Role of an extracellular loop in determining the stoichiometry of Na +-HCO 3 - cotransporters

Journal of Physiology

Volumn 589, Issue 4, 2011, Pages 877-890

  Chen, Li Ming ^a,b   Liu, Ying ^a,b   Boron, Walter F ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE SODIUM COTRANSPORTER; BICARBONATE SODIUM COTRANSPORTER E1 A; BICARBONATE SODIUM COTRANSPORTER N1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; EXTRACELLULAR FLUID; EXTRACELLULAR LOOP; FEMALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; STOICHIOMETRY; TRANSPORT KINETICS; VESTIBULE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CHIMERA; EXTRACELLULAR FLUID; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; SODIUM-BICARBONATE SYMPORTERS; STEREOISOMERISM; XENOPUS LAEVIS;

EID: 79951717294     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.198713     Document Type: Article

References (59)

1. Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A & Kurtz I (1998). Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem 273, 17689-17695.
2. Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Morrison J, Maranian M, Pooley KA, Luben R, Eccles D, Evans DG, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Stratton MR, Rahman N, Jacobs K, Prentice R, Anderson GL, Rajkovic A, Curb JD, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Diver WR, Bojesen S, Nordestgaard BG, Flyger H, Dork T, Schurmann P, Hillemanns P, Karstens JH, Bogdanova NV, Antonenkova NN, Zalutsky IV, Bermisheva M, Fedorova S, Khusnutdinova E, Kang D, Yoo KY, Noh DY, Ahn SH, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Garcia-Closas M, Lissowska J, Brinton L, Peplonska B, Nevanlinna H, Heikkinen T, Aittomaki K, Blomqvist C, Hopper JL, Southey MC, Smith L, Spurdle AB, Schmidt MK, Broeks A, van Hien RR, Cornelissen S, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Schmutzler RK, Burwinkel B, Bartram CR, Meindl A, Brauch H, Justenhoven C, Hamann U, Chang-Claude J, Hein R, Wang-Gohrke S, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Kataja V, Olson JE, Wang X, Fredericksen Z, Giles GG, Severi G, Baglietto L, English DR, Hankinson SE, Cox DG, Kraft P, Vatten LJ, Hveem K, Kumle M, Sigurdson A, Doody M, Bhatti P, Alexander BH, Hooning, MJ, Van Den Ouweland AM, Oldenburg RA, Schutte M, Hall P, Czene K, Liu J, Li Y, Cox A, Elliott G, Brock I, Reed MW, Shen CY, Yu JC, Hsu GC, Chen ST, Anton-Culver H, Ziogas A, Andrulis IL, Knight JA, Beesley J, Goode EL, Couch F, Chenevix-Trench G, Hoover RN, Ponder BA, Hunter DJ, Pharoah PD, Dunning AM, Chanock SJ & Easton DF (2009). Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41, 585-590.
3. +-coupled phosphate cotransporter. Proc Natl Acad Sci U S A 102, 12606-12611.
4. 3 cotransport. J Gen Physiol 110, 467-483.
5. 3 cotransporter (NBC) with a novel C terminus, cloned from rat brain. Am J Physiol Cell Physiol 278, C1200-C1211.
6. Bok D, Galbraith G, Lopez I, Woodruff M, Nusinowitz S, BeltrandelRio H, Huang WH, Zhao SL, Geske R, Montgomery C, Van Sligtenhorst I, Friddle C, Platt K, Sparks MJ, Pushkin A, Abuladze N, Ishiyama A, Dukkipati R, Liu WX & Kurtz I (2003). Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet 34, 313-319.
7. - transport. J Gen Physiol 81, 53-94.
8. Boron WF, Chen L & Parker MD (2009). Modular structure of sodium-coupled bicarbonate transporters. J Exp Biol 212, 1697-1706.
9. - blocked by cyanide. Nature 259, 240-241.
10. 3 and metabolic inhibitors. J Gen Physiol 67, 91-112.
