Benzyldihydroxyoctenone, a novel anticancer agent, induces apoptosis via mitochondrial-mediated pathway in androgen-sensitive LNCaP prostate cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 742-744

  Moon, Hong Sang ^a   Lim, Haeyoung ^a   Moon, Sangik ^a   Oh, Ha Lim ^a   Kim, Young Tae ^a   Kim, Min Kyoung ^b   Lee, Chul Hoon ^a  

^a Hanyang University   (South Korea)

^b Choongwae Pharma Co   (South Korea)

Author keywords

Androgen receptor; Apoptosis; Benzyldihydroxyoctenone; LNCaP cells; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; ANTINEOPLASTIC AGENT; BENZYLDIHYDROXYOCTENONE; BETA ACTIN; CYTOCHROME C; DNA FRAGMENT; F3 2 5; INHIBITOR OF APOPTOSIS PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROSTATE SPECIFIC ANTIGEN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

APOPTOSIS; AR GENE; ARTICLE; CELL CYCLE G1 PHASE; CELL STRAIN LNCAP; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG MECHANISM; DRUG POTENCY; ENZYME RELEASE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MITOCHONDRION; NICK END LABELING; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PSA GENE; QUANTITATIVE ANALYSIS; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; UPREGULATION; WESTERN BLOTTING;

ANDROGENS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DNA FRAGMENTATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU NICK-END LABELING; MALE; MITOCHONDRIA; MODELS, CHEMICAL; OCTANOLS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS;

STREPTOMYCES SP.;

EID: 58549091063     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.029     Document Type: Article

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