Genetic effects on toxic and essential elements in humans: Arsenic, cadmium, copper, lead, mercury, selenium, and zinc in erythrocytes

Environmental Health Perspectives

Volumn 118, Issue 6, 2010, Pages 776-782

  Whitfield, John B ^a   Dy, Veronica ^b   Mcquilty, Robert ^b   Zhu, Gu ^a   Heath, Andrew C ^c   Montgomery, Grant W ^a   Martin, Nicholas G ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

Arsenic; Cadmium; Copper; Erythrocytes; Genetics; Lead; Mercury; Selenium; Twins; Zinc

Indexed keywords

ARSENIC; CADMIUM; COPPER; GENE PRODUCT; LEAD; MERCURY; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; SELENIUM; SOLUTE CARRIER FAMILY 4 SODIUM BICARBONATE COTRANPORTER MEMBER 7; UNCLASSIFIED DRUG; ZINC; HEAVY METAL;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CHROMOSOMAL LOCALIZATION; CHROMOSOME 18; CHROMOSOME 2; CHROMOSOME 20; CHROMOSOME 3; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME 8; DIZYGOTIC TWINS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ERYTHROCYTE; FEMALE; GENETIC LINKAGE; GENOTOXICITY; HUMAN; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SOCIAL STATUS; X CHROMOSOME; ANALYSIS; AUSTRALIA; BLOOD; CHEMISTRY; CHROMOSOME MAP; GENE; GENETIC VARIABILITY; GENETICS; HUMAN CHROMOSOME; MIDDLE AGED; SOCIOECONOMICS; TWINS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ARSENIC; AUSTRALIA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; ENVIRONMENTAL EXPOSURE; ERYTHROCYTES; FEMALE; GENES; GENETIC VARIATION; HUMANS; MALE; MASS SPECTROMETRY; METALS, HEAVY; MIDDLE AGED; SELENIUM; SOCIOECONOMIC FACTORS; TWINS;

EID: 77953267514     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0901541     Document Type: Article

References (59)