11. - uptake into the rat choroid plexus epithelium is partially DIDS sensitive. Am J Physiol Cell Physiol 289, C1448-C1456.
12. Chen LM, Choi I, Haddad GG & Boron WF (2007). Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain. Am J Physiol Regul Integr Comp Physiol 293, R2412-R2420.
13. Chen LM, Kelly ML, Rojas JD, Parker MD, Gill HS, Davis BA & Boron WF (2008). Use of a new polyclonal antibody to study the distribution and glycosylation of the sodium-coupled bicarbonate transporter NCBE in rodent brain. Neuroscience 151, 374-385.
14. Chen LM, Zhao J, Musa-Aziz R, Pelletier MF, Drummond IA & Boron WF (2010). Cloning and characterization of a zebrafish homologue of human AQP1: a bifunctional water and gas channel. Am J Physiol Regul Integr Comp Physiol 299, 1163-1174.
15. Choi I, Aalkjær C, Boulpaep EL & Boron WF (2000). An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Nature 405, 571-575.
16. - cotransporter (NBCe1). Am J Physiol Renal Physiol 284, F1199-F1206.
17. Choi I, Yang HS & Boron WF (2007). The electrogenicity of the rat sodium-bicarbonate cotransporter NBCe1 requires interactions among transmembrane segments of the transporter. J Physiol 578, 131-142.
18. Compton EL, Taylor EM & Mindell JA (2010). The 3-4 loop of an archaeal glutamate transporter homolog experiences ligand-induced structural changes and is essential for transport. Proc Natl Acad Sci U S A 107, 12840-12845.
19. 3 cotransporter NBCn1 in rat hippocampal neurons. J Biol Chem 280, 17823-17830.
20. Dinour D, Chang MH, Satoh J, Smith BL, Angle N, Knecht A, Serban I, Holtzman EJ & Romero MF (2004). A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. J Biol Chem 279, 52238-52246.
21. Fei YJ, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, Boron WF & Hediger MA (1994). Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368, 563-566.
22. Fujinaga J, Tang XB & Casey JR (1999). Topology of the membrane domain of human erythrocyte anion exchange protein, AE1. J Biol Chem 274, 6626-6633.
23. +-coupled inorganic phosphate cotransporter (NaPi-IIc). J Physiol 587, 4293-4307.
24. 3 exchanger. J Biol Chem 276, 8358-8363.
25. +. J Physiol 531, 375-382.
26. + stoichiometry from 3:1 to 2:1 in murine proximal tubule cells. J Physiol 537, 659-665.
27. Groves JD & Tanner MJ (1994). Role of N-glycosylation in the expression of human band 3-mediated anion transport. Mol Membr Biol 11, 31-38.
28. Gurnett CA, Veile R, Zempel J, Blackburn L, Lovett M & Bowcock A (2008). Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. Arch Neurol 65, 550-553.
29. Hmani M, Ghorbel A, Boulila-Elgaied A, Ben Zina Z, Kammoun W, Drira M, Chaabouni M, Petit C & Ayadi H (1999). A novel locus for Usher syndrome type II, USH2B, maps to chromosome 3 at p23-24.2. Eur J Hum Genet 7, 363-367.
30. Horita S, Yamada H, Inatomi J, Moriyama N, Sekine T, Igarashi T, Endo Y, Dasouki M, Ekim M, Al Gazali L, Shimadzu M, Seki G & Fujita T (2005). Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities. J Am Soc Nephrol 16, 2270-2278.
31. Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G & Endou H (1999). Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nat Genet 23, 264-266.
32. - cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma. J Am Soc Nephrol 12, 713-718.
33. Inatomi J, Horita S, Braverman N, Sekine T, Yamada H, Suzuki Y, Kawahara K, Moriyama N, Kudo A, Kawakami H, Shimadzu M, Endou H, Fujita T, Seki G & Igarashi T (2004). Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis. Pflugers Archiv 448, 438-444.
