Effects of cytochrome P450 1A substrate (difloxacin) on enzyme gene expression and pharmacokinetics in crucian carp (hybridized Prussian carp)

Environmental Toxicology and Pharmacology

Volumn 31, Issue 2, 2011, Pages 307-313

  Fu, Gui Hong ^a   Yang, Xian Le ^a   Zhang, Hai Xin ^a   Yu, Wen Juan ^a   Hu, Kun ^a  

^a SHANGHAI OCEAN UNIVERSITY   (China)

Author keywords

Cytochromes P450 1A; Difloxacin; Gene expression; Pharmacokinetics

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450 1A; DIFLOXACIN; HEME; MESSENGER RNA;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CARP; CONTROLLED STUDY; CRUCIAN CARP; CYTOCHROME P450 1A GENE; DNA SEQUENCE; DRUG ABSORPTION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG METABOLISM; ENZYME ANALYSIS; ENZYME STRUCTURE; GENE; GENE EXPRESSION REGULATION; INTESTINE; KIDNEY PARENCHYMA; LIVER PARENCHYMA; MAXIMUM PLASMA CONCENTRATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PISCICULTURE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE HOMOLOGY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CARPS; CIPROFLOXACIN; CLONING, MOLECULAR; CYTOCHROME P-450 CYP1A1; DNA, COMPLEMENTARY; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HALF-LIFE; LIVER; MOLECULAR SEQUENCE DATA; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; TISSUE DISTRIBUTION;

ANIMALIA; CARASSIUS; CYPRINIDAE;

EID: 79951720916     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2010.11.009     Document Type: Article

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