1. Abecasis GR, Burt RA, Hall D, Bochum S, Doheny KF, Lundy SL, et al. 2004. Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1. Am J Hum Genet 74(3):403-417.
2. Alfven T, Elinder CG, Carlsson MD, Grubb A, Hellstrom L, Persson B, et al. 2000. Low-level cadmium exposure and osteoporosis. J Bone Miner Res 15:1579-1586.
3. Alfven T, Elinder CG, Hellstrom L, Lagarde F, Jarup L. 2004. Cadmium exposure and distal forearm fractures. J Bone Miner Res 19:900-905.
4. Axelrad DA, Bellinger DC, Ryan LM, Woodruff TJ. 2007. Dose-response relationship of prenatal mercury exposure and IQ: an integrative analysis of epidemiologic data. Environ Health Perspect 115:609-615.
5. Balshaw S, Edwards J, Daughtry B, Ross K. 2007. Mercury in seafood: mechanisms of accumulation and consequences for consumer health. Rev Environ Health 22:91-113.
6. Beekman M, Heijmans BT, Martin NG, Whitfield JB, Pedersen NL, DeFaire U, et al. 2003. Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population. Eur J Hum Genet 11(11):845-850.
7. Bellinger DC. 2008. Late neurodevelopmental effects of early exposures to chemical contaminants: reducing uncertainty in epidemiological studies. Basic Clin Pharmacol Toxicol 102:237-244.
8. Bjorkman L, Vahter M, Pedersen NL. 2000. Both the environment and genes are important for concentrations of cadmium and lead in blood. Environ Health Perspect 108:719-722.
9. Borak J, Hosgood HD. 2007. Seafood arsenic: implications for human risk assessment. Regul Toxicol Pharmacol 47:204-212.
10. Canfield RL, Henderson CR Jr, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP. 2003. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med 348:1517-1526.
11. Coronado-Gonzalez JA, Del Razo LM, Garcia-Vargas G, Sanmiguel-Salazar F, Escobedo-de la Pena J. 2007. Inorganic arsenic exposure and type 2 diabetes mellitus in Mexico. Environ Res 104:383-389.
12. Davidson PW, Myers GJ, Weiss B. 2004. Mercury exposure and child development outcomes. Pediatrics 113(suppl 4):1023-1029.
13. Ekino S, Susa M, Ninomiya T, Imamura K, Kitamura T. 2007. Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning. J Neurol Sci 262:131-144.
14. Friberg L, Piscator M, Nordberg GF, Kjellstrom T. 1974. Cadmium in the Environment. 2nd ed. Cleveland, OH:CRC Press.
15. Grandjean P, Olsen NB, Hollnagel H. 1981. Influence of smoking and alcohol consumption on blood lead levels. Int Arch Occup Environ Health 48:391-397.
16. Grasmick C, Huel G, Moreau T, Sarmini H. 1985. The combined effect of tobacco and alcohol consumption on the level of lead and cadmium in blood. Sci Total Environ 41:207-217.
17. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488.
18. Hasselbalch AL, Heitmann BL, Kyvik KO, Sorensen TI. 2008. Studies of twins indicate that genetics influence dietary intake. J Nutr 138:2406-2412.
19. Hense HW, Filipiak B, Novak L, Stoeppler M. 1992. Nonoccupational determinants of blood lead concentrations in a general population. Int J Epidemiol 21:753-762.
20. Hodgson S, Nieuwenhuijsen MJ, Elliott P, Jarup L. 2007. Kidney disease mortality and environmental exposure to mercury. Am J Epidemiol 165:72-77.
21. Hopper JL, Balderas A, Mathews JD. 1982. Analysis of variation in blood lead levels in Melbourne families. Med J Aust 2:573-576.
22. Hopper JL, Mathews JD. 1983. Extensions to multivariate normal models for pedigree analysis. II. Modeling the effect of shared environment in the analysis of variation in blood lead levels. Am J Epidemiol 117:344-355.
23. Jemal A, Graubard BI, Devesa SS, Flegal KM. 2002. The association of blood lead level and cancer mortality among whites in the United States. Environ Health Perspect 110:325-329.
24. Lloyd B, Lloyd RS, Clayton BE. 1983. Effect of smoking, alcohol, and other factors on the selenium status of a healthy population. J Epidemiol Community Health 37:213-217.
25. Lugon-Moulin N, Martin F, Krauss MR, Ramey PB, Rossi L. 2006. Cadmium concentration in tobacco (Nicotiana tabacum L.) from different countries and its relationship with other elements. Chemosphere 63:1074-1086.
26. Lustberg M, Silbergeld E. 2002. Blood lead levels and mortality. Arch Intern Med 162:2443-2449.
27. Manton WI, Rothenberg SJ, Manalo M. 2001. The lead content of blood serum. Environ Res 86:263-273.
28. Martin MD, Naleway C. 2004. The inhibition of mercury absorption by dietary ethanol in humans: cross-sectional and case-control studies. Occup Environ Med 61:e8; doi:10.1136/oem.2003.007542.
29. Menke A, Muntner P, Batuman V, Silbergeld EK, Guallar E. 2006. Blood lead below 0.48 micromol/L (10 microg/dL) and mortality among US adults. Circulation 114:1388-1394.
30. Miller SA, Dykes DD, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215.
