HY253, a novel decahydrofluorene analog, from Aralia continentalis, induces cell cycle arrest at the G1 phase and cytochrome c-mediated apoptosis in human lung cancer A549 cells

Journal of Ethnopharmacology

Volumn 129, Issue 1, 2010, Pages 135-139

  Oh, Ha Lim ^a   Lee, Dong Keun ^b   Lim, Haeyoung ^a   Lee, Chul Hoon ^a  

^a Hanyang University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

A549 cells; Apoptotic induction; Aralia continentalis; Cell cycle arrest

Indexed keywords

7,8A DIVINYL 2,4A,4B,5,6,7,8,8A,9,9A DECAHYDRO 1H FLUORENE 2,4A,4B,9A TETRAOL; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CELL DNA; CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; DECAHYDROFLUORENE DERIVATIVE; HY 253; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; SERINE; UNCLASSIFIED DRUG; 7,8A-DIVINYL-2,4A,4B,5,6,7,8,8A,9,9A-DECAHYDRO-1H-FLUORENE-2,4A,4B,9A-TETRAOL; CASPASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EID1 PROTEIN, HUMAN; FLUORENE DERIVATIVE; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

APOPTOSIS; ARALIA; ARALIA CONTINENTALIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; GENE ACTIVATION; HUMAN; HUMAN CELL; LUNG CANCER; NONHUMAN; PLANT ROOT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CHEMISTRY; DRUG EFFECTS; FLOW CYTOMETRY; ISOLATION AND PURIFICATION; LUNG NEOPLASMS; METABOLISM; MITOCHONDRION; NICK END LABELING; PHOSPHORYLATION; PHYTOTHERAPY; TUMOR CELL LINE; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ARALIA; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CYCLIN D; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROMES C; FLOW CYTOMETRY; FLUORENES; G1 PHASE; HUMANS; IN SITU NICK-END LABELING; LUNG NEOPLASMS; MITOCHONDRIA; NUCLEAR PROTEINS; PHOSPHORYLATION; PHYTOTHERAPY; PLANT ROOTS; POLY(ADP-RIBOSE) POLYMERASES; REPRESSOR PROTEINS; SERINE; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

ARALIA CONTINENTALIS;

EID: 77951977344     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.02.010     Document Type: Article

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