The 3-4 loop of an archaeal glutamate transporter homolog experiences ligand-induced structural changes and is essential for transport

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 29, 2010, Pages 12840-12845

  Compton, Emma L R ^a,b   Taylor, Erin M ^a   Mindell, Joseph A ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Conformational change; Mechanism; Neurotransmitter; Transporters

Indexed keywords

5 MALEIMIDOFLUORESCEIN; ASPARTIC ACID; BLOOD CLOTTING FACTOR 10A; CYSTEINE; GLUTAMATE TRANSPORTER; MALEIMIDE; PROTEINASE; SODIUM ION; TRYPSIN; UNCLASSIFIED DRUG;

ARCHAEBACTERIUM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; PYROCOCCUS HORIKOSHII; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; BIOLOGICAL TRANSPORT; CATTLE; FACTOR XA; FLUORESCEINS; GLUTAMATES; LIGANDS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PYROCOCCUS HORIKOSHII; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRYPSIN;

ARCHAEA; BACTERIA (MICROORGANISMS); PYROCOCCUS HORIKOSHII;

EID: 77955644600     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003046107     Document Type: Article

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