34. Jacobs S, Ruusuvuori E, Sipila ST, Haapanen A, Damkier HH, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatikainen LM, Tyynela J, Praetorius J, Voipio J & Hubner CA (2008). Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci U S A 105, 311-316.
35. Lauritzen G, Jensen MB, Boedtkjer E, Dybboe R, Aalkjaer C, Nylandsted J & Pedersen SF (2010). NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance. Exp Cell Res 316, 2538-2553.
36. 3 cotransporter (hNBCe1-A): Importance of K558, K559 and K562 within the KKMIK motif of transmembrane segment 5. Am J Physiol Cell Physiol 292, C1787-C1798.
37. 3 cotransporter NBCe1-A in Xenopus oocytes. J Biol Chem 281, 19241-19250.
38. Majumdar D, Maunsbach AB, Shacka JJ, Williams JB, Berger UV, Schultz KP, Harkins LE, Boron WF, Roth KA & Bevensee MO (2008). Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain. Neuroscience 155, 818-832.
39. - cotransporter in human pancreas. Am J Physiol Gastrointest Liver Physiol 277, G487-G494.
40. 2+ concentration. Pflugers Archiv 442, 718-728.
41. Musa-Aziz R, Boron WF & Parker MD (2010). Using fluorometry and ion-sensitive microelectrodes to study the functional expression of heterologously-expressed ion channels and transporters in Xenopus oocytes. Methods 51, 134-145.
42. - self-exchange activity. J Biol Chem 283, 12777-12788.
43. +/glucose cotransporter SGLT1. J Biol Chem 282, 25222-25230.
44. Pushkin A, Abuladze N, Lee I, Newman D, Hwang J & Kurtz I (1999). Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family. J Biol Chem 274, 16569-16575.
45. 2-) transporters: classification, function, structure, genetic diseases, and knockout models. Am J Physiol Renal Physiol 290, F580-F599.
46. Romero MF (2005). Molecular pathophysiology of SLC4 bicarbonate transporters. Curr Opin Nephrol Hypertens 14, 495-501.
47. - transporters. Pflugers Archiv 447, 495-509.
48. - cotransporter. Nature 387, 409-413.
49. Sassani P, Pushkin A, Gross E, Gomer A, Abuladze N, Dukkipati R, Carpenito G & Kurtz I (2002). Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter. Am J Physiol Cell Physiol 282, C408-C416.
50. - cotransporter, rkNBC, expressed in oocytes. Am J Physiol Renal Physiol 277, F611-F623.
51. - cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. J Clin Invest 79, 1276-1280.
52. Stewart AK, Kurschat CE & Alper SL (2007a). Role of nonconserved charged residues of the AE2 transmembrane domain in regulation of anion exchange by pH. Pflugers Arch 454, 373-384.
53. Stewart AK, Kurschat CE & Alper SL (2007b). The SLC4 anion exchanger gene family. In Seldin and Giebisch's The Kidney: Physiology and Pathophysiology, eds. Alpern RJ & Hebert SC, pp. 1499-1537.
54. - cotransporter NBCe1 is associated with familial migraine. Proc Natl Acad Sci U S A 107, 15963-15968.
55. Tamura S, Nelson H, Tamura A & Nelson N (1995). Short external loops as potential substrate binding site of γ-aminobutyric acid transporters. J Biol Chem 270, 28712-28715.
56. - cotransporter (NBCe2). Am J Physiol Cell Physiol 282, C1278-C1289.
57. - exchanger: Cloning, tissue distribution, and functional characterization. J Biol Chem 275, 35486-35490.
58. Whitfield JB, Dy V, McQuilty R, Zhu G, Heath AC, Montgomery GW & Martin NG (2010). Genetic effects on toxic and essential elements in humans: arsenic, cadmium, copper, lead, mercury, selenium and zinc in erythrocytes. Environ Health Perspect 118, 776-782.
59. Zhu Q, Lee DW & Casey JR (2003). Novel topology in C-terminal region of the human plasma membrane anion exchanger, AE1. J Biol Chem 278, 3112-3120.