31. Moreau T, Orssaud G, Lellouch J, Claude JR, Juguet B, Festy B. 1983. Blood cadmium levels in a general male population with special reference to smoking. Arch Environ Health 38:163-167.
32. Navarro Silvera SA, Rohan TE. 2007. Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control 18:7-27.
33. Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. 2007. Lead exposure and cardiovascular disease-a systematic review. Environ Health Perspect 115:472-482.
34. Navas-Acien A, Selvin E, Sharrett AR, Calderon-Aranda E, Silbergeld E, Guallar E. 2004. Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circulation 109:3196-3201.
35. Navas-Acien A, Silbergeld EK, Streeter RA, Clark JM, Burke TA, Guallar E. 2006. Arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidence. Environ Health Perspect 114:641-648.
36. Neale MC. 1999. Mx: Statistical Modeling. 5th ed. Richmond, VA: Medical College of Virginia.
37. Needleman H. 2004. Lead poisoning. Annu Rev Med 55:209-222.
38. Oakes EJ, Lyon TD, Duncan A, Gray A, Talwar D, O'Reilly DS. 2008. Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium. Clin Nutr 27:115-120.
39. Peraza MA, Ayala-Fierro F, Barber DS, Casarez E, Rael LT. 1998. Effects of micronutrients on metal toxicity. Environ Health Perspect 106(suppl 1):203-216.
40. Pocock SJ, Smith M, Baghurst P. 1994. Environmental lead and children's intelligence: a systematic review of the epidemiological evidence. BMJ 309:1189-1197.
41. Ringstad J, Knutsen SF, Nilssen OR, Thomassen Y. 1993. A comparative study of serum selenium and vitamin E levels in a population of male risk drinkers and abstainers. A population-based matched-pair study. Biol Trace Elem Res 36:65-71.
42. Satarug S, Baker JR, Urbenjapol S, Haswell-Elkins M, Reilly PE, Williams DJ, et al. 2003. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol Lett 137:65-83.
43. Schober SE, Mirel LB, Graubard BI, Brody DJ, Flegal KM. 2006. Blood lead levels and death from all causes, cardiovascular disease, and cancer: results from the NHANES III mortality study. Environ Health Perspect 114:1538-1541.
44. Schutz A, Bergdahl IA, Ekholm A, Skerfving S. 1996. Measurement by ICP-MS of lead in plasma and whole blood of lead workers and controls. Occup Environ Med 53:736-740.
45. Schwartz BS, Hu H. 2007. Adult lead exposure: time for change. Environ Health Perspect 115:451-454.
46. Schwartz J. 1994. Low-level lead exposure and children's IQ: a meta-analysis and search for a threshold. Environ Res 65:42-55.
47. Shaper AG, Pocock SJ, Walker M, Wale CJ, Clayton B, Delves HT, et al. 1982. Effects of alcohol and smoking on blood lead in middle-aged British men. Br Med J (Clin Res Ed) 284:299-302.
48. Shih RA, Hu H, Weisskopf MG, Schwartz BS. 2007. Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Environ Health Perspect 115:483-492.
49. Snook JT. 1991. Effect of ethanol use and other lifestyle variables on measures of selenium status. Alcohol 8:13-16.
50. Thompson WW, Price C, Goodson B, Shay DK, Benson P, Hinrichsen VL, et al. 2007. Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years. N Engl J Med 357:1281-1292.
51. Vahter M, Lind B. 1986. Concentrations of arsenic in urine of the general population in Sweden. Sci Total Environ 54:1-12.
52. Virtanen JK, Rissanen TH, Voutilainen S, Tuomainen TP. 2007. Mercury as a risk factor for cardiovascular diseases. J Nutr Biochem 18:75-85.
53. Vitoux D, Arnaud J, Chappuis P. 1999. Are copper, zinc and selenium in erythrocytes valuable biological indexes of nutrition and pathology? J Trace Elem Med Biol 13:113-128.
54. von Ehrenstein OS, Poddar S, Yuan Y, Mazumder DG, Eskenazi B, Basu A, et al. 2007. Children's intellectual function in relation to arsenic exposure. Epidemiology 18:44-51.
55. Wang CH, Hsiao CK, Chen CL, Hsu LI, Chiou HY, Chen SY, et al. 2007. A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. Toxicol Appl Pharmacol 222:315-326.
56. Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline J, et al. 2007. Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh. Environ Health Perspect 115:285-289.
57. Weisskopf MG, Wright RO, Schwartz J, Spiro A III, Sparrow D, Aro A, et al. 2004. Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study. Am J Epidemiol 160:1184-1193.
58. Whitfield JB, Dy V, McQuilty R, Zhu G, Montgomery GW, Ferreira MA, et al. 2007. Evidence of genetic effects on blood lead concentration. Environ Health Perspect 115:1224-1230.
59. Whitfield JB, Fletcher LM, Murphy TL, Powell LW, Halliday J, Heath AC, et al. 1998. Smoking, obesity, and hypertension alter the dose-response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake. Clin Chem 44(12):2480-2489