2